KR20240076768A - Liquid external skin composition - Google Patents

Abstract

It contains (A) a coolant, (B) maltotetraose, and (C) a polyhydric alcohol with a molecular weight of 350 or less, and (C) relative to the sum of the contents of the component (A) and the component (B). ) is a liquid external composition for skin, characterized in that the mass ratio of the content of ingredients [(C)/{(A)+(B)}] is 5 or more and 30 or less.

Description

Liquid external skin composition

The present invention relates to a liquid external skin composition.

In recent years, compositions for external use on the skin that relieve itching on the skin are required to have no stickiness on the skin immediately after application, low-temperature stability of the preparation, and immediate and long-lasting anti-inflammatory effect.

Conventionally, as a technique for alleviating itchiness occurring on the skin, itching relief by cold stimulation of L-menthol and NK1 receptor antagonism compositions by maltooligosaccharide, etc. have been proposed (for example, see Patent Document 1).

However, the composition used in Patent Document 1 requires further improvement in terms of the immediate effect of the absorptive effect from the viewpoint of the penetration rate and amount of the active ingredient into the skin and the mechanism of action. In addition, since the composition used in Patent Document 1 above contains a large amount of emulsion components, further improvement was required regarding stickiness of the skin after use.

In addition, an itch suppressant has been proposed that suppresses itching derived from stimulant components such as histamine and Substance P by containing maltooligosaccharide, an anti-inflammatory agent, and an anti-inflammatory agent (for example, see Patent Document 2).

However, the itch suppressant used in Patent Document 2 has insufficient penetration of the active ingredient into the skin, and further improvement is needed regarding the sustainability of the absorptive effect.

Additionally, for the purpose of stabilizing compositions containing anti-septic active ingredients, cosmetic compositions containing surfactants such as anionic surfactants, cationic surfactants, and amphoteric surfactants, and ethyl alcohol have been proposed (for example, (See Patent Document 3).

However, the surfactant and ethyl alcohol used in Patent Document 3 may promote drying of the skin, and further improvement was needed regarding the sustainability of the lubricating effect. In addition, if the composition used in Patent Document 3 does not contain a surfactant or ethanol, the solubility of the components decreases, so further improvement in low-temperature stability was required.

Accordingly, a liquid skin external composition that is excellent in the absence of stickiness on the skin immediately after application, the low-temperature stability of the formulation, and the immediate effect and sustainability of the absorptive effect has not yet been provided, and its rapid development is currently strongly desired.

International Publication No. 08/047709 Japanese Patent Application Publication No. 2009-221190 Japanese Patent Application Publication No. 2011-148773

The present invention aims to solve the above-described various problems in the prior art and achieve the following objectives. That is, the purpose is to provide a liquid skin external composition that is excellent in the absence of stickiness on the skin immediately after application, the low-temperature stability of the preparation, and the immediate effect and sustainability of the absorptive effect.

As a result of repeated studies by the present inventors to achieve the above object, the liquid external skin composition of the present invention has (A) a cooling agent, (B) maltotetraose, and (C) a molecular weight of 350. Contains the following polyhydric alcohol, and the mass ratio of the content of the component (C) to the sum of the contents of the component (A) and the component (B) [(C)/{(A) + (B)}] When the value was 5 or more and 30 or less, it was confirmed that the skin was not sticky immediately after application, that the preparation was excellent in low-temperature stability, and in the immediate efficacy and sustainability of the absorptive effect.

The present invention is based on the above confirmation by the present inventors, and means for solving the above problem are as follows.

<1>

(A) a cooling agent,

(B) maltotetraose,

(C) contains a polyhydric alcohol with a molecular weight of 350 or less,

Characterized in that the mass ratio [(C)/{(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B) is 5 or more and 30 or less. It is a liquid skin external composition.

<2>

The content of the component (A) is 0.2% by mass or more and 0.4% by mass or less with respect to the total amount of the liquid external skin composition,

The content of the component (B) is 0.5% by mass or more and 1.5% by mass or less with respect to the total amount of the liquid external skin composition,

The liquid external skin composition according to <1> above, wherein the content of the component (C) is 15% by mass or more and 25% by mass or less with respect to the total amount of the liquid external skin composition.

<3>

The liquid external skin composition according to any one of <1> to <2>, wherein the content of ethyl alcohol in the liquid external skin composition is less than 1.0% by mass based on the total amount of the liquid external skin composition.

<4>

The content of surfactant in the liquid external skin composition is less than 1.0% by mass based on the total amount of the liquid external skin composition,

The liquid external skin composition according to any one of <1> to <3>, wherein the surfactant is at least one selected from an anionic surfactant, a cationic surfactant, and an amphoteric surfactant.

<5>

The liquid external skin composition according to any one of <1> to <4> above, wherein the content of purified water in the liquid external skin composition is 60% by mass or more based on the total amount of the liquid external skin composition.

<6>

The liquid external skin composition according to any one of <1> to <5> above, which is a type that cannot be washed off.

<7>

The liquid external skin composition according to any one of <1> to <6> above, which is filled into a mist spray container.

According to the present invention, the above-described various problems in the prior art can be solved, the above-described object can be achieved, and the liquid external use on the skin is excellent in the absence of stickiness on the skin immediately after application, low-temperature stability of the preparation, and immediate efficacy and sustainability of the absorptive effect. A composition may be provided.

(Liquid skin external composition)

The liquid external skin composition of the present invention contains (A) a cooling agent, (B) maltotetraose, (C) a polyhydric alcohol with a molecular weight of 350 or less, and, if necessary, other components.

In addition, in this specification, (A) the coolant is referred to as “component (A),” (B) maltotetraose is referred to as “component (B),” and (C) a polyhydric alcohol with a molecular weight of 350 or less is referred to as “component (C).” Alternatively, there is something called “(C) polyhydric alcohol.”

<(A) Coolant>

The cooling agent (A) is contained to improve the immediate effect of the cooling effect.

