KR880001091B1 - Antiinflammatory analgesic poultice - Google Patents

Abstract

Antiinflammatory and analgesic surgical dressings, which produce cool sensation to the skin, consist of 2 layers of materials; a layer of a water-insol. and water-absorbing resin and a layer of a drug-contg. adhesive. Thus, an acrylic acid-starch copolymer is applied to a polyethylene unwoven sheet at 0.5g/100cm2, and the copolymer is sandwiched by covering with another polyethylene sheet. This is laminated with 8 layer of an adhesive (1g/100cm2) prepd. by mixing polystyrene rubber 10, rosin 3, and liq. paraffin 15 parts at 140≰C in N2 and combining with Me salicylate 1.5, menthol 1.0, and camphor 1.0 parts.

Description

Anti-inflammatory analgesic

1 is an enlarged cross-sectional perspective view of the main portion showing an example of the composition of the coating agent of the present invention,

2 is a graph showing the change in skin temperature over time,

3 is a graph showing the diffusion rate in the poultice over time.

* Explanation of symbols for main parts of the drawings

1: poultice agent 4: support

2, 2: bubble 5: chemical layer

3: Water Insoluble Absorbent Resin Layer 6: Release Paper

The present invention relates to an anti-inflammatory analgesic poultice. More specifically, it relates to an anti-inflammatory analgesic poultice having a cooling effect.

The poultice agent of the present invention has a synergistic effect of cold feeling and anti-inflammatory analgesic effect on various symptoms such as bruises, saccharin or arthritis that requires a cold feeling effect, and a dog's syndrome. will be.

The anti-inflammatory analgesic agent for the various symptoms is an anti-inflammatory analgesic agent such as salicylic acid, menthol, or camphor, which is directly applied to or attached to the skin as a main ingredient, for example, a prestar agent, a liquid. ), Aerosol, ointment, poultice and the like has been widely used in general. The therapeutic effect of these anti-inflammatory drugs only comes from the anti-inflammatory analgesic effect of the anti-inflammatory analgesic drug itself as a main medicine, and its own effects can be obtained.

However, on the other hand, the temperature of the inflammatory site is higher than usual, so that the patient is expected to be provided with a poultice agent which can provide an anti-inflammatory analgesic effect and a sufficient cooling effect at the same time to be freed from the heat of the inflammatory site. However, from this point of view, there is nothing that satisfies the above-mentioned requirements in conventional products, in particular, conventional poultices.

In other words, in the conventional products, the cooling effect itself is insufficient, and the sustainability of the cooling effect is insufficient, and in the case of continuing to compress for a long time, the patient feels a burning sensation because the poultice itself loses moisture and solidifies by drying. .

The reason for the above-mentioned drawback of the conventional product is because, after all, there is a certain limit that high water content cannot be expected from the description of the conventional product. In general, in the conventional products, the absorption capacity of the base material is about 10 to 30 ml / g even when using either of the synthetic polymer and the natural polymer, and naturally, if the product is considered to prevent the phenomenon of falling in summer, The water content is limited to a lower range.

Minil and poultice itself can contain a large amount of water, and if a large amount of water can be maintained for a long time, first, a large amount of water volatilizes and takes away the heat of vaporization, thereby creating a cool feeling in the inflammatory area. Secondly, the poultice itself is dry solidified and cracked, so that the anti-inflammatory analgesic effect is not significantly reduced.

In view of this, the present inventors are antifoaming agents containing anti-inflammatory analgesic, and have a stronger water-retaining pore-forming agent, that is, both effects are increased while simultaneously cooling effect and anti-inflammatory analgesic effect for a long time, and further results are obtained. The structure of the poultice agent which can be heightened was examined in various ways.

As a result, an anti-inflammatory analgesic drug and an adhesive layer made of an adhesive base material are superimposed in layers on the support in which the water-insoluble absorbent resin is inserted in the send position between the two bubbles, and a predetermined object is formed. It has been found that this is achieved, and the present invention can be completed.

