JP3044352B2 - Patch - Google Patents
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- Publication number
- JP3044352B2 JP3044352B2 JP1301303A JP30130389A JP3044352B2 JP 3044352 B2 JP3044352 B2 JP 3044352B2 JP 1301303 A JP1301303 A JP 1301303A JP 30130389 A JP30130389 A JP 30130389A JP 3044352 B2 JP3044352 B2 JP 3044352B2
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- Japan
- Prior art keywords
- patch
- water
- moisture permeability
- support
- plaster
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【発明の詳細な説明】 産業上の利用分野 本発明は、含水性膏体を用いた貼付剤に関する。Description: TECHNICAL FIELD The present invention relates to a patch using a water-containing plaster.
従来の技術 従来、含水性膏体を用いる貼付剤においては、支持体
として不織布、織布等の透湿性の極めて高い素材が用い
られてきた。しかしながら、含水性の膏体は、30〜60％
が水であるため、皮膚へ貼付後の水分の蒸散により、膏
体が硬化し、有効成分の皮膚への移行性の低下、粘着力
の低下が問題であった。2. Description of the Related Art Conventionally, in a patch using a water-containing plaster, a material having extremely high moisture permeability, such as a nonwoven fabric or a woven fabric, has been used as a support. However, hydrous plasters are 30-60%
Since water is water, the plaster hardens due to the evaporation of water after being applied to the skin, and there has been a problem that the transferability of the active ingredient to the skin and the adhesive strength are reduced.
一方、支持体の透湿性を極めて低くすることにより有
効成分の皮膚への移行を高める手法は、ODT療法と呼ば
れ既に公知であり、ステロイド剤を非水系基材に配合
し、密封性の高い（透湿性の低い）高分子フィルムに展
延した製剤が用いられている。しかしながら、このステ
ロイド系製剤は、有効成分の皮膚への移行は高いもの
の、皮膚刺激性の点で問題があった。On the other hand, a technique of increasing the transfer of the active ingredient to the skin by making the moisture permeability of the support extremely low is known as ODT therapy, and a steroid agent is blended with a non-aqueous base material, and the sealing property is high. Formulations spread on polymer films (low moisture permeability) are used. However, this steroid-based preparation has a problem in terms of skin irritation although the active ingredient is highly transferred to the skin.
含水ゲル基材を30μｍ程度の厚さの透湿性の低い高分
子フィルム（ポリエチレン等）に展延した場合において
は、膏体中の水分の蒸散がほぼ完全に抑えられるととも
に、生体中の水分も加わり膏体が“むれた”状態とな
る。その結果、非水系基材を用いた場合と同様に有効成
分の皮膚移行性は高まるが、一方において皮膚刺激性も
高まりカユミ、カブレの原因となったり、剥離後の皮膚
へのベタツキが生じる。When the hydrogel base material is spread on a low moisture-permeable polymer film (eg, polyethylene) having a thickness of about 30 μm, the evaporation of water in the plaster is almost completely suppressed, and the water in the living body is also reduced. In addition, the plaster is in a "peeled" state. As a result, as in the case of using a non-aqueous base material, the ability of the active ingredient to migrate to the skin is enhanced, but on the other hand, the skin irritation is also enhanced, causing swelling and rash, and sticking to the skin after peeling.
