KR20250011932A - 피펫팅 장치 및 방법 - Google Patents

피펫팅 장치 및 방법 Download PDF

Info

Publication number
KR20250011932A
KR20250011932A KR1020247041218A KR20247041218A KR20250011932A KR 20250011932 A KR20250011932 A KR 20250011932A KR 1020247041218 A KR1020247041218 A KR 1020247041218A KR 20247041218 A KR20247041218 A KR 20247041218A KR 20250011932 A KR20250011932 A KR 20250011932A
Authority
KR
South Korea
Prior art keywords
plunger
tip
liquid
pipette tip
pipetting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247041218A
Other languages
English (en)
Korean (ko)
Inventor
토마스 페루
토마스 로린스
한스-위어겐 티트케
카이 하슬러
Original Assignee
레비티 헬스 사이언시스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 레비티 헬스 사이언시스, 인코포레이티드 filed Critical 레비티 헬스 사이언시스, 인코포레이티드
Publication of KR20250011932A publication Critical patent/KR20250011932A/ko
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/022—Capillary pipettes, i.e. having very small bore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0231—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having several coaxial pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0237—Details of electronic control, e.g. relating to user interface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/029—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type provided with electric controlling means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0615—Loss of fluid by dripping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Human Computer Interaction (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
KR1020247041218A 2022-05-11 2023-04-20 피펫팅 장치 및 방법 Pending KR20250011932A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17/741,647 US20230366904A1 (en) 2022-05-11 2022-05-11 Pipetting apparatus and methods
US17/741,647 2022-05-11
PCT/US2023/065982 WO2023220517A1 (en) 2022-05-11 2023-04-20 Pipetting apparatus and methods

Publications (1)

Publication Number Publication Date
KR20250011932A true KR20250011932A (ko) 2025-01-22

Family

ID=86330995

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247041218A Pending KR20250011932A (ko) 2022-05-11 2023-04-20 피펫팅 장치 및 방법

Country Status (7)

Country Link
US (2) US20230366904A1 (https=)
EP (1) EP4486510A1 (https=)
JP (1) JP2025517696A (https=)
KR (1) KR20250011932A (https=)
CN (1) CN119212793A (https=)
AU (2) AU2023269766B2 (https=)
WO (1) WO2023220517A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060716A1 (en) * 2017-09-25 2019-03-28 Freenome Holdings, Inc. SAMPLE EXTRACTION METHODS AND SYSTEMS
US20220268796A1 (en) * 2021-02-19 2022-08-25 Roche Molecular Systems, Inc. Method of Operating a Laboratory Instrument
EP4692757A3 (en) * 2022-12-14 2026-04-29 Tecan Trading AG Determining physical parameters of a liquid
US20240255538A1 (en) * 2023-01-30 2024-08-01 Agilent Technologies, Inc. Liquid dispensing device for filling multiple containers

