KR870003047A - Method for preparing benzoic acid derivative - Google Patents

Method for preparing benzoic acid derivative Download PDF

Info

Publication number
KR870003047A
KR870003047A KR1019850008050A KR850008050A KR870003047A KR 870003047 A KR870003047 A KR 870003047A KR 1019850008050 A KR1019850008050 A KR 1019850008050A KR 850008050 A KR850008050 A KR 850008050A KR 870003047 A KR870003047 A KR 870003047A
Authority
KR
South Korea
Prior art keywords
group
compound
salt
formula
following general
Prior art date
Application number
KR1019850008050A
Other languages
Korean (ko)
Inventor
아끼라 노하라
요시따가 마끼
Original Assignee
구라바야시 이꾸시로
다께다 야꾸힝 고오교 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 구라바야시 이꾸시로, 다께다 야꾸힝 고오교 가부시끼 가이샤 filed Critical 구라바야시 이꾸시로
Publication of KR870003047A publication Critical patent/KR870003047A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음No content

Description

벤조산 유도체의 제조방법Method for preparing benzoic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (12)

하기 일반식(Ⅱ)의 화합물 또는 이들의 염과 아실화제 R1CO-Y와 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 벤조산 유도체 또는 이들의 염 제조방법.A method for producing a benzoic acid derivative of the following general formula (I) or a salt thereof, characterized by reacting a compound of the following general formula (II) or a salt thereof with an acylating agent R 1 CO-Y. (상기 일반식들에서, R1은 저급 알킬기이고, R2는 임의로 보호시킨 카르복실기이며, X는 할로겐이고, Y는 화합물(Ⅱ)를 아실화시킬 경우에 이탈기임)(In the formulas above, R 1 is a lower alkyl group, R 2 is an optionally protected carboxyl group, X is halogen, and Y is a leaving group when acylating compound (II).) 제1항에 있어서, R1이 메틸기인 방법.The method of claim 1, wherein R 1 is a methyl group. 제1항에 있어서, R2가 카르복실기인 방법.The method of claim 1, wherein R 2 is a carboxyl group. 제1항에 있어서,기인 방법.The method of claim 1, Attributed method. (상기 일반식에서, n는 2-4의 정수이고, R3및 R4는 각각 수소 또는 C1-3알킬이고, R3및 R4는 인접한 질소원자와 함께 5-6 또는 6원 헤테로 싸이클링을 형성할 수도 있음).(Wherein n is an integer of 2-4, R 3 and R 4 are each hydrogen or C 1-3 alkyl, and R 3 and R 4 together with adjacent nitrogen atoms undergo 5-6 or 6 membered heterocycling May form). 제1항에 있어서, X가 브롬인 방법.The method of claim 1 wherein X is bromine. 하기 일반식(Ⅱ)의 화합물 또는 이들의 염을 카르복실기의 보호기 주입 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 벤조산 유도체 및 이들의 염 제조방법.A benzoic acid derivative of the following general formula (I) and a method for producing a salt thereof, characterized by reacting a compound of the following general formula (II) or a salt thereof with a protecting group injection reaction of a carboxyl group. (상기 일반식들에서, R1은 저급 알킬기이고, R2는 보호시킨 카르복실기이며, X는 할로겐임)(Wherein R 1 is a lower alkyl group, R 2 is a protected carboxyl group and X is a halogen) 하기 일반식(Ⅱ)의 화합물을 보호기(R5')제거 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 벤조산 유도체 또는 이들의 염 제조방법.A process for preparing a benzoic acid derivative of the following general formula (I) or a salt thereof, characterized by reacting a compound of the following general formula (II) with a protecting group (R 5 ′). (상기일반식들에서, R1은 저급 알킬기이고, R2''는 보호기 R5'에 의해서 보호된 카르복실기이며,(In the above formula, R 1 is a lower alkyl group, R 2 '' is a carboxyl group protected by a protecting group R 5 ', X는 할로겐임)X is halogen 제7항에 있어서, R1이 메틸기인 방법.8. The method of claim 7, wherein R 1 is a methyl group. 제7항에 있어서, X가 브롬인 방법.8. The method of claim 7, wherein X is bromine. 하기 일반식(Ⅱ)의 화합물 또는 이들의 염에 카르복실기의 보호기(R5')를 주입시켜서 하기 일반식(Ⅲ)의 화합물을 얻고, 이 화합물을 일반식 R1CO-Y인 아실화제와 반응시켜서 하기 일반식(Ⅳ)이 화합물을 얻으며, 이 화합물에서 보호기(R5')를 제거시킴을 특징으로 하는 하기 일반식(Ⅰ)의 벤조산 유도체 또는 이들의 염 제조방법.Injecting a carboxyl protecting group (R 5 ′) into a compound of formula (II) or a salt thereof to obtain a compound of formula (III), and reacting the compound with an acylating agent of formula R 1 CO-Y To obtain a compound, wherein the protecting group (R 5 ′) is removed from the compound to produce a benzoic acid derivative of formula (I) or a salt thereof. (상기 일반식들에서, R1은 저급 알킬기이고, X는 할로겐이며, Y는 일반식(Ⅲ)의 화합물을 아실화시킬 경우 이탈기이고, R2''는 보호시킨 카르복실기임)(Wherein R 1 is a lower alkyl group, X is halogen, Y is a leaving group when acylating a compound of formula (III), and R 2 '' is a protected carboxyl group) 제10항에 있어서, R1이 메틸기인 방법.The method of claim 10, wherein R 1 is a methyl group. 제10항에 있어서, X가 브롬인 방법.The method of claim 10, wherein X is bromine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850008050A 1984-10-30 1985-10-30 Method for preparing benzoic acid derivative KR870003047A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPPCT/JP84/00520 1984-10-30
PCT/JP1984/000520 WO1986002636A1 (en) 1984-10-30 1984-10-30 Benzoic acid derivatives and process for their preparation
JP213578 1985-09-25
JP60213578A JPS61267539A (en) 1984-10-30 1985-09-25 Benzoic acid derivative and production thereof