発明が解決しようとする課題 本発明は、含水性膏体を用いた貼付剤において、皮膚
刺激性および剥離後の皮膚へのベタツキを抑えて、しか
も、有効性と粘着性を向上することを目的とする。Problems to be Solved by the Invention The present invention has an object to provide a patch using a water-containing plaster, which suppresses skin irritation and stickiness to the skin after exfoliation, and furthermore, aims to improve effectiveness and adhesiveness. And
発明の構成 本発明の貼付剤は、支持体部と含水性膏体部とを有す
る貼付剤において、支持体部が高分子フィルムと多孔性
シートとが一体化されたシート状体からなり、この支持
体部のJIS一般試験法「防湿包装材料の透湿度試験法
（カップ法）」（JIS Z 0208−1976）の条件Ａにより測
定したとき透湿度が100〜4000g/m2/24hr、好ましくは10
00〜3000g/m2/24hrの範囲にあり、含水性膏体部のボー
ルタック法（JIS Z 0237−1980）粘着力がNo.10以上で
あることを特徴とする。Constitution of the invention The patch of the present invention is a patch having a support portion and a water-containing plaster portion, wherein the support portion is formed of a sheet-like body in which a polymer film and a porous sheet are integrated. The moisture permeability of the support is 100 to 4000 g / m 2/24 hr, preferably 100 to 4000 g / m 2, measured under the condition A of JIS General Test Method “Moisture Permeability Test Method for Moistureproof Packaging Materials (Cup Method)” (JIS Z 0208-1976). Ten
In the range of 00~3000g / m 2 / 24hr, hydrous plaster of the ball tack method (JIS Z 0237-1980) adhesive strength and wherein the at No.10 more.
この透湿度が100g/m2/24hr未満であると、皮膚刺激性
や剥離後の皮膚のベタツキが問題となる。一方、4000g/
m2/24hrを超えると、水分の蒸散により膏体が硬化して
粘着性が低下したり、有効成分の吸収性が低下する。If the moisture permeability is less than 100g / m 2 / 24hr, stickiness of the skin after skin irritation and peeling becomes a problem. On the other hand, 4000g /
exceeds m 2/24 hr or, lowered tackiness and curing plaster by evaporation of water, absorption of the active ingredient is reduced.
このような支持体の一例としては、透湿度が100〜400
0g/m2/24hrの範囲にある高分子フィルム、例えば透湿度
が2000g/m2/24hr前後のポリウレタン系フィルムと、従
来から用いられている不織布、織布、編布等の繊維集合
体などの透湿性の大きな多孔性シートとを、熱融着、接
着剤による接着などで積層一体化したものを挙げること
ができる。また、多孔性シートに高分子フィルム溶液を
塗布して、その場で高分子フィルムを積層一体化するこ
ともできる。第１図はこの層構成を示す断面図であり、
高分子フィルム13と不織布15とが積層一体化された支持
体11に、含水性膏体層21が塗工され、ライナー31が被覆
されている。An example of such a support has a moisture permeability of 100 to 400.
Polymeric film in the range of 0g / m 2 / 24hr, e.g. permeability and humidity 2000g / m 2 / 24hr before and after the polyurethane film, a nonwoven fabric which has been conventionally used, a woven fabric, a fiber aggregate such as knitted fabric, etc. And a porous sheet having high moisture permeability and laminated by heat fusion, adhesion with an adhesive, or the like. Alternatively, a polymer film solution can be applied to the porous sheet, and the polymer films can be laminated and integrated on the spot. FIG. 1 is a sectional view showing this layer structure.
The support 11 on which the polymer film 13 and the nonwoven fabric 15 are laminated and integrated is coated with the water-containing plaster layer 21 and covered with the liner 31.
また、透湿度が小さい（例えば100g/m2/24hr未満）の
高分子フィルムを用いて、この高分子フィルムと不織
布、織布、編布等の多孔性シートとの積層一体化を熱融
着により行なうことにより、高分子フィルムに繊維等の
一部がくい込んで細孔があき、適度な透湿度を有する支
持体を得ることも可能である。第２図は、この層構成を
示す断面図であり、高分子フィルム13′を不織布15,17
でサインドイッチ状に挟んで熱融着した支持体11に、含
水性膏体層21が塗工され、ライナー31が被覆されてい
る。Further, by using a polymer film of moisture permeability is small (e.g., 100 g / m less than 2/24 hr or), the polymeric film and the nonwoven fabric, a woven fabric, a laminated integrated with the porous sheet, such as a knitted fabric heat-sealing By doing so, a part of fibers or the like can be penetrated into the polymer film to form pores, and a support having appropriate moisture permeability can be obtained. FIG. 2 is a cross-sectional view showing this layer structure.