The cooling agent (A) above is not particularly limited and can be appropriately selected depending on the purpose. From the viewpoint of improving the immediate anti-repellent effect and the low-temperature stability of the preparation, L-menthol, menthyl lactate, menthyl acetate, and L-menthyl glycerin are selected. Lithyl ether, N-ethyl-p-menthane-3-carboamide and peppermint oil are preferred, L-menthol and N-ethyl-p-menthane-3-carboamide are more preferred, and L-menthol is particularly preferred. do. These may be used individually, or two or more types may be used together.

The L-menthol can be represented by the following structural formula.

[Formula 1]

The component (A) may be appropriately synthesized or a commercially available product may be used.

The method for synthesizing the component (A) is not particularly limited and can be appropriately selected depending on the purpose.

Commercially available products of the cooling agent (A) include, for example, L-menthol (manufactured by Takasako Fragrance Industries), menthyl lactate Frescolat mL (manufactured by Shimuraisu Corporation), and white peppermint oil (manufactured by Nagaoka Kogyo Industries).

The content of the component (A) in the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose. From the viewpoint of the immediate efficacy of the absorptive effect and the excellent low-temperature stability of the preparation, the liquid external skin composition is It is preferably 0.1% by mass or more and 0.5% by mass or less, and more preferably 0.2% by mass or more and 0.4% by mass or less with respect to the total amount.

It is appropriate that the content of the component (A) is 0.1% by mass or more based on the total amount of the liquid external composition for skin, as this can solve the problem that the immediate efficacy of the absorptive effect is reduced.

It is appropriate that the content of the component (A) is 0.5% by mass or less based on the total amount of the liquid external composition for skin, as this can solve the problem that the low-temperature stability of the preparation is reduced.

<(B) maltotetraose>

(B) Maltotetraose is contained to improve the sustainability of the absorptive effect.

In general, maltotetraose has an NK1 (new quinolone 1) receptor antagonistic action and suppresses itching caused by ingredients such as Substance P. In addition, the maltotetraose forms a film on the surface of the liquid external skin composition, thereby suppressing volatilization of the cooling agent component (A) and improving the sustainability of the cooling effect.

The maltotetraose (B) above may be appropriately synthesized or a commercially available product may be used.

The method for synthesizing maltotetraose (B) is not particularly limited and can be appropriately selected depending on the purpose.

Examples of commercially available products of maltotetraose (B) include Leoguard MT (manufactured by Lion Specialty Chemicals) and Tetorab (manufactured by Hayashibara).

The content of the component (B) in the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose. It is excellent in the immediate efficacy and sustainability of the absorptive effect and does not make the skin sticky immediately after use. From a good viewpoint, it is preferably 0.1% by mass or more and 3.0% by mass or less, and more preferably 0.5% by mass or more and 1.5% by mass or less with respect to the total amount of the liquid external composition for skin.

It is appropriate that the content of the component (B) is 0.1% by mass or more based on the total amount of the liquid external skin composition, as it can solve the problem that the immediate effectiveness and sustainability of the absorptive effect are reduced.

If the content of the component (B) is 3.0% by mass or less based on the total amount of the liquid external skin composition, it is appropriate to solve the problem of the skin becoming sticky immediately after use of the liquid external skin composition.

<(C) polyhydric alcohol with a molecular weight of 350 or less>

The (C) polyhydric alcohol with a molecular weight of 350 or less is contained to improve the immediate effect and sustainability of the absorptive effect.

In the present invention, the (C) polyhydric alcohol with a molecular weight of 350 or less can provide an immediate absorptive effect by suppressing volatilization of the coolant (A). In addition, the polyhydric alcohol can provide sustainability to the absorptive effect by promoting penetration of the (B) maltotetraose into the skin.

There are no particular restrictions on the component (C), and it can be appropriately selected depending on the purpose. From the viewpoint of being excellent in the immediate effect and sustainability of the absorptive effect, and having a good lack of stickiness on the skin immediately after use, ethylene glycol, diethylene Glycol, propylene glycol, butylene glycol, pentylene glycol, dibutylene glycol, glycerin, diglycerin, polyglycerin, sucrose, lactose, maltose, mannitol, erythritol and xylitol are preferred, butylene glycol and glycerin are preferred. It is more desirable.

The component (C) may be appropriately synthesized or a commercially available product may be used.

The method for synthesizing the component (C) is not particularly limited and can be appropriately selected depending on the purpose.

Commercially available products containing the component (C) include, for example, butylene glycol (manufactured by OQ Chemicals Japan Co., Ltd.), Propylene Glycol JSQI (manufactured by Dow Chemical Co., Ltd.), dipropylene glycol (manufactured by AGC Co., Ltd.), and glycerin for cosmetics (manufactured by Sakamoto Pharmaceutical Co., Ltd.). Industrial Co., Ltd.) etc. can be mentioned.

The content of the component (C) in the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose, and is excellent in the immediate efficacy and sustainability of the absorptive effect and does not make the skin sticky immediately after use. From the viewpoint of good, it is preferably 10% by mass or more and 30% by mass or less, and more preferably 15% by mass or more and 25% by mass or less with respect to the total amount of the liquid external composition for skin.

It is appropriate that the content of the component (C) is 10% by mass or more based on the total amount of the liquid external composition for skin, as this can solve the problems of deterioration of the immediate efficacy and sustainability of the absorptive effect and the low-temperature stability of the preparation.

If the content of the component (C) is 30% by mass or less based on the total amount of the liquid external skin composition, it is suitable to solve the problem of the skin becoming sticky immediately after use of the liquid external skin composition.

There is no particular limitation as a method for measuring the molecular weight of the (C) polyhydric alcohol, but it can be measured, for example, by mass spectrometry. Specifically, the molecular weight in polyhydric alcohol can be measured by performing gas chromatography mass spectrometry.

