KR20240080233A - Composition for inner beauty comprising phyto collagen and Manufacturing method thereof - Google Patents
Composition for inner beauty comprising phyto collagen and Manufacturing method thereof Download PDFInfo
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- KR20240080233A KR20240080233A KR1020220162012A KR20220162012A KR20240080233A KR 20240080233 A KR20240080233 A KR 20240080233A KR 1020220162012 A KR1020220162012 A KR 1020220162012A KR 20220162012 A KR20220162012 A KR 20220162012A KR 20240080233 A KR20240080233 A KR 20240080233A
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- extract
- collagen
- vegetable collagen
- yam
- vegetable
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Abstract
본 발명은 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것으로서, 보다 상세하게는 저분자 식물성 콜라겐 추출물, 참마 추출물을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것이다.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나로부터 식물성 콜라겐 추출물을 제조하는 식물성 콜라겐 추출물 제조단계(S100);와 참마 추출물 제조단계(S200);와 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합하는 혼합단계(S300)를 포함한다.The present invention relates to a composition for inner beauty containing vegetable collagen and a manufacturing method thereof, and more specifically, to a composition for inner beauty containing low molecular weight vegetable collagen extract and yam extract and a manufacturing method thereof.
The method for producing a composition for inner beauty containing vegetable collagen according to the present invention includes a vegetable collagen extract manufacturing step of producing a vegetable collagen extract from at least one of Geumhwagyu leaves, soybean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots. (S100); and a yam extract manufacturing step (S200); and a mixing step of mixing the vegetable collagen extract, yam extract, and additives (S300).
Description
본 발명은 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것으로서, 보다 상세하게는 저분자 식물성 콜라겐 추출물, 참마 추출물을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a composition for inner beauty containing vegetable collagen and a manufacturing method thereof, and more specifically, to a composition for inner beauty containing low molecular weight vegetable collagen extract and yam extract and a manufacturing method thereof.
'이너뷰티'는 '이너(Inner·내면)'와 '뷰티(Beauty·아름다움)'의 합성어로, 몸 속부터 건강을 채워서 아름다움을 찾는다는 의미로 단순히 화장품을 바르는 등 피부 겉만 가꾸는 걸 뛰어넘어 '먹는 것'을 통해 피부를 속부터 개선하는‘먹는 화장품’이란 개념으로 확대되고 있다. 'Inner beauty' is a compound word of 'inner' and 'beauty', meaning finding beauty by filling the body with health from the inside out. It goes beyond simply taking care of the outside of the skin, such as simply applying cosmetics. The concept of 'edible cosmetics' is expanding to improve skin from the inside through 'eating'.
피부는 바깥층인 각질층(Cornified layer)을 포함한 표피(Epidermis), 그 아래 진피 (Dermis), 가장 아래 피하지방층(Hypodermis)으로 구성되어 있으며, 대부분의 피부 보습 화장품은 표피에 작용하지 못하고 각질층의 수분 및 유효성분 흡수에만 도움을 주지만 기능성 물질이 함유된 이너뷰티(Inner Beauty)소재는 피부에 직접 사용하지 않고 소화기를 통해 섭취함으로써 체내의 피부건강 환경을 조성함으로써 각질뿐만 아니라 표피층 전체와, 진피층의 피부 조직에 작용하여 보습, 주름개선 및 미백효과를 나타낼 수 있다.The skin is composed of the epidermis, which includes the outer cornified layer, the dermis below it, and the lowest subcutaneous fat layer (Hypodermis). Most skin moisturizing cosmetics do not work on the epidermis, but rather lose moisture and moisture in the stratum corneum. Inner beauty materials that only help absorb active ingredients, but contain functional substances, are not used directly on the skin but are ingested through the digestive tract, thereby creating a healthy skin environment in the body, thereby improving not only the keratin but also the entire epidermal layer and the skin tissue of the dermal layer. It can provide moisturizing, wrinkle improvement, and whitening effects by acting on the skin.
한편, 콜라겐(collagen)은 동물의 결합조직, 피부, 뼈, 힘줄, 피부, 연골, 손톱, 발톱, 치아, 혈관 등을 구성하는 섬유상 구조단백질이다. 콜라겐은 인체 단백질의 약 30%를 차지하고, 결합조직의 주성분이며 피부 진피층의 70~90%를 차지한다.Meanwhile, collagen is a fibrous structural protein that makes up animal connective tissue, skin, bones, tendons, skin, cartilage, fingernails, toenails, teeth, blood vessels, etc. Collagen accounts for approximately 30% of human protein, is the main component of connective tissue, and accounts for 70-90% of the dermal layer of the skin.
콜라겐은 피부의 구성성분으로 콜라겐을 섭취하여 피부 탄력 등을 개선하고자 하는 시도가 있었다. 하지만, 통상 식품으로 섭취될 수 있는 콜라겐은 분자의 크기가 매우 크기 때문에 체내에서 대부분 흡수하지 못하고 그대로 배출된다. 콜라겐의 분자크기는 약 50만 Da이나, 실제 피부에 흡수되기 위해서는 분자량이 작아야 유리하며 대체적으로 500Da이하여야 한다. 이에 저분자 콜라겐을 개발하고자 하는 시도가 있었다. Collagen is a component of skin, and there have been attempts to improve skin elasticity by consuming collagen. However, because collagen, which can be normally consumed as food, has a very large molecule, most of it is not absorbed by the body and is excreted as is. The molecular size of collagen is about 500,000 Da, but in order to be actually absorbed into the skin, the molecular weight must be small and generally should be less than 500 Da. Accordingly, attempts were made to develop low-molecular-weight collagen.
한편, 콜라겐이 식품으로 체내에 공급되더라도 여러 소화기관에서 콜라겐을 다양한 형태의 아미노산으로 분해하여 온전한 콜라겐의 형태로 체내로 바로 흡수되기가 어렵기 때문에 콜라겐 단일 제재로 섭취하기 보다는 다양한 미네랄 및 영양소 등의 함께 섭취할 경우 체내 흡수 및 합성을 돕는다는 연구 결과가 있다.On the other hand, even if collagen is supplied to the body as food, collagen is broken down into various types of amino acids in various digestive organs, making it difficult to be absorbed directly into the body in the form of intact collagen. Therefore, rather than consuming collagen as a single product, it must be supplemented with various minerals and nutrients. Research has shown that when taken together, it helps the body's absorption and synthesis.
콜라겐의 종류는 크게 원재료에서부터 나누어지며 동물성 콜라겐, 어류 콜라겐, 식물성 콜라겐으로 나눠지며, 이중 식물성 콜라겐은 식물성 원료로부터 유래된 것으로 글라이신(Glycin), 프롤린(Proline) 및 하이드록시프롤린(Hydroxyproline) 중 적어도 어느 하나의 콜라겐 펩타이드를 포함한다.Types of collagen are largely divided from raw materials into animal collagen, fish collagen, and vegetable collagen. Vegetable collagen is derived from vegetable raw materials and contains at least one of glycine, proline, and hydroxyproline. Contains one collagen peptide.
본 발명자는 콜라겐을 포함하는 이너뷰티용 조성물을 개발하고자 하는 연구의 일환으로, 금화규 잎, 콩잎 등의 식물 원료로부터 식물성 콜라겐 추출물을 수득하였으며, 상기 식물성 콜라겐 추출물을 수득함에 있어 수득률을 높이고, 저분자화하고자 하였으며, 그 외 파이토 뮤신(mucin), 사포닌(saponin), 아르기닌(arginine) 등의 약리성분을 갖는 참마추출물을 혼합하여 이너뷰티용 조성물을 제조하여 본 발명에 이르게 되었다.As part of the research to develop a composition for inner beauty containing collagen, the present inventor obtained a vegetable collagen extract from plant raw materials such as Geumhwagyu leaves and soybean leaves. In obtaining the vegetable collagen extract, the yield was increased, and the low molecule The present invention was achieved by preparing a composition for inner beauty by mixing yam extracts with pharmacological ingredients such as phytomucin, saponin, and arginine.
상기와 같은 문제점을 해결하기 위한 본 발명의 목적은 저분자 식물성 콜라겐 추출물, 참마 추출물을 포함하는 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법을 제공하는 것이다.The purpose of the present invention to solve the above problems is to provide a composition for inner beauty containing vegetable collagen including low molecular weight vegetable collagen extract and yam extract, and a method for producing the same.
