KR830010086A - New Preparation of Letosteine - Google Patents

New Preparation of Letosteine Download PDF

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Publication number
KR830010086A
KR830010086A KR1019820001732A KR820001732A KR830010086A KR 830010086 A KR830010086 A KR 830010086A KR 1019820001732 A KR1019820001732 A KR 1019820001732A KR 820001732 A KR820001732 A KR 820001732A KR 830010086 A KR830010086 A KR 830010086A
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KR
South Korea
Prior art keywords
aldehyde
cysteine
general formula
quinidine
quinine
Prior art date
Application number
KR1019820001732A
Other languages
Korean (ko)
Inventor
앙리 쉬브레 무슈
Original Assignee
무슈 쟝 쉬브레
떼아(떼라뾔띠끄 에 아쁠리까시용)쏘씨에떼 아노님
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Application filed by 무슈 쟝 쉬브레, 떼아(떼라뾔띠끄 에 아쁠리까시용)쏘씨에떼 아노님 filed Critical 무슈 쟝 쉬브레
Priority to KR1019820001732A priority Critical patent/KR830010086A/en
Publication of KR830010086A publication Critical patent/KR830010086A/en

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Abstract

내용 없음No content

Description

레토스테인의 새로운 제법New Preparation of Letosteine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

3-티오-프로파날과 에틸 모노클로르 아세테이트를 반응시켜 다음 일반식(2)의 알데히드를 얻고 이 알데히드를 증류후 L-시스테인과 반응시키거나, D,L-시스테인과 반응시켜 얻어진 라세미혼합물을 퀴닌, 퀴니딘 또는 이들 유도체로 분해시킨 후 산성화에 의해 유리시켜 침전 분리함을 특징으로 하는 다음 일반식(1)으로 표시된 L-레토스테인의 새로운 제조방법.By reacting 3-thio-propanal with ethyl monochlor acetate, the aldehyde of the following general formula (2) is obtained, and this aldehyde is distilled and then reacted with L-cysteine, or D, L-cysteine to obtain a racemic mixture. A new process for producing L-letosterine represented by the following general formula (1), characterized by decomposition by quinine, quinidine or derivatives thereof, followed by freezing by acidification to precipitate out. C2H5-O-CO-CH2-S-CH2-CH2-CHO (2)C 2 H 5 -O-CO-CH 2 -S-CH 2 -CH 2 -CHO (2) 청구범위 1항에 있어서 엄격한 pH 조절하에 40℃에서 반응시켜 생성된 염산을 탄산칼슘으로 포착하고 생성된 알데히드를 진공증류시킴을 특징으로 하는 일반식(1)으로 표시된 L-레토스테인의 새로운 제조방법.A new process for preparing L-letosterone represented by the general formula (1) according to claim 1, characterized by trapping the resulting hydrochloric acid with calcium carbonate under vacuum reaction under strict pH control and distilling the produced aldehyde under vacuum. . 청구범위 1항 및 2항에 있어서 알데히드 중간체를 D,L-시스테인과 반응시켜 얻어진 라세미혼합물을 광활성 퀴닌, 퀴니딘 또는 부르신이나 이들 유도체를 분해시킨 후 산성화에 의해 유리시킴을 특징으로 하는 일반식(1)으로 표시된 L-레토스테인의 새로운 제조방법.Formulas according to claims 1 and 2 characterized in that the racemic mixture obtained by reacting an aldehyde intermediate with D, L-cysteine is liberated by acidification after decomposing the photoactive quinine, quinidine or bourcine or their derivatives. A new method for producing L-lettosteine, indicated by (1). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820001732A 1982-04-19 1982-04-19 New Preparation of Letosteine KR830010086A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019820001732A KR830010086A (en) 1982-04-19 1982-04-19 New Preparation of Letosteine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019820001732A KR830010086A (en) 1982-04-19 1982-04-19 New Preparation of Letosteine

Publications (1)

Publication Number Publication Date
KR830010086A true KR830010086A (en) 1983-12-26

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ID=55025769

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820001732A KR830010086A (en) 1982-04-19 1982-04-19 New Preparation of Letosteine

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KR (1) KR830010086A (en)

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