<Mass ratio[(C)/{(A)+(B)}]>

In the present invention, the mass ratio [(C)/{(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B) is the absorptive effect. It is 5 or more and 30 or less from the viewpoint of excellent immediate efficacy and sustainability, good lack of stickiness on the skin immediately after use, and improved low-temperature stability of the preparation.

In the present invention, the mass ratio [(C)/{(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B) is 7 or more. 20 or less is preferable.

In addition, in this specification, “mass ratio of the content of the component (C) to the sum of the contents of the component (A) and the component (B) [(C)/{(A)+(B)}]” is sometimes called the “mass ratio.”

The above mass ratio of 5 or more is suitable because it can solve the problems of persistence in the absorptive effect, its immediate effect, and low-temperature stability in the preparation.

If the mass ratio is 30 or less, the problem of the persistence and immediate effect of the oily effect being reduced or the skin becoming sticky immediately after use of the liquid external skin composition can be solved.

<Other ingredients>

In addition to the above-mentioned component (A), component (B), and component (C), the liquid external skin composition of the present invention may contain other components as necessary within the range that does not impair the effect of the present invention.

Examples of the other ingredients include ethyl alcohol, surfactants, water-soluble polymers, oils, cellulose, keratolytic agents, anti-inflammatory agents, antihistamine compounds, silicones, alcohols other than ethyl alcohol, lanolin derivatives, and proteins. Drugs such as derivatives, amino acids, and vitamins, disinfectants, moisturizers, preservatives, thickeners, pH adjusters such as potassium hydroxide, citric acid, and hydrochloric acid, antioxidants, metal sequestrants, ultraviolet absorbers, ultraviolet scattering agents, animal and plant extracts or derivatives thereof, Examples include chelating agents such as edetic acid, colorants, fragrances, pigments, inorganic powders, clay minerals, water-insoluble polymer compound powders such as nylon and polyethylene, and purified water.

These may be used individually, or two or more types may be used together.

The other components mentioned above may be appropriately synthesized or commercially available products.

The content of the other ingredients in the liquid external skin composition is not particularly limited and can be appropriately selected depending on the purpose.

<<Ethyl Alcohol>>

The liquid external skin composition of the present invention may contain ethyl alcohol in addition to the component (A), the component (B), and the component (C).

The content of the ethyl alcohol is preferably less than 1.0% by mass based on the total amount of the liquid external skin composition from the viewpoint of improving the sustainability of the lubricating effect.

If the content of ethyl alcohol is less than 1.0% by mass based on the total amount of the liquid external composition for skin, it is appropriate to solve the problem that drying of the skin is accelerated and the sustainability of the lubricating effect is reduced.

The ethyl alcohol may be appropriately synthesized or a commercially available product may be used.

The method for synthesizing ethyl alcohol is not particularly limited and can be appropriately selected depending on the purpose.

Examples of commercially available products of the ethyl alcohol include Specific Alcohol 95% Synthetic (manufactured by Nippon Synthetic Alcohol Company).

<<Surfactant>>

The liquid external skin composition of the present invention may contain a surfactant in addition to the component (A), the component (B), and the component (C).

The surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include anionic surfactants, cationic surfactants, and amphoteric surfactants.

<<Anionic surfactant>>

Specific examples of the anionic surfactant include higher fatty acid salts, polyoxyethylene (POE) alkyl ether sulfate, ether carboxylate, and amino acid-based surfactants. Among these, higher fatty acid salts are preferable.

These may be used individually, or two or more types may be used together.

-Advanced fatty acids-

The higher fatty acid salts are not particularly limited and can be appropriately selected depending on the purpose, and examples include laurate, myristate, palmitate, and stearate. Among these, laurate and myristate are preferred.

These may be used individually, or two or more types may be used together.

The salt of the higher fatty acid salt is not particularly limited and can be appropriately selected depending on the purpose, and examples include alkali metal salts, amine salts, and amino acid salts.

The alkali metal salt is not particularly limited and can be appropriately selected depending on the purpose, and examples include sodium salt and potassium salt.

The amine salt is not particularly limited and can be appropriately selected depending on the purpose, for example, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, 2-amino-2-methylpropanol and 2-amino salt. Alkanolamine salts such as -2-methylpropanediol, etc. can be mentioned.

The amino acid salt is not particularly limited and can be appropriately selected depending on the purpose, and examples include lysine salt and arginine salt.

Among these, alkali metal salts are preferable and potassium salts are more preferable.

The above higher fatty acid salts may be appropriately synthesized or commercially available products may be used.

The method for synthesizing the above-mentioned higher fatty acid salts is not particularly limited and can be appropriately selected depending on the purpose. For example, fatty acid salts obtained by routine methods may be mixed as is, and in the process of mixing the liquid external skin composition, the higher fatty acid salt may be used. Higher fatty acid salts may be synthesized by neutralizing an alkali such as potassium hydroxide in a mixing tank.

Commercially available products of the above higher fatty acid salts include, for example, NIKKOL potassium laurate LK-120 (potassium laurate), NIKKOL potassium myristate MK-140 (potassium myrstate), and Taisofu MNK-40 under brand names. (Potassium palm oil fatty acid) (above, manufactured by Nikko Chemicals Co., Ltd.) and Nonsal PK-1 (potassium palmitate) (manufactured by Nichiyu Co., Ltd.).

-Polyoxyethylene (POE) alkyl ether sulfate-

The polyoxyethylene alkyl ether sulfate is not particularly limited and can be appropriately selected depending on the purpose, and examples include compounds represented by the following general formula (A1).

The polyoxyethylene alkyl ether sulfate may be used individually or in combination of two or more types.

[Formula 2]

In the general formula (A1), R ⁷ represents an alkyl group, and the number of carbon atoms in the alkyl group portion is preferably 10 to 14.

In the general formula (A1), n represents the average added mole number of ethylene oxide (E.O.), and the average added mole number of ethylene oxide is preferably 1 to 5.

In the general formula (A1), X represents an alkali metal or ammonium.

The alkali metal is not particularly limited and can be appropriately selected depending on the purpose, and examples include sodium and potassium.