상기 과제를 해결하기 위한 본 발명의 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나로부터 식물성 콜라겐 추출물을 제조하는 식물성 콜라겐 추출물 제조단계(S100);와 참마 추출물 제조단계(S200);와 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합하는 혼합단계(S300)를 포함한다.The method for producing a composition for inner beauty containing vegetable collagen of the present invention to solve the above problems involves producing a vegetable collagen extract from at least one of Geumhwagyu leaves, soybean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots. It includes a vegetable collagen extract manufacturing step (S100); a yam extract manufacturing step (S200); and a mixing step of mixing the vegetable collagen extract, yam extract, and additives (S300).
상기 식물성 콜라겐 추출물 제조단계(S100)에서는 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 식물성 콜라겐 추출물을 수득하는 것을 특징으로 한다.In the vegetable collagen extract manufacturing step (S100), the vegetable collagen extract is obtained using at least one of the ultrasonic extraction method and the supercritical extraction method.
상기 혼합단계에서 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함하는 것을 특징으로 한다.In the mixing step, the additive is characterized in that it includes at least one of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
본 발명의 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나의 콜라겐 식물로부터 추출되는 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합하여 제조되는 것을 특징으로 한다.The composition for inner beauty containing vegetable collagen of the present invention is a mixture of vegetable collagen extract, yam extract, and additives extracted from at least one collagen plant among Geumhwagyu leaves, bean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots. It is characterized in that it is manufactured.
상기 식물성 콜라겐 추출물은 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 수득되는 것을 특징으로 한다.The vegetable collagen extract is characterized in that it is obtained using at least one of an ultrasonic extraction method and a supercritical extraction method.
상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함하는 것을 특징으로 한다.The additive is characterized in that it contains at least one of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
본 발명에 따른 식물성 콜라겐 국수는 상기 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 포함하는 것을 특징으로 한다.Vegetable collagen noodles according to the present invention are characterized in that they contain a composition for inner beauty containing the vegetable collagen.
본 발명에 따른 식물성 콜라겐 젤리는 상기 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 포함하는 것을 특징으로 한다.The vegetable collagen jelly according to the present invention is characterized in that it contains a composition for inner beauty containing the vegetable collagen.
상술한 바와 같이, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 의하면, 식물성 콜라겐 추출물을 높은 수율로 수득할 수 있는 효과가 있다.As described above, according to the inner beauty composition containing vegetable collagen and the method for producing the same according to the present invention, vegetable collagen extract can be obtained in high yield.
또한, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 의하면, 식물성 콜라겐 추출물을 저분자화하여 체내 흡수성이 좋은 효과가 있다. In addition, according to the composition for inner beauty containing vegetable collagen and the method for producing the same according to the present invention, the vegetable collagen extract is reduced to a low molecular weight, thereby improving absorption into the body.
또한, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 의하면, 참마 추출물 및 첨가제를 포함하여 식물성 콜라겐 추출물의 체내 흡수를 돕고, 다양한 영양성분 공급이 가능한 효과가 있다. In addition, according to the composition for inner beauty containing vegetable collagen and its manufacturing method according to the present invention, it has the effect of helping the body absorb the vegetable collagen extract, including yam extract and additives, and supplying various nutrients.
도 1은 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법을 보여주는 순서도.1 is a flowchart showing a method of manufacturing a composition for inner beauty containing vegetable collagen according to the present invention.
본 발명의 구체적 특징 및 이점들은 이하에서 첨부도면을 참조하여 상세히 설명한다. 이에 앞서 본 발명에 관련된 기능 및 그 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 구체적인 설명을 생략하기로 한다.Specific features and advantages of the present invention will be described in detail below with reference to the accompanying drawings. Prior to this, if it is determined that a detailed description of the functions and configuration related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description will be omitted.
본 발명은 식물성 콜라겐을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것으로서, 보다 상세하게는 저분자 식물성 콜라겐 추출물, 참마 추출물을 포함하는 이너뷰티용 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a composition for inner beauty containing vegetable collagen and a manufacturing method thereof, and more specifically, to a composition for inner beauty containing low molecular weight vegetable collagen extract and yam extract and a manufacturing method thereof.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법을 설명하도록 한다.A method for producing an inner beauty composition containing vegetable collagen according to the present invention will be described.
도 1은 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법을 보여주는 순서도이다. Figure 1 is a flowchart showing a method of manufacturing a composition for inner beauty containing vegetable collagen according to the present invention.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나로부터 식물성 콜라겐 추출물을 제조하는 식물성 콜라겐 추출물 제조단계(S100)와 참마 추출물 제조단계(S200)와 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합하는 혼합단계(S300)를 포함한다.The method for producing a composition for inner beauty containing vegetable collagen according to the present invention includes a vegetable collagen extract manufacturing step of producing a vegetable collagen extract from at least one of Geumhwagyu leaves, soybean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots. (S100), a yam extract manufacturing step (S200), and a mixing step (S300) of mixing vegetable collagen extract, yam extract, and additives.
식물성 콜라겐 추출물 제조단계(S100)에서는 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나의 식물원료로부터 식물성 콜라겐 추출물을 제조한다.In the vegetable collagen extract manufacturing step (S100), a vegetable collagen extract is prepared from at least one plant material selected from the group consisting of Geumhwagyu leaves, soybean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots.
상기 식물은 글라이신(Glycin), 프롤린(Proline), 하이드록시프롤린(Hydroxyproline) 중 어느 하나의 콜라겐 펩타이드를 포함하거나 콜라겐의 흡수 및 생성을 촉진하는 영양성분을 포함한다.The plant contains collagen peptides such as glycine, proline, or hydroxyproline, or contains nutrients that promote the absorption and production of collagen.
식물성 콜라겐 추출물 제조단계(S100)는 분쇄된 콜라겐 식물을 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 추출하여 추출물을 수득하는 추출단계(S110)와 상기 추출물과 참마 유래 올리고당을 교반하여 반응물을 형성하는 반응물 형성단계(S120)와 상기 반응물을 분말화하는 분말화단계(S130)를 포함한다.The vegetable collagen extract manufacturing step (S100) includes an extraction step (S110) of obtaining an extract by extracting the pulverized collagen plant using at least one of the ultrasonic extraction method and the supercritical extraction method, and stirring the extract and yam-derived oligosaccharides. It includes a reactant forming step (S120) of forming a reactant and a powdering step (S130) of powdering the reactant.
추출단계(S110)에서는 분쇄된 콜라겐 식물을 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 추출하여 추출물을 수득한다. In the extraction step (S110), the pulverized collagen plant is extracted using at least one of ultrasonic extraction and supercritical extraction to obtain an extract.
상기 초음파 추출법은 100 내지 300 kHz 하에서 15 내지 60분간 수행될 수 있다. The ultrasonic extraction method may be performed at 100 to 300 kHz for 15 to 60 minutes.
상기 초임계 추출법은 2 내지 50 ml/min 유량의 초임계 이산화탄소로 25 내지 50℃, 80 내지 250 bar의 압력 하에서 1 내지 5 시간 수행될 수 있다.The supercritical extraction method may be performed for 1 to 5 hours at a pressure of 25 to 50°C and 80 to 250 bar with supercritical carbon dioxide at a flow rate of 2 to 50 ml/min.
바람직하게는, 상기 추출단계(S110)에서는 1차로 초음파 추출법을 수행하고, 2차로 초임계 추출법을 수행할 수 있다.Preferably, in the extraction step (S110), ultrasonic extraction may be performed first and supercritical extraction may be performed secondly.
상기 추출물은 추출단계(S110)가 종료된 후 콜라겐 식물 추출잔사와 추출액을 포함하는데, 상기 콜라겐 식물 추출잔사는 별도 여과 및 분리되지 않고, 후공정인 반응물 형성단계(S120)에서 사용된다.The extract includes collagen plant extraction residue and extract liquid after the extraction step (S110) is completed. The collagen plant extraction residue is not separately filtered or separated and is used in the reactant forming step (S120), which is a post-process.
반응물 형성단계(S120)에서는 상기 추출단계(S110)을 거쳐 수득된 추출물과 참마 유래 올리고당을 교반하여 반응물을 형성한다.In the reactant forming step (S120), the extract obtained through the extraction step (S110) and the yam-derived oligosaccharide are stirred to form a reactant.
상기 반응물 형성단계(S120)에서는 상기 추출물 100중량부에 대하여 참마 유래 올리고당 1 내지 20중량부를 25 내지 35℃에서 15 내지 60분간 50 내지 200 rpm으로 교반한다. 교반 후 반응액을 여과하여 잔사를 제거하고, 여과액을 취하여 20 내지 45 °Brix 를 갖도록 감압농축시킨 것을 반응물로 수득한다.In the reactant forming step (S120), 1 to 20 parts by weight of yam-derived oligosaccharides are stirred at 50 to 200 rpm for 15 to 60 minutes at 25 to 35 ° C. based on 100 parts by weight of the extract. After stirring, the reaction solution is filtered to remove residue, and the filtrate is taken and concentrated under reduced pressure to have 20 to 45 °Brix to obtain the reaction product.
