KR870007875A - 사이클로헥센 카복실산 에스테르 및 아미드 - Google Patents
사이클로헥센 카복실산 에스테르 및 아미드 Download PDFInfo
- Publication number
- KR870007875A KR870007875A KR870001290A KR870001290A KR870007875A KR 870007875 A KR870007875 A KR 870007875A KR 870001290 A KR870001290 A KR 870001290A KR 870001290 A KR870001290 A KR 870001290A KR 870007875 A KR870007875 A KR 870007875A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- nitrogen atoms
- adjacent nitrogen
- formula
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 일반식(Ⅰ)의 화합물, 이의 모든 라세미 형태, 광학적 활성형태 및 입체이성체 형태, 및 약학적으로 무독한 이의 염.상기식에서, R1은 C1-C4알킬 카복실레이트 또는(여기서, R4및 R5는 독립적으로 수소, C1-C4알킬 또는 C4-C7사이클로알킬이다)이고; R2및 R3는 독립적으로 수소, C3-C7사이클로알킬 또는 C1내지 C4알킬이거나, 인접한 질소원자와 함께 질소, 산소 또는 황으로부터 선택된 1 내지 2개의 헤테로원자와 4 내지 6개의 탄소원자를 함유하는 5 내지 7원 포화 헤테로사이클릭 환을 형성하며; n은 2 또는 3이다.
- 제1항에 있어서, R1이 C1-C3알킬 카복실레이트이고, R2및 R|3는 독립적으로 수소 또는 C1-C3알킬이거나, 인접한 질소원자와 함께 1개의 질소원자와 4 내지 5개의 탄소원자를 함유하는 포화 헤테로사이클릭환을 형성하며, R4및 R5는 독립적으로 수소 또는 C1-C3알킬이고, n은 2 또는 3인 화합물.
- 제1항에 있어서, R2및 R3가 인접한 질소원자와 함께 피페리디닐을 형성하고, R1은이며, n이 3인 화합물.
- 제1항에 있어서, R2및 R3가 인접한 질소원자와 함께 피페리디닐을 형성하고, R1이이며, n이 3인 화합물.
- 제1항에 있어서, R2및 R3가 인접한 질소원자와 함께 피페리디닐을 형성하고, R1이이며, n이 3인 화합물.
- 제1항에 있어서, R2및 R3가 인접한 질소원자와 함께 피페리디닐을 형성하고, R1이며, n은 3인 화합물.
- 라세미형의 제3항의 화합물 및 약제학적으로 무독한 이의 모든 염.
- 라세미형의 제4항의 화합물 및 약제학적으로 무독한 이의 모든 염.
- 라세미형의 제5항의 화합물 및 약제학적으로 무독한 이의 모든 염.
- 라세미형의 제6항의 화합물 및 약제학적으로 무독한 이의 모든 염.
- 일반식(2)의 화합물을 일반식(3)의 화합물과 반응시킴을 특징으로 하여 일반식(1)의 화합물을 제조하는 방법.상기식에서, R1,R2및 R3은 제1항에서 정의한 바와 같다.
- 제1항에서 정의한 화합물의 유효량을 심장부정맥의 치료를 필요로 하는 포유동물에게 투여함을 특징으로 하여 부정맥의 심장상태를 처리하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/830,592 US4760146A (en) | 1986-02-18 | 1986-02-18 | Cyclohexene carboxylic esters and amides as antidysrhythmic agents |
US830592 | 1986-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870007875A true KR870007875A (ko) | 1987-09-22 |
Family
ID=25257271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR870001290A KR870007875A (ko) | 1986-02-18 | 1987-02-17 | 사이클로헥센 카복실산 에스테르 및 아미드 |
Country Status (12)
Country | Link |
---|---|
US (1) | US4760146A (ko) |
EP (1) | EP0233512A1 (ko) |
JP (1) | JPS62246544A (ko) |
KR (1) | KR870007875A (ko) |
AU (1) | AU6764487A (ko) |
DE (1) | DE233512T1 (ko) |
DK (1) | DK78587A (ko) |
ES (1) | ES2000110A4 (ko) |
FI (1) | FI870662A (ko) |
IL (1) | IL81132A0 (ko) |
NO (1) | NO870631L (ko) |
ZA (1) | ZA871172B (ko) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2812331A (en) * | 1957-11-05 | Substituted butyric acid amide com- | ||
CH471124A (de) * | 1965-09-29 | 1969-04-15 | Ciba Geigy | Verfahren zur Herstellung von neuen Cyclohexanderivaten |
FR5978M (ko) * | 1965-11-19 | 1968-04-22 | ||
US3951978A (en) * | 1972-04-22 | 1976-04-20 | Istituto Luso Farmaco D'italia S.R.L. | 1,3-Disubstituted 3-aroylpropanes and process for the preparation thereof |
US3974157A (en) * | 1974-03-04 | 1976-08-10 | Pennwalt Corporation | 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters |
US4452745A (en) * | 1981-02-06 | 1984-06-05 | Eli Lilly And Company | 9-Aminoalkylfluorenes |
US4595759A (en) * | 1983-08-19 | 1986-06-17 | Pennwalt Corporation | Cyclohexane carboxylic acids and derivatives thereof as antidysrhythmic agents |
-
1986
- 1986-02-18 US US06/830,592 patent/US4760146A/en not_active Expired - Fee Related
- 1986-12-31 IL IL81132A patent/IL81132A0/xx unknown
-
1987
- 1987-01-16 AU AU67644/87A patent/AU6764487A/en not_active Abandoned
- 1987-01-26 DE DE198787101040T patent/DE233512T1/de active Pending
- 1987-01-26 ES ES87101040T patent/ES2000110A4/es active Pending
- 1987-01-26 EP EP87101040A patent/EP0233512A1/en not_active Withdrawn
- 1987-02-13 JP JP62029959A patent/JPS62246544A/ja active Pending
- 1987-02-17 DK DK078587A patent/DK78587A/da unknown
- 1987-02-17 NO NO870631A patent/NO870631L/no unknown
- 1987-02-17 FI FI870662A patent/FI870662A/fi not_active Application Discontinuation
- 1987-02-17 KR KR870001290A patent/KR870007875A/ko not_active Application Discontinuation
- 1987-02-18 ZA ZA871172A patent/ZA871172B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US4760146A (en) | 1988-07-26 |
EP0233512A1 (en) | 1987-08-26 |
FI870662A0 (fi) | 1987-02-17 |
NO870631L (no) | 1987-08-19 |
ZA871172B (en) | 1987-09-30 |
AU6764487A (en) | 1987-08-20 |
DE233512T1 (de) | 1988-01-14 |
DK78587A (da) | 1987-08-19 |
NO870631D0 (no) | 1987-02-17 |
DK78587D0 (da) | 1987-02-17 |
IL81132A0 (en) | 1987-03-31 |
FI870662A (fi) | 1987-08-19 |
ES2000110A4 (es) | 1987-12-16 |
JPS62246544A (ja) | 1987-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |