KR20240155975A - 장 질환에 대한 면역원성 조성물 및 이의 제조 방법 - Google Patents

장 질환에 대한 면역원성 조성물 및 이의 제조 방법 Download PDF

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Publication number
KR20240155975A
KR20240155975A KR1020247034650A KR20247034650A KR20240155975A KR 20240155975 A KR20240155975 A KR 20240155975A KR 1020247034650 A KR1020247034650 A KR 1020247034650A KR 20247034650 A KR20247034650 A KR 20247034650A KR 20240155975 A KR20240155975 A KR 20240155975A
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South Korea
Prior art keywords
antigen
typhi
polysaccharide
saccharide
carrier protein
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KR1020247034650A
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English (en)
Korean (ko)
Inventor
라지브 말라사칸트 데레
삼브하지 샨카르 피살
다타트레야 사르마 안남라주
니킬 다타트레이 아발라스카르
요게시 투카람 훈데카리
아닐 피라지라오 타클리카르
수닐 쿠마르 고엘
찬드라셰카르 드와르카나트 카마트
비샬 바라트 차반
Original Assignee
세럼 인스티튜트 오브 인디아 프라이비트 리미티드
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Publication of KR20240155975A publication Critical patent/KR20240155975A/ko
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0275Salmonella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247034650A 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법 Pending KR20240155975A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201921035435 2019-09-03
IN201921035435 2019-09-03
KR1020227011108A KR20220087437A (ko) 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법
PCT/IN2020/050763 WO2021044436A2 (en) 2019-09-03 2020-09-02 Immunogenic compositions against enteric diseases and methods for its preparation thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020227011108A Division KR20220087437A (ko) 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법

Publications (1)

Publication Number Publication Date
KR20240155975A true KR20240155975A (ko) 2024-10-29

Family

ID=72659843

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247034650A Pending KR20240155975A (ko) 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법
KR1020227011108A Pending KR20220087437A (ko) 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020227011108A Pending KR20220087437A (ko) 2019-09-03 2020-09-02 장 질환에 대한 면역원성 조성물 및 이의 제조 방법

Country Status (23)

Country Link
US (2) US20230149524A1 (https=)
EP (2) EP4249061A3 (https=)
JP (2) JP7732974B2 (https=)
KR (2) KR20240155975A (https=)
CN (1) CN114728053A (https=)
AR (1) AR119884A1 (https=)
AU (1) AU2020343943A1 (https=)
BR (1) BR112022003892A2 (https=)
CA (1) CA3149972A1 (https=)
CO (1) CO2022003789A2 (https=)
CR (1) CR20220132A (https=)
EC (1) ECSP22031077A (https=)
GB (2) GB2603362B (https=)
GE (2) GEP20257808B (https=)
IL (1) IL291006B2 (https=)
JO (1) JOP20200214A1 (https=)
MA (1) MA56283A1 (https=)
MX (1) MX2022002693A (https=)
PE (1) PE20221442A1 (https=)
PH (1) PH12022550525A1 (https=)
PY (1) PY2051122A (https=)
WO (1) WO2021044436A2 (https=)
ZA (1) ZA202203368B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121569027A (zh) * 2023-07-21 2026-02-24 葛兰素史克生物有限公司 免疫原性组合物
WO2025217253A1 (en) * 2024-04-12 2025-10-16 Neogen Corporation Neutralizing compositions and related methods

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US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
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US20070184072A1 (en) 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
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Also Published As

Publication number Publication date
US20230149524A1 (en) 2023-05-18
IL291006A (en) 2022-05-01
JP2024178271A (ja) 2024-12-24
AU2020343943A1 (en) 2022-03-24
PH12022550525A1 (en) 2023-03-20
CA3149972A1 (en) 2021-03-11
GEAP202515919A (en) 2025-05-27
JOP20200214A1 (ar) 2021-03-03
PY2051122A (es) 2021-08-11
EP4249061A3 (en) 2023-11-15
EP4025246A2 (en) 2022-07-13
PE20221442A1 (es) 2022-09-21
CR20220132A (es) 2022-05-06
IL291006B2 (en) 2026-03-01
WO2021044436A3 (en) 2021-05-27
MX2022002693A (es) 2022-07-12
GB202204276D0 (en) 2022-05-11
JP7732974B2 (ja) 2025-09-02
GB2629746B (en) 2025-01-29
GB2603362A (en) 2022-08-03
IL291006B1 (en) 2025-11-01
GEP20257808B (en) 2025-10-27
US20250134980A1 (en) 2025-05-01
ZA202203368B (en) 2022-05-25
GB2629746A (en) 2024-11-06
WO2021044436A2 (en) 2021-03-11
BR112022003892A2 (pt) 2022-05-24
KR20220087437A (ko) 2022-06-24
GB2603362B (en) 2025-01-15
ECSP22031077A (es) 2022-05-31
AR119884A1 (es) 2022-01-19
CN114728053A (zh) 2022-07-08
JP2022546763A (ja) 2022-11-08
CO2022003789A2 (es) 2022-04-19
MA56283A1 (fr) 2023-01-31
EP4249061A2 (en) 2023-09-27

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