KR850007063A - Method for preparing glycerol ether phosphide - Google Patents

Method for preparing glycerol ether phosphide Download PDF

Info

Publication number
KR850007063A
KR850007063A KR1019850001631A KR850001631A KR850007063A KR 850007063 A KR850007063 A KR 850007063A KR 1019850001631 A KR1019850001631 A KR 1019850001631A KR 850001631 A KR850001631 A KR 850001631A KR 850007063 A KR850007063 A KR 850007063A
Authority
KR
South Korea
Prior art keywords
alkyl
residues
substituted
compound
formula
Prior art date
Application number
KR1019850001631A
Other languages
Korean (ko)
Inventor
브로우닝거(외 1) 맨프레드
Original Assignee
얀-아퀘스 오게이, 노버트 에이. 코통
에프.호프만-라 롯슈 앤드 캄파니 아코티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 얀-아퀘스 오게이, 노버트 에이. 코통, 에프.호프만-라 롯슈 앤드 캄파니 아코티엔 게젤샤프트 filed Critical 얀-아퀘스 오게이, 노버트 에이. 코통
Publication of KR850007063A publication Critical patent/KR850007063A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음No content

Description

글리세롤 에테르 포스파타이드의 제조방법Method for preparing glycerol ether phosphide

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

일반식(Ⅱ)의 글리세롤 에테르를, 포스포러스옥시클로라이드와 염기 존재하에 반응시킨 다음 알코올 R4OH(여기서, R4는 후술한다)와 반응시키거나, 일반식(Ⅲ)의 화합물과 염기 존재하에 반응시킨 다음 트리-저급 알킬아민과 반응시킴을 특징으로 하는 일반식(Ⅰ)의 글리세롤 에테르 포스파타이드를 제조하는 방법.The glycerol ether of formula (II) is reacted with phosphorus oxychloride in the presence of a base and then with alcohol R 4 OH (wherein R 4 is described later) or in the presence of a compound of formula (III) with a base A process for preparing glycerol ether phosphide of formula (I), characterized in that the reaction is followed by reaction with a tri-lower alkylamine. 상기 식에서, R1, R2및 R3잔기중 둘은 최소한 8개의 탄소원자로 된 직쇄를 갖는 C10-30-알킬 잔기이며, 이때 이들 잔기중 적어도 하나는 최소한 2개의 C1-3-알킬 잔기로 치환되었으며 두 잔기에 있는 탄소수의 합이 20이상이고, 세번째 잔기는 -P(O)(O-)OR4이며, 여기서 R4는 사급 암모늄기에 의해 치환된 저급 알킬 또는 C5-7-시클로알킬잔기 또는 디-(저급-알킬)-치환된 질소원자를 함유하는 C5-7-시클로알킬 잔기이며, 잔기 R11, R21및 R31중 하나는 수소이고, 나머지 잔기들은 전술한 바와 같은 C10-30-알킬잔기이며 m은 2또는 3이다.Wherein two of the R 1 , R 2 and R 3 residues are C 10-30 -alkyl moieties having a straight chain of at least eight carbon atoms, wherein at least one of these residues is at least two C 1-3 -alkyl moieties It has been substituted with at least 20 carbon atoms and the sum of which the two moieties, the third residue is -P (O) (O -) and oR 4, where R 4 is lower alkyl or C 5-7 substituted by a quaternary ammonium group-bicyclo A C 5-7 -cycloalkyl moiety containing an alkyl residue or a di- (lower-alkyl) -substituted nitrogen atom, one of the residues R 11 , R 21 and R 31 is hydrogen, and the remaining residues are as described above C 10-30 -alkyl residue and m is 2 or 3. 제1항에 있어서, R1및 R2가 각각 최소한 2개의 C1-3알킬잔기로 치환된 최소한 탄소수 8개의 직쇄를 갖는 C10-30-알킬잔기인 방법.The process of claim 1, wherein R 1 and R 2 are each a C 10-30 -alkyl residue having at least 8 straight chains substituted with at least 2 C 1-3 alkyl residues. 제1 또는 2항에 있어서, 잔기 R1,R2및 R3중 두개가 하기 일반식의 잔기인 방법.The method of claim 1 or 2, wherein two of the residues R 1, R 2 and R 3 are residues of the general formula: 상기 식에서 n은 0내지 4의 정수이다.Where n is an integer from 0 to 4. 제3항에 있어서, 잔기 R1, R2및 R3중 두개가 테트라히드로게라닐, 헥사히드로파르네실 또는 디히드로피틸인 방법.The method of claim 3, wherein two of the residues R 1 , R 2 and R 3 are tetrahydrogeranyl, hexahydrofarnesyl or dihydrofittyl. 제1내지 4항중 어느 한 항에 있어서, R4가 트리-(저급-알킬)-암모니오-저급-알킬, 트리-(저급-알킬)-암모니오-C5-7-시클로알킬 또는 N, N -디-저급-알킬-C4-6-아자시클로알킬인 방법.5. The compound of claim 1, wherein R 4 is tri- (lower-alkyl) -ammonio-lower-alkyl, tri- (lower-alkyl) -ammonio-C 5-7 -cycloalkyl or N, N-di-lower-alkyl-C 4-6 -azacycloalkyl. 제1내지 5항중 어느 한 항에 있어서, R4가 2-(트리메틸암모니오)에틸, 4-(트리메틸암모니오)-부틸, 4-(트리메틸암모니오)시클로헥실 또는 N, N -디메틸-4-피페리딜인방법.The compound of claim 1, wherein R 4 is 2- (trimethylammonio) ethyl, 4- (trimethylammonio) -butyl, 4- (trimethylammonio) cyclohexyl or N, N-dimethyl-4 How to be piperidyl. 제1내지 6항중 어느 한 항에 있어서, 〔4-〔〔〔(RS)-2, 3-비스〔〔(3RS, 7RS, 11RS)-3, 7, 11, 45-테트라메틸헥사데실〕옥시〕프로폭시〕히드록시포스피닐〕옥시〕부틸〕트리메틸-암모늄히드록시드(내부염)을 제조하는 방법.The compound according to any one of claims 1 to 6, wherein [4-[[((RS) -2,3-bis [[(3RS, 7RS, 11RS) -3, 7, 11, 45-tetramethylhexadecyl] oxy ] Propoxy] hydroxyphosphinyl] oxy] butyl] trimethyl-ammonium hydroxide (internal salt). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850001631A 1984-03-15 1985-03-14 Method for preparing glycerol ether phosphide KR850007063A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1287/84 1984-03-15
CH128784 1984-03-15