Specific examples of the polyoxyethylene alkyl ether sulfate include polyoxyethylene (1) sodium lauryl ether sulfate, polyoxyethylene (2) sodium lauryl ether sulfate (aka: POE (2) sodium laureth sulfate), and polyoxyethylene (3). ) Sodium lauryl ether sulfate (aka: POE (3) sodium laureth sulfate), polyoxyethylene (4) sodium lauryl ether sulfate, sodium polyoxyethylene (5) lauryl ether sulfate, polyoxyethylene (3) alkyl (C12, 13) ) Sodium ether sulfate, polyoxyethylene (2) lauryl ether ammonium sulfate, polyoxyethylene (3) lauryl ether ammonium sulfate, etc.

In addition, the numerical value in () above represents the average added mole number (n) of ethylene oxide (E.O.).

The polyoxyethylene alkyl ether sulfate may be appropriately synthesized or a commercially available product may be used.

Commercially available products of the polyoxyethylene alkyl ether sulfate include, for example, Texapon (registered trademark) N70 (sodium polyoxyethylene (2) lauryl ether sulfate) (manufactured by BASF) and Shinorin SPE- 1250 (sodium polyoxyethylene (2) lauryl ether sulfate) (manufactured by Nippon Ewha Corporation), etc. can be mentioned.

-Ether carboxylate-

The ether carboxylate is not particularly limited and can be appropriately selected depending on the purpose, and examples include compounds represented by the following general formula (A2) or (A3).

The above ether carboxylates may be used individually, or two or more types may be used in combination.

[Formula 3]

In the general formulas (A2) and (A3), R ⁸ is a straight-chain or branched alkyl group or alkenyl group having 5 to 23 carbon atoms, a straight-chain or branched alkyl group having 5 to 23 carbon atoms, or a phenyl group substituted with an alkenyl group. , and the number of carbon atoms in the R ⁸ portion is preferably 10 to 14.

In the general formula (A2), R ⁹ may be the same or different, and represents an alkylene group having 2 to 4 carbon atoms, preferably 2 carbon atoms.

In the general formula (A2), o represents the average added mole number of alkylene oxide of 1 to 20, and the average added mole number of alkylene oxide is preferably 1 to 5.

In the general formulas (A2) and (A3), M ¹ represents a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, or an alkaline amino acid.

Specific examples of the ether carboxylate represented by the general formula (A2) or (A3) include sodium polyoxyethylene (3) lauryl ether acetate, potassium polyoxyethylene (4) lauryl ether acetate, and lauryl glycol acetic acid. Sodium, etc. can be mentioned.

In addition, the numerical value in () above represents the average added mole number (o) of alkylene oxide.

The ether carboxylate may be an appropriately synthesized salt or a commercially available salt.

Commercially available products of the ether carboxylate include, for example, Enagicol EC-30 (sodium polyoxyethylene (3) lauryl ether acetate) (manufactured by Lion Specialty Chemicals Co., Ltd.) and Burite LCA-25F under the brand names. (Sodium polyoxyethylene (3) lauryl ether acetate), Burite LCA-30D (Sodium polyoxyethylene (3) lauryl ether acetate), Burite LCA-H (Polyoxyethylene (4) lauryl ether acetate) , Burite LCA-25NH (laureth-tetracarboxylic acid), Burite SHAA (sodium lauryl glycol carboxylate), Burite LCA (sodium polyoxyethylene (3) lauryl ether acetate) (above, Sanyo Kasei Industry Co., Ltd. ), Kaoakipo RLM-45NV (sodium polyoxyethylene (4.5) lauryl ether acetate) and Kaoakipo RLM-100NV (sodium polyoxyethylene (10) lauryl ether acetate) (above, manufactured by Gao Corporation) ), etc.

In addition, the numerical value in () above represents the average added mole number (o) of alkylene oxide.

-Amino acid surfactant-

The amino acid-based surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include compounds represented by the following general formula (A4).

The amino acid-based surfactants may be used individually, or two or more types may be used in combination.

[Formula 4]

In the general formula (A4), R ¹⁰ represents a straight-chain or branched alkyl group having 5 to 23 carbon atoms, or an alkenyl group, or a phenyl group substituted with a straight-chain or branched alkyl group or an alkenyl group having 5 to 23 carbon atoms, The carbon number of the R ¹⁰ portion is preferably 8 to 18.

In the general formula (A4), R ¹¹ represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.

In the general formula (A4), R ¹² and R ¹³ may be the same or different, and represent a hydrogen atom or -(CH ₂ ) _m -COOM ² .

In the general formula (A4), m and n may be the same or different, and represent numbers from 0 to 20.

In the general formula (A4), M ¹ and M ² may be the same or different and represent a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, or a basic amino acid.

The amino acid structure of the hydrophilic portion of the amino acid-based surfactant is not particularly limited and can be appropriately selected depending on the purpose, with glycine, glutamic acid, and methylalanine being preferred.

Specific examples of the amino acid-based surfactant represented by the general formula (A4) include N-acyl-glycine and its salts such as N-cocoyl-glycine potassium (N-cocoyl-glycine potassium); N-acyl-N-carboxyethyl-glycine and its salts such as N-myristoyl-N-carboxyethyl-glycine sodium; N-myristoyl-L-sodium glutamate, N-myristoyl-L-potassium glutamate, N-acyl palm oil fatty acid-L-potassium glutamate, N-acyl palm fatty acid-L-sodium glutamate, N-stearoyl- N-acylglutamic acid and its salts such as sodium L-glutamate; N-lauroyl-N-methyl-β-alanine potassium, etc. can be mentioned.

The amino acid-based surfactant may be an appropriately synthesized surfactant, or a commercially available product may be used.

