KR20250025712A - 당뇨병성 인지증에 대한 예방약 및 치료약 - Google Patents

당뇨병성 인지증에 대한 예방약 및 치료약 Download PDF

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Publication number
KR20250025712A
KR20250025712A KR1020257001813A KR20257001813A KR20250025712A KR 20250025712 A KR20250025712 A KR 20250025712A KR 1020257001813 A KR1020257001813 A KR 1020257001813A KR 20257001813 A KR20257001813 A KR 20257001813A KR 20250025712 A KR20250025712 A KR 20250025712A
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KR
South Korea
Prior art keywords
lps
stz
administration
group
diabetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257001813A
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English (en)
Korean (ko)
Inventor
겐이치로 소마
히로유키 이나가와
치에 코우치
하루카 미조부치
Original Assignee
겐이치로 소마
바이오메디칼 리서치 그룹 인코포레이티드
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Publication of KR20250025712A publication Critical patent/KR20250025712A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020257001813A 2022-06-22 2022-06-22 당뇨병성 인지증에 대한 예방약 및 치료약 Pending KR20250025712A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2022/024854 WO2023248374A1 (ja) 2022-06-22 2022-06-22 糖尿病性認知症に対する予防薬及び治療薬

Publications (1)

Publication Number Publication Date
KR20250025712A true KR20250025712A (ko) 2025-02-24

Family

ID=89379623

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257001813A Pending KR20250025712A (ko) 2022-06-22 2022-06-22 당뇨병성 인지증에 대한 예방약 및 치료약

Country Status (5)

Country Link
US (1) US20250381216A1 (https=)
JP (1) JPWO2023248374A1 (https=)
KR (1) KR20250025712A (https=)
AU (1) AU2022464309A1 (https=)
WO (1) WO2023248374A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030938A1 (ja) 2003-09-26 2005-04-07 Biomedical Research Group Inc. 発酵及び培養方法、植物発酵エキス、植物発酵エキス末並びに該植物発酵エキス配合物
JP2018199643A (ja) 2017-05-28 2018-12-20 自然免疫制御技術研究組合 リポ多糖を用いた脳機能改善剤、食品及び医薬品

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006326642B2 (en) * 2005-12-09 2012-05-03 Technion Research And Development Foundation Ltd. Use of low-dose ladostigil for neuroprotection
CN108567792A (zh) * 2017-03-07 2018-09-25 上海泽生科技开发股份有限公司 一种治疗阿尔茨海默病的复合维生素组合物
JP6861264B1 (ja) * 2019-11-19 2021-04-21 慶昌 木島 組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030938A1 (ja) 2003-09-26 2005-04-07 Biomedical Research Group Inc. 発酵及び培養方法、植物発酵エキス、植物発酵エキス末並びに該植物発酵エキス配合物
JP2018199643A (ja) 2017-05-28 2018-12-20 自然免疫制御技術研究組合 リポ多糖を用いた脳機能改善剤、食品及び医薬品

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
"혈액뇌관문", [on line], 일반재단법인 일본 구급의학회, 의학용어 해설집, [20224년 6월 20일 검색], 인터넷 <URL: https://www.jaam.jp/dictionary/dictionary/word/0111.html>
H. Inagawa et al., "Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea agglomerans", in vivo 30: 205-211(2016).
H. Mizobuchi et al., "Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans", Front. Immunol.,(2021) <https://doi.org/10.3389/fimmu.2021.650176>
K. Nakata et al., "A mixture of Salacia extract and IP-PA1 reduces fasting plasma glucose (FPG) levels and LDL cholesterol levels", Nutrition Research and Practice 5: 435-442(2011).
M. Gulyas et al., "AnimalTracker: An ImageJ-Based Tracking API to Create a Customized Behaviour Analyser Program", Neuroinformatics 14: 479-81(2016).
M. Hokama et al., "Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study", Cereb. Cortex 24: 2476-2488(2014).
M. Salkovic-Petrisic et al., "Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study", J. Neural. Transm. 118: 765-772(2011).
P. Grieb, "Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer's Disease: in Search of a Relevant Mechanism", Molecular Neurobiology 53: 1741-1752(2016)
Y. Kobayashi et al.,"Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer's disease-related memory loss in senescence-accelerated prone 8(SAMP8) mice fed a high-fat diet", PLoS ONE (2018)13(6): e0198493.
Y. Zhang et al., "Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice", Experimental and Therapeutic Medicine (2018) <https://doi.org/10.3892/etm.2018.6487>
오사와 마사히로, 야마다 아키히로, 「당뇨병과 인지기능 장애」, 일약리지, Vol. 142, 2013, p201-202

Also Published As

Publication number Publication date
WO2023248374A1 (ja) 2023-12-28
JPWO2023248374A1 (https=) 2023-12-28
US20250381216A1 (en) 2025-12-18
AU2022464309A1 (en) 2025-01-23

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PA0105 International application

Patent event date: 20250117

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination
PG1501 Laying open of application