Publications (1)

Publication Number Publication Date
KR870003047A true KR870003047A (en) 1987-04-14

Family

ID=13818454

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008050A KR870003047A (en) 1984-10-30 1985-10-30 Method for preparing benzoic acid derivative

Country Status (7)

Country Link
JP (1) JPS61267539A (en)
KR (1) KR870003047A (en)
AU (1) AU4900085A (en)
ES (1) ES8702877A1 (en)
SU (1) SU1454247A3 (en)
WO (1) WO1986002636A1 (en)
ZA (1) ZA858341B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters

Also Published As

Publication number Publication date
ES548360A0 (en) 1987-01-16
ZA858341B (en) 1987-06-24
SU1454247A3 (en) 1989-01-23
WO1986002636A1 (en) 1986-05-09
ES8702877A1 (en) 1987-01-16
JPS61267539A (en) 1986-11-27
AU4900085A (en) 1986-05-08

Similar Documents

Publication Publication Date Title
KR840004712A (en) Method for preparing benzoquinone derivative
KR870002056A (en) Process for preparing substituted propargyloxyacetonitrile derivatives
KR860000243A (en) Method for preparing amine derivative
KR850001905A (en) Method for preparing benzocyclo alkan derivatives
KR920008018A (en) Method for preparing piperazine derivatives
KR840000563A (en) Process for preparing cefem compound
KR850005845A (en) Process for preparing 7-amino-3-substituted-methyl-3-cepem-4-carboxylic acid and lower alkylsilyl derivatives thereof
KR890014435A (en) Phenoxyalkylcarboxylic acid derivatives and preparation method thereof
KR840006482A (en) Method for preparing [3,4-b] pyridine derivative with dihydropyrazolo
KR850002459A (en) Dihydroxybenzamide derivatives and preparation method thereof
KR840001555A (en) Method for preparing substituted 2-phenyl-2- (pyridylbath) -ethylamine and its back distributor compounds and their acid addition salts
KR860001048A (en) Method for preparing fluoroallylamine derivative
KR830005110A (en) Method for preparing fluorene derivative
KR890006620A (en) Quinoline derivatives and their preparation
KR850004959A (en) Process for preparing aryloxy-N- (aminoalkyl) -1-pyrrolidine and piperidine carbox amide and carbothio amide
KR870003047A (en) Method for preparing benzoic acid derivative
KR850004460A (en) Production method of indole
KR840005717A (en) Method for preparing benzamide derivative
KR850004470A (en) Process for preparing organic compound
KR840006238A (en) Method for preparing novel α-aryl-α-pyridylalkanoic acid derivatives
KR850002979A (en) New Preparation Method of 1,2,3-Trithian Compound
KR840005107A (en) Method for preparing pyrimidion and acid addition salts thereof
KR860002443A (en) Method for preparing anthracene derivative
KR840004747A (en) Method for preparing cardiac quinoazoline
KR870003060A (en) Method for producing benzoic acid derivative

Legal Events

Date Code Title Description
SUBM Submission of document of abandonment before or after decision of registration