Commercially available products of the amino acid-based surfactant include, for example, brand names such as Amirite (registered trademark) GCK-11 (N-acyl glycine potassium from palm oil) and Amylite (registered trademark) GCK-12K (Acyl glycine from N-coconut oil fatty acid). Glycine potassium), Amirite (registered trademark) GCS-12K (Sodium acylglycine N-coconut oil fatty acid), Amirite (Registered trademark) GCS-11 (Sodium acylglycine N-coconut oil fatty acid), Amisoft (Registered trademark) CS- 11 (N-myristoyl-L-sodium glutamate), Amisoft (registered trademark) CS-22 (Sodium N-acyl palm oil fatty acid-L-glutamate), Amisoft (registered trademark) LS-11 (N-Lauro) Monosodium monol-L-glutamate), Amisoft (registered trademark) MS-11 (sodium N-myristoyl-L-glutamate), Amisoft (registered trademark) HS-11P (sodium N-stearoyl-L-glutamate) ), Amisoft (registered trademark) HS-11P(F) (sodium N-stearoyl-L-glutamate), Amisoft (registered trademark) HS21 (disodium N-stearoyl-L-glutamate), Amirite (registered trademark) ACS-12 (sodium cocoyl alanine) (above, manufactured by Ajinomoto Healthy Supply Co., Ltd.), Aminosurpact (registered trademark) AMMS-P1 (sodium N-myristoyl-L-glutamate) (Asahi Kasei Chemical) (manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Salcosinate MN (sodium myristoylmethylaminoacetate), NIKKOL Araninate LN-30 (sodium lauroylmethyl-β-alanine) (above, manufactured by Nikko Chemicals Co., Ltd.), Aranone ACE (sodium palm oil fatty acid methylalanine), Aranone AME (sodium myristoylmethyl-β-alanine), Aranone ALE (sodium lauroylmethyl-β-alanine) (above, manufactured by Kawaken Fine Chemical Co., Ltd.), Ena Zicol L-30AN (sodium lauroylmethyl-β-alanine) (manufactured by Lion Specialty Chemicals Co., Ltd.) and Softilt AT-L (sodium lauroylmethyl-β-alanine) (manufactured by Nichiyu Co., Ltd.). I can hear it.

<<Non-ionic surfactant>>

The nonionic surfactant is not particularly limited and can be appropriately selected depending on the purpose, for example, polyoxyethylene alkyl ether (hereinafter also referred to as “POE alkyl ether”) having an average added mole number of ethylene oxide of 40 to 120. ) and fatty acid monoethanolamide. These may be used individually, or two or more types may be used together.

-POE alkyl ether-

The average added mole number (average EO added mole number) of ethylene oxide (EO) of the POE alkyl ether is not particularly limited and can be appropriately selected depending on the purpose, preferably 40 to 120, more preferably 50 to 100, 70 to 100 is particularly preferable.

The number of carbon atoms of the alkyl group in the POE alkyl ether is preferably 10 to 22, and more preferably 12 to 18.

As the POE alkyl ether, an appropriately synthesized one may be used, or a commercially available product may be used.

Examples of the commercial products include Emmax 550 (POE (50) oleyl ether), Emmax 750 (POE (50) lauryl ether) (manufactured by Nippon Emulsion Co., Ltd.), Nonion K-2100W (POE (POE (50) 100) lauryl ether, manufactured by Nichiyu Co., Ltd.) and Burunone SR-750 (POE (50) stearyl ether, manufactured by Aoki Yuji Industry Co., Ltd.).

In addition, the number in () after POE represents the average added mole number of ethylene oxide.

-Fatty acid monoethanolamide-

The number of carbon atoms of the fatty acid in the fatty acid monoethanolamide is preferably 8 to 18.

As the fatty acid monoethanolamide, an appropriately synthesized product may be used, or a commercially available product may be used.

Examples of the commercial products include amidol CME (coconut oil fatty acid monoethanolamide) and amidol SME (stearic acid monoethanolamide) (manufactured by Kawaken Fine Chemical Co., Ltd.).

<<<Amphoteric surfactant>>>

The amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, for example, alkyl betaine type amphoteric surfactant, amide betaine type amphoteric surfactant, sulfo betaine type amphoteric surfactant, hydroxysulfobetaine type amphoteric surfactant. Examples include amphoteric surfactants, amide sulfobetaine type amphoteric surfactants, phosphobetaine type amphoteric surfactants, imidazoline type amphoteric surfactants, and amine oxide type amphoteric surfactants. These may be used individually, or two or more types may be used together.

The alkyl betaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include lauryl dimethyl amino acetic acid betaine and lauryl betaine. These may be used individually, or two or more types may be used together.

The amide betaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, for example, amide propyl betaine laurate (lauramid propyl betaine), stearyldimethylaminoacetic acid betaine and coca. Midpropyl betaine (coconut oil fatty acid amide propyl betaine), etc. can be mentioned. These may be used individually, or two or more types may be used together.

The sulfobetaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include dimethyl sulfopropyl betaine palm oil fatty acid. These may be used individually, or two or more types may be used together.

The hydroxysulfobetaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include laurylhydroxysulfobetaine. These may be used individually, or two or more types may be used together.

The amide sulfobetaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include cocamidepropylhydroxysulfobetaine and lauramidepropylhydroxysulfobetaine. These may be used individually, or two or more types may be used together.

The phosphobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include laurylhydroxyphosphobetaine and the like. These may be used individually, or two or more types may be used together.

The imidazoline type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, for example, palm oil alkyl-N-hydroxyethylimidazolinium betaine and 2-alkyl-N-carboxymethyl. -N-Hydroxyethylimidazolinium betaine, etc. can be mentioned. These may be used individually, or two or more types may be used together.

The amine oxide type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples include lauryl dimethyl amine oxide and coconut oil alkyl dimethyl amine oxide. These may be used individually, or two or more types may be used together.

The amphoteric surfactant may be appropriately synthesized or a commercially available product may be used.

