KR850008172A - 7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid - Google Patents

7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid Download PDF

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Publication number
KR850008172A
KR850008172A KR1019840002423A KR840002423A KR850008172A KR 850008172 A KR850008172 A KR 850008172A KR 1019840002423 A KR1019840002423 A KR 1019840002423A KR 840002423 A KR840002423 A KR 840002423A KR 850008172 A KR850008172 A KR 850008172A
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KR
South Korea
Prior art keywords
substituted
general formula
thimethylmethyl
parosporanic
carboxyxamido
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Application number
KR1019840002423A
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Korean (ko)
Inventor
채정석, (외 1)
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박춘거
주식회사 유한양행
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Application filed by 박춘거, 주식회사 유한양행 filed Critical 박춘거
Priority to KR1019840002423A priority Critical patent/KR850008172A/en
Publication of KR850008172A publication Critical patent/KR850008172A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

내용 없음No content

Description

7[D(-)-α-(4-알킬-2,3-디옥소-1-피페라진 카복시아미도)-α-페닐(또는 하이드록시페닐)아세트아미도]-3-치환치오메틸세 파로스포란산의 제조방법7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

1) 일반식 1) General formula (식중 R은 수소 또는 탄소수가 1-4인 저급 알킬기고 R1은 수소 또는 수산기임) 및 일반식(Wherein R is hydrogen or lower alkyl group having 1-4 carbon atoms and R 1 is hydrogen or hydroxyl group) and general formula (식중 R2는 Where R 2 is 또는, 질소나유황물을 하나 혹은 둘이상 함유하는 치환, 혹은 비치환헤테로 사이클릴 그룹임)로 표시하는 화합물을 동일반응기에서, 상기일반식(Ⅹ)으로 표시하는 화합물을 먼저 실릴화제로 보호한후에 탈수적 축합제 즉, 일반식Alternatively, the compound represented by the above-described general formula (i) in the same reactor with a substituted or unsubstituted heterocyclyl group containing one or two or more nitrogens or sulfurs is first protected with a silylating agent. Dehydrating condensing agents, ie general formula 으로 표시하는 화합물과 촉매를 사용하여 일반식(Ⅰ)Formula (I) using compounds and catalysts represented by (식중 R1,R2는 상기와 같음)로 표시되는 화합물을 제조하는 방법.Wherein R 1 and R 2 are the same as described above. 2) 제1항에 있어서 촉매를 일반식2) The catalyst of claim 1 wherein 로 표시되는 물질을 사용하여 수율을 높이는 것을 특징으로 하는 방법. (식중 R5R6는 동종 또는 이종의 탄소수 1-4인 저급 알킬기 또는 (CH2)4, C(NMe2)2임.Method of increasing the yield using a material represented by. Wherein R 5 R 6 is the same or different lower alkyl group having 1 to 4 carbon atoms or (CH 2 ) 4 , C (NMe 2 ) 2 . 3) 제1항에 있어서 조작이 용이한 온도(0°-30℃)중에서 특히 실온(15°-25℃)에서 목적물을 제조함을 특징으로 하는 방법.3) The method according to claim 1, characterized in that the desired product is produced at an easily operated temperature (0 ° -30 ° C) at room temperature (15 ° -25 ° C). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840002423A 1984-05-04 1984-05-04 7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid KR850008172A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840002423A KR850008172A (en) 1984-05-04 1984-05-04 7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840002423A KR850008172A (en) 1984-05-04 1984-05-04 7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid

Publications (1)

Publication Number Publication Date
KR850008172A true KR850008172A (en) 1985-12-13

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Application Number Title Priority Date Filing Date
KR1019840002423A KR850008172A (en) 1984-05-04 1984-05-04 7 [D (-)-α- (4-alkyl-2,3-dioxo-1-piperazine carboxyxamido) -α-phenyl (or hydroxyphenyl) acetamido] -3-substituted thimethylmethyl Method for preparing parosporanic acid

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KR (1) KR850008172A (en)

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