Hereinafter, the present invention will be described in detail. First, the overall configuration of the poultice agent of the present invention is as follows.

The basic structure of the whole consists of two parts of a support body and a chemical | medical agent layer, both are layered, and both are overlapped in a layered form, and they are further folded on the upper surface of a release paper and a chemical | medical agent layer as needed. . In the case of adhesion to the affected part, when there is no release paper, the release paper is peeled off, and when the release paper is present, the drug layer is attached to the skin surface so that the support is upward. The support is sprayed with water on its upper surface before or after it is repeatedly attached to it to contain water. Referring to this embodiment, as shown in FIG. 1, the poultice agent 1 of the present invention is inserted in the send position of the water-insoluble absorbent resin layer 3 between two bubbles 2 and 2 to form the support 4. The chemical | medical agent layer 5 is laminated | stacked in the layered form on one side of the support body 4, The poultice agent by which the support body 4 was cut | disconnected in the suitable dimension is made with the appropriate non-breathable cloth material, for example, aluminum foil, aluminum foil laminate paper, synthetic resin cord paper, etc. Is packed.

Reference numeral 6 denotes a release paper attached to the chemical layer 5.

In the method for preparing the support, for example, a polyethylene nonwoven fabric or a cotton planar is used as a bubble in a flat surface, and a particulate water-insoluble absorbent resin is spread thereon, and the other foam is further covered from the top, and the whole is in the send position. Shall be.

Next, the mixture is treated with water vapor to be dried, and the whole is thermally bonded through an emposol. Alternatively, the water-insoluble absorbent resin may be sprayed onto paper or the like to form a sheet, which may be cut in a fixed manner, set between two bubbles, and the peripheral edge may be thermally bonded. In this case, paper or the like is used only to facilitate spreading and set-up, so that the use and the structure of inserting the paper or the like fall within the technical scope of the present invention.

Even if the water-soluble insoluble absorbent resin is inserted into the send position between the two bubbles, the support is actually laminated in the form of two bubbles in a packaged state, and has a structure in which the water-insoluble absorbent resin is filled therein. It is. Herein, the water-insoluble absorbent resin corresponds to a concept that has conventionally been referred to simply as a superabsorbent resin, a superabsorbent high subsidiary material, or a super absorbent. That is, for example, as described in several of the following documents, it refers to a group of polymer materials that absorb hundreds of times its own weight and do not significantly deteriorate its shape thereon. Or Super Abzovent, etc., but there is no unified and widely used expression.

ㅇ Chemical Technology MOL November 1979, pages 25 to 29. Tsunah Shogo's "All of Super Absorbent Polymers"

ㅇ Organic synthetic chemistry, Vol. 38, No. 6 (1980) pages 546 to 554, by Genji Atsuhina, "Super Abzovent"

However, the thing of common concept which means by these names already exists and resin which belongs to this concept is defined as water-insoluble water absorbing resin in this invention.

Illustrative specific materials include the following.

Polymers obtained by polymerizing a water-soluble monomer and / or a monomer (A) which is passive by hydrolysis with starch and / or cellulose (B) and / or a crosslinking agent (C) as essential components and hydrolyzing as necessary, eg Starch polyacrylic acid copolymers. Or polymerized (A) and (B): for example, hydrolyzate of starch acrylonitrile graft copolymer, cellulose acrylic acid copolymer and salts thereof; Copolymers of (B) and (C), for example polyacrylamides crosslinked with divinyl compounds (methylene pastatamide, etc.) and partial hydrolysates thereof, crosslinked sulfonated polystyrenes, crosslinked polyvinyl alcohols, crosslinking Polyvinylpyrrolidone, crosslinked polyvinyl toluene sulfonate, crosslinked vinyl ester unsaturated carboxylic acid copolymer saponified, crosslinked polyethylene oxide and the like.