상기 참마 유래 올리고당은 참마 유래 전분을 cyclodextrin glucanotransferase(CGTase)효소와 반응시켜 제조된 것으로, α-시클로덱스트린, β-시클로덱스트린 및 γ-시클로덱스트린 중 적어도 어느 하나의 시클로덱스트린과 참마 자체의 사포닌, 피토뮤신 등의 유효성분을 포함한다. The yam-derived oligosaccharide is manufactured by reacting yam-derived starch with cyclodextrin glucanotransferase (CGTase) enzyme, and contains at least one cyclodextrin among α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, saponin of yam itself, and phyto. Contains active ingredients such as mucin.
상기 참마 유래 올리고당은 상기 추출단계(S110)에서 콜라겐 식물로부터 추출되지 못한 유효성분의 추출특성을 향상시키고, 식물성 콜라겐을 저분자로 분해시켜 체내 흡수율을 높이며, 추출된 식물성 콜라겐 추출물의 변성을 방지하는 보호제로서 역할을 수행한다.The yam-derived oligosaccharides are a protective agent that improves the extraction characteristics of the active ingredients that were not extracted from collagen plants in the extraction step (S110), decomposes vegetable collagen into low molecules to increase absorption in the body, and prevents denaturation of the extracted vegetable collagen extract. performs the role as
또한, 참마 유래 올리고당은 감미를 가져 식물성 콜라겐 추출물의 고미 및 이취를 마스킹함과 동시에 건조시 부형제로서 역할을 수행할 수 있다.In addition, yam-derived oligosaccharides have a sweet taste and can mask the bitter taste and off-flavor of vegetable collagen extract and at the same time serve as an excipient during drying.
분말화단계(S130)에서는 상기 반응물을 분무건조, 동결건조 및 저온 진공건조 중 어느 하나의 건조방법을 이용하여 분말 및 과립화한다. 이때, 분말의 평균입도는 10 내지 200 ㎛를 갖도록 제어될 수 있다.In the powdering step (S130), the reactant is powdered and granulated using any one of spray drying, freeze drying, and low temperature vacuum drying. At this time, the average particle size of the powder can be controlled to be 10 to 200 ㎛.
참마 추출물 제조단계(S200)에서는 마쇄된 참마를 산성 또는 염기성의 전분분리용매와 혼합한 후 잔사를 여과시킨 참마 여과액을 감압농축 및 건조시킨 것이다.In the yam extract manufacturing step (S200), the ground yam is mixed with an acidic or basic starch separation solvent, the residue is filtered, and the yam filtrate is concentrated and dried under reduced pressure.
마쇄된 참마를 산성 또는 염기성의 용매와 혼합한 후 생성되는 잔사는 참마 유래 전분에 해당하는 것이며, 상기 잔사를 여과시킨 여과액에는 점질성 당단백질인 뮤신, 디오신(diosin), 디오게닌(diosgenin), 바타신(batasin), 사포닌(steroidal saponin), 아르기닌(arginine), 클로린(choline) 등의 약리성분이 잔여한다. 상기 참마 여과액은 감압농축 및 건조하여 분말 및 과립화된다.The residue produced after mixing the ground yam with an acidic or basic solvent corresponds to yam-derived starch, and the filtrate after filtering the residue contains the viscous glycoproteins mucin, diosin, and diogenin ( Pharmacological ingredients such as diosgenin, batasin, steroidal saponin, arginine, and choline remain. The yam filtrate is concentrated under reduced pressure, dried, and powdered and granulated.
상기 참마 여과액은 분무건조, 동결건조 및 저온 진공건조 중 어느 하나의 건조방법을 이용하여 분말 및 과립화한다. 이때, 분말의 평균입도는 10 내지 200 ㎛를 갖도록 제어될 수 있다.The yam filtrate is powdered and granulated using any one of spray drying, freeze drying, and low temperature vacuum drying. At this time, the average particle size of the powder can be controlled to be 10 to 200 ㎛.
이후, 참마 유래 전분은 cyclodextrin glucanotransferase(CGTase)효소와 반응시켜 참마 유래 올리고당으로 제조하여 식물성 콜라겐 추출물 제조단계(S100)에서 활용될 수 있다.Thereafter, yam-derived starch can be reacted with cyclodextrin glucanotransferase (CGTase) enzyme to produce yam-derived oligosaccharides and used in the vegetable collagen extract manufacturing step (S100).
상기 전분분리용매는 마쇄된 참마에서 전분을 분리하기 위한 용매로, 산성용매로는 유기산 수용액을 사용하며, 염기성 용매로는 탄산수소나트륨 수용액을 사용할 수 있다.The starch separation solvent is a solvent for separating starch from ground yam. An aqueous organic acid solution can be used as an acidic solvent, and an aqueous solution of sodium bicarbonate can be used as a basic solvent.
바람직하게는, 상기 참마 추출물 제조단계(S200)에서는 전분분리용매로 유기산 수용액을 사용할 수 있으며, 상기 유기산 수용액은 구연산 수용액, 말릭산 수용액 및 사과 추출액 중 적어도 어느 하나를 포함할 수 있다. Preferably, in the yam extract manufacturing step (S200), an aqueous organic acid solution may be used as a starch separation solvent, and the aqueous organic acid solution may include at least one of an aqueous citric acid solution, an aqueous malic acid solution, and an apple extract.
더욱 바람직하게는, 상기 참마 추출물 제조단계(S200)에서는 사과 추출액을 전분분리용매로 사용할 수 있다.More preferably, in the yam extract manufacturing step (S200), apple extract can be used as a starch separation solvent.
사과추출액은 다량의 유기산(organic acid)을 포함하고 있어 참마의 유효성분 추출률을 향상시킬 수 있으며, 자체 항산화 효과가 뛰어나 참마로부터 추출된 유효성분의 변성을 방지할 수 있는 효과가 있다.Apple extract contains a large amount of organic acid, so it can improve the extraction rate of active ingredients from yam, and has an excellent antioxidant effect, preventing denaturation of active ingredients extracted from yam.
이때, 상기 사과추출액은 사과껍질을 효소처리한 것으로, 구체적으로는, 사과껍질 마쇄액 100g당 효소 0.1 내지 3g을 첨가한 후 온도 30 내지 45 ℃ 회전속도 50 내지 100rpm에서 6 내지 36시간 반응시킨 후 사과껍질 잔사를 제거한 여액을 사과추출액으로 수득한다.At this time, the apple extract is obtained by treating apple peel with enzymes. Specifically, 0.1 to 3 g of enzyme is added per 100 g of apple peel grinding liquid, and then reacted at a temperature of 30 to 45 ° C. and a rotation speed of 50 to 100 rpm for 6 to 36 hours. The filtrate from which the apple peel residue is removed is obtained as apple extract.
상기 효소는 셀룰라아제 및 펙티나아제 중 적어도 어느 하나를 포함하는 것으로, 바람직하게는, 셀룰라아제와 펙티나아제는 1 : 1 내지 2의 중량비로 혼합한 것을 사용할 수 있다. The enzyme includes at least one of cellulase and pectinase. Preferably, cellulase and pectinase can be used mixed at a weight ratio of 1:1 to 2.
혼합단계(S300)에서는 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합한다.In the mixing step (S300), vegetable collagen extract, yam extract, and additives are mixed.
상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함할 수 있다. The additive may include at least one of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
바람직하게는, 상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균, 비타민 C 모두를 포함할 수 있다.Preferably, the additive may include all of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
구체적으로는, 상기 혼합단계에서는 포도당 100중량부에 대하여 참마추출물 15 내지 25 중량부, 식물성 콜라겐 추출물 15 내지 25 중량부, 프락토올리고당 10 내지 20 중량부, 자일리톨 10 내지 15 중량부, 타우린 5 내지 15 중량부, 유산균 1 내지 5 중량부, 비타민 1 내지 5 중량부가 포함되도록 혼합할 수 있다. Specifically, in the mixing step, 15 to 25 parts by weight of yam extract, 15 to 25 parts by weight of vegetable collagen extract, 10 to 20 parts by weight of fructooligosaccharide, 10 to 15 parts by weight of xylitol, and 5 to 5 parts by weight of taurine, based on 100 parts by weight of glucose. It can be mixed to include 15 parts by weight, 1 to 5 parts by weight of lactic acid bacteria, and 1 to 5 parts by weight of vitamins.