Commercially available products of the amphoteric surfactant include, for example, NIKKOL AM-3130N (cocamide propyl betaine, manufactured by Nikko Chemicals Co., Ltd.), TEGO Betain (cocamide propyl betaine, manufactured by Evonik), and Anhytol 20AB (under brand names). Propyl lauric acid amide betaine, manufactured by Gao Co., Ltd.), MITAINE L (lauryl betaine, manufactured by Miwon Commercial Co., Ltd.), Anhorex LSB (lauryl hydroxysulfobetaine, Miyoshi Oil Co., Ltd.), Anhytol 20HD (lauryl hyde) Roxysulfobetaine, manufactured by Gao Co., Ltd.), Soputazoline LSB (Lauramidpropylhydroxysulfobetaine, Kawaken Fine Chemicals Co., Ltd.), Soputazolin CH (2-alkyl-N-carboxymethyl-N-hydroxy Ethylimidazolinium Betaine, Kawaken Fine Chemicals Co., Ltd.), Anhytol 20N (lauryl dimethylamine oxide, manufactured by Gao Co., Ltd.), and Unicepu (registered trademark) A-LM (lauryl dimethylamine oxide, nitric acid) Healing Co., Ltd.) and the like.

The total content of the above surfactants is not particularly limited and can be appropriately selected depending on the purpose, but is preferably less than 1.0% by mass based on the total amount of the liquid external skin composition from the viewpoint of improving the sustainability of the oiling effect.

If the total content of the above surfactants is less than 1.0% by mass based on the total amount of the liquid external composition for skin, it is appropriate to solve the problem that drying of the skin is accelerated and the sustainability of the absorptive effect is reduced.

<<Cellulose>>

The above-mentioned cellulose is not particularly limited and can be appropriately selected depending on the purpose, and examples include hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose.

The content of the cellulose is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.05% by mass or more and 1.0% by mass or less with respect to the total amount of the liquid external skin composition.

<<Anti-inflammatory agent>>

The anti-inflammatory agent is not particularly limited and can be appropriately selected depending on the purpose, for example, dexamethasone, dexamethasone acetate, clobetasone, clobetasone acetate, glycyrrhizic acid, glycyrrhetinic acid, dipotassium glycyrrhizinate and glycyrrhetin. Sanstearyl, etc. can be mentioned.

The content of the anti-inflammatory agent is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.01% by mass or more and 1.0% by mass or less with respect to the total amount of the liquid external skin composition.

<<Antihistamine compound medication>>

The antihistamine compound agent is not particularly limited and can be appropriately selected depending on the purpose, for example, hydroxyphenylpropamide benzoic acid, acrivastine, brompheniramine, chlorpheniramine, dexchlorpheniramine, dimethindene, and trimethylamine. Prolidine, bromodiphenhydramine, clemastine, phenyltoloxamine, fiprinhydrinate, pyrilamine, tripelenamine, cetirizine, hydroxyzine, metdilazine, promethazine, trimeprazine , azatadine, cyproheptadine, loratadine, astemizole, diphenhydramine, levocabastine, and terfenadine.

The content of the antihistamine compound agent is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.005% by mass or more and 0.5% by mass or less with respect to the total amount of the liquid external skin composition.

The hydroxyphenylpropamide benzoic acid can be represented by the following structural formula.

[Formula 5]

<<Oil fraction>>

The oil component is not particularly limited and can be appropriately selected depending on the purpose. For example, castor oil, olive oil, cacao oil, hydrogenated palm oil, camellia oil, palm oil, Japanese wax, jojoba oil, grapeseed oil, avocado oil, etc. Oils and fats and their ester compounds: animal fats and oils such as mink oil and egg yolk oil, beeswax, spermaceti wax, lanolin, hydrogenated lanolin, carnauba wax, candelilla wax, etc., liquid paraffin, squalene, microcrystalline wax, ceresin wax, paraffin wax. , hydrocarbons such as vaseline, natural and synthetic fatty acids such as oleic acid, isostearic acid, behenic acid, etc.: glycerol tri-2-ethylhexanoic acid ester, 2-ethylhexyl stearate, butyl stearate, isopropyl myristate, palmitic acid. Ester, such as isopropyl, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate, etc. are mentioned.

The content of the oil is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 10% by mass or less with respect to the total amount of the liquid external skin composition.

<<Alcohols other than ethyl alcohol>>

Alcohols other than the above ethyl alcohol are not particularly limited and can be appropriately selected depending on the purpose, for example, cetyl alcohol, oleyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, and lauryl alcohol. These include natural and synthetic higher alcohols.

The content of alcohols other than the above-mentioned ethyl alcohol is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 10% by mass or less with respect to the total amount of the liquid external skin composition.

<<Moisturizer>>

The moisturizing agent is not particularly limited and can be appropriately selected depending on the purpose, for example, isoprene glycol, 1,2-pentanediol, diethylene glycol, diethylene glycol monoalkyl ether, polypropylene glycol, hydrogenated castor oil ( 30E. O.), diglycerin, triglycerin, polyglycerins, trehalose, glycosyltrehalose, and hydrolyzed hydrogenated starch.

The content of the moisturizer is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.05% by mass or more and 10% by mass or less with respect to the total amount of the liquid external skin composition.

<<Preservatives>>

The above preservative is not particularly limited and can be appropriately selected depending on the purpose, for example, ethylhexylglycerin, benzoate, sorbate, dihydroacetate, paraoxybenzoic acid ester, 2,4,4'-trichloro. -2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarubanilide, benzalkonium chloride, hinokitiol, resorcinone, methylchloroisothiazolinone, methylisothiazolinone solution (Product name: Cason CG , manufactured by Rohm & Haas Japan), salicylic acid, pentanediol, phenoxyethanol, and ethanol.

The content of the preservative is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 1% by mass or less with respect to the total amount of the liquid external skin composition.

<<Antioxidant>>

The antioxidant is not particularly limited and can be appropriately selected depending on the purpose, and examples include dibutylhydroxytoluene, butylhydroxyanisole, and ascorbic acid.

The content of the antioxidant is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 1% by mass or less with respect to the total amount of the liquid external skin composition.