Moreover, the following various parts are listed for reference about the manufacturing method, the property, etc. of these polymers. JP-A 52-149190, JP-A 51-125468, JP-A 52-25886, JP-A 52-59690, JP-A 52-14689, JP-A 52-27455, etc. to be.

In the present invention, the water-insoluble water-absorbent resin preferably has a particle size of 2000 µm or less, and the amount of the water-insoluble absorbent resin that is inserted into a layer on the send position between two bubbles is preferably 0.01 to 1.0 g / 100 cm 2.

For example, when Sunwood IM-300 (the all-polyacrylic acid copolymer made from Sanyo Chemical Co., Ltd.) is used, it is appropriate to insert a thing having a particle diameter of 300 µ or less so as to be 0.5 g / 100 cm 2.

Next, the two bubbles thermally bonded at the periphery may be any water-permeable material such as cotton planar, car-made, paper, or non-woven fabric. However, non-water-permeable materials such as synthetic resin films may be used for the bubbles on the chemical layer side. have. Preferable examples include the case where the polyethylene nonwoven fabric or the upper surface is cotton planar, and the lower surface is a polyethylene nonwoven fabric.

As described above, the support contains a water-insoluble absorbent resin that absorbs water hundreds of times its own weight, so that the support contains a large amount of water by adding water from its upper surface. As a result, the moisture content in the poultice agent of the present invention is remarkably high, and exhibits an excellent cooling effect on the affected part, and prevents the chemical layer from drying and cracking. It is as shown in the effect example 1 which mentions the outstanding cooling effect by the water contained in this invention's poultice support body.

Further, in order to increase the absorption rate of the support, the pump quality can be mixed in a layer formed from the water-insoluble absorbent resin. That is, the water added to the upper surface of the support is quickly pumped into the resin layer, and has a function of repairing this in water-insoluble absorbent resin, which can meet the demand of emergency use in a patient. Use of this technique is included in the embodiments of the present invention. In addition, the water to the support can be wetted with the preservative in addition to the use of the foaming agent, during the preparation process, to cover the wet support with a non-breathable cloth, so that the support can be used without watering the support.

Next, the pharmaceutical ingredient used as the pharmaceutical layer may be applied with the usual anti-inflammatory anti-inflammatory plaster or puff as it is, but basically the anti-inflammatory analgesic and the base which are main drugs are composed of a so-called adhesive base. Use it.

As an anti-inflammatory analgesic drug, at least one of salicylic acids, such as methyl salicylate and glycol salicylate, menthol and camphor, is used. These are urea for the antifoaming agent of the present invention.

As an anti-inflammatory analgesic agent, it is free to add, in addition, extracts of plant components, fruit extracts of Chil-seop-su, yellow-tree powder, or saisaicin. In addition, it is also free to add vitamin E rouge for the purpose of enhancing anti-inflammatory analgesic effect, and for promoting antihistamines such as diphenhydramine or peripheral forms.

The adhesive base is mainly composed of an elastic body, an adhesive enhancer, a deteriorating agent, a plasticizer, and the like. In the present invention, the elastic body includes raw rubber, refined paragora rubber, polystyrene rubber, polyvinyl butyra, ester rubber, vinyl chloride, and vinyl acetate copolymer. In addition, rosin, rosin, polyester resin, etc., and vegetable oil and mineral oil are used as a softening agent. The drug layer exerts an anti-inflammatory analgesic effect directly on the affected area, but rises with the cooling effect of the support, and can show more therapeutic results, and the results are as shown in Effect Example 2 described later.

The preparation of the poultice agent of the present invention is carried out as follows. First, the support is made as follows. Water-insoluble water-absorbent resin is added to a bubble, for example, a polyethylene nonwoven fabric, and then another bubble is stacked thereon, onto the send position, water vapor is added, and then dried and fixed through an emposor roll.