A water-containing plaster layer 21 is applied to the support 11 which is heat-fused while being sandwiched in a sign-like manner, and a liner 31 is coated.
高分子フィルム13′としては、ポリエチレン、エチレ
ン−酢酸ビニル共重合体、ポリプロピレン等の５〜15μ
ｍ程度の厚さのフィルムが好適である。As the polymer film 13 ', polyethylene, ethylene-vinyl acetate copolymer, 5 to 15μ
A film having a thickness of about m is preferred.
多孔性支持体15,17として用いる不織布としては、ポ
リエステル、レーヨン、ナイロン、ポリオレフィン、ポ
リエチレン等の繊維を用い、ニードルパンチ法、スパン
レース法、スパンボンド法、ステッチボンド法、メルト
ブローン法等で製造したものが挙げられる。As the nonwoven fabric used as the porous supports 15, 17, polyester, rayon, nylon, polyolefin, using fibers of polyethylene, etc., were manufactured by a needle punch method, a spunlace method, a spunbond method, a stitch bond method, a melt blown method, or the like. Things.
用いられる含水性膏体はボールタック法粘着力がNo.1
0以上のものを用いることにより、粘着力の低下を防止
できるという本発明の特徴を生かして、使用性の良好な
貼付剤が得られる。The water-containing plaster used has the No. 1 ball tack adhesion.
By using 0 or more, a patch having good usability can be obtained by taking advantage of the feature of the present invention that a decrease in adhesive strength can be prevented.
このような基材の一例として、ポリアクリル酸とポリ
アクリル酸塩を重量比で9/1〜1/9で配合したものが挙げ
られる。ポリアクリル酸の重量が上記範囲より少ないと
肌への十分な粘着力が得られず、一方、ポリアクリル酸
塩の配合量が少ないと十分な増粘が実現できず、“裏じ
み”が起こりやすい。また、ポリアクリル酸とポリアク
リル酸塩とは合計で１〜20重量％、好ましくは３〜10重
量％となるように含水性膏体中に配合することが望まし
い。合計配合量が、１重量％未満であると“裏じみ”の
原因となり、一方、20重量％より多いと製造時の作業性
が低下する。As an example of such a base material, a material in which polyacrylic acid and polyacrylate are blended at a weight ratio of 9/1 to 1/9 is exemplified. If the weight of the polyacrylic acid is less than the above range, sufficient adhesion to the skin cannot be obtained, while if the amount of the polyacrylic acid salt is too small, sufficient thickening cannot be realized, and "back bleeding" occurs. Cheap. It is desirable that the polyacrylic acid and the polyacrylic acid salt be blended in the water-containing plaster so that the total amount is 1 to 20% by weight, preferably 3 to 10% by weight. If the total amount is less than 1% by weight, "bleeding" may be caused. On the other hand, if the total amount is more than 20% by weight, the workability at the time of production decreases.
ポリアクリル酸としては、分子量10万〜600万のもの
が適当である。10万未満であると粘度が不足し“裏じ
み”を起こしやすく、また、十分な粘着力を得ることが
できない。一方、600万を超えると粘度が高すぎ、展
延、練合等の作業性が低下する。Polyacrylic acid having a molecular weight of 100,000 to 6,000,000 is suitable. If it is less than 100,000, the viscosity is insufficient and "bleeding-in" tends to occur, and sufficient adhesive strength cannot be obtained. On the other hand, if it exceeds 6 million, the viscosity is too high, and workability such as spreading and kneading is reduced.
ポリアクリル酸塩としては、ナトリウム塩、カリウム
塩、アンモニウム塩等があり、特にナトリウム塩は入手
しやすい原料である。また、ポリアクリル酸塩の中和度
は50％以上が好ましく、それ未満の中和度では十分な粘
度が得られず、“裏じみ”が起こりやすい。Examples of the polyacrylate include a sodium salt, a potassium salt, an ammonium salt, and the like. In particular, the sodium salt is an easily available raw material. In addition, the degree of neutralization of the polyacrylate is preferably 50% or more. If the degree of neutralization is less than 50%, sufficient viscosity cannot be obtained, and "bleeding-in" tends to occur.