<<Chelating agent>>

The chelating agent is not particularly limited and can be appropriately selected depending on the purpose, and examples include disodium edetate, ethylenediamine tetraacetate, hexametaphosphate, and gluconic acid.

The content of the chelating agent is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.1% by mass or more and 1% by mass or less with respect to the total amount of the liquid external skin composition.

<<pH adjuster>>

The pH adjuster is not particularly limited and can be appropriately selected according to the purpose, for example, sodium hydroxide, potassium hydroxide, citric acid, sodium citrate, succinic acid, triethanolamine, aqueous ammonia, triisopropanolamine, phosphoric acid and glycolic acid. I can hear it.

<<UV absorber and UV scattering agent>>

The ultraviolet absorber and the ultraviolet ray scattering agent are not particularly limited and can be appropriately selected depending on the purpose, for example, 2-hydroxy-4-methoxybenzophenone, octyldimethylparaminobenzoate, and ethylhexylparam. Examples include toxycynamate, titanium oxide, kaolin, and talc.

The content of the ultraviolet absorber and the ultraviolet ray scattering agent is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.01% by mass or more and 10% by mass or less with respect to the total amount of the liquid external skin composition.

<<Vitamin>>

The above vitamins are not particularly limited and can be appropriately selected depending on the purpose, for example, vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, vitamin U, Carnitine, ferulic acid, γ-oryzanol α-lipoic acid, orotinic acid and derivatives thereof, etc. may be mentioned.

The content of the above vitamins is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.001% by mass or more and 0.5% by mass or less with respect to the total amount of the liquid external skin composition.

<<Amino acids>>

The above amino acids are not particularly limited and can be appropriately selected according to the purpose, for example, glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, and aspartic acid. , glutamic acid, arginine, histidine, lysine, and derivatives thereof.

The content of the above amino acids is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.001% by mass or more and 0.5% by mass or less with respect to the total amount of the liquid external skin composition.

<<Thickener>>

The thickener is not particularly limited and can be appropriately selected depending on the purpose, and examples include gellan gum, guar gum, carboxyvinyl polymer, and xanthan gum.

The content of the thickener is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.005% by mass or more and 1.0% by mass or less with respect to the total amount of the liquid external skin composition.

<<Purified water>>

The content of purified water in the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose; however, from the viewpoint of improving the immediate efficacy of the absorptive effect, it is preferably 60% by mass or more with respect to the total amount of the liquid external skin composition. do.

It is appropriate that the purified water content is 60% by mass or more based on the total amount of the liquid external skin composition, as this can solve the problem that the immediate efficacy of the absorptive effect is reduced.

<pH>

The pH of the liquid external skin composition at 25°C is preferably 5.0 to 7.0, and more preferably 5.5 to 6.5.

There are no particular restrictions on the pH measurement method, and examples include a method of measuring using a glass electrode color hydrogen ion concentration indicator HM-30R (electrode type GST-5721 manufactured by Toadike Co., Ltd.).

<Viscosity>

The viscosity of the liquid external skin composition at 25°C is not particularly limited and can be appropriately selected depending on the purpose, preferably 4 mPa·s or more and 40 mPa·s or less, and 8 mPa·s or more and 30 mPa·s or less. is more preferable.

There are no particular restrictions on the method for measuring the viscosity, but for example, a BM type viscometer (Tokyo Measuring Instruments Co., Ltd.) was used at a sample temperature of 25°C, a rotation speed of 60 rpm, and No. Examples include the method of measuring the viscosity after 1 minute using the rotor of 3.

<Courage>

The container filled with the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose, and examples include mist spray containers and tubes. Among these, a container for mist spray is preferable.

<Method for producing liquid external skin composition>

The method for producing the liquid external skin composition of the present invention is not particularly limited and can be appropriately selected depending on the purpose, and may include the above-mentioned component (A), the above-mentioned component (B), the above-mentioned component (C), and the above-mentioned others as necessary. It can be obtained by mixing the ingredients and purified water (mixed as the remaining amount so that the liquid external skin composition is 100% by mass).

As a specific example of the method for producing the liquid external skin composition, polyhydric alcohol, maltotetraose, nonionic surfactant, etc. are added to purified water heated to 70 to 80°C, and stirred until uniform. After that, oil-soluble components such as hydroxyphenylpropamide benzoic acid are gradually added while stirring, and stirred until uniform. Afterwards, it can be prepared by gradually lowering the temperature to 40°C or lower, gradually adding L-menthol while stirring, and stirring until uniform.

The liquid external skin composition may be prepared using a device. The above device is not particularly limited and can be appropriately selected depending on the purpose. Examples include a stirring device having a shearing force and a stirring blade capable of mixing the whole.

The stirring blade is not particularly limited and can be appropriately selected depending on the purpose, and examples include propellers, turbines, and dispers.

<Use>

The use of the liquid external skin composition is not particularly limited and can be appropriately selected depending on the purpose, but it is preferable that it is a liquid external skin composition of the type that cannot be washed off.

Specific examples of uses of the liquid external skin composition include pharmaceuticals, cosmetics, and the like.

Example

Below, the present invention will be described in more detail based on examples and comparative examples, but the present invention is not limited to these examples.

In addition, the content of each component described in the Examples, Comparative Examples, and Prescription Examples is expressed in “mass%” and is all converted to pure content.

(Examples 1 to 15 and Comparative Examples 1 to 6)

Liquid external skin compositions with compositions and contents shown in Tables 1 to 4 below were prepared by the following method.

Polyhydric alcohol, maltotetraose and other components were dissolved with stirring in purified water maintained at 70°C, cooled to 40°C or lower, and then dissolved with stirring in the coolant, thereby producing the desired Examples 1 to 15 and Liquid external skin compositions of Comparative Examples 1 to 6 were obtained. Additionally, stirring was performed using a three-one motor (HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.), and a propeller was used as the stirring blade.