상기 첨가제는 분말상, 액상 중 어느 하나의 형태를 가질 수 있으며, 바람직하게는, 분말상의 형태로 첨가될 수 있으며, 분말의 경우 평균입도는 10 내지 200 ㎛를 갖는 것을 사용한다.The additive may be in either powder or liquid form, and is preferably added in powder form. In the case of powder, an average particle size of 10 to 200 ㎛ is used.
포도당은 에너지 공급 및 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 기호도를 상승시키기 위한 감미료 용도로 첨가된다. 또한, 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 액상화할 경우 포도당은 참마추출물과 식물성 콜라겐 추출물과의 혼합특성을 향상시킬 수 있다.Glucose is added as a sweetener to provide energy and increase the preference of inner beauty compositions containing vegetable collagen. In addition, when liquefying an inner beauty composition containing vegetable collagen, glucose can improve the mixing characteristics of yam extract and vegetable collagen extract.
프락토올리고당은 채소 및 과일류에 함유된 천연 물질로부터 수득되며, 자당(sucrose)에 과당(fructose)1~3개 가 결합된 탄수화물로, 감미료로 사용된다.Fructooligosaccharide is obtained from natural substances contained in vegetables and fruits, and is a carbohydrate containing 1 to 3 fructose bonds to sucrose, and is used as a sweetener.
또한, 프락토올리고당은 장내 유산균의 먹이인 프리바이오틱스로 쓰일 수 있어 유산균 증식에 유리한 환경을 만들고, 대사 산물로 나오는 물질들은 미네랄 흡수 촉진 등 다양한 생리적 기능을 수행할 수 있다.In addition, fructooligosaccharides can be used as prebiotics, which are food for intestinal lactic acid bacteria, creating a favorable environment for the growth of lactic acid bacteria, and substances produced as metabolites can perform various physiological functions, such as promoting mineral absorption.
자일리톨은 식물에서 수득되는 것으로, 정제 설탕 대비 혈당지수가 낮아 천연 감미료로 사용될 수 있다. 또한, 자일리톨은 당을 발효시켜 산을 생성함으로써 충치균을 약화시켜 충치 예방에 효과적이다. Xylitol is obtained from plants and has a lower glycemic index than refined sugar, so it can be used as a natural sweetener. In addition, xylitol is effective in preventing tooth decay by fermenting sugar and producing acid, thereby weakening cavity-causing bacteria.
타우린은 아미노산의 일종으로, 간기능을 강화하고, 혈압을 떨어뜨리며, 근육의 수축을 도와 부종을 예방할 수 있다. 또한, 타우린은 항산화 효과, 중금속 독성 완화 효과 및 체중감소 효과가 알려져 있고, 과도한 운동에서 오는 산화 스트레스(oxidative stress) 방지에도 효과가 있다. Taurine is a type of amino acid that strengthens liver function, lowers blood pressure, helps muscle contraction, and prevents edema. In addition, taurine is known to have antioxidant effects, heavy metal toxicity alleviation effects, and weight loss effects, and is also effective in preventing oxidative stress caused by excessive exercise.
유산균은 장내 유해균 억제하고 면역력을 강화하는 효과가 있으며, 비타민 C는 식물성 콜라겐 추출물을 보호하고, 체내 콜라겐 생성을 촉진시키는 효과가 있다.Lactobacillus has the effect of suppressing harmful bacteria in the intestines and strengthening immunity, and vitamin C has the effect of protecting vegetable collagen extract and promoting collagen production in the body.
이하, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 설명하도록 한다. Hereinafter, a composition for inner beauty containing vegetable collagen according to the present invention will be described.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 상술된 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법으로 제조된다.The composition for inner beauty containing vegetable collagen according to the present invention is manufactured by the method for producing the composition for inner beauty containing vegetable collagen described above.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나의 콜라겐 식물로부터 추출되는 식물성 콜라겐 추출물, 참마 추출물, 첨가제를 포함한다.The composition for inner beauty containing vegetable collagen according to the present invention includes vegetable collagen extract, yam extract, and additives extracted from at least one collagen plant among Geumhwagyu leaves, bean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots. Includes.
식물성 콜라겐 추출물은 금화규 잎, 콩잎, 베리류, 버섯류, 아스파라거스, 아보카도, 카놀라 및 당근 중 적어도 어느 하나의 식물원료로부터 수득된다. Vegetable collagen extract is obtained from at least one plant material selected from the group consisting of Geumhwagyu leaves, soybean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots.
상기 식물은 글라이신(Glycin), 프롤린(Proline), 하이드록시프롤린(Hydroxyproline) 중 어느 하나의 콜라겐 펩타이드를 포함하거나 콜라겐의 흡수 및 생성을 촉진하는 영양성분을 포함한다.The plant contains collagen peptides such as glycine, proline, or hydroxyproline, or contains nutrients that promote the absorption and production of collagen.
식물성 콜라겐 추출물은 분쇄된 콜라겐 식물을 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 추출하여 추출물을 수득하고, 이후 상기 추출물과 참마 유래 올리고당을 교반하여 반응물을 형성하고, 상기 반응물을 분말화한 것이다.The vegetable collagen extract is obtained by extracting pulverized collagen plants using at least one of ultrasonic extraction and supercritical extraction, and then stirring the extract and yam-derived oligosaccharides to form a reactant, and powdering the reactant. It was angry.
상기 식물성 콜라겐 추출물을 추출시에는 분쇄된 콜라겐 식물을 초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 추출한다.When extracting the vegetable collagen extract, the pulverized collagen plant is extracted using at least one of ultrasonic extraction and supercritical extraction.
상기 초음파 추출법은 100 내지 300 kHz 하에서 15 내지 60분간 수행될 수 있다. The ultrasonic extraction method may be performed at 100 to 300 kHz for 15 to 60 minutes.
상기 초임계 추출법은 2 내지 50 ml/min 유량의 초임계 이산화탄소로 25 내지 50℃, 80 내지 250 bar의 압력 하에서 1 내지 5 시간 수행될 수 있다.The supercritical extraction method may be performed for 1 to 5 hours at a pressure of 25 to 50°C and 80 to 250 bar with supercritical carbon dioxide at a flow rate of 2 to 50 ml/min.
바람직하게는, 상기 추출공정에서는 1차로 초음파 추출법을 수행하고, 2차로 초임계 추출법을 수행할 수 있다.Preferably, in the extraction process, ultrasonic extraction may be performed first and supercritical extraction may be performed secondly.
상기 추출물은 추출공정이 종료된 후 콜라겐 식물 추출잔사와 추출액을 포함하는데, 상기 콜라겐 식물 추출잔사는 별도 여과 및 분리되지 않고, 후공정인 반응물 형성공정에서 사용된다.The extract includes collagen plant extraction residue and extract liquid after the extraction process is completed. The collagen plant extraction residue is not separately filtered or separated and is used in the reactant forming process, which is a post-process.
반응물은 상기 추출공정을 거쳐 수득된 추출물과 참마 유래 올리고당을 교반하여 형성된다.The reactant is formed by stirring the extract obtained through the above extraction process and the yam-derived oligosaccharide.
상기 추출물 100중량부에 대하여 참마 유래 올리고당 1 내지 20중량부를 25 내지 35℃에서 15 내지 60분간 50 내지 200 rpm으로 교반 후 반응액을 여과하여 잔사를 제거하고, 여과액을 취하여 20 내지 45 °Brix 를 갖도록 감압농축시킨 것을 반응물로 수득한다.With respect to 100 parts by weight of the extract, 1 to 20 parts by weight of yam-derived oligosaccharides were stirred at 50 to 200 rpm for 15 to 60 minutes at 25 to 35°C, the reaction solution was filtered to remove residue, and the filtrate was taken and stirred at 20 to 45 °Brix. A reactant was obtained by concentrating under reduced pressure to have .
상기 참마 유래 올리고당은 참마 유래 전분을 cyclodextrin glucanotransferase(CGTase)효소와 반응시켜 제조된 것으로, α-시클로덱스트린, β-시클로덱스트린 및 γ-시클로덱스트린 중 적어도 어느 하나의 시클로덱스트린과 참마 자체의 사포닌, 피토뮤신 등의 유효성분을 포함한다. The yam-derived oligosaccharide is manufactured by reacting yam-derived starch with cyclodextrin glucanotransferase (CGTase) enzyme, and contains at least one cyclodextrin among α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, saponin of yam itself, and phyto. Contains active ingredients such as mucin.
