KR850007063A - Method for preparing glycerol ether phosphide - Google Patents

Abstract

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Description

Method for preparing glycerol ether phosphide

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Claims (7)

The glycerol ether of formula (II) is reacted with phosphorus oxychloride in the presence of a base and then with alcohol R ⁴ OH (wherein R ⁴ is described later) or in the presence of a compound of formula (III) with a base A process for preparing glycerol ether phosphide of formula (I), characterized in that the reaction is followed by reaction with a tri-lower alkylamine. Wherein ^{two of the} R ¹ , R ² and R ³ residues are C _10-30 -alkyl moieties having a straight chain of at least eight carbon atoms, wherein at least one of these residues is at least two C _1-3 -alkyl moieties It has been substituted with at least 20 carbon atoms and the sum of which the two moieties, the third residue is -P (O) (O ^-) and oR ^4, where R ⁴ is lower alkyl or C _5-7 substituted by a quaternary ammonium group-bicyclo A C _5-7 -cycloalkyl moiety containing an alkyl residue or a di- (lower-alkyl) -substituted nitrogen atom, one of the residues R ¹¹ , R ²¹ and R ³¹ is hydrogen, and the remaining residues are as described above C _10-30 -alkyl residue and m is 2 or 3. The process of claim 1, wherein R ¹ and R ² are each a C _10-30 -alkyl residue having at least 8 straight _chains substituted with at least 2 C _1-3 alkyl residues. The method of claim 1 or 2, wherein two of the residues R ^1, R ² and R ³ are residues of the general formula: Where n is an integer from 0 to 4. The method of claim 3, wherein two of the residues R ¹ , R ² and R ³ are tetrahydrogeranyl, hexahydrofarnesyl or dihydrofittyl. 5. The compound of claim 1, wherein R ⁴ is tri- (lower-alkyl) -ammonio-lower-alkyl, tri- (lower-alkyl) -ammonio-C _5-7 -cycloalkyl or N, N-di-lower-alkyl-C _4-6 -azacycloalkyl. The compound of claim 1, wherein R ⁴ is 2- (trimethylammonio) ethyl, 4- (trimethylammonio) -butyl, 4- (trimethylammonio) cyclohexyl or N, N-dimethyl-4 How to be piperidyl. The compound according to any one of claims 1 to 6, wherein [4-[[((RS) -2,3-bis [[(3RS, 7RS, 11RS) -3, 7, 11, 45-tetramethylhexadecyl] oxy ] Propoxy] hydroxyphosphinyl] oxy] butyl] trimethyl-ammonium hydroxide (internal salt). ※ Note: The disclosure is based on the initial application.