Publications (1)

Publication Number Publication Date
KR850007063A true KR850007063A (en) 1985-10-30

Family

ID=4206896

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001631A KR850007063A (en) 1984-03-15 1985-03-14 Method for preparing glycerol ether phosphide

Country Status (4)

Country Link
JP (1) JPS60215693A (en)
KR (1) KR850007063A (en)
GR (1) GR850632B (en)
ZA (1) ZA851774B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4518910B2 (en) * 2004-10-28 2010-08-04 独立行政法人産業技術総合研究所 Branched glycero compounds
AU2012347637B2 (en) * 2011-12-07 2017-09-14 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents

Also Published As

Publication number Publication date
GR850632B (en) 1985-07-05
JPS60215693A (en) 1985-10-29
ZA851774B (en) 1986-10-29

Similar Documents

Publication Publication Date Title
KR850007593A (en) Method for preparing 4-substituted piperazine-2-carboxylic acid
KR830009094A (en) 9- [2- (3-Indolyl) ethyl] -1-oxa-4.9-diazaspiro [5.5] undecane-3-one
KR840001145A (en) Method for preparing amino compound of pyridazine
KR860000243A (en) Method for preparing amine derivative
KR850005845A (en) Process for preparing 7-amino-3-substituted-methyl-3-cepem-4-carboxylic acid and lower alkylsilyl derivatives thereof
KR840003260A (en) Preparation of [(3-amino-3-carboxy) -propyl-1] phosphinic acid derivative
KR860001064A (en) Method for preparing β-lactam compound
KR850007063A (en) Method for preparing glycerol ether phosphide
KR830008549A (en) Method for preparing glutamine derivatives
KR840006983A (en) Method for preparing piperazine derivatives
KR890006620A (en) Quinoline derivatives and their preparation
KR860002517A (en) Method for preparing tris (β, β-dimethylphenethyl) tin compound
KR860001789A (en) Method for preparing dihydropyridine derivative
KR920009833A (en) Method for preparing 3-alkoxymethyl sephalosporin derivative
ATE120750T1 (en) ETHER-FREE ORGANOMETALLIC AMIDE COMPOUNDS.
KR850002979A (en) New Preparation Method of 1,2,3-Trithian Compound
KR870010065A (en) Phosphoric Acid Ester and Process for Preparing the Same
KR910014388A (en) Process for preparing alkyl methyl- (2-carboalkoxyethyl) phosphinate
KR840002351A (en) Method for preparing chialkanoyl-carnitine and composition prepared by slime solution containing the same
KR870003114A (en) Tetrahydroisoquinoline derivatives
KR840001125A (en) Method for preparing iodine-bromine-benzene compound
KR910011785A (en) Process for preparing piperidine derivative hydrochloride
ES8502675A1 (en) Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates.
KR880011114A (en) Process for preparing substituted acetylene compound
KR910007914A (en) Novel Method for Preparing Benzimidazole Derivatives

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application