상기 참마 유래 올리고당은 상기 추출공정에서 콜라겐 식물로부터 추출되지 못한 유효성분의 추출특성을 향상시키고, 식물성 콜라겐을 저분자로 분해시켜 체내 흡수율을 높이며, 추출된 식물성 콜라겐 추출물의 변성을 방지하는 보호제로서 역할을 수행한다.The yam-derived oligosaccharides improve the extraction characteristics of the active ingredients that were not extracted from collagen plants in the extraction process, decompose vegetable collagen into low molecules to increase absorption in the body, and serve as a protective agent to prevent denaturation of the extracted vegetable collagen extract. Perform.
또한, 참마 유래 올리고당은 감미를 가져 식물성 콜라겐 추출물의 고미 및 이취를 마스킹함과 동시에 건조시 부형제로서 역할을 수행할 수 있다.In addition, yam-derived oligosaccharides have a sweet taste and can mask the bitter taste and off-flavor of vegetable collagen extract and at the same time serve as an excipient during drying.
분말화공정에서는 상기 반응물을 분무건조, 동결건조 및 저온 진공건조 중 어느 하나의 건조방법을 이용하여 분말 및 과립화한다. 이때, 분말의 평균입도는 10 내지 200 ㎛를 갖도록 제어될 수 있다.In the powdering process, the reactant is powdered and granulated using any one of spray drying, freeze drying, and low temperature vacuum drying. At this time, the average particle size of the powder can be controlled to be 10 to 200 ㎛.
참마 추출물은 마쇄된 참마를 산성 또는 염기성의 전분분리용매와 혼합한 후 잔사를 여과시킨 참마 여과액을 감압농축 및 건조시킨 것이다.Yam extract is obtained by mixing ground yam with an acidic or basic starch separation solvent, filtering the residue, and concentrating and drying the yam filtrate under reduced pressure.
마쇄된 참마를 산성 또는 염기성의 용매와 혼합한 후 생성되는 잔사는 참마 유래 전분에 해당하는 것이며, 상기 잔사를 여과시킨 여과액에는 점질성 당단백질인 뮤신, 디오신(diosin), 디오게닌(diosgenin), 바타신(batasin), 사포닌(steroidal saponin), 아르기닌(arginine), 클로린(choline) 등의 약리성분이 잔여한다. 상기 참마 여과액은 감압농축 및 건조하여 분말 및 과립화된다.The residue produced after mixing the ground yam with an acidic or basic solvent corresponds to yam-derived starch, and the filtrate after filtering the residue contains the viscous glycoproteins mucin, diosin, and diogenin ( Pharmacological ingredients such as diosgenin, batasin, steroidal saponin, arginine, and choline remain. The yam filtrate is concentrated under reduced pressure, dried, and powdered and granulated.
상기 참마 여과액은 분무건조, 동결건조 및 저온 진공건조 중 어느 하나의 건조방법을 이용하여 분말 및 과립화한다. 이때, 분말의 평균입도는 10 내지 200 ㎛를 갖도록 제어될 수 있다.The yam filtrate is powdered and granulated using any one of spray drying, freeze drying, and low temperature vacuum drying. At this time, the average particle size of the powder can be controlled to be 10 to 200 ㎛.
이후, 참마 유래 전분은 cyclodextrin glucanotransferase(CGTase)효소와 반응시켜 참마 유래 올리고당으로 제조하여 식물성 콜라겐 추출물 제조공정에서 활용될 수 있다.Afterwards, yam-derived starch can be reacted with cyclodextrin glucanotransferase (CGTase) enzyme to produce yam-derived oligosaccharides and used in the vegetable collagen extract manufacturing process.
상기 전분분리용매는 마쇄된 참마에서 전분을 분리하기 위한 용매로, 산성용매로는 유기산 수용액을 사용하며, 염기성 용매로는 탄산수소나트륨 수용액을 사용할 수 있다.The starch separation solvent is a solvent for separating starch from ground yam. An aqueous organic acid solution can be used as an acidic solvent, and an aqueous solution of sodium bicarbonate can be used as a basic solvent.
바람직하게는, 상기 참마 추출물 제조시 전분분리용매로 유기산 수용액을 사용할 수 있으며, 상기 유기산 수용액은 구연산 수용액, 말릭산 수용액 및 사과 추출액 중 적어도 어느 하나를 포함할 수 있다. Preferably, when preparing the yam extract, an aqueous organic acid solution may be used as a starch separation solvent, and the aqueous organic acid solution may include at least one of an aqueous citric acid solution, an aqueous malic acid solution, and an apple extract.
더욱 바람직하게는, 상기 참마 추출물 제조공정에서는 사과 추출액을 전분분리용매로 사용할 수 있다.More preferably, in the yam extract manufacturing process, apple extract can be used as a starch separation solvent.
사과추출액은 다량의 유기산(organic acid)을 포함하고 있어 참마의 유효성분 추출률을 향상시킬 수 있으며, 자체 항산화 효과가 뛰어나 참마로부터 추출된 유효성분의 변성을 방지할 수 있는 효과가 있다.Apple extract contains a large amount of organic acid, so it can improve the extraction rate of active ingredients from yam, and has an excellent antioxidant effect, preventing denaturation of active ingredients extracted from yam.
이때, 상기 사과추출액은 사과껍질을 효소처리한 것으로, 구체적으로는, 사과껍질 마쇄액 100g당 효소 0.1 내지 3g을 첨가한 후 온도 30 내지 45 ℃ 회전속도 50 내지 100rpm에서 6 내지 36시간 반응시킨 후 사과껍질 잔사를 제거한 여액을 사과추출액으로 수득한다.At this time, the apple extract is obtained by treating apple peel with enzymes. Specifically, 0.1 to 3 g of enzyme is added per 100 g of apple peel grinding liquid, and then reacted at a temperature of 30 to 45 ° C. and a rotation speed of 50 to 100 rpm for 6 to 36 hours. The filtrate from which the apple peel residue is removed is obtained as apple extract.
상기 효소는 셀룰라아제 및 펙티나아제 중 적어도 어느 하나를 포함하는 것으로, 바람직하게는, 셀룰라아제와 펙티나아제는 1 : 1 내지 2의 중량비로 혼합한 것을 사용할 수 있다. The enzyme includes at least one of cellulase and pectinase. Preferably, cellulase and pectinase can be used mixed at a weight ratio of 1:1 to 2.
상기와 같이 준비된 식물성 콜라겐 추출물, 참마 추출물은 첨가제와 혼합한다. The vegetable collagen extract and yam extract prepared as above are mixed with additives.
상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함할 수 있다. The additive may include at least one of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
바람직하게는, 상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균, 비타민 C 모두를 포함할 수 있다.Preferably, the additive may include all of glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
구체적으로는, 상기 혼합공정에서는 포도당 100중량부에 대하여 참마추출물 15 내지 25 중량부, 식물성 콜라겐 추출물 15 내지 25 중량부, 프락토올리고당 10 내지 20 중량부, 자일리톨 10 내지 15 중량부, 타우린 5 내지 15 중량부, 유산균 1 내지 5 중량부, 비타민 1 내지 5 중량부가 포함되도록 혼합할 수 있다. Specifically, in the mixing process, 15 to 25 parts by weight of yam extract, 15 to 25 parts by weight of vegetable collagen extract, 10 to 20 parts by weight of fructooligosaccharide, 10 to 15 parts by weight of xylitol, and 5 to 5 parts by weight of taurine, based on 100 parts by weight of glucose. It can be mixed to include 15 parts by weight, 1 to 5 parts by weight of lactic acid bacteria, and 1 to 5 parts by weight of vitamins.
상기 첨가제는 분말상, 액상 중 어느 하나의 형태를 가질 수 있으며, 바람직하게는, 분말상의 형태로 첨가될 수 있으며, 분말의 경우 평균입도는 10 내지 200 ㎛를 갖는 것을 사용한다.The additive may be in either powder or liquid form, and is preferably added in powder form. In the case of powder, an average particle size of 10 to 200 ㎛ is used.
포도당은 에너지 공급 및 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 기호도를 상승시키기 위한 감미료 용도로 첨가된다. 또한, 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 액상화할 경우 포도당은 참마추출물과 식물성 콜라겐 추출물과의 혼합특성을 향상시킬 수 있다.Glucose is added as a sweetener to provide energy and increase the preference of inner beauty compositions containing vegetable collagen. In addition, when liquefying an inner beauty composition containing vegetable collagen, glucose can improve the mixing characteristics of yam extract and vegetable collagen extract.
