KR20240149415A - 올리고뉴클레오티드의 제조 방법 - Google Patents

올리고뉴클레오티드의 제조 방법 Download PDF

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Publication number
KR20240149415A
KR20240149415A KR1020247029387A KR20247029387A KR20240149415A KR 20240149415 A KR20240149415 A KR 20240149415A KR 1020247029387 A KR1020247029387 A KR 1020247029387A KR 20247029387 A KR20247029387 A KR 20247029387A KR 20240149415 A KR20240149415 A KR 20240149415A
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KR
South Korea
Prior art keywords
nucleoside
group
amount
phosphoroamidite
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247029387A
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English (en)
Korean (ko)
Inventor
케이 요시다
토모요시 이다
마사푸미 이와모토
에리 매타
준 마츠나미
Original Assignee
닛토덴코 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 닛토덴코 가부시키가이샤 filed Critical 닛토덴코 가부시키가이샤
Publication of KR20240149415A publication Critical patent/KR20240149415A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020247029387A 2022-02-04 2023-02-06 올리고뉴클레오티드의 제조 방법 Pending KR20240149415A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2022016005 2022-02-04
JPJP-P-2022-016005 2022-02-04
JPJP-P-2022-142048 2022-09-07
JP2022142048 2022-09-07
PCT/JP2023/003686 WO2023149564A1 (ja) 2022-02-04 2023-02-06 オリゴヌクレオチドを製造する方法

Publications (1)

Publication Number Publication Date
KR20240149415A true KR20240149415A (ko) 2024-10-14

Family

ID=87552623

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247029387A Pending KR20240149415A (ko) 2022-02-04 2023-02-06 올리고뉴클레오티드의 제조 방법

Country Status (5)

Country Link
US (1) US20250145656A1 (https=)
EP (1) EP4474388A4 (https=)
JP (1) JPWO2023149564A1 (https=)
KR (1) KR20240149415A (https=)
WO (1) WO2023149564A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102943957B1 (ko) * 2024-02-02 2026-03-30 에스티팜 주식회사 올리고뉴클레오티드 합성을 위한 개선된 방법
WO2025165064A1 (ko) * 2024-02-02 2025-08-07 에스티팜 주식회사 올리고뉴클레오티드 합성을 위한 개선된 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170111137A (ko) 2016-03-25 2017-10-12 박노창 온실 모니터링 시스템

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6067494A (ja) 1983-09-23 1985-04-17 ジェネックス・コーポレイション オリゴヌクレオチドを固体支持体上に合成する方法
AU2005275801B2 (en) * 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
JP7033402B2 (ja) * 2017-07-05 2022-03-10 日東電工株式会社 固相核酸合成方法、固相核酸合成用溶液組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170111137A (ko) 2016-03-25 2017-10-12 박노창 온실 모니터링 시스템

Also Published As

Publication number Publication date
EP4474388A4 (en) 2025-10-01
US20250145656A1 (en) 2025-05-08
JPWO2023149564A1 (https=) 2023-08-10
WO2023149564A1 (ja) 2023-08-10
EP4474388A1 (en) 2024-12-11

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240830

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application