KR850002468A - Drawing method of new acyl indole derivative - Google Patents

Drawing method of new acyl indole derivative Download PDF

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Publication number
KR850002468A
KR850002468A KR1019840005895A KR840005895A KR850002468A KR 850002468 A KR850002468 A KR 850002468A KR 1019840005895 A KR1019840005895 A KR 1019840005895A KR 840005895 A KR840005895 A KR 840005895A KR 850002468 A KR850002468 A KR 850002468A
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KR
South Korea
Prior art keywords
iii
reacting
lower alkyl
alkyl group
halogenated
Prior art date
Application number
KR1019840005895A
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Korean (ko)
Inventor
가스하루 이에나가 (외 1)
Original Assignee
고니시 진우에몬
니혼소오끼 세이야꾸 가부시기가이샤
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Application filed by 고니시 진우에몬, 니혼소오끼 세이야꾸 가부시기가이샤 filed Critical 고니시 진우에몬
Publication of KR850002468A publication Critical patent/KR850002468A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음No content

Description

신규 아실인돌 유도체의 제도방법Drawing method of new acyl indole derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

일반식(Ⅰ)로서 표시되는 아실인돌 유도체 및 그 약학적으로 허용할 수 있는 염을 제조함에 있어서,In preparing the acylindole derivatives represented by the general formula (I) and pharmaceutically acceptable salts thereof, (식중, R1,R2는 각각 동일 혹은 다르며 수소, 탄소수 1내지 5의 저급알킬기, 수산기로서 치환된 탄소수 1내지 5의 저급알킬기, 또는(R3은 탄소수 1내지 5의 저급알킬기)를 표시하며, -OR2기는 o- 위 또는 p-위이다.)Wherein R 1 and R 2 are the same or different and each is hydrogen, a lower alkyl group of 1 to 5 carbon atoms, a lower alkyl group of 1 to 5 carbon atoms substituted as a hydroxyl group, or (R 3 represents a lower alkyl group of 1 to 5 carbon atoms), and -OR 2 group is o- or p-phase.) (ⅰ) 인돌에 그리나드시약을 반응시킨 후 산염화물(R2COCI)을 반응시키든가, 또는(Iii) reacting the Grignard reagent with indole followed by an acid chloride (R 2 COCI), or (ⅱ) 인돌에 아미드화합물(R2CONR2′, R′는 C1-4저급알킬기)를 옥시염화인을 사용하여서 반응시키든가, 또한 필요에 따라서,(Ii) reacting an indole amide compound (R 2 CONR 2 ′, R ′ is a C 1-4 lower alkyl group) with phosphorus oxychloride or, if necessary, (ⅲ) 할로겐화 알칸 또는 할로겐화 히드록시알칸(할로겐화 R1H 또는 할로겐화 R2H)을 (ⅰ) 또는 (ⅱ)로서 얻어지는 화합물과 염기촉매존재하에서 반응시키든가, 또는(Iii) reacting a halogenated alkane or halogenated hydroxyalkane (halogenated R 1 H or halogenated R 2 H) with a compound obtained as (iii) or (ii) in the presence of a base catalyst, or (ⅳ) 알데히드(R1COH 또는 R2COH)를 (ⅰ) 또는 (ⅱ)로서 얻어지는 화합물과 산촉매 존재하에서 반응시키든가, 또는(Iii) reacting the aldehyde (R 1 COH or R 2 COH) with the compound obtained as (i) or (ii) in the presence of an acid catalyst, or (ⅴ) 카르본산 또는 그 무수물(R3COOH 또는 R3OCOOR3)DMF (ⅰ) 또는 (ⅱ)로서 얻어지는 화합물과 산 또는 염기촉매 존재하에서 반응시키는 것을 특징으로 하는 아실인돌 유도체의 제조방법.(Iv) a carboxylic acid or an anhydride thereof (R 3 COOH or R 3 OCOOR 3 ) DMF (iii) or a compound obtained as (ii) in the presence of an acid or a base catalyst. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840005895A 1983-09-28 1984-09-25 Drawing method of new acyl indole derivative KR850002468A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58-181084 1983-09-28
JP58181084A JPH0751560B2 (en) 1983-09-28 1983-09-28 Novel acylindole derivative and pharmaceutical composition containing the compound

Publications (1)

Publication Number Publication Date
KR850002468A true KR850002468A (en) 1985-05-13

Family

ID=16094531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005895A KR850002468A (en) 1983-09-28 1984-09-25 Drawing method of new acyl indole derivative

Country Status (2)

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JP (1) JPH0751560B2 (en)
KR (1) KR850002468A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647574B2 (en) * 1984-08-11 1994-06-22 日本臓器製薬株式会社 Novel acylindole derivative and platelet aggregation inhibitor containing the compound as an active ingredient
WO2005094842A1 (en) * 2004-03-30 2005-10-13 Transition Therapeutics Inc. Vitamin b12-containing compositions and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5663960A (en) * 1979-10-29 1981-05-30 Teijin Ltd Acylated indole derivative and platelet coagulation inhibitor containing the same as active constituent
JPS5683472A (en) * 1979-12-12 1981-07-08 Teijin Ltd Preparation of 3-acyl-1-substituted indole derivative
JPS574972A (en) * 1980-06-12 1982-01-11 Teijin Ltd Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent

Also Published As

Publication number Publication date
JPH0751560B2 (en) 1995-06-05
JPS6072861A (en) 1985-04-24

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