프락토올리고당은 채소 및 과일류에 함유된 천연 물질로부터 수득되며, 자당(sucrose)에 과당(fructose)1~3개 가 결합된 탄수화물로, 감미료로 사용된다.Fructooligosaccharide is obtained from natural substances contained in vegetables and fruits, and is a carbohydrate made by combining 1 to 3 fructose units with sucrose, and is used as a sweetener.
또한, 프락토올리고당은 장내 유산균의 먹이인 프리바이오틱스로 쓰일 수 있어 유산균 증식에 유리한 환경을 만들고, 대사 산물로 나오는 물질들은 미네랄 흡수 촉진 등 다양한 생리적 기능을 수행할 수 있다.In addition, fructooligosaccharides can be used as prebiotics, which are food for intestinal lactic acid bacteria, creating a favorable environment for the growth of lactic acid bacteria, and substances produced as metabolites can perform various physiological functions, such as promoting mineral absorption.
자일리톨은 식물에서 수득되는 것으로, 정제 설탕 대비 혈당지수가 낮아 천연 감미료로 사용될 수 있다. 또한, 자일리톨은 당을 발효시켜 산을 생성함으로써 충치균을 약화시켜 충치 예방에 효과적이다. Xylitol is obtained from plants and has a lower glycemic index than refined sugar, so it can be used as a natural sweetener. In addition, xylitol is effective in preventing tooth decay by fermenting sugar and producing acid, thereby weakening cavity-causing bacteria.
타우린은 아미노산의 일종으로, 간기능을 강화하고, 혈압을 떨어뜨리며, 근육의 수축을 도와 부종을 예방할 수 있다. 또한, 타우린은 항산화 효과, 중금속 독성 완화 효과 및 체중감소 효과가 알려져 있고, 과도한 운동에서 오는 산화 스트레스(oxidative stress) 방지에도 효과가 있다. Taurine is a type of amino acid that strengthens liver function, lowers blood pressure, helps muscle contraction, and prevents edema. In addition, taurine is known to have antioxidant effects, heavy metal toxicity alleviation effects, and weight loss effects, and is also effective in preventing oxidative stress caused by excessive exercise.
유산균은 장내 유해균 억제하고 면역력을 강화하는 효과가 있으며, 비타민 C는 식물성 콜라겐 추출물을 보호하고, 체내 콜라겐 생성을 촉진시키는 효과가 있다.Lactobacillus has the effect of suppressing harmful bacteria in the intestines and strengthening immunity, and vitamin C has the effect of protecting vegetable collagen extract and promoting collagen production in the body.
본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 및 바로 이루어지는 군에서 선택되는 하나 이상의 제형으로 제공될 수 있으며, 각종 식품류, 예를 들어, 음료, 껌, 캔디, 차, 비타민 복합제, 및/또는 기능성 식품에 대한 식품 첨가물로 활용될 수 있다.The composition for inner beauty containing vegetable collagen according to the present invention may be provided in one or more dosage forms selected from the group consisting of tablets, capsules, pills, granules, liquid, powder, flakes, paste, syrup, gel, jelly, and bar. It can be used as a food additive for various foods, such as beverages, gum, candy, tea, vitamin complexes, and/or functional foods.
일 예에서, 상기 식품은 특수영양식품(예를 들어, 조제유류, 영아식, 유아식), 식육가공품, 어육제품, 두부류, 묵류, 면류(예를 들어, 라면류, 국수류 등), 건강보조식품, 조미식품(예를 들어, 간장, 된장, 고추장, 혼합장), 소스류, 과자류 (예를 들어, 스낵류), 유가공품(예를 들어, 발효유, 치즈, 요구르트), 기타 가공식품, 김치, 절임식품(예를 들어, 장아찌), 음료(예를 들어, 과실음료, 채소류 음료, 두유류, 발효음료류, 차류), 아이스크림류, 천연조미료, 비타민 복합제, 알코올 음료, 주류 및 기타 건강보조식품류를 포함할 수 있으나 이에 제한되지 않으며, 상기 식품, 음료 및/또는 식품첨가제는 통상의 제조방법으로 제조될 수 있다.In one example, the food includes special nutritional foods (e.g., infant formula, infant food, baby food), processed meat products, fish products, tofu, jelly, noodles (e.g., ramen, noodles, etc.), health supplements, Seasoned foods (e.g., soy sauce, soybean paste, red pepper paste, mixed paste), sauces, confectionery (e.g., snacks), dairy products (e.g., fermented milk, cheese, yogurt), other processed foods, kimchi, pickled foods ( For example, pickles), beverages (for example, fruit drinks, vegetable drinks, soy milk, fermented drinks, tea), ice cream, natural seasoning, vitamin complexes, alcoholic beverages, alcoholic beverages, and other health supplements. However, it is not limited thereto, and the food, beverage and/or food additive may be manufactured by conventional manufacturing methods.
본 발명이 제공하는 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 식품에 사용하기에 적절한 것으로 알려져 있는 첨가제, 예를 들어 부형제, 안정제, 보존제, 및/또는 완충제를 포함할 수 있다. 일 예에서, 상기 부형제는 전분, 유당, 포도당, 과당, 만니톨, 덱스트린, 알긴산나트륨, 메칠셀룰로오스, 카르복시메칠셀룰로오스나트륨, 카올린, 요소, 콜로이드성실리카겔, 히드록시프로필스타치, 히드록시프로필메칠셀룰로옷, 프로필렌글리콜, 카제인, 젖산칼슘, 프리모젤, 정제 라놀린, 탄산수소낱륨, 염화나트륨, 황산칼슘, 인산일수소칼슘, 합성규산알루미늄, 및 침강탄산칼슘으로 이루어지는 군에서 선택되는 하나 이상일 수 있으나, 이에 제한되지 않는다.The composition for inner beauty containing vegetable collagen provided by the present invention may include additives known to be suitable for use in foods, such as excipients, stabilizers, preservatives, and/or buffers. In one example, the excipients include starch, lactose, glucose, fructose, mannitol, dextrin, sodium alginate, methylcellulose, sodium carboxymethylcellulose, kaolin, urea, colloidal silica gel, hydroxypropyl starch, and hydroxypropylmethylcellulose. It may be one or more selected from the group consisting of clothes, propylene glycol, casein, calcium lactate, Primogel, purified lanolin, sodium bicarbonate, sodium chloride, calcium sulfate, calcium monohydrogen phosphate, synthetic aluminum silicate, and precipitated calcium carbonate. Not limited.
일 예로, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 국수에 적용되어 식물성 콜라겐 국수를 제조할 수 있으며, 식물성 콜라겐 국수는 밀가루, 전분, 쌀가루, 보릿가루 및 이들의 조합 중 어느 하나의 베이스 분말 100 중량%에 대하여 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 0.001 내지 10중량%포함하여 제조될 수 있다.As an example, the composition for inner beauty containing vegetable collagen according to the present invention can be applied to noodles to produce vegetable collagen noodles, and the vegetable collagen noodles include any one of wheat flour, starch, rice flour, barley flour, and combinations thereof. It can be prepared by containing 0.001 to 10% by weight of an inner beauty composition containing vegetable collagen based on 100% by weight of the base powder.
다른 예로, 본 발명에 따른 식물성 콜라겐을 포함하는 이너뷰티용 조성물은 젤리에 적용되어 식물성 콜라겐 젤리를 제조할 수 있으며, 식물성 콜라겐 젤리는 카라기난, 한천, 곤약분말, 로커스트콩검, 타라검, 구아검, 젤란검, 잔탄검, 타마린드검, 아라비아검, 셀룰로오스검, 펙틴, 변성전분 및 이의 혼합물로 이루어진 군에서 선택된 겔화물질 100중량%에 대하여 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 0.0005 내지 15중량% 포함하여 제조될 수 있다. 상기 식물성 콜라겐 젤리는 그외 당, 구연산, 과일즙 및 이들의 조합 중 어느 하나의 첨가제를 혼합하여 제조하는 것도 가능하다.As another example, the composition for inner beauty containing vegetable collagen according to the present invention can be applied to jelly to produce vegetable collagen jelly, and the vegetable collagen jelly includes carrageenan, agar, konjac powder, locust bean gum, tara gum, guar gum, 0.0005 to 15% by weight of an inner beauty composition containing vegetable collagen based on 100% by weight of a gelling material selected from the group consisting of gellan gum, xanthan gum, tamarind gum, gum Arabic, cellulose gum, pectin, modified starch, and mixtures thereof. It can be manufactured including. The vegetable collagen jelly can also be manufactured by mixing any one of the following additives: sugar, citric acid, fruit juice, and combinations thereof.