ポリアクリル酸塩の分子量は10万〜600万が適当であ
る。10万未満であると粘度が不足して“裏じみ”を起こ
しやすく、また、十分な粘着力を得ることができない。
一方、600万を超えると粘度が高すぎて展延、練合等の
作業性が低下する。The molecular weight of the polyacrylate is suitably from 100,000 to 6,000,000. If it is less than 100,000, the viscosity is insufficient and "bleeding-in" tends to occur, and sufficient adhesive strength cannot be obtained.
On the other hand, if it exceeds 6 million, the viscosity is too high, and workability such as spreading and kneading is reduced.
発明の効果 本発明では、含水系膏体を用いた貼付剤において、10
0〜4000g/m2/24hrの適度な透湿度を有する支持体および
ボールタック法粘着力がNo.10以上の含水性膏体を用い
ることにより、皮膚刺激性の低減および剥離後のベタツ
キ防止を可能にして使用感に優れ、しかも、水分の蒸散
を抑えて膏体の粘着性および有効成分の皮膚への移行を
改善することができる。Effects of the Invention In the present invention, in a patch using a water-containing plaster, 10
By support and ball tack method adhesion has proper moisture permeability of 0~4000g / m 2 / 24hr is used No.10 or more hydrous plaster, a stickiness prevention after reduction and separation of the skin irritation As a result, it is possible to improve the feeling of use and to suppress the evaporation of water, thereby improving the adhesiveness of the plaster and the transfer of the active ingredient to the skin.
実施例１ 1.5デニールのポリエステルのウェブをニードルパン
チして得た不織布（100g/m2）にポリウレタン溶液を塗
布、乾燥して貼付剤の支持体を得た。この支持体の透湿
度を前述のJIS一般試験法により測定したところ、透湿
度は2300g/m2/24hrであった。Example 1 A polyurethane solution was applied to a nonwoven fabric (100 g / m 2 ) obtained by needle-punching a 1.5 denier polyester web and dried to obtain a patch support. Was the moisture permeability of the support was measured by the above-described JIS General Tests, the moisture permeability was 2300g / m 2 / 24hr.
この支持体に上記第１表に示した含水性膏体を1m2当
たり900gの割合で展延し、貼付剤（6cm×8cm）を得た。The hydrous plaster shown in Table 1 was spread on this support at a rate of 900 g per 1 m 2 to obtain a patch (6 cm × 8 cm).
実施例２ 2.0デニールのポリオレフィンのウェブを用いてスパ
ンレース法によりシート状体として得た不織布（30g/
m2）と、1.0デニールのレーヨンのウェブをニードルパ
ンチして得た不織布（50g/m2）とを使用し、押出機（エ
クストルダー）から溶融した８μｍ厚のポリエチレン薄
膜を２枚の不織布の間に流し込み、熱融着し一体化して
貼付剤の支持体を得た。この支持体の透湿度を実施例１
と同様に測定したところ、透湿度は1300g/m2/24hrであ
った。Example 2 A nonwoven fabric (30 g / 30 g / m) obtained as a sheet by a spunlace method using a 2.0-denier polyolefin web.
m 2 ) and a non-woven fabric (50 g / m 2 ) obtained by needle-punching a 1.0 denier rayon web, and an 8 μm-thick polyethylene thin film melted from an extruder (extruder) was used to form two non-woven fabrics. The mixture was poured into the gap, heat-sealed and integrated to obtain a patch support. Example 1 shows the moisture permeability of this support.
It was measured in the same manner as, the moisture permeability was 1300g / m 2 / 24hr.
この支持体のレーヨン不織布側に実施例１と同様の含
水性膏体を展延し、貼付剤（6cm×8cm）を得た。The same water-containing plaster as in Example 1 was spread on the rayon nonwoven fabric side of this support to obtain a patch (6 cm × 8 cm).