The obtained liquid external skin compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were evaluated for “immediate efficacy and sustainability in sebum effect,” “no stickiness on the skin immediately after use,” and “low-temperature stability of the formulation.” , judged. The results are shown in Tables 1 to 4 below.

<Evaluation of immediate effectiveness and sustainability in avoidance effect>

The obtained liquid external skin compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were filled into a mist spray container (P28-150DX, manufactured by Guracell).

At the time of evaluation, the following [Evaluation criteria for itching intensity] 10 evaluators (5 men, 5 women) with medium to moderate itch and intense itch were administered Examples 1 to 15 and One push (0.15 g/10 cm x 15 cm) of the liquid external skin compositions of Comparative Examples 1 to 6 was applied. After application, the itching intensity was sensory evaluated 10 seconds and 24 hours later according to the following evaluation criteria. Calculate the degree of itching relief at each evaluation time for each evaluator, "(itching intensity before application) - (itching intensity after a certain period of time after application)", and obtain the average rating of 10 evaluators, Judgment was made according to the judgment criteria below. In addition, the evaluation 10 seconds after application indicates the evaluation of the “immediate effectiveness” of the liquid external skin composition of the present invention, and the evaluation 24 hours after application indicates the “sustainability” of the liquid external skin composition of the present invention. Indicates evaluation.

[Evaluation criteria for itching intensity]

4 points: Intense itching

3 points: Moderate itchiness

2 points: Mild itching

1 point: mild itching

0 points: No itching (I don't feel itchy at all)

[Judgment criteria for suppression effect]

◎: Itching relief is 3.5 points or more and 4.0 points or less.

◎∼○: Itching relief is 3.0 points or more but less than 3.5 points.

○: Itching relief is 2.5 points or more but less than 3.0 points.

○∼△: Itching relief is 2.0 points or more but less than 2.5 points.

△: Itching relief is 1.5 points or more and less than 2.0 points.

△∼×: Itching relief is 1.0 or more but less than 1.5 points.

×: Itching relief is less than 1.0 points

<Evaluation of lack of stickiness on the skin immediately after use>

The obtained liquid external skin compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were filled into a mist spray container (P28-150DX, manufactured by Guracell).

The liquid external skin compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were applied in one push (0.15 g/10 cm x 15 cm) and evaluated based on the following evaluation criteria. The average rating of 10 evaluators was obtained, and the absence of stickiness on the skin was determined based on the following criteria.

[Evaluation criteria for lack of stickiness on the skin immediately after use]

5 points: Does not feel sticky on the skin at all

4 points: Feel a slight stickiness on the skin

3 points: Skin feels sticky

2 points: The skin feels quite sticky.

1 point: Skin feels very sticky

[Criteria for judging the absence of stickiness on the skin immediately after use]

◎: 4.5 points or more and 5.0 points or less

○: 4.0 points or more but less than 4.5 points

△: 3.0 points or more but less than 4.0 points

×: Less than 3.0 points

<Evaluation of low temperature stability>

The obtained liquid external skin compositions of Examples 1 to 15 and Comparative Examples 1 to 6 were placed in a polyethylene container (50 ml) and stored at 10°C for 1 month, and then the appearance of the liquid external skin composition was visually evaluated as follows. .

[Judgment criteria for low-temperature stability]

◎: No change

○: Slightly cloudy

△: It is cloudy.

×: Precipitation of components is recognized

[Table 1]

[Table 2]

[Table 3]

[Table 4]

(Prescription examples 1 to 10)

Liquid external skin compositions with compositions and contents shown in Tables 5 to 6 below were prepared by routine methods to obtain liquid external skin compositions of Prescription Examples 1 to 10.

[Table 5]

[Table 6]

Details of each component used in Examples 1 to 15, Comparative Examples 1 to 6, and Prescription Examples 1 to 10 are shown in Table 7 below.

[Table 7]

[Industrial applicability]

The liquid external composition for skin of the present invention is excellent in the non-stickiness of the skin immediately after application, the low-temperature stability of the preparation, and the immediate and long-lasting effect of the absorptive effect, and is therefore quite effective in alleviating and treating skin diseases, and can be used as medicine, cosmetics, etc. It can be used appropriately and continuously on a daily basis.

This international application claims priority based on Japanese Patent Application No. 2021-159207 filed on September 29, 2021, and the entire contents of Japanese Patent Application No. 2021-159207 are used in this international application.

Claims (7)

(A) a cooling agent,
(B) maltotetraose,
(C) contains a polyhydric alcohol with a molecular weight of 350 or less,
Characterized in that the mass ratio [(C)/{(A)+(B)}] of the content of the component (C) to the sum of the contents of the component (A) and the component (B) is 5 or more and 30 or less. A liquid skin external composition. According to paragraph 1,
The content of the component (A) is 0.2% by mass or more and 0.4% by mass or less with respect to the total amount of the liquid external skin composition,
The content of the component (B) is 0.5% by mass or more and 1.5% by mass or less with respect to the total amount of the liquid external skin composition,
A liquid external skin composition, characterized in that the content of the component (C) is 15% by mass or more and 25% by mass or less with respect to the total amount of the liquid external skin composition. According to any one of claims 1 and 2,
A liquid external skin composition, characterized in that the content of ethyl alcohol in the liquid external skin composition is less than 1.0% by mass based on the total amount of the liquid external skin composition. According to any one of claims 1 to 3,
The content of surfactant in the liquid external skin composition is less than 1.0% by mass based on the total amount of the liquid external skin composition,
A liquid external skin composition, wherein the surfactant is at least one selected from anionic surfactants, cationic surfactants, and amphoteric surfactants. According to any one of claims 1 to 4,
A liquid external skin composition, characterized in that the content of purified water in the liquid external skin composition is 60% by mass or more based on the total amount of the liquid external skin composition. According to any one of claims 1 to 5,
A liquid external composition for skin, characterized in that it is of a type that cannot be washed off. According to any one of claims 1 to 6,
A liquid composition for external use on the skin, characterized in that it is filled in a container for mist spray.