이하, 본 발명을 바람직한 일 실시예를 참조하여 다음에서 구체적으로 상세하게 설명한다. 단, 다음의 실시예는 본 발명을 구체적으로 예시하기 위한 것이며, 이것만으로 한정하는 것은 아니다.Hereinafter, the present invention will be described in detail below with reference to a preferred embodiment. However, the following examples are intended to specifically illustrate the present invention and are not limited thereto.
1. 원료의 준비1. Preparation of raw materials
1-1. 참마 추출물1-1. yam extract
안동지역에서 재배된 참마를 구입하여 세척 후 마쇄하였다. 전분 성분을 분리하기 위하여 산성용액으로 사과추출액 100g당 말릭산 3g을 혼합한 유기산 수용액을 준비하였다.Yams grown in the Andong region were purchased, washed, and ground. To separate the starch component, an aqueous organic acid solution was prepared by mixing 3 g of malic acid per 100 g of apple extract as an acidic solution.
마쇄된 참마와 유기산 수용액(5% w/v)을 믹서를 이용하여 3분간 혼합 및 분쇄하고 160 mesh의 망에 부어 전분유를 회수하고, 회수된 전분유를 원심분리하여 하단의 참마 전분과 참마 여과액을 분리하였다.The ground yam and organic acid aqueous solution (5% w/v) are mixed and pulverized for 3 minutes using a mixer, poured into a 160 mesh mesh to recover whole milk powder, and the recovered whole milk powder is centrifuged to separate the yam starch and yam at the bottom. The filtrate was separated.
이후 참마 여과액을 동결건조 후 분쇄하여 평균입도 150㎛를 갖는 분말을 수득하였다.Afterwards, the yam filtrate was freeze-dried and ground to obtain powder with an average particle size of 150㎛.
이때, 수득된 참마 전분은 cyclodextrin glucanotransferase(CGTase)효소와 반응시켜 참마 유래 올리고당으로 제조하여 후공정에서 사용하였다.At this time, the obtained yam starch was reacted with cyclodextrin glucanotransferase (CGTase) enzyme to produce yam-derived oligosaccharides and used in the subsequent process.
1-2. 식물성 콜라겐 추출물1-2. vegetable collagen extract
세척된 금화규잎을 건조 및 분쇄한 후 추출하였다. 추출방법에 따른 추출특성을 확인하기 위하여 초음파 추출, 초임계 추출, 복합추출(1차 초음파+ 2차 초임계)법을 수행하였다.Washed Geumhwagyu leaves were dried, ground, and extracted. To confirm the extraction characteristics according to the extraction method, ultrasonic extraction, supercritical extraction, and combined extraction (1st ultrasonic + 2nd supercritical) methods were performed.
초음파 추출은 200 kHz 하에서 30분간 수행하였고, 초임계 추출 23~25 ml/min 유량의 초임계 이산화탄소로 35℃, 180 bar의 압력 하에서 3시간 수행하였다. 복합 추출은 1차로 초음파 추출을 200kHz 하에서 15분간 수행하였고, 2차로 초임계 추출을 상기 언급된 동일한 조건 하에서 90분간 수행하였다.Ultrasonic extraction was performed at 200 kHz for 30 minutes, and supercritical extraction was performed at 35°C and 180 bar pressure for 3 hours with supercritical carbon dioxide at a flow rate of 23 to 25 ml/min. For the complex extraction, first, ultrasonic extraction was performed at 200 kHz for 15 minutes, and second, supercritical extraction was performed for 90 minutes under the same conditions mentioned above.
참마 유래 올리고당 유무에 따른 금화규잎의 추출특성 및 영양성분을 비교하기 위하여 하기와 같이 실험설계하였다.To compare the extraction characteristics and nutritional components of Geumhwagyu leaves with and without yam-derived oligosaccharides, an experiment was designed as follows.
참마 유래 올리고당 미첨가 그룹: 추출 후 금화규잎 추출물(금화규잎 추출잔사+추출액)을 42 °Brix 를 갖도록 감압농축시킨 것을 반응물로 수득하였다. 이후 상기 반응물을 동결건조 및 분쇄하여 평균입도 80 ㎛을 갖는 분말상의 식물성 콜라겐 추출물을 수득하였다.Group without addition of yam-derived oligosaccharides: After extraction, Geumhwagyu leaf extract (Geumhwagyu leaf extraction residue + extract) was concentrated under reduced pressure to have 42 °Brix, and was obtained as a reactant. The reactant was then freeze-dried and pulverized to obtain a powdery vegetable collagen extract with an average particle size of 80 ㎛.
참마 유래 올리고당 첨가 그룹: 추출 후 금화규잎 추출물(금화규잎 추출잔사+추출액) 100g 당 상술된 참마 유래 올리고당 15g을 30℃에서 30분간 150 rpm으로 교반하였고, 교반 후 반응액을 여과하여 잔사를 제거하고, 여과액을 취하여 42 °Brix 를 갖도록 감압농축시킨 것을 반응물로 수득하였다. 이후 상기 반응물을 동결건조 및 분쇄하여 평균입도 80 ㎛을 갖는 분말상의 식물성 콜라겐 추출물을 수득하였다.Yam-derived oligosaccharide addition group: After extraction, 15 g of the above-mentioned yam-derived oligosaccharides per 100 g of Geumhwagyu leaf extract (Geumhwagyu leaf extraction residue + extract) was stirred at 150 rpm for 30 minutes at 30°C, and after stirring, the reaction solution was filtered to remove residues. , the filtrate was taken and concentrated under reduced pressure to have 42 °Brix, and the reaction product was obtained. The reactant was then freeze-dried and pulverized to obtain a powdery vegetable collagen extract with an average particle size of 80 ㎛.
하기의 표 1은 상기 실험설계에 따른 히드록시프롤린 함량과 분자량을 보여준다. Table 1 below shows the hydroxyproline content and molecular weight according to the experimental design.
첨가 유무Yam oligosaccharide
Addition or not
추출방법에 따른 특성을 확인하였을 때, 복합추출 > 초임계 추출 > 초음파 추출 순으로 히드록시프롤린 함량은 높게, 분자량은 낮게 측정되었다.When the characteristics according to the extraction method were confirmed, the hydroxyproline content was measured to be high and the molecular weight to be low in the order of complex extraction > supercritical extraction > ultrasonic extraction.
참마올리고당 첨가 유무에 따른 특성을 확인하였을 때, 참마올리고당 첨가 그룹이 미첨가그룹보다 히드록시프롤린 함량이 높고, 분자량은 낮게 측정되었는데 이는 참마 유래 올리고당이 콜라겐 식물로부터 추출되지 못한 유효성분의 추출특성을 향상시키고, 식물성 콜라겐을 저분자로 분해시킬 수 있음에 기인한 것으로 판단하였다. When checking the characteristics according to the presence or absence of yam oligosaccharide addition, the hydroxyproline content in the group with yam oligosaccharide addition was measured to be higher and the molecular weight was lower than the group without addition, which indicates the extraction characteristics of the active ingredient that yam-derived oligosaccharide cannot extract from collagen plants. It was judged that this was due to the fact that vegetable collagen could be broken down into low molecules.
이후 실험에는 실시예 6의 식물성 콜라겐 추출물을 사용하였다.In subsequent experiments, the vegetable collagen extract of Example 6 was used.
1-3. 혼합1-3. mix
첨가제로 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균, 비타민 C를 준비하였다. 포도당 100g당 참마추출물 20g, 식물성 콜라겐 추출물(실시예 6) 18g, 프락토올리고당 16g, 자일리톨 13g, 타우린 11g, 유산균 3g, 비타민 3g를 배합하여 분말상의 식물성 콜라겐을 포함하는 이너뷰티용 조성물을 제조하였다.Glucose, fructooligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C were prepared as additives. An inner beauty composition containing powdered vegetable collagen was prepared by mixing 20 g of yam extract, 18 g of vegetable collagen extract (Example 6), 16 g of fructooligosaccharide, 13 g of xylitol, 11 g of taurine, 3 g of lactic acid bacteria, and 3 g of vitamins per 100 g of glucose. .
2. 항산화효과2. Antioxidant effect
제조된 식물성 콜라겐을 포함하는 이너뷰티용 조성물의 항산화효과를 확인하였다.The antioxidant effect of the inner beauty composition containing the manufactured vegetable collagen was confirmed.
