KR870008871A - 피리딘 유도체의 제조방법 - Google Patents

피리딘 유도체의 제조방법 Download PDF

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Publication number
KR870008871A
KR870008871A KR870002347A KR870002347A KR870008871A KR 870008871 A KR870008871 A KR 870008871A KR 870002347 A KR870002347 A KR 870002347A KR 870002347 A KR870002347 A KR 870002347A KR 870008871 A KR870008871 A KR 870008871A
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South Korea
Prior art keywords
compound
formula
case
groups
phenyl
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KR870002347A
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English (en)
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뵈트커 헨닝
제이 프리트 크리스토프
밍크 클라우스-오토
Original Assignee
노우만, 헤우만
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
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Application filed by 노우만, 헤우만, 메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁 filed Critical 노우만, 헤우만
Publication of KR870008871A publication Critical patent/KR870008871A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나, 또는 일반식(Ⅰ)에 상응하되, 단 하나 또는 그 이상의 수소원자 대신에 하나 또는 그 이상의 환원성 그룹 및/또는 하나 또는 그 이상의 추가적 C-C 및/또는 C-N 결합을 함유하는 화합물은 환원제로 처리하거나, 또는 R이인 일반식(Ⅰ)의 화합물이 생성될 수 있도록 일반식(Ⅳ)의 화합물을 HE를 분리하는 시약으로 처리하고/하거나, 필요시 OH 그룹이 형성되도록 일반식(Ⅰ)의 화합물중 O-알킬그룹을 분리시키고/시키거나, 일반식(Ⅰ)의 염기를 산으로 처리하여 이의 염의 하나로 전환시킴을 특징으로 하는 일반식(Ⅰ)의 피리딘 유도체 및 이의 염의 제조방법.
    상기식에서,
    Y 및 Z 그룹중 하나는 N이고 이들 그룹중 다른 하나는 각 경우 CH이고,
    n은 1,2 또는 3이고,
    R은
    R1및 R2는 각 경우 페닐 또는 2- 또는 3-티에닐 래리칼이며, 이들은 비치환되거나 또는 각기 탄소수 1 내지 4의 알킬 및/또는 알콕시, F,Cl,Br,OH 및/또는 CF3로 일치환 또는 이치환되고, R3및 R4는 각 경우 H, 각기 탄소수 1 내지 4의 알킬 또는 알콕시, F,Cl,Br,OH 또는 CF3이며,
    단, R이이면 Y는 CH이고,
    Py는 래디칼이고,
    A는 -CnH2n-그룹이고,
    X1는 X 또는 NH2이고,
    X는 Cl,Br,I,OH 또는 반응적 및 기능으로 변형된 OH그룹이고,
    X2및 X3는 같거나 다르고, X1이 NH2이면, 각 경우, X이거나 또는 함께 NH이고,
    G는 -CHR2-CH2-, -CR2=CH-, CR2(OH)-CH2-,
    래디칼 E중 하나가 X, CN 또는 NH2이면 다른 래디칼 E는 H이다.
  2. 제 1 항에 있어서,
    최종생성물이 다음 화합물인 것을 특징으로 하는 방법.
    ⒜ 2-(4-페닐-1,2,3,6-테트라히드로피리딜-메틸)-4-페닐피리딘
    ⒝ 3-페닐-5-(4-페닐-피페리디노메틸)-피리딘
  3. 일반식(Ⅰ)의 화합물 및/또는 이의 생리학적으로 허용 가능한 염을 적어도 하나의 고체, 액체 또는 반-액체 부형제 또는 보조제와 함께, 필요에 따라 하나 또는 그 이상의 다른 활성화 합물과 혼합하여 적합한 용량 형태로 만드는 것을 특징으로 하는 약학적 제형의 제조방법.
  4. 적어도 하나의 일반식(Ⅰ)의 화합물 및/또는 이의 생리학적으로 허용 가능한 염의 하나를 함유하는 것을 특징으로 하는 약학적 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870002347A 1986-03-19 1987-03-16 피리딘 유도체의 제조방법 KR870008871A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3609142.1 1986-03-19
DE19863609142 DE3609142A1 (de) 1986-03-19 1986-03-19 Pyridinderivate

Publications (1)

Publication Number Publication Date
KR870008871A true KR870008871A (ko) 1987-10-21

Family

ID=6296716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870002347A KR870008871A (ko) 1986-03-19 1987-03-16 피리딘 유도체의 제조방법

Country Status (11)

Country Link
US (1) US4906642A (ko)
EP (1) EP0237908B1 (ko)
JP (1) JPS62226977A (ko)
KR (1) KR870008871A (ko)
AT (1) ATE56005T1 (ko)
AU (1) AU596831B2 (ko)
DE (2) DE3609142A1 (ko)
ES (1) ES2016941B3 (ko)
HU (1) HU196994B (ko)
PT (1) PT84507B (ko)
ZA (1) ZA871994B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
WO1996016058A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Aminomethyl aryl compounds; dopamine receptor subtype selective ligands

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1112087A (en) * 1966-03-10 1968-05-01 Seperic New pyridazone derivatives and process for preparing same
DE3438394A1 (de) * 1984-10-19 1986-04-30 Merck Patent Gmbh, 6100 Darmstadt Pyridinderivate

Also Published As

Publication number Publication date
PT84507A (en) 1987-04-01
ATE56005T1 (de) 1990-09-15
PT84507B (pt) 1989-11-10
HU196994B (en) 1989-02-28
ES2016941B3 (es) 1990-12-16
AU7017287A (en) 1987-09-24
EP0237908A2 (de) 1987-09-23
EP0237908B1 (de) 1990-08-29
JPS62226977A (ja) 1987-10-05
DE3764500D1 (de) 1990-10-04
AU596831B2 (en) 1990-05-17
DE3609142A1 (de) 1987-09-24
EP0237908A3 (en) 1988-10-19
HUT43585A (en) 1987-11-30
US4906642A (en) 1990-03-06
ZA871994B (en) 1987-09-09

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