KR830008550A - 4-[n-(3',4'-디하이드록시벤질리덴)아미노메틸] 사이클로헥산-1-카복실산 유도체의 제조방법 - Google Patents
4-[n-(3',4'-디하이드록시벤질리덴)아미노메틸] 사이클로헥산-1-카복실산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830008550A KR830008550A KR1019810003286A KR810003286A KR830008550A KR 830008550 A KR830008550 A KR 830008550A KR 1019810003286 A KR1019810003286 A KR 1019810003286A KR 810003286 A KR810003286 A KR 810003286A KR 830008550 A KR830008550 A KR 830008550A
- Authority
- KR
- South Korea
- Prior art keywords
- cyclohexane
- aminomethyl
- carboxylic acid
- dihydroxybenzylidene
- preparing
- Prior art date
Links
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 title claims 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical class OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 title claims 2
- 238000000034 method Methods 0.000 title description 2
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- PCYGLFXKCBFGPC-UHFFFAOYSA-N 3,4-Dihydroxy hydroxymethyl benzene Natural products OCC1=CC=C(O)C(O)=C1 PCYGLFXKCBFGPC-UHFFFAOYSA-N 0.000 claims 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 3
- 208000009386 Experimental Arthritis Diseases 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명 화합물(산형태)의 KBr 정제법에 의한 적외부 흡수 스펙트럼(IR)을 나타내며,
제2도는 본 발명 화합물(나트륨염)의 IR 스펙트럼을 나타내며,
제3도는 본 발명 화합물(에틸 에스 테르)의 IR 스펙트럼을 나타내며,
제4도는 시간 경과에 따라 낭속으로 삼출된 다핵 백혈구의 수를 나타내며,
제5도는 시간 경과에 따른 보조액 관절염(adjuvant arthritis)에 기인된 뒷발 부피의 변화를 나타내며,
제6도는 시간 경과에 따른 보조액 관절염에 기인된 체중의 변화를 나타낸다.
Claims (1)
- 다음 구조식(Ⅱ)의 3,4-디하이드록시벤즈알데하이드를 다음 구조식(Ⅲ)의 4-아미노메틸-사이클로헥산-1-카복실산 또는 그의 에스테르와 반응시킴을 특징으로 하여 다음 구조식(Ⅰ)의 4-[N-(3',4'-디하이드록시벤질리덴) 아미노메틸] 사이클로헥산-1-카복실산 또는 그의 염 또는 에스테르를 제조하는 방법.상기식에서 사이클로헥산환은 트란스 및 시스형을 포함한다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56025990A JPS57140714A (en) | 1981-02-24 | 1981-02-24 | Medicine containing n-(3,4-dihydroxybenzylidene)- aminomethylcarboxylic acid, salt or ester thereof |
| JP25990/81 | 1981-02-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830008550A true KR830008550A (ko) | 1983-12-10 |
| KR860000998B1 KR860000998B1 (ko) | 1986-07-26 |
Family
ID=12181145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810003286A KR860000998B1 (ko) | 1981-02-24 | 1981-09-03 | 4-[n-(3',4'-디하이드록시벤질리덴)아미노메틸] 사이클로헥산-1-카복실산 유도체의 제조방법 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS57140714A (ko) |
| KR (1) | KR860000998B1 (ko) |
-
1981
- 1981-02-24 JP JP56025990A patent/JPS57140714A/ja active Granted
- 1981-09-03 KR KR1019810003286A patent/KR860000998B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0140805B2 (ko) | 1989-08-31 |
| JPS57140714A (en) | 1982-08-31 |
| KR860000998B1 (ko) | 1986-07-26 |
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