항산화효과는 DPPH 라디칼 소거능과 ABTS 라디칼 소거능을 측정하여 확인하였다. Antioxidant effect was confirmed by measuring DPPH radical scavenging ability and ABTS radical scavenging ability.
DPPH (1,1'-diphenyl-2-picrylhydrazyl) radical scavenging activity는 각 용매 별 시료 추출물 0.2 mL와 0.1 mM DPPH 2.8 mL를 혼합하고 암실에서 30분간 반응시킨 후 517 nm에서 흡광도를 측정하여 나타내었다. 각 시료 추출물의 free radical scavenging activity 는 시료를 첨가하지 않은 blank의 흡광도가 50% 감소하는데 필요한 시료의 농도인 IC50 (50% inhibitoryconcentration)으로 결과를 표시하였다. 이 때 활성 비교를 위하여 control 로 합성항산화제인 butylated hydroxyanisole (BHA)을 사용하여 같은 방법으로 흡광도를 측정하였다.DPPH (1,1'-diphenyl-2-picrylhydrazyl) radical scavenging activity was expressed by mixing 0.2 mL of sample extract for each solvent and 2.8 mL of 0.1 mM DPPH, reacting in the dark for 30 minutes, and measuring absorbance at 517 nm. The free radical scavenging activity of each sample extract was expressed as IC 50 (50% inhibitory concentration), which is the concentration of the sample required to reduce the absorbance of the blank to which no sample was added by 50%. At this time, to compare activity, butylated hydroxyanisole (BHA), a synthetic antioxidant, was used as a control and the absorbance was measured in the same manner.
그 결과, DPPH(mg/mL)가 93.74±0.07% 로 높은 소거활성을 보였으며, 이는 control로 사용한 합성항산화제인 BHA와 비슷한 90% 이상의 높은 결과를 나타내었다. As a result, DPPH (mg/mL) showed a high scavenging activity of 93.74±0.07%, which was similar to BHA, a synthetic antioxidant used as a control, showing a high result of over 90%.
ABTS 라디칼 소거능의 측정은 ABTS cation decolorization assay에 의한 방법(Floegel et al., 2011)을 변형하여 항산화력 측정을 시행하였다. 7 mM ABTS와 2.45 mM potassium persulfate를 1:1 (v/v)의 비율로 섞어 16시간 동안 암소에 방치하여 ABTS radical을 형성시킨 후, ethanol로 희석하여 735 nm에서 흡광도 값이 0.70(±0.02)이 되도록 하였다. 희석된 용액 3.9 mL에 시료 추출액 0.1 mL를 넣은 후 10분 뒤 734 nm에서 흡광도를 측정하였다. Control은 BHA를 사용하였다. The ABTS radical scavenging ability was measured by modifying the ABTS cation decolorization assay (Floegel et al., 2011) to measure the antioxidant power. 7mM ABTS and 2.45mM potassium persulfate were mixed at a ratio of 1:1 (v/v) and left in the dark for 16 hours to form ABTS radicals. Then, diluted with ethanol to obtain an absorbance value of 0.70 (±0.02) at 735 nm. This was done. 0.1 mL of sample extract was added to 3.9 mL of the diluted solution, and the absorbance was measured at 734 nm 10 minutes later. Control used BHA.
그 결과, ABTS(mg/mL)가 control로 사용한 합성항산화제인 BHA의 ABTS와 비슷한 85% 유사수준으로 확인되었다. As a result, ABTS (mg/mL) was confirmed to be 85% similar to the ABTS of BHA, a synthetic antioxidant used as a control.
이상과 같이 본 발명은 첨부된 도면을 참조하여 바람직한 실시예를 중심으로 설명하였지만 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 본 발명의 특허청구범위에 기재된 기술적 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 또는 변형하여 실시할 수 있다. 따라서 본 발명의 범주는 이러한 많은 변형의 예들을 포함하도록 기술된 청구범위에 의해서 해석되어야 한다.As described above, the present invention has been described with a focus on preferred embodiments with reference to the accompanying drawings, but within the scope of those skilled in the art in the technical field to which the present invention pertains without departing from the technical spirit and scope described in the claims of the present invention. The present invention can be implemented with various modifications or modifications. Accordingly, the scope of the present invention should be construed by the appended claims to include examples of many such modifications.
Claims (8)
참마 추출물 제조단계(S200);와
식물성 콜라겐 추출물, 참마 추출물, 첨가제를 혼합하는 혼합단계(S300)를 포함하는 것을 특징으로 하는
식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법.
A vegetable collagen extract manufacturing step (S100) of producing a vegetable collagen extract from at least one of Geumhwagyu leaves, bean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots;
Yam extract manufacturing step (S200); and
Characterized by comprising a mixing step (S300) of mixing vegetable collagen extract, yam extract, and additives.
Method for producing an inner beauty composition containing vegetable collagen.
상기 식물성 콜라겐 추출물 제조단계(S100)에서는
초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 식물성 콜라겐 추출물을 수득하는 것을 특징으로 하는
식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법.
According to clause 1,
In the vegetable collagen extract manufacturing step (S100),
Characterized in obtaining a vegetable collagen extract using at least one of ultrasonic extraction and supercritical extraction.
Method for producing an inner beauty composition containing vegetable collagen.
상기 혼합단계에서 첨가제는
포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함하는 것을 특징으로 하는
식물성 콜라겐을 포함하는 이너뷰티용 조성물의 제조방법.
According to clause 1,
In the mixing step, additives are
Characterized in that it contains at least one of glucose, fructo-oligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
Method for producing an inner beauty composition containing vegetable collagen.
식물성 콜라겐을 포함하는 이너뷰티용 조성물.
Characterized in that it is manufactured by mixing vegetable collagen extract extracted from at least one of the collagen plants of Geumhwagyu leaves, bean leaves, berries, mushrooms, asparagus, avocado, canola, and carrots, yam extract, and additives.
A composition for inner beauty containing vegetable collagen.
상기 식물성 콜라겐 추출물은
초음파 추출법 및 초임계 추출법 중 적어도 어느 하나의 추출법을 이용하여 수득되는 것을 특징으로 하는
식물성 콜라겐을 포함하는 이너뷰티용 조성물.
According to clause 4,
The vegetable collagen extract is
Characterized in that it is obtained using at least one of the ultrasonic extraction method and the supercritical extraction method.
A composition for inner beauty containing vegetable collagen.
상기 첨가제는 포도당, 프락토올리고당, 자일리톨, 타우린, 유산균 및 비타민 C 중 적어도 어느 하나를 포함하는 것을 특징으로 하는
식물성 콜라겐을 포함하는 이너뷰티용 조성물.
According to clause 4,
The additive is characterized in that it contains at least one of glucose, fructo-oligosaccharide, xylitol, taurine, lactic acid bacteria, and vitamin C.
A composition for inner beauty containing vegetable collagen.
Vegetable collagen noodles containing a composition for inner beauty containing the vegetable collagen of any one of claims 4 to 6.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101654125B1 (en) | 2014-08-20 | 2016-09-05 | 김구환 | Chicken feet, dandelion, per ear and are made to go week herbal collagen beauty enhancement food manufacturing method |
| KR101918452B1 (en) | 2018-06-30 | 2018-11-13 | 구태훈 | Composition having Carboxymethyl Chitosan, cross-linked hyaluronic acid and collagen and, manufacturing methods for the same |
| KR102387667B1 (en) | 2020-09-01 | 2022-04-20 | 농업회사법인 주식회사 옻가네 | Method for extracting collagen using rhus verniciflua fermentation broth and composition for extracting collagen containing nontoxic fermented extract of rhus verniciflua as an active ingredient |
| KR20220149401A (en) | 2021-04-30 | 2022-11-08 | 모던 메도우 아이엔씨. | Collagen compositions and methods of use thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101654125B1 (en) | 2014-08-20 | 2016-09-05 | 김구환 | Chicken feet, dandelion, per ear and are made to go week herbal collagen beauty enhancement food manufacturing method |
| KR101918452B1 (en) | 2018-06-30 | 2018-11-13 | 구태훈 | Composition having Carboxymethyl Chitosan, cross-linked hyaluronic acid and collagen and, manufacturing methods for the same |
| KR102387667B1 (en) | 2020-09-01 | 2022-04-20 | 농업회사법인 주식회사 옻가네 | Method for extracting collagen using rhus verniciflua fermentation broth and composition for extracting collagen containing nontoxic fermented extract of rhus verniciflua as an active ingredient |
| KR20220149401A (en) | 2021-04-30 | 2022-11-08 | 모던 메도우 아이엔씨. | Collagen compositions and methods of use thereof |
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