As a poultice agent, it cuts to predetermined size as needed, and heat-bonds the peripheral part as a support body. Alternatively, the sheet or sheet may be formed into a sheet in advance, cut into a predetermined size, set between two bubbles, and, for example, thermally bonded to the periphery to serve as a support. The acid value is suitably 0.01 to 1.0 / 100 cm 2 here. In addition, the cutting size is preferably 8 cm x 13 cm, for example.

Next, the pharmaceutical ingredient may be prepared according to a conventional method, but for example, the adhesive base is heated to 140 ° C. to be in the liquid phase, and an anti-inflammatory analgesic drug containing any one or more of salicylic acid, menthol and camphor is added thereto, and homogeneously. It is mixed.

Finally, when the chemical ingredient is hot, it is applied to the support, and the release paper is put thereon to form the final product through the rolls. On the contrary, the chemical | medical agent layer may be apply | coated to a release paper, the support body may be placed on it, and it may pass through between rolls, and any method is possible. Although the thickness of the applied chemical | medical agent layer is not specifically limited, For example, the thickness of 50 micrometers-200 micrometers is preferable.

The effect of the poultice agent of this invention is demonstrated with the effect example described below.

[Effect Example 1]

sample

The poultice agent of the present invention produced by the method described in Example 1 was used as a specimen. As a control sample, a poultice agent prepared as follows is used. 10 parts of gelatin, 6 parts of carboxymethyl cellulose, 15 parts of kaolin, 30 parts of glycerin, 0.15 parts of sodium polyacrylate, 3 parts of zinc oxide, 35.15 parts of purified water, 0.3 parts of methyl salicylate, 0.2 parts of menthol, 0.2 parts of camphor Then, paint it on the surface flannel to 16g / 100 ㎠. The content of drug per 100 cm 2 area is almost the same between the sample and the control sample.

Way

(A) In the control sample, 100 cm 2 width of the poultice agent is left as it is, and in the sample sample, 100 cm width of the poultice agent, 16 g of water was injected into the opposite side of the drug layer, and after 2-3 minutes, the water was washed off. It is attached to the left and right inner side arms, and the skin temperature of the attached part is measured over time. Furthermore, skin temperature is measured by a sensor fixed with a band-aid between the sample and the skin.

(B) For each of the sample and the control, 16 g of water was injected into the opposite side of the drug layer, and after 2 to 3 minutes, the product was wiped off, attached to the left and right arms, and the weight of the attached poultice agent itself was measured over time. Obtain the volatilization rate as

×100%Volatilization rate =

× 100%

result

(A) The result of the time course of skin temperature change is shown in FIG. In the meantime, the dashed line indicates the control and the solid line indicates the sample. The control shows an example of a conventional product, and from FIG. 2 it is found that the poultice agent of the present invention produces a constant cooling effect over a long time compared with the conventional product.

표선은 대조에 대한것,

표선은 검체에 대한 것을 표시한다. 여기서 본 발명 습포제는 장시간에 걸쳐서 일정량의 수분의 휘산이 계속 이어져 있고, 따라서 피부면으로부터 상당량의 기화열이 빼앗겨 있어, 냉감효과에 관한(A)의 결과를 잘 설명하고 있다. 이에 반하여 대조습포제에 있어서는 첨부후 즉시 휘산이 정지되어, 이미 기화열을 빼앗을 수분이 존재하지 않는 것이 판명된다.(B) The result about the time-dependent change of the volatilization rate in a poultice agent is shown in FIG. In Figure 3,

The election is about contrasts,

Mark marks indicate specimens. Herein, the poultice agent of the present invention continues a volatilization of a certain amount of water over a long period of time, and therefore a considerable amount of heat of vaporization is deprived from the skin surface, and the results of (A) regarding the cooling effect are well explained. On the other hand, in the case of the control foam, volatilization is stopped immediately after attachment, and it turns out that there is no moisture which will take away heat of vaporization already.

[Effect Example 2]

sample

Example 2 The present invention poultice produced by the method described.

