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Application filed by Fujisawa Pharmaceutical CofiledCriticalFujisawa Pharmaceutical Co
Priority to KR7401508ApriorityCriticalpatent/KR790000101B1/en
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Publication of KR790000101B1publicationCriticalpatent/KR790000101B1/en
The penams(I) and cephams(II) (e.g. R =PhCH2, PhOCH2, 2-thienylmethyl, protected phCHNH2; R1 = CH2CCl3, Me; R2 = Cl, Br, OAc, OMe, SCN), useful as antimicrobial agent, were prepd. by cyclizing(III) with a suitable reagent for providing R2. III was prepd. by reaction of thiol compound and 2-methyl-2-lower alkyl-6-substituted penam-3-carboxylicacid-1-oxide. Subsequent reaction of I and II included deacylation, ester hydrolysis, S-oxidn. and substitution at R2..
KR7401508A1974-02-151974-02-15Method of preparing penam and cepham derivatives
KR790000101B1
(en)
THE AMINOGLYCOSIDE BU-2183D AND PROCEDURE FOR PREPARING THE ANTIBIOTIC COMPLEX BU-2183, BY CULTIVATION OF THE PSEUDOMONAS STOCK D946-B83, ITS COMPONENTS AND ITS ACID ADDITION SALTS