KR20240027693A - α1-항트립신 결핍의 치료를 위한 조성물 및 그의 용도 - Google Patents

α1-항트립신 결핍의 치료를 위한 조성물 및 그의 용도 Download PDF

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Publication number
KR20240027693A
KR20240027693A KR1020247001332A KR20247001332A KR20240027693A KR 20240027693 A KR20240027693 A KR 20240027693A KR 1020247001332 A KR1020247001332 A KR 1020247001332A KR 20247001332 A KR20247001332 A KR 20247001332A KR 20240027693 A KR20240027693 A KR 20240027693A
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KR
South Korea
Prior art keywords
a1at
piperidine
sulfonyl
trifluoromethyl
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247001332A
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English (en)
Korean (ko)
Inventor
니겔 램스덴
데이비드 존 폭스
제임스 앤드류 헌팅턴
Original Assignee
센테사 파마슈티칼스 (유케이) 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 센테사 파마슈티칼스 (유케이) 리미티드 filed Critical 센테사 파마슈티칼스 (유케이) 리미티드
Publication of KR20240027693A publication Critical patent/KR20240027693A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020247001332A 2021-06-15 2022-06-15 α1-항트립신 결핍의 치료를 위한 조성물 및 그의 용도 Pending KR20240027693A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2108523.8A GB202108523D0 (en) 2021-06-15 2021-06-15 Compositions and their use for the treatment of alpha1-antitrypsin deficiency
GB2108523.8 2021-06-15
PCT/GB2022/051502 WO2022263816A1 (en) 2021-06-15 2022-06-15 COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

Publications (1)

Publication Number Publication Date
KR20240027693A true KR20240027693A (ko) 2024-03-04

Family

ID=76954605

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247001332A Pending KR20240027693A (ko) 2021-06-15 2022-06-15 α1-항트립신 결핍의 치료를 위한 조성물 및 그의 용도

Country Status (12)

Country Link
US (1) US20240197707A1 (https=)
EP (1) EP4355328A1 (https=)
JP (1) JP7854001B2 (https=)
KR (1) KR20240027693A (https=)
CN (1) CN117794538A (https=)
AU (1) AU2022295130A1 (https=)
BR (1) BR112023026510A2 (https=)
CA (1) CA3223130A1 (https=)
GB (1) GB202108523D0 (https=)
IL (1) IL309355A (https=)
MX (1) MX2023015398A (https=)
WO (1) WO2022263816A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201918410D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2071621C (en) 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
WO2008143633A2 (en) 2007-01-10 2008-11-27 University Of Florida Compounds and methods for treatment of alpha-1 antitrypsin deficiency
US8258158B2 (en) 2009-09-11 2012-09-04 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
WO2012097371A2 (en) 2011-01-14 2012-07-19 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
MX2020013853A (es) 2018-06-22 2021-05-27 Ucl Business Ltd Compuestos innovadores.
CA3114672A1 (en) 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
GB201918410D0 (en) * 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency

Also Published As

Publication number Publication date
JP7854001B2 (ja) 2026-04-30
MX2023015398A (es) 2024-04-29
CN117794538A (zh) 2024-03-29
JP2024523406A (ja) 2024-06-28
EP4355328A1 (en) 2024-04-24
WO2022263816A1 (en) 2022-12-22
IL309355A (en) 2024-02-01
GB202108523D0 (en) 2021-07-28
US20240197707A1 (en) 2024-06-20
CA3223130A1 (en) 2022-12-22
BR112023026510A2 (pt) 2024-03-05
AU2022295130A1 (en) 2024-01-18

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240112

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250610

Comment text: Request for Examination of Application