KR830005236A - How to prepare cepradine - Google Patents

How to prepare cepradine Download PDF

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Publication number
KR830005236A
KR830005236A KR1019810000560A KR810000560A KR830005236A KR 830005236 A KR830005236 A KR 830005236A KR 1019810000560 A KR1019810000560 A KR 1019810000560A KR 810000560 A KR810000560 A KR 810000560A KR 830005236 A KR830005236 A KR 830005236A
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KR
South Korea
Prior art keywords
general formula
amino
desacetoxy
acid
toluene
Prior art date
Application number
KR1019810000560A
Other languages
Korean (ko)
Other versions
KR840002043B1 (en
Inventor
리취 뒤르쉬 프리드
Original Assignee
죠오지 제이. 케이설
이. 알. 스큅 앤드 썬즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 죠오지 제이. 케이설, 이. 알. 스큅 앤드 썬즈 인코포레이티드 filed Critical 죠오지 제이. 케이설
Priority to KR1019810000560A priority Critical patent/KR840002043B1/en
Publication of KR830005236A publication Critical patent/KR830005236A/en
Application granted granted Critical
Publication of KR840002043B1 publication Critical patent/KR840002043B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Abstract

내용 없음No content

Description

세프라딘을 제조하는 방법How to prepare cepradine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

하기 일반식(Ⅰ)을 가진 산을 하기 일반식(Ⅱ)를 가진 7-아미노-데스아세톡시 세팔로스포라닌산의 아미노기와 결합시켜서 얻은 생성물을 p-톨루엔 황산과 반응시켜서 요구하는 생성물의 p-톨루엔 황산염을 얻은 다음 이 염을 다시 중화시킴을 특징으로 하는 하기 일반식(Ⅲ)을 가진 생성물인 7-[D-2-아미노-2-(1,4-시클로헥사디엔-1-일)아세트아미도]데스아세톡시 세팔로스포라닌산을 제조하는 방법.P of the product required by reacting a product obtained by combining an acid having the general formula (I) with an amino group of 7-amino-desacetoxy cephalosporanic acid having the general formula (II) 7- [D-2-amino-2- (1,4-cyclohexadien-1-yl), a product having the general formula (III) characterized by obtaining toluene sulfate and then neutralizing the salt again Acetamido] desacetoxy cephalosporanic acid. 하기 일반식(Ⅰ)을 가진 화합물을 하기 일반식(Ⅱ)를 가진 7-아미노-데스아세톡시 세팔로스포라닌산의 아미노기와 반응시킴을 특징으로 하는 하기 일반식(Ⅲ)를 가진 7-[D-2-아미노-(1,4-시클로헥사디엔-1-일)아세트아미도]데스아세톡시 세팔로스포라닌산을 제조하는 방법.A compound having the following general formula (I) is reacted with an amino group of 7-amino-desacetoxy cephalosporanoic acid having the following general formula (II). D-2-amino- (1,4-cyclohexadien-1-yl) acetamido] desacetoxy cephalosporanic acid. 그 반응생성물을 p-톨루엔 황산과 반응시켜서 7-[D-2-아미노-2-2-(1,4-시클로헥사디엔일)아세트아미도]-데스아세톡시 세팔로스포라닌산과 p-톨루엔 황산염을 생성시킴을 특징으로 하는 특허청구의 범위 제2항에 의한 방법.The reaction product was reacted with p-toluene sulfuric acid to produce 7- [D-2-amino-2-2- (1,4-cyclohexadienyl) acetamido] -desacetoxy cephalosporanoic acid and p-toluene Process according to claim 2 characterized in that it produces a sulfate. 하기 일반식(Ⅰ)을 가진 화합물을 하기 일반식(Ⅱ)를 가진 7-데스아세톡시 세팔로스포라닌산의 아미노기와 반응시켜서 얻은 생성물을 p-톨루엔 황산과 반응시켜 요구하는 p-톨루엔 황산염을 얻은 다음 다시 이염을 중화시킴을 특징으로 하는 하기 일반식(Ⅲ)을 가진 7-[D-2-아미노-2-(1,4-시클로헥사디엔-1-일)아세트아미도]데스아세톡시 세팔로스포라닌산을 제조하는 방법.The product obtained by reacting a compound having the following general formula (I) with an amino group of 7-desacetoxy cephalosporanic acid having the following general formula (II) is reacted with p-toluene sulfuric acid to obtain the required p-toluene sulfate. 7- [D-2-amino-2- (1,4-cyclohexadien-1-yl) acetamido] desacetoxy with the general formula (III) Method for preparing cephalosporanic acid. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810000560A 1981-02-20 1981-02-20 Process for preparing cephradine KR840002043B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019810000560A KR840002043B1 (en) 1981-02-20 1981-02-20 Process for preparing cephradine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810000560A KR840002043B1 (en) 1981-02-20 1981-02-20 Process for preparing cephradine

Publications (2)

Publication Number Publication Date
KR830005236A true KR830005236A (en) 1983-08-03
KR840002043B1 KR840002043B1 (en) 1984-11-06

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ID=19220252

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000560A KR840002043B1 (en) 1981-02-20 1981-02-20 Process for preparing cephradine

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KR (1) KR840002043B1 (en)

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Publication number Publication date
KR840002043B1 (en) 1984-11-06

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