KR860002488A - Method for preparing furan derivative - Google Patents

Method for preparing furan derivative Download PDF

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Publication number
KR860002488A
KR860002488A KR1019850006858A KR850006858A KR860002488A KR 860002488 A KR860002488 A KR 860002488A KR 1019850006858 A KR1019850006858 A KR 1019850006858A KR 850006858 A KR850006858 A KR 850006858A KR 860002488 A KR860002488 A KR 860002488A
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KR
South Korea
Prior art keywords
process according
reaction
alkali metal
carried out
salt
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KR1019850006858A
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Korean (ko)
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KR870001166B1 (en
Inventor
버기 토마스
Original Assignee
배리 안토니 뉴삼
글락소 그룹 리밋티드
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Publication of KR860002488A publication Critical patent/KR860002488A/en
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Publication of KR870001166B1 publication Critical patent/KR870001166B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

푸란 유도체의 제조방법Method for preparing furan derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (10)

일반식(Ⅱ)의 화합물을 메틸화제와 반응시킴을 특징으로 하여, 구조식(Ⅰ)의 라니티딘을 제조하는 방법.A process for preparing ranitidine of formula (I), characterized by reacting a compound of formula (II) with a methylating agent. 상기식에서, R은 수소원자 또는 메틸그룹이다.Wherein R is a hydrogen atom or a methyl group. 제1항에 있어서, R이 메틸그룹인 방법.The method of claim 1, wherein R is a methyl group. 제1항 또는 2항에 있어서, 메틸화제가 메틸할라이드, 디메틸설페이트 또는 메틸 설폰산 에스테르인 방법.The process according to claim 1 or 2, wherein the methylating agent is methylhalide, dimethylsulfate or methyl sulfonic acid ester. 제1항 내지 3항중 어느 한 항에 있어서, 반응을 염기의 존재하에서 수행하는 방법.The process according to claim 1, wherein the reaction is carried out in the presence of a base. 제4항에 있어서, 염기가 탄산나트륨, 탄산 칼륨, 중탄산나트륨, 중탄산칼륨, 피리딘 또는 트리에틸아민인 방법.The method of claim 4, wherein the base is sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, pyridine or triethylamine. 제1항 내지 3항중 어느 한 항에 있어서, 반응을 알칼리금속 메틸설피닐 메티드염의 존재하에서 수행하는 방법.The process according to any one of claims 1 to 3, wherein the reaction is carried out in the presence of an alkali metal methylsulfinyl meted salt. 제6항에 있어서, 알칼리금속 메틸설피닐메티드염이 동일반응계 내에서 알칼리금속 수화물 및 디메틸 설폭사이드로 부터 제조되는 방법.The process of claim 6, wherein the alkali metal methylsulfinylmethide salt is prepared from alkali metal hydrate and dimethyl sulfoxide in situ. 제1항 내지 7항중 어느 한 항에 있어서, 반응을 0 내지 50℃의 온도에서 수행하는 방법.The process according to claim 1, wherein the reaction is carried out at a temperature of from 0 to 50 ° C. 9. 제1항 내지 8항중 어느 한 항에 있어서, 구조식(Ⅰ)의 푸란 유도체를 계속해서 산 부가염으로 전환시키는 방법.The process according to any one of claims 1 to 8, wherein the furan derivative of structural formula (I) is subsequently converted to an acid addition salt. 제9항에 있어서, 산 부가염이 염산염인 방법.The method of claim 9, wherein the acid addition salt is hydrochloride. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850006858A 1984-09-20 1985-09-19 Process for preparing furan derivatives KR870001166B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB84/23804 1984-09-20
GB848423804A GB8423804D0 (en) 1984-09-20 1984-09-20 Chemical process
GB8423804 1984-09-20

Publications (2)

Publication Number Publication Date
KR860002488A true KR860002488A (en) 1986-04-26
KR870001166B1 KR870001166B1 (en) 1987-06-15

Family

ID=10567015

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006858A KR870001166B1 (en) 1984-09-20 1985-09-19 Process for preparing furan derivatives

Country Status (11)

Country Link
JP (1) JPS61106566A (en)
KR (1) KR870001166B1 (en)
AT (1) AT392639B (en)
CA (1) CA1237440A (en)
DK (1) DK426085A (en)
ES (1) ES8604918A1 (en)
FI (1) FI853599L (en)
GB (2) GB8423804D0 (en)
GR (1) GR852283B (en)
IT (1) IT1200117B (en)
PT (1) PT81161B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
NL8303965A (en) * 1982-12-08 1984-07-02 Degussa NEW FOOD DIAMINE AND GUANIDINE DERIVATIVES; METHOD FOR PREPARING THEREOF MEDICINES CONTAINING THEM; METHOD FOR PREPARING SUCH MEDICINES; APPLICATION OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINAL PRODUCTS AND IN MEDICINE.

Also Published As

Publication number Publication date
FI853599A0 (en) 1985-09-19
GB8523178D0 (en) 1985-10-23
ES8604918A1 (en) 1986-02-16
AT392639B (en) 1991-05-10
PT81161A (en) 1985-10-01
CA1237440A (en) 1988-05-31
IT1200117B (en) 1989-01-05
PT81161B (en) 1988-01-22
ES547108A0 (en) 1986-02-16
DK426085D0 (en) 1985-09-19
DK426085A (en) 1986-03-21
IT8548572A0 (en) 1985-09-19
GR852283B (en) 1985-12-23
ATA274085A (en) 1990-10-15
KR870001166B1 (en) 1987-06-15
FI853599L (en) 1986-03-21
GB2164647A (en) 1986-03-26
GB8423804D0 (en) 1984-10-24
GB2164647B (en) 1988-02-03
JPS61106566A (en) 1986-05-24

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