KR20250004876A - 한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법 - Google Patents

한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법 Download PDF

Info

Publication number
KR20250004876A
KR20250004876A KR1020247039474A KR20247039474A KR20250004876A KR 20250004876 A KR20250004876 A KR 20250004876A KR 1020247039474 A KR1020247039474 A KR 1020247039474A KR 20247039474 A KR20247039474 A KR 20247039474A KR 20250004876 A KR20250004876 A KR 20250004876A
Authority
KR
South Korea
Prior art keywords
plasma
pool
fraction
protein
concentrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247039474A
Other languages
English (en)
Korean (ko)
Inventor
이바노 마르텔리
올리버 미셀베르거
프란체스카 미켈리
알렉산더 자이덴베르크
재로드 핸슨
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다케다 야쿠힌 고교 가부시키가이샤 filed Critical 다케다 야쿠힌 고교 가부시키가이샤
Publication of KR20250004876A publication Critical patent/KR20250004876A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027—Nanofiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/16—Use of chemical agents
    • B01D2321/162—Use of acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Water Supply & Treatment (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
KR1020247039474A 2022-05-02 2023-05-01 한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법 Pending KR20250004876A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263337439P 2022-05-02 2022-05-02
US63/337,439 2022-05-02
US202363498470P 2023-04-26 2023-04-26
US63/498,470 2023-04-26
PCT/US2023/066457 WO2023215722A1 (en) 2022-05-02 2023-05-01 Methods of preparing cohn pool concentrate from blood plasma through ultrafiltration

Publications (1)

Publication Number Publication Date
KR20250004876A true KR20250004876A (ko) 2025-01-08

Family

ID=86646677

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247039474A Pending KR20250004876A (ko) 2022-05-02 2023-05-01 한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법

Country Status (9)

Country Link
US (1) US20250281530A1 (https=)
EP (1) EP4518875A1 (https=)
JP (1) JP2025514479A (https=)
KR (1) KR20250004876A (https=)
CN (1) CN119300842A (https=)
AU (1) AU2023264066A1 (https=)
MX (1) MX2024013454A (https=)
TW (1) TW202400621A (https=)
WO (1) WO2023215722A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2390074A (en) 1942-02-09 1945-12-04 Research Corp Protein product and process
DE2902158A1 (de) * 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen
US8304524B2 (en) * 2009-07-23 2012-11-06 Baxter International Inc. Manufacture of factor H (FH) and FH-derivatives from plasma
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
SG187599A1 (en) * 2010-07-23 2013-03-28 Baxter Int Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma
US9403899B2 (en) * 2011-08-26 2016-08-02 Baxalta Incorporated Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
AU2013203043B2 (en) * 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
CN116322920A (zh) * 2020-11-09 2023-06-23 武田药品工业株式会社 使用氧化硅吸附从血浆中纯化fviii

Also Published As

Publication number Publication date
JP2025514479A (ja) 2025-05-02
TW202400621A (zh) 2024-01-01
EP4518875A1 (en) 2025-03-12
MX2024013454A (es) 2024-12-06
CN119300842A (zh) 2025-01-10
WO2023215722A1 (en) 2023-11-09
US20250281530A1 (en) 2025-09-11
AU2023264066A1 (en) 2024-10-31

Similar Documents

Publication Publication Date Title
AU2021286395B2 (en) Removal of serine proteases by treatment with finely divided silicon dioxide
US11891431B2 (en) Removal of serine proteases by treatment with finely divided silicon dioxide
CA2941230C (en) Method for purifying immunoglobulin
CN101501059A (zh) 奶中一种或多种蛋白的提取方法
CN103476786B (zh) 一种生产血液来源蛋白质注射制剂的方法，以及使用上述方法获得的蛋白质物料
EP3118210A1 (en) Method for purifying immunoglobulin
CN108779144A (zh) 从血液原料中提取蛋白质的方法
CN104245730A (zh) 源自血浆的免疫球蛋白的级分i-iv-1沉淀
TWI610937B (zh) 用於降低血漿來源免疫球蛋白組成物之血栓性栓塞可能性的方法
CA2621025A1 (en) An ultra-high yield intravenous immune globulin preparation
JP2014520829A (ja) 多価免疫グロブリン濃縮物の製造方法
EP0512883A1 (fr) Concentré de facteur XI de la coagulation sanguine à haute activité spécifique, approprié à un usage thérapeutique et son procédé de préparation
US20240092828A1 (en) Systems and methods for process scale isolation of a protein
AU2006287833B2 (en) An ultra-high yield intravenous immune globulin preparation
KR20250004876A (ko) 한외여과를 통한 혈장으로부터 콘 풀 농축액을 제조하는 방법
KR20220161332A (ko) C-1 억제제 고갈 혈장으로부터 면역글로불린 조제물을 제조하는 방법
JP2003501480A (ja) 静注用免疫グロブリンの製造方法および製剤
RU2324495C1 (ru) Способ получения препарата фактора свертывания viii крови человека
CN120309712A (zh) 人纤维蛋白原的纯化方法及应用
WO2025085544A1 (en) Integrated process for isolation of plasma proteins

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18 Changes to party contact information recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000