Way

First, without adding water to the support, the present invention is attached to the affected part of the patient as it is once or twice a day to test the treatment in anticipation of only the anti-inflammatory analgesic effect by the main medicine as in the conventional product, and do not obtain special therapeutic results. In the case of the unsuccessful patient, 25 ml of water is added to the upper surface of the supporter, water is added to the poultice agent of the present invention, and it is attached to the affected part 1-2 times a day, and the therapeutic result is observed after 2 days. In addition, for patients with arthritis, hay fever, and dog arthropathy syndrome, only patients deemed to have a cooling effect are selected.

result

The results are shown in Table 1.

From Table 1, it can be seen that the present invention, the poultice agent in addition to the anti-inflammatory analgesic effect as well as the cooling effect can obtain excellent therapeutic results not seen in the conventional products.

TABLE 1

The present invention will be described in more detail with reference to the following examples.

Example 1

Spread 0.5 g / 100 cm2 of Sunwood IM-300 on a polyethylene nonwoven fabric, place dozens of polyethylene nonwovens on it, sprinkle it with water vapor, dry it, fix it with an emposol, cut it into a size of 9cm × 14cm, and heat-bond all sides to support it. do.

10 parts of polystyrene polymers, 3 parts of rosin, and 15 parts of liquid paraffin are heated and melted at 140 DEG C in a nitrogen gas stream. After cooling to 120 ° C., 1.5 parts of methyl salicylate, 1.0 part of menthol, and 1.0 part of camphor are stirred and mixed in a nitrogen gas stream to form a pharmaceutical ingredient.

The pharmaceutical ingredient is applied on a support using a hot melt applicator so as to be 1 g / 100 cm 2, and a silicone film-processed release film is attached thereon to obtain the present invention's poultice agent.

Example 2

Sprinkle 0.5 g / 100 cm2 of Sunwood IM-300 on the polyethylene nonwoven fabric, place the polyethylene nonwoven fabric on top of it, sprinkle with water vapor, dry it, and fix it with emposrol. 425 parts of polystyrene rubber, 340 parts of rosin and 85 parts of liquid paraffin are heated and dissolved in 140 degreeC in nitrogen gas stream. After cooling to 120 ° C., 15 parts of methyl salicylate, 60 parts of salicylic acid monoglycone, 45 parts of menthol, and 30 parts of camphor are added and mixed to form a pharmaceutical ingredient. The drug ingredient is extended so as to be 1 g / 100 cm 2 on the support using an injector, covered with a liner, cooled to room temperature, cut into a size of 9 cm x 14 cm to form the poultice agent of the present invention.

Claims (7)

The water-absorbing water-absorbing resin layer is layered between the support and the anti-inflammatory analgesic drug containing at least one of salicylic acid, menthol, camphor and the drug layer made of a sticky base layer are layered between two bubbles Anti-inflammatory analgesic poultice. The water-insoluble water-absorbent resin layer is obtained by polymerizing a component selected from the group consisting of a water-soluble monomer and a hydrolysis-soluble monomer (A), a whole, and a cellulose (B) and a crosslinking agent (C). Anti-inflammatory analgesic poultice which is a polymer. The antifoaming antifoaming agent according to claim 2, wherein the polymer is an all-polyacrylic acid copolymer. The anti-inflammatory analgesic foaming agent according to claim 1, wherein the bubbles are cotton cloth, rayon, lint cloth, paper, synthetic water film, and nonwoven fabric. The antifoaming antifoaming agent of Claim 1 in which the bubble of the support body which a chemical | medical agent layer contacts is a non-water-permeable material. The anti-inflammatory analgesic poultice according to claim 1, wherein the water-insoluble absorbent resin layer is kept wet. The antifoaming antifoaming agent of Claim 1 in which the support body and chemical | medical agent layer which contain a water-insoluble absorptive resin layer are covered with the non-permeable foam.

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