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791890A (fr) * 1971-11-26 1973-03-16 Rohe Scientific Corp Echantillonneur et dilueur
JPS5984453U (ja) 1982-11-30 1984-06-07 株式会社島津製作所 希釈ピペツタ−
US4523484A (en) * 1983-09-26 1985-06-18 Shimadzu Corporation Dilution pipetter
US5192511A (en) 1991-05-31 1993-03-09 Tri-Continent Scientific, Inc. Pipette tip and piston
JP3318629B2 (ja) * 1993-06-18 2002-08-26 ソニー株式会社 液体の吸引／排出装置及び方法
DE10118875C1 (de) * 2001-04-18 2002-09-12 Eppendorf Ag Verfahren zum kontrollierten Dosieren von Flüssigkeiten unter Verdrängung eines Gaspolsters
US20070059215A1 (en) 2005-09-14 2007-03-15 Pacific Image Electronics Co., Ltd. Micro pipette sensing device
US7581660B2 (en) * 2005-11-09 2009-09-01 Hamilton Bonaduz Ag Drip-resistant pipetting device and drip-resistant pipetting method
FR2895920B1 (fr) 2006-01-06 2008-04-18 Gilson Sas Soc Par Actions Sim Pipette multivolumes.
US8096197B2 (en) 2006-03-31 2012-01-17 Artel, Inc. Air displacement liquid delivery system and related method
JP5186430B2 (ja) * 2009-04-27 2013-04-17 日立アロカメディカル株式会社 分注装置
US8231842B2 (en) 2010-01-22 2012-07-31 Tecan Trading Ag Positive displacement pump with pressure sensor
DE202013003390U1 (de) 2013-04-11 2014-07-14 Brand Gmbh + Co Kg Pipettiervorrichtung mit einer Mikrodosiereinheit
CA2957420A1 (en) * 2014-08-15 2016-02-18 Biomerieux, Inc. Methods, systems, and computer program products for verifying dispensing of a fluid from a pipette
US10379131B2 (en) 2015-11-18 2019-08-13 Elbit Systems Of America/Kmc Systems, Inc. Systems and methods for detecting a liquid level
CH712735A1 (de) 2016-07-22 2018-01-31 Tecan Trading Ag Pipettiervorrichtung mit einem Flüssigkeitsvolumensensor und Flüssigkeitsbearbeitungssystem.
CH712764A2 (de) 2016-07-22 2018-01-31 Tecan Trading Ag Pipettenspitze aufweisend eine Volumenmesselektrode sowie Verfahren zu deren Herstellung und Pipettiervorrichtung.
US10859592B2 (en) 2017-01-31 2020-12-08 Tecan Trading Ag Method of aspirating by pipetting and pipetting apparatus
JP7372245B2 (ja) * 2017-12-28 2023-10-31 フォーミュラトリクス・インターナショナル・ホールディング・リミテッド 自動液体移送最適化分注を行う装置とその方法
EP3851191A1 (de) * 2020-01-17 2021-07-21 Eppendorf AG Verfahren zum betreiben einer kolbenhubpipette, kolbenhubpipette, datenverarbeitungsgerät und system
CA3218868C (en) 2020-02-14 2025-08-05 DeNovix, Inc. Dynamic broad volumetric range pipette

Also Published As

Publication number Publication date
AU2023269766A1 (en) 2024-10-17
US20230366904A1 (en) 2023-11-16
CN119212793A (zh) 2024-12-27
AU2023269766B2 (en) 2026-02-26
AU2025283504A1 (en) 2026-01-15
EP4486510A1 (en) 2025-01-08
US20230364600A1 (en) 2023-11-16
US12496577B2 (en) 2025-12-16
JP2025517696A (ja) 2025-06-10
WO2023220517A1 (en) 2023-11-16

Similar Documents

Publication Publication Date Title
KR20250011932A (ko) 피펫팅 장치 및 방법
US7814805B2 (en) Automated pipette machine
JP6240163B2 (ja) 流体を供給するカートリッジ
JP5475695B2 (ja) 圧力センサを備える容積型ポンプ
TWI422801B (zh) 分注量檢測方法及吸液監測器型分注裝置
CA2679675A1 (en) Hand pipetting device
MXPA03001262A (es) Un sistema y metodo para verificar la integridad de la condicion y operacion de un dispositivo de pipeta para manipular muestras de fluido.
CN110753581A (zh) 集成移液器
JP2025517696A5 (https=)
CN110893352B (zh) 微流控器件以及在微流控器件中加载流体的方法
US20260124611A1 (en) Pipetting apparatus and methods
CN100434181C (zh) 计量一定剂量的样品液体
EP4578547A1 (en) Microfluidic device for a laboratory automation device
CN116099582A (zh) 一种自动脱离吸液头的移液器
EP4381298A1 (en) Apparatus for the automated pipetting and related process
HK40088180A (zh) 多点滤波液体液位检测方法和装置
KR20230002308A (ko) 피펫 장치 및 분석 장치

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000