KR870003060A - Method for producing benzoic acid derivative - Google Patents

Method for producing benzoic acid derivative Download PDF

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Publication number
KR870003060A
KR870003060A KR1019850008051A KR850008051A KR870003060A KR 870003060 A KR870003060 A KR 870003060A KR 1019850008051 A KR1019850008051 A KR 1019850008051A KR 850008051 A KR850008051 A KR 850008051A KR 870003060 A KR870003060 A KR 870003060A
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KR
South Korea
Prior art keywords
heterocycling
membered
lower alkyl
nitrogen atoms
adjacent nitrogen
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KR1019850008051A
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Korean (ko)
Inventor
아끼라 노하라
요시따가 마끼
Original Assignee
구라바야시 이꾸시로
다께다 야꾸힝 고오교 가부시끼 가이샤
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Application filed by 구라바야시 이꾸시로, 다께다 야꾸힝 고오교 가부시끼 가이샤 filed Critical 구라바야시 이꾸시로
Publication of KR870003060A publication Critical patent/KR870003060A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음No content

Description

벤조산 유도체의 제조 방법Method for producing benzoic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (12)

하기 일반식(Ⅱ)의 반응성 유도체를 일반식(Ⅲ)의 반응성 유도체Reactive derivatives of the general formula (II) 와 반응 시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물 또는 이들의 염 제조 방법.A method for producing a compound of formula (I) or a salt thereof, characterized in that the reaction with and. (상기 일반식들에서, R1및 R2는 각각 수소원자, 저급알킬기이거나, 인접한 질소원자와 함께 5- 또는 6원 헤테로싸이클링을 형성하며, n는 2-4의 정수이고, X는 할로겐 원자임)(Wherein R 1 and R 2 are each a hydrogen atom, a lower alkyl group, or form a 5- or 6-membered heterocycling with adjacent nitrogen atoms, n is an integer from 2-4 and X is a halogen atom Self) 제1항에 있어서, R1및 R2가 저급알킬기들인 방법.The method of claim 1, wherein R 1 and R 2 are lower alkyl groups. 제1항에 있어서, R1및 R2가 인접한 질소원자와 함께 6원 헤테로 싸이클링을 형성하는 방법.The method of claim 1, wherein R 1 and R 2 together with adjacent nitrogen atoms form a six membered heterocycling. 제1항에 있어서, n이 2인 방법.The method of claim 1, wherein n is two. 제1항에 있어서, n인 3인 방법.The method of claim 1 wherein n is 3. 제1항에 있어서, X가 브롬인 방법.The method of claim 1 wherein X is bromine. 하기 일반식(Ⅱ)의 화합물 또는 이들의 염을 일반식(Ⅲ)의 반응성 유도체Reactive derivatives of the general formula (III) 와 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 벤조산 유도체 또는 이들의 염 제조 방법.A method for producing a benzoic acid derivative of the following general formula (I) or a salt thereof, characterized by reacting with a. (상기 일반식들에서, R1및 R2는 각각 수소원자, 저급 알킬기이거나, 인접한 질소원자와 함께 5- 또는 6원 헤테로싸이클링을 형성하며, n는 2-4의 정수이고, X는 할로겐 원자이며, Z는 화합물(Ⅱ)을 에스테르화 시킬 경우 이탈기임)(Wherein R 1 and R 2 are each a hydrogen atom, a lower alkyl group, or form a 5- or 6-membered heterocycling with adjacent nitrogen atoms, n is an integer from 2-4 and X is a halogen atom Z is a leaving group when esterifying compound (II) 제7항에 있어서, R1및 R2가 저급 알킬기인 방법.8. The method of claim 7, wherein R 1 and R 2 are lower alkyl groups. 제7항에 있어서, R1및 R2가 인접한 질소원자와 함께 6원 헤테로 싸이클링을 형성하는 방법.8. The method of claim 7, wherein R 1 and R 2 together with adjacent nitrogen atoms form a six membered heterocycling. 제7항에 있어서, n이 2인 방법.8. The method of claim 7, wherein n is two. 제7항에 있어서, n이 3인 방법.8. The method of claim 7, wherein n is three. 제7항에 있어서, X가 브롬인 방법.8. The method of claim 7, wherein X is bromine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850008051A 1984-10-30 1985-10-30 Method for producing benzoic acid derivative KR870003060A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP1984/000521 WO1986002637A1 (en) 1984-10-30 1984-10-30 Benzoic acid derivatives and process for their preparation
JP60213579A JPS61129153A (en) 1984-10-30 1985-09-25 Benzoic acid derivative and preparation thereof
JP213579 1985-09-25

Publications (1)

Publication Number Publication Date
KR870003060A true KR870003060A (en) 1987-04-14

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Application Number Title Priority Date Filing Date
KR1019850008051A KR870003060A (en) 1984-10-30 1985-10-30 Method for producing benzoic acid derivative

Country Status (3)

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JP (1) JPS61129153A (en)
KR (1) KR870003060A (en)
WO (1) WO1986002637A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0771791B2 (en) * 1991-04-05 1995-08-02 福島製鋼株式会社 Rotary tilt positioner

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JPS61129153A (en) 1986-06-17
WO1986002637A1 (en) 1986-05-09

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