KR20240040724A - IFN-γ 신호 전달 경로 조절을 위한 올리고 뉴클레오티드 - Google Patents
IFN-γ 신호 전달 경로 조절을 위한 올리고 뉴클레오티드 Download PDFInfo
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- KR20240040724A KR20240040724A KR1020247000555A KR20247000555A KR20240040724A KR 20240040724 A KR20240040724 A KR 20240040724A KR 1020247000555 A KR1020247000555 A KR 1020247000555A KR 20247000555 A KR20247000555 A KR 20247000555A KR 20240040724 A KR20240040724 A KR 20240040724A
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- nucleotides
- antisense strand
- dsrna
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- sense strand
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163213506P | 2021-06-22 | 2021-06-22 | |
| US63/213,506 | 2021-06-22 | ||
| US202263331563P | 2022-04-15 | 2022-04-15 | |
| US63/331,563 | 2022-04-15 | ||
| PCT/US2022/034297 WO2022271666A1 (en) | 2021-06-22 | 2022-06-21 | OLIGONUCLEOTIDES FOR IFN-γ SIGNALING PATHWAY MODULATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240040724A true KR20240040724A (ko) | 2024-03-28 |
Family
ID=84544753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247000555A Pending KR20240040724A (ko) | 2021-06-22 | 2022-06-21 | IFN-γ 신호 전달 경로 조절을 위한 올리고 뉴클레오티드 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240287514A1 (https=) |
| EP (1) | EP4359537A4 (https=) |
| JP (1) | JP2024523466A (https=) |
| KR (1) | KR20240040724A (https=) |
| AU (1) | AU2022298641A1 (https=) |
| CA (1) | CA3223577A1 (https=) |
| WO (1) | WO2022271666A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| EP4676443A1 (en) * | 2023-03-03 | 2026-01-14 | University of Massachusetts | Dendritic conjugates for the skin delivery of therapeutic oligonucleotides |
| TW202516004A (zh) * | 2023-06-16 | 2025-04-16 | 瑞士商赫孚孟拉羅股份公司 | 調節ｊａｋ１表現之雙股寡核苷酸 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006094293A2 (en) * | 2005-03-03 | 2006-09-08 | President And Fellows Of Harvard College | Slim compositions and methods of use thereof |
| EP2227558A1 (en) * | 2007-11-30 | 2010-09-15 | GlaxoSmithKline Biologicals SA | Method for classifying cancer patients as responder or non-responder to immunotherapy |
| JP5813778B2 (ja) * | 2010-11-19 | 2015-11-17 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物 |
| CN113811311A (zh) * | 2019-03-15 | 2021-12-17 | 马萨诸塞大学 | 用于组织特异性apoe调节的寡核苷酸 |
-
2022
- 2022-06-21 WO PCT/US2022/034297 patent/WO2022271666A1/en not_active Ceased
- 2022-06-21 CA CA3223577A patent/CA3223577A1/en active Pending
- 2022-06-21 AU AU2022298641A patent/AU2022298641A1/en active Pending
- 2022-06-21 KR KR1020247000555A patent/KR20240040724A/ko active Pending
- 2022-06-21 JP JP2023578896A patent/JP2024523466A/ja active Pending
- 2022-06-21 EP EP22829131.6A patent/EP4359537A4/en active Pending
-
2023
- 2023-12-21 US US18/393,044 patent/US20240287514A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3223577A1 (en) | 2022-12-29 |
| AU2022298641A1 (en) | 2024-02-01 |
| EP4359537A1 (en) | 2024-05-01 |
| EP4359537A4 (en) | 2026-05-06 |
| JP2024523466A (ja) | 2024-06-28 |
| US20240287514A1 (en) | 2024-08-29 |
| WO2022271666A1 (en) | 2022-12-29 |
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| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
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| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |