KR20240144932A - 체액 내 적어도 하나의 분석물 농도를 결정하기 위한 방법 및 장치 - Google Patents
체액 내 적어도 하나의 분석물 농도를 결정하기 위한 방법 및 장치 Download PDFInfo
- Publication number
- KR20240144932A KR20240144932A KR1020247026619A KR20247026619A KR20240144932A KR 20240144932 A KR20240144932 A KR 20240144932A KR 1020247026619 A KR1020247026619 A KR 1020247026619A KR 20247026619 A KR20247026619 A KR 20247026619A KR 20240144932 A KR20240144932 A KR 20240144932A
- Authority
- KR
- South Korea
- Prior art keywords
- color
- optical test
- training set
- values
- test strip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 159
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 91
- 239000010839 body fluid Substances 0.000 title claims abstract description 84
- 239000012491 analyte Substances 0.000 title claims abstract description 40
- 238000012360 testing method Methods 0.000 claims abstract description 399
- 230000003287 optical effect Effects 0.000 claims abstract description 261
- 238000012549 training Methods 0.000 claims abstract description 160
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 79
- 238000004458 analytical method Methods 0.000 claims abstract description 41
- 238000000691 measurement method Methods 0.000 claims abstract description 29
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- 238000011161 development Methods 0.000 claims description 42
- 238000005259 measurement Methods 0.000 claims description 34
- 238000004422 calculation algorithm Methods 0.000 claims description 11
- 238000010801 machine learning Methods 0.000 claims description 9
- 238000002372 labelling Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 4
- 238000009795 derivation Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 38
- 210000004369 blood Anatomy 0.000 description 38
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 32
- 239000008103 glucose Substances 0.000 description 32
- 238000003860 storage Methods 0.000 description 25
- 238000004590 computer program Methods 0.000 description 19
- 230000000875 corresponding effect Effects 0.000 description 16
- 230000008859 change Effects 0.000 description 15
- 239000000758 substrate Substances 0.000 description 13
- 239000000126 substance Substances 0.000 description 11
- 238000001514 detection method Methods 0.000 description 10
- 239000003086 colorant Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 239000002105 nanoparticle Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 210000003722 extracellular fluid Anatomy 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 230000015654 memory Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 108091023037 Aptamer Proteins 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000007705 chemical test Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003936 working memory Effects 0.000 description 2
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- -1 Volume 10 Substances 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000013527 convolutional neural network Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011545 laboratory measurement Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000010295 mobile communication Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000007637 random forest analysis Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012706 support-vector machine Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22156307.5 | 2022-02-11 | ||
| EP22156307 | 2022-02-11 | ||
| PCT/EP2023/053265 WO2023152266A1 (en) | 2022-02-11 | 2023-02-10 | Methods and devices for determining the concentration of at least one analyte in a bodily fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240144932A true KR20240144932A (ko) | 2024-10-04 |
Family
ID=80682739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247026619A Pending KR20240144932A (ko) | 2022-02-11 | 2023-02-10 | 체액 내 적어도 하나의 분석물 농도를 결정하기 위한 방법 및 장치 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240418728A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4476532B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2025507363A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20240144932A (cg-RX-API-DMAC7.html) |
| CN (1) | CN118696227A (cg-RX-API-DMAC7.html) |
| CA (1) | CA3247869A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW202346839A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2023152266A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025162741A1 (en) * | 2024-01-30 | 2025-08-07 | Roche Diabetes Care Gmbh | Method of detecting an analyte in a sample of bodily fluid |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009145250A1 (ja) | 2008-05-29 | 2009-12-03 | アークレイ株式会社 | 免疫分析装置および免疫分析方法 |
| KR101669739B1 (ko) | 2011-11-14 | 2016-10-27 | 에프. 호프만-라 로슈 아게 | 샘플에서 적어도 하나의 분석물을 검출하기 위한 분석 장치 |
| US9311520B2 (en) | 2012-08-08 | 2016-04-12 | Scanadu Incorporated | Method and apparatus for performing and quantifying color changes induced by specific concentrations of biological analytes in an automatically calibrated environment |
| US20150247874A1 (en) | 2014-02-28 | 2015-09-03 | Government Of The United States As Represented By The Secretary Of The Air Force | Metal nanoparticle-aptamer conjugates for detection of small molecules and in-the-field use thereof |
| EP2916117A1 (en) | 2014-03-05 | 2015-09-09 | Scanadu Incorporated | Quantifying color changes of chemical test pads induced by specific concentrations of biological analytes under different lighting conditions |
| TWI810247B (zh) | 2018-02-26 | 2023-08-01 | 瑞士商赫孚孟拉羅股份公司 | 用於校準和使用攝影機來偵測樣品中的分析物之方法及系統 |
| US11243160B2 (en) * | 2018-03-28 | 2022-02-08 | Detekt Biomedical, Llc | Custom optical reference calibrator fabrication system |
| US11112406B2 (en) | 2018-06-15 | 2021-09-07 | Reliant Immune Diagnostics, Inc. | System and method for digital remote primary, secondary, and tertiary color calibration via smart device in analysis of medical test results |
| EP3983805B1 (en) * | 2019-06-14 | 2024-06-26 | DeLaval Holding AB | System for determining validity of a lateral flow test result |
-
2023
- 2023-02-10 WO PCT/EP2023/053265 patent/WO2023152266A1/en not_active Ceased
- 2023-02-10 CA CA3247869A patent/CA3247869A1/en active Pending
- 2023-02-10 JP JP2024547546A patent/JP2025507363A/ja active Pending
- 2023-02-10 CN CN202380021184.7A patent/CN118696227A/zh active Pending
- 2023-02-10 KR KR1020247026619A patent/KR20240144932A/ko active Pending
- 2023-02-10 EP EP23704139.7A patent/EP4476532B1/en active Active
- 2023-02-10 TW TW112104804A patent/TW202346839A/zh unknown
-
2024
- 2024-07-31 US US18/789,842 patent/US20240418728A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW202346839A (zh) | 2023-12-01 |
| EP4476532A1 (en) | 2024-12-18 |
| WO2023152266A1 (en) | 2023-08-17 |
| CA3247869A1 (en) | 2023-08-17 |
| CN118696227A (zh) | 2024-09-24 |
| JP2025507363A (ja) | 2025-03-18 |
| EP4476532B1 (en) | 2026-01-28 |
| EP4476532C0 (en) | 2026-01-28 |
| US20240418728A1 (en) | 2024-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11189056B2 (en) | Methods and devices for performing an analytical measurement based on a color formation reaction | |
| US11781973B2 (en) | Methods and systems for calibrating and using a camera for detecting an analyte in a sample | |
| US12287327B2 (en) | Method of determining a concentration of an analyte in a bodily fluid | |
| US20170098137A1 (en) | Method, apparatus and system for detecting and determining compromised reagent pads by quantifying color changes induced by exposure to a hostile environment | |
| EP2883037A2 (en) | Method and apparatus for performing and quantifying color changes induced by specific concentrations of biological analytes in an automatically calibrated environment | |
| KR20210081415A (ko) | 분석 측정을 수행하기 위한 방법 및 디바이스 | |
| US20230084800A1 (en) | Method of evaluating the quality of a color reference card | |
| JP2023543881A (ja) | 体液中の少なくとも１つの分析物の濃度を決定する方法 | |
| US20240402088A1 (en) | Methods and devices for performing an analytical measurement | |
| US20240418728A1 (en) | Methods and devices for determining the concentration of at least one analyte in a bodily fluid | |
| EP4476525B1 (en) | Method of determining a color expectation range for assessing the plausibility of an assumed reaction time value used in an analytical measurement based on a color formation reaction, system and mobile device | |
| HK40116947A (en) | Methods and devices for determining the concentration of at least one analyte in a bodily fluid | |
| HK40117003A (en) | Methods and devices for determining the concentration of at least one analyte in a bodily fluid | |
| US20230384305A1 (en) | Method, apparatus and system for detecting and determining comprised reagent pads by quantifying color changes induced by exposure to a hostile environment | |
| US20260095455A1 (en) | Methods and devices for providing blacklist information on the suitability of a mobile device for performing analytical measurements | |
| CA3079334C (en) | Methods and devices for performing an analytical measurement based on a color formation reaction | |
| HK40079521A (en) | Method of determining a concentration of an analyte in a bodily fluid | |
| HK40031609A (en) | Methods and devices for performing an analytical measurement based on a color formation reaction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20240807 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application |