実施例３ トリコット織布にポリウレタン溶液を塗布、乾燥して
貼布剤の支持体を得た。この支持体の透湿度を実施例１
と同じ方法で測定したところ1800g/m2/24hrであった。
この支持体に実施例１と同様に含水性膏体を展延し、貼
布剤（6cm×8cm）を作成した。Example 3 A polyurethane solution was applied to a tricot woven fabric and dried to obtain a patch support. Example 1 shows the moisture permeability of this support.
It was 1800 g / m < 2 > / 24hr when measured by the same method.
A water-containing plaster was spread on this support in the same manner as in Example 1 to prepare a patch (6 cm × 8 cm).
比較例１ ポリエステル100％の不織布について実施例１と同じ
方法で透湿度を測定したところ、透湿度は8500g/m2/24h
rであった。Comparative Example 1 The moisture permeability of a 100% polyester nonwoven fabric was measured in the same manner as in Example 1. The moisture permeability was 8500 g / m 2 / 24h.
r.
この支持体に実施例１と同様にして含水性膏体を展延
し、貼付剤（6cm×8cm）を得た。A water-containing plaster was spread on this support in the same manner as in Example 1 to obtain a patch (6 cm × 8 cm).
比較例２ ポリエステル100％の不織布に厚さ30μｍのポリエチ
レンフィルムを接着剤により一体化したものについて、
実施例１と同様の方法で透湿度を測定したところ、透湿
度は35g/m2/24hrであった。Comparative Example 2 A non-woven fabric made of 100% polyester and a 30 μm-thick polyethylene film integrated with an adhesive were used.
The measured moisture permeability in the same manner as in Example 1, the moisture permeability was 35g / m 2 / 24hr.
この支持体に実施例１と同様に含水性膏体を展延し、
貼付剤（6cm×8cm）を得た。A water-containing plaster was spread on this support in the same manner as in Example 1,
A patch (6 cm × 8 cm) was obtained.
試験例１ 実施例1,2,3および比較例1,2で製造した貼付剤を、う
さぎ（体重2.3〜2.8kg）の、背部をバリカンにて徐毛し
た後、貼付し、一定時間毎に血清中サリチル酸濃度を測
定して、その結果を第２表に示した。Test Example 1 The patches prepared in Examples 1, 2, and 3 and Comparative Examples 1 and 2 were applied to rabbits (body weight: 2.3 to 2.8 kg), after the back of the rabbit was gradually haired with a clipper, and then applied at regular intervals. The serum salicylic acid concentration was measured and the results are shown in Table 2.
試験例２ 実施例1,2,3および比較例1,2で製造した貼付剤を、健
常男子20名の上腕部に貼付し、３時間経過後の粘着性
（第３表）、剥離後のベタツキ（第４表）、皮膚刺激性
（第５表）を評価し、以下の各表に示した。 Test Example 2 The patches prepared in Examples 1, 2, and 3 and Comparative Examples 1 and 2 were applied to the upper arm of 20 healthy males, and the adhesiveness after 3 hours (Table 3), The stickiness (Table 4) and the skin irritation (Table 5) were evaluated and are shown in the following tables.
実施例４〜11 下記の第６表に示した組成の膏体を、支持体（透湿度
は同表中に記載）に塗工して本発明の貼付剤を得た。 Examples 4 to 11 Plasters having the composition shown in Table 6 below were applied to a support (moisture permeability is described in the same table) to obtain a patch of the present invention.
これら貼付剤は、いずれも実施例１と同様の優れた特
性を示した。Each of these patches showed the same excellent properties as in Example 1.
