KR20240039006A - 신규 항-sirpa 항체 - Google Patents

신규 항-sirpa 항체 Download PDF

Info

Publication number
KR20240039006A
KR20240039006A KR1020247006211A KR20247006211A KR20240039006A KR 20240039006 A KR20240039006 A KR 20240039006A KR 1020247006211 A KR1020247006211 A KR 1020247006211A KR 20247006211 A KR20247006211 A KR 20247006211A KR 20240039006 A KR20240039006 A KR 20240039006A
Authority
KR
South Korea
Prior art keywords
seq
sequence
antibody
cancer
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247006211A
Other languages
English (en)
Korean (ko)
Inventor
홍타오 루
시아오팽 니우
팽리 왕
춘니안 왕
진팽 자오
루메이 싱
하이잉 왕
징팽 유
레이 리
지하오 우
루이 가오
양성 취우
Original Assignee
엘피사이언스 (쑤저우) 바이오파마, 엘티디.
엘피사이언스 바이오파마, 엘티디.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엘피사이언스 (쑤저우) 바이오파마, 엘티디., 엘피사이언스 바이오파마, 엘티디. filed Critical 엘피사이언스 (쑤저우) 바이오파마, 엘티디.
Publication of KR20240039006A publication Critical patent/KR20240039006A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cell Biology (AREA)
KR1020247006211A 2021-07-28 2022-07-28 신규 항-sirpa 항체 Pending KR20240039006A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/109041 2021-07-28
CN2021109041 2021-07-28
CNPCT/CN2022/104562 2022-07-08
CN2022104562 2022-07-08
PCT/US2022/074286 WO2023010100A1 (en) 2021-07-28 2022-07-28 Novel anti-sirpa antibodies

Publications (1)

Publication Number Publication Date
KR20240039006A true KR20240039006A (ko) 2024-03-26

Family

ID=85087323

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247006211A Pending KR20240039006A (ko) 2021-07-28 2022-07-28 신규 항-sirpa 항체

Country Status (9)

Country Link
US (1) US20250270315A1 (https=)
EP (1) EP4377358A4 (https=)
JP (1) JP2024531900A (https=)
KR (1) KR20240039006A (https=)
CN (1) CN118076638A (https=)
AU (1) AU2022317822A1 (https=)
CA (1) CA3227854A1 (https=)
TW (1) TW202313699A (https=)
WO (1) WO2023010100A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025239669A1 (en) * 2024-05-14 2025-11-20 Genome&Company, Inc. Anti-bcam antibody and conjugate thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120569409A (zh) * 2023-01-18 2025-08-29 科望(苏州)生物医药科技有限公司 靶向sirpa和claudin 18.2的双特异性分子
EP4702053A1 (en) * 2023-04-27 2026-03-04 LaNova Medicines Limited Combination treatment targeting sirpa and claudin 18.2
WO2025140296A1 (zh) * 2023-12-26 2025-07-03 上海宏成药业有限公司 抗dll3抗体或其抗原结合片段及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3334757A4 (en) * 2015-08-14 2019-04-03 Merck Sharp & Dohme Corp. ANTI-Tigit ANTIBODY
KR20250079073A (ko) * 2018-07-10 2025-06-04 고쿠리츠다이가쿠호진 고베다이가쿠 항 SIRPα 항체
WO2021032078A1 (en) * 2019-08-20 2021-02-25 Elpiscience (Suzhou) Biopharma, Ltd. Novel anti-sirpa antibodies
JP7437815B2 (ja) * 2019-12-24 2024-02-26 ラノバ メディシンズ リミテッド 抗ＳＩＲＰαモノクローナル抗体およびその使用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025239669A1 (en) * 2024-05-14 2025-11-20 Genome&Company, Inc. Anti-bcam antibody and conjugate thereof

Also Published As

Publication number Publication date
CA3227854A1 (en) 2023-02-02
AU2022317822A1 (en) 2024-02-22
EP4377358A1 (en) 2024-06-05
US20250270315A1 (en) 2025-08-28
WO2023010100A1 (en) 2023-02-02
TW202313699A (zh) 2023-04-01
JP2024531900A (ja) 2024-09-03
CN118076638A (zh) 2024-05-24
EP4377358A4 (en) 2025-12-17

Similar Documents

Publication Publication Date Title
CN112867507B (zh) 新型抗sirpa抗体
JP7840511B2 (ja) 抗クローディン１８抗体及びそれらの使用の方法
ES2801873T3 (es) Anticuerpo de PDL-1, composición farmacéutica del mismo y sus usos
JP2022545585A (ja) 新規の抗ｃｄ３９抗体
KR20240128709A (ko) 신규한 항-tslp 항체
US20250270315A1 (en) Novel anti-sirpa antibodies
JP2024508672A (ja) 新規抗ｃｄ２４抗体
EP4640708A1 (en) Novel anti-gprc5d antibody
US20250368734A1 (en) Novel anti-gprc5d antibodies, bispecific antigen binding molecules that bind gprc5d and cd3, and uses thereof
TW202348630A (zh) 新穎抗ｃｄ３抗體及其用途
TW202304997A (zh) 新型抗ｃｄ４抗體
WO2022063272A1 (en) Novel anti-claudin18 antibodies
KR20240039005A (ko) 신규 다중-특이적 분자
CN116120461B (zh) 新型抗药抗体以及其用途
HK40106257A (zh) 新型抗sirpa抗体
KR20240113488A (ko) 신규 항-il-36r 항체
TW202542184A (zh) 與ｃｄ３及ｌｉｌｒｂ４結合之新穎抗體及其用途
HK40045149A (en) Novel anti-sirpa antibodies
EA052500B1 (ru) Новые антитела против cd24

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240223

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application