KR20240112252A - B 세포 수용체에 특이적인 키메라 항원 수용체에 대한 조성물 및 방법 - Google Patents

B 세포 수용체에 특이적인 키메라 항원 수용체에 대한 조성물 및 방법 Download PDF

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KR20240112252A
KR20240112252A KR1020247008799A KR20247008799A KR20240112252A KR 20240112252 A KR20240112252 A KR 20240112252A KR 1020247008799 A KR1020247008799 A KR 1020247008799A KR 20247008799 A KR20247008799 A KR 20247008799A KR 20240112252 A KR20240112252 A KR 20240112252A
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cells
car
cell
seq
amino acid
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Korean (ko)
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마르코 루엘라
스테판 슈스터
코스타스 스타마토폴루스
파올로 프로스페로 기아
이그나시오 산즈
이반 코헨
Original Assignee
더 트러스티스 오브 더 유니버시티 오브 펜실바니아
오스페달레 산 라파엘 에스.알.엘.
에모리 유니버시티
인스티튜트 오브 어플라이드 바이오사이언스 (아이엔에이비) / 센터 포 리서치 앤드 테크놀로지 헬라스 (씨이알티에이치)
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Application filed by 더 트러스티스 오브 더 유니버시티 오브 펜실바니아, 오스페달레 산 라파엘 에스.알.엘., 에모리 유니버시티, 인스티튜트 오브 어플라이드 바이오사이언스 (아이엔에이비) / 센터 포 리서치 앤드 테크놀로지 헬라스 (씨이알티에이치) filed Critical 더 트러스티스 오브 더 유니버시티 오브 펜실바니아
Publication of KR20240112252A publication Critical patent/KR20240112252A/ko
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    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001112—CD19 or B4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/22—Intracellular domain
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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KR1020247008799A 2021-08-18 2022-08-18 B 세포 수용체에 특이적인 키메라 항원 수용체에 대한 조성물 및 방법 Pending KR20240112252A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163234514P 2021-08-18 2021-08-18
US63/234,514 2021-08-18
PCT/US2022/075140 WO2023023596A1 (en) 2021-08-18 2022-08-18 Compositions and methods for chimeric antigen receptors specific to b cell receptors

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KR20240112252A true KR20240112252A (ko) 2024-07-18

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KR1020247008799A Pending KR20240112252A (ko) 2021-08-18 2022-08-18 B 세포 수용체에 특이적인 키메라 항원 수용체에 대한 조성물 및 방법

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US (1) US20240376197A1 (https=)
EP (1) EP4387990A4 (https=)
JP (1) JP2024532851A (https=)
KR (1) KR20240112252A (https=)
CN (1) CN118613499A (https=)
AU (1) AU2022330127A1 (https=)
CA (1) CA3229193A1 (https=)
IL (1) IL310901A (https=)
MX (1) MX2024002172A (https=)
WO (1) WO2023023596A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105641A (zh) * 2018-03-19 2020-12-18 科塔生物治疗有限责任公司 用于经修饰的b细胞表达重新分配的生物剂的组合物和方法
KR20260005221A (ko) * 2023-03-09 2026-01-09 허밍버드 바이오사이언스 피티이. 엘티디. Vh4-34 항원 결합 분자

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015524255A (ja) * 2012-07-13 2015-08-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法
CA3035081A1 (en) * 2016-09-02 2018-03-08 Dana-Farber Cancer Institute, Inc. Composition and methods of treating b cell disorders
EP3529268B1 (en) * 2016-10-19 2025-02-26 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
EP3424527A1 (de) * 2017-07-07 2019-01-09 AVA Lifescience GmbH Diagnostisches verfahren
US20200085869A1 (en) * 2018-05-16 2020-03-19 Novartis Ag Therapeutic regimens for chimeric antigen receptor therapies
CA3105816A1 (en) * 2018-07-10 2020-01-16 Precigen, Inc. Ror-1 specific chimeric antigen receptors and uses thereof
IL281428B2 (en) * 2018-09-27 2024-10-01 Autolus Ltd Chimeric antigen receptor
JP7748935B2 (ja) * 2019-08-27 2025-10-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＩＬ１３Ｒα２陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成ＣＡＲ
EP4469067A1 (en) * 2022-01-25 2024-12-04 Ramot at Tel-Aviv University Ltd. Engineering b cells to express chimeric antigen receptors (cars) and uses thereof for t cell independent activation
CA3262006A1 (en) * 2022-07-25 2024-02-01 Sinabiosolution Gmbh Humanized chimeric antigen receptors targeting the B-lymphocyte receptor in chronic lymphocytic leukemia and their uses

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JP2024532851A (ja) 2024-09-10
CA3229193A1 (en) 2023-02-23
EP4387990A1 (en) 2024-06-26
EP4387990A4 (en) 2025-07-30
IL310901A (en) 2024-04-01
AU2022330127A1 (en) 2024-03-07
CN118613499A (zh) 2024-09-06
MX2024002172A (es) 2024-07-10
US20240376197A1 (en) 2024-11-14
WO2023023596A1 (en) 2023-02-23

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