第１図および第２図は、本発明の貼付剤の構成例の層構
成を示す断面図である。 11……支持体、13,13′……高分子フィルム 15,17……不織布、21……含水性膏体層 31……ライナーFIG. 1 and FIG. 2 are cross-sectional views showing a layer configuration of a configuration example of the patch of the present invention. 11: Support, 13, 13 ': Polymer film 15, 17: Non-woven fabric, 21: Water-containing plaster layer 31: Liner
フロントページの続き (56)参考文献 特開 昭62−230720（ＪＰ，Ａ) 特開 昭56−51412（ＪＰ，Ａ) 特開 昭56−140927（ＪＰ，Ａ) 特開 昭61−267512（ＪＰ，Ａ) 実開 昭63−144031（ＪＰ，Ｕ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 9/70 Continuation of front page (56) References JP-A-62-230720 (JP, A) JP-A-56-51412 (JP, A) JP-A-56-140927 (JP, A) JP-A-61-267512 (JP, A) , A) Real opening 63-144031 (JP, U) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 9/70
Claims (1)
において、支持体部が高分子フィルムと多孔性シートと
が一体化されたシート状体からなり、この支持体部の透
湿度がJIS一般試験法「防湿包装材料の透湿度試験法
（カップ法）」条件Ａで試験するとき100〜4000g/m2/24
hrであり、含水性膏体部のボールタック法粘着力がNo.1
0以上であることを特徴とする貼付剤。1. A patch having a support portion and a water-containing plaster portion, wherein the support portion is formed of a sheet in which a polymer film and a porous sheet are integrated, and the transparency of the support portion is controlled. 100~4000g / m 2/24 when humidity test in JIS general tests "moisture permeability test method of dry packing material (cup method)" condition a
hr, and the ball-tack adhesion of the water-containing plaster is No. 1
A patch characterized by being 0 or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1301303A JP3044352B2 (en) | 1989-11-20 | 1989-11-20 | Patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1301303A JP3044352B2 (en) | 1989-11-20 | 1989-11-20 | Patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03161435A JPH03161435A (en) | 1991-07-11 |
| JP3044352B2 true JP3044352B2 (en) | 2000-05-22 |
Family
ID=17895219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1301303A Expired - Lifetime JP3044352B2 (en) | 1989-11-20 | 1989-11-20 | Patch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3044352B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058232A1 (en) * | 2002-12-26 | 2004-07-15 | Kowa Co., Ltd. | Adhesive patch |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09124462A (en) * | 1995-11-01 | 1997-05-13 | Nitto Denko Corp | Transdermal patch material and transdermal patch preparation |
| US20060093656A1 (en) * | 2002-11-27 | 2006-05-04 | Hisamitu Pharmaceutical Co., Inc. | Warming patch |
| CN101094662A (en) * | 2004-12-28 | 2007-12-26 | 兴和株式会社 | Hydrous adhesive patch |
| CN101094669B (en) * | 2004-12-28 | 2010-05-12 | 兴和株式会社 | Indometacin-containing adhesive patch |
| JP4720312B2 (en) * | 2005-06-20 | 2011-07-13 | 救急薬品工業株式会社 | Tulobuterol-containing patch |
| HUE040015T2 (en) | 2010-07-12 | 2019-02-28 | Teikoku Seiyaku Kk | Backing having three-layer structure and aqueous adhesive patch including the backing |
| US9884030B2 (en) | 2010-07-12 | 2018-02-06 | Toyobo Co., Ltd. | Patch backing for water-based pasty preparation |
| JP2012164776A (en) | 2011-02-04 | 2012-08-30 | Toshiba Corp | Nonvolatile semiconductor storage device |
| JP6580305B2 (en) * | 2014-03-30 | 2019-09-25 | 小林製薬株式会社 | Pharmaceutical composition for external use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS597688B2 (en) * | 1979-09-29 | 1984-02-20 | 日東電工株式会社 | Anti-inflammatory/analgesic patch |
| JPS56140927A (en) * | 1980-04-07 | 1981-11-04 | Nitto Electric Ind Co Ltd | Medical member |
| JPS61267512A (en) * | 1985-05-20 | 1986-11-27 | Nitto Electric Ind Co Ltd | Laminated structure |
| JP2557046B2 (en) * | 1986-03-31 | 1996-11-27 | 日東電工株式会社 | Layered formulation |
-
1989
- 1989-11-20 JP JP1301303A patent/JP3044352B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058232A1 (en) * | 2002-12-26 | 2004-07-15 | Kowa Co., Ltd. | Adhesive patch |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03161435A (en) | 1991-07-11 |
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