KR830007074A - 중추 벤조디아제핀 수용체에 벤조디아제핀의 결합을 증진시키기 위한 조성물 - Google Patents
중추 벤조디아제핀 수용체에 벤조디아제핀의 결합을 증진시키기 위한 조성물 Download PDFInfo
- Publication number
- KR830007074A KR830007074A KR1019810003920A KR810003920A KR830007074A KR 830007074 A KR830007074 A KR 830007074A KR 1019810003920 A KR1019810003920 A KR 1019810003920A KR 810003920 A KR810003920 A KR 810003920A KR 830007074 A KR830007074 A KR 830007074A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- benzodiazepine
- general formula
- chloro
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940049706 benzodiazepine Drugs 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title claims 5
- 150000001557 benzodiazepines Chemical class 0.000 title claims 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 5
- 239000000730 antalgic agent Substances 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052709 silver Inorganic materials 0.000 claims 2
- 239000004332 silver Substances 0.000 claims 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- BUCORZSTKDOEKQ-UHFFFAOYSA-N 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine Chemical compound C=12C=C(Cl)C=CC2=NC(=NC)CN(O)C=1C1=CC=CC=C1 BUCORZSTKDOEKQ-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- YLCXGBZIZBEVPZ-UHFFFAOYSA-N Medazepam Chemical compound C12=CC(Cl)=CC=C2N(C)CCN=C1C1=CC=CC=C1 YLCXGBZIZBEVPZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- CDCHDCWJMGXXRH-UHFFFAOYSA-N estazolam Chemical compound C=1C(Cl)=CC=C(N2C=NN=C2CN=2)C=1C=2C1=CC=CC=C1 CDCHDCWJMGXXRH-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- IQWYAQCHYZHJOS-UHFFFAOYSA-N tetrazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CCCCC1 IQWYAQCHYZHJOS-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US197872 | 1980-10-17 | ||
| US06/197,872 US4320124A (en) | 1980-10-17 | 1980-10-17 | Composition for enhancing binding of a benzodiazepine to central benzodiazepine receptors and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830007074A true KR830007074A (ko) | 1983-10-14 |
Family
ID=22731077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810003920A Abandoned KR830007074A (ko) | 1980-10-17 | 1981-10-16 | 중추 벤조디아제핀 수용체에 벤조디아제핀의 결합을 증진시키기 위한 조성물 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4320124A (enExample) |
| EP (1) | EP0050487B1 (enExample) |
| JP (1) | JPS5795912A (enExample) |
| KR (1) | KR830007074A (enExample) |
| AU (1) | AU529307B2 (enExample) |
| DE (1) | DE3166349D1 (enExample) |
| GR (1) | GR75097B (enExample) |
| IL (1) | IL64062A0 (enExample) |
| NZ (1) | NZ198657A (enExample) |
| PT (1) | PT73746B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406888A (en) * | 1981-01-09 | 1983-09-27 | Pfizer Inc. | Aqueous micellar solutions of levonantradol and N-methyllevonantradol and lyophilic forms thereof for reconstitution |
| US6031098A (en) * | 1997-08-11 | 2000-02-29 | California Institute Of Technology | Detection and treatment of duplex polynucleotide damage |
| US6617321B2 (en) * | 1997-09-30 | 2003-09-09 | Eli Lilly And Company | 2-methyl-thieno-benzodiazepine formulation |
| US20030199496A1 (en) * | 2002-04-22 | 2003-10-23 | Simon David Lew | Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use |
| WO2006060736A2 (en) * | 2004-12-03 | 2006-06-08 | The Children's Hospital Of Philadelphia | A composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug |
| SI1838716T1 (sl) * | 2005-01-05 | 2011-10-28 | Lilly Co Eli | Olanzapin pamoat dihidrat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862986A (en) * | 1966-07-01 | 1975-01-28 | Hoffmann La Roche | 1-Hydroxymethyl-amino-2-alkyl-or allyl-2-(3{40 -methoxy-phenyl)-chclohexanes |
| BE854655A (fr) * | 1976-05-17 | 1977-11-16 | Pfizer | 9-hydroxyhexahydrobenzo (c) quinoleines et intermediaires de synthese |
| US4206225A (en) * | 1978-09-22 | 1980-06-03 | Pfizer Inc. | 2,10-Disubstituted dibenzo[b,d]pyrans and benzo[c]quinolines |
| US4228169A (en) * | 1979-06-26 | 1980-10-14 | Pfizer Inc. | 1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones as antiemetic agents |
-
1980
- 1980-10-17 US US06/197,872 patent/US4320124A/en not_active Expired - Lifetime
-
1981
- 1981-09-30 PT PT73746A patent/PT73746B/pt unknown
- 1981-10-13 GR GR66267A patent/GR75097B/el unknown
- 1981-10-15 NZ NZ198657A patent/NZ198657A/en unknown
- 1981-10-16 AU AU76517/81A patent/AU529307B2/en not_active Ceased
- 1981-10-16 IL IL64062A patent/IL64062A0/xx unknown
- 1981-10-16 DE DE8181304822T patent/DE3166349D1/de not_active Expired
- 1981-10-16 KR KR1019810003920A patent/KR830007074A/ko not_active Abandoned
- 1981-10-16 JP JP56165567A patent/JPS5795912A/ja active Pending
- 1981-10-16 EP EP81304822A patent/EP0050487B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GR75097B (enExample) | 1984-07-13 |
| DE3166349D1 (en) | 1984-10-31 |
| AU529307B2 (en) | 1983-06-02 |
| JPS5795912A (en) | 1982-06-15 |
| PT73746A (en) | 1981-10-01 |
| AU7651781A (en) | 1982-04-22 |
| EP0050487A1 (en) | 1982-04-28 |
| NZ198657A (en) | 1985-05-31 |
| IL64062A0 (en) | 1982-01-31 |
| EP0050487B1 (en) | 1984-09-26 |
| PT73746B (en) | 1983-11-08 |
| US4320124A (en) | 1982-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19811016 |
|
| PG1501 | Laying open of application | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19850701 Patent event code: PE09021S01D |
|
| PC1902 | Submission of document of abandonment before decision of registration |