KR880000446A - Method for preparing cephalosporan acid derivative - Google Patents

Method for preparing cephalosporan acid derivative Download PDF

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Publication number
KR880000446A
KR880000446A KR1019860004653A KR860004653A KR880000446A KR 880000446 A KR880000446 A KR 880000446A KR 1019860004653 A KR1019860004653 A KR 1019860004653A KR 860004653 A KR860004653 A KR 860004653A KR 880000446 A KR880000446 A KR 880000446A
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KR
South Korea
Prior art keywords
formula
represented
condensing agent
following structural
agent represented
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KR1019860004653A
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Korean (ko)
Inventor
김완주
이철해
박태호
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채영복
재단법인 한국화학연구소
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Priority to KR1019860004653A priority Critical patent/KR880000446A/en
Publication of KR880000446A publication Critical patent/KR880000446A/en

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Abstract

내용 없음No content

Description

세팔로스포란산 유도체의 제조방법Method for preparing cephalosporan acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

유기용매중에서 다음 구조식(Ⅱ)으로 표시되는 화합물과 다음 구조식(Ⅲ)으로 표시되는 유기산을 유기염기와 함께 다음 구조식(Ⅳ) 또는 (Ⅴ)으로 표시되는 축합제의 존재하여 반응시킴을 특징으로 하는 다음 구조식(Ⅰ)으로 표시되는 세팔로스포란산 유도체를 제조하는 방법.Characterized by reacting the compound represented by the following structural formula (II) and the organic acid represented by the following structural formula (III) in the organic solvent with an organic base in the presence of a condensing agent represented by the following structural formula (IV) or (V) The method for producing the cephalosporan acid derivative represented by the following structural formula (I). 상기식에서 R1은 카르복시기 또는 카르복시음이온을 나타내고, R2는 아세톡시기 또는 피리디늄기를 나타내며, R3는 수소 또는 알킬기를 나타내고 R4는 알킬 또는 알킬기를 나타내며, Ra와 Rb는 수소나 저급알킬기를 나타낸다.Wherein R 1 represents a carboxyl group or a carboxyanion, R 2 represents an acetoxy group or a pyridinium group, R 3 represents a hydrogen or alkyl group, R 4 represents an alkyl or alkyl group, and Ra and Rb represent a hydrogen or lower alkyl group Indicates. 제 1 항에 있어서, 구조식(Ⅲ)으로 표시된 유기산의 아미노기를 보호하지 않고 구조식(Ⅳ) 또는 (Ⅴ)로 표시되는 축합제와 유기염기를 사용하여 아실화함을 특징으로 하는 방법.The method according to claim 1, wherein the acylation is carried out using a condensing agent and an organic base represented by the formula (IV) or (V) without protecting the amino group of the organic acid represented by the formula (III). 제 1 항에 있어서, 구조식(Ⅳ)으로 표시되는 축합제가 디알킬 2-피리돈-1-일 포스페이트임을 특징으로 하는 방법.A process according to claim 1, wherein the condensing agent represented by formula (IV) is dialkyl 2-pyridone-1-yl phosphate. 제 1 항에 있어서, 구조식(Ⅴ)로 표시되는 축합제가 디-2-피리딜 설페이트임을 특징으로 하는 방법.The method of claim 1 wherein the condensing agent represented by formula (V) is di-2-pyridyl sulfate. 제 1 항에 있어서, 일반구조식(Ⅳ) 또는 (Ⅴ)로 표시된 축합제의 존재하에 사용되는 유기염기는 트리에틸아민, 피리딘, 디메틸아민, 이소프로필아민, N,N-디메틸아닐린, 4-N,N-디메틸아미노 피리딘등으로부터 선택됨을 특징으로 하는 방법.The organic base according to claim 1, wherein the organic base used in the presence of a condensing agent represented by the general formula (IV) or (V) is triethylamine, pyridine, dimethylamine, isopropylamine, N, N-dimethylaniline, 4-N. , N-dimethylamino pyridine and the like. 제 1 항에 있어서, 구조식(Ⅳ)로 표시되는 축합제는 N-하이드록시-2-피리돈과 디알킬클로포르스페이트와 반응시켜서 제조하는 방법.The method of claim 1, wherein the condensing agent represented by the formula (IV) is prepared by reacting N-hydroxy-2-pyridone with dialkyl chlorophosphate. 제 1 항에 있어서, 구조식(Ⅳ)로 표시되는 축합제는 티오닐 클로라이드와 2-하이드록시 피리딘과 반응시켜 제조하는 방법.The method of claim 1, wherein the condensing agent represented by formula (IV) is prepared by reacting thionyl chloride with 2-hydroxy pyridine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860004653A 1986-06-12 1986-06-12 Method for preparing cephalosporan acid derivative KR880000446A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860004653A KR880000446A (en) 1986-06-12 1986-06-12 Method for preparing cephalosporan acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860004653A KR880000446A (en) 1986-06-12 1986-06-12 Method for preparing cephalosporan acid derivative

Publications (1)

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KR880000446A true KR880000446A (en) 1988-03-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004653A KR880000446A (en) 1986-06-12 1986-06-12 Method for preparing cephalosporan acid derivative

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KR (1) KR880000446A (en)

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