KR20240019091A - 신규한 에르골린 및 기분장애의 치료방법 - Google Patents

신규한 에르골린 및 기분장애의 치료방법 Download PDF

Info

Publication number
KR20240019091A
KR20240019091A KR1020237040483A KR20237040483A KR20240019091A KR 20240019091 A KR20240019091 A KR 20240019091A KR 1020237040483 A KR1020237040483 A KR 1020237040483A KR 20237040483 A KR20237040483 A KR 20237040483A KR 20240019091 A KR20240019091 A KR 20240019091A
Authority
KR
South Korea
Prior art keywords
disorder
alkyl
group
compound
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237040483A
Other languages
English (en)
Korean (ko)
Inventor
앤드류 캐리 크뤼겔
Original Assignee
길가메쉬 파마슈티컬스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 길가메쉬 파마슈티컬스, 인코포레이티드 filed Critical 길가메쉬 파마슈티컬스, 인코포레이티드
Publication of KR20240019091A publication Critical patent/KR20240019091A/ko
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06Lysergic acid amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/48Ergoline derivatives, e.g. lysergic acid, ergotamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06Lysergic acid amides
    • C07D457/08Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020237040483A 2021-04-23 2022-04-25 신규한 에르골린 및 기분장애의 치료방법 Pending KR20240019091A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163179053P 2021-04-23 2021-04-23
US63/179,053 2021-04-23
US202263308376P 2022-02-09 2022-02-09
US63/308,376 2022-02-09
PCT/US2022/026186 WO2022226408A1 (en) 2021-04-23 2022-04-25 Novel ergolines and methods of treating mood disorders

Publications (1)

Publication Number Publication Date
KR20240019091A true KR20240019091A (ko) 2024-02-14

Family

ID=81648213

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237040483A Pending KR20240019091A (ko) 2021-04-23 2022-04-25 신규한 에르골린 및 기분장애의 치료방법

Country Status (10)

Country Link
US (1) US20240368151A1 (https=)
EP (1) EP4326718A1 (https=)
JP (1) JP2024516174A (https=)
KR (1) KR20240019091A (https=)
AU (1) AU2022262659A1 (https=)
BR (1) BR112023021970A2 (https=)
CA (1) CA3223210A1 (https=)
IL (1) IL307880A (https=)
MX (1) MX2023012447A (https=)
WO (1) WO2022226408A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230116703A1 (en) * 2021-04-23 2023-04-13 Gilgamesh Pharmaceuticals, Inc. Novel ergolines and methods of treating mood disorders
CN117355302A (zh) 2021-04-30 2024-01-05 思维医学股份有限公司 Lsd盐晶体形式
JP2024529727A (ja) 2021-08-19 2024-08-08 マインド メディシン, インコーポレイテッド 治療適用のためのd-リゼルグ酸ジエチルアミドの凍結乾燥された口腔内崩壊錠製剤
JP2025525375A (ja) * 2022-06-20 2025-08-05 マインド メディシン, インコーポレイテッド 修飾lsd様作用を有するリゼルグ酸誘導体
EP4630418B1 (en) * 2022-12-31 2026-03-18 Ceruvia Lifesciences LLC Salts of 2-bromolysergic acid diethylamide
EP4704846A2 (en) * 2023-05-04 2026-03-11 Gilgamesh Pharmaceuticals, Inc. Novel ergolines and methods of treating mood disorders
WO2025194238A1 (en) * 2024-03-22 2025-09-25 Blife Therapeutics Inc. 2-bromo-lsd salts and polymorphs
WO2025235800A1 (en) 2024-05-08 2025-11-13 Cy Biopharma Ag Ergoline derivatives and uses thereof
WO2025235784A2 (en) * 2024-05-08 2025-11-13 Cy Biopharma Ag Ergoline derivatives and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2438259A (en) * 1948-03-23 D-lysergic acid diethyl amide
CN1087725C (zh) * 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
EP4219498A1 (en) * 2019-03-07 2023-08-02 Arbormentis LLC Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations
US20230295106A1 (en) * 2019-10-14 2023-09-21 The Regents Of The University Of California Ergoline-like compounds for promoting neural plasticity
EP4178956A2 (en) * 2020-07-07 2023-05-17 COMPASS Pathfinder Limited Improved method for the production of lysergic acid diethylamide (lsd) and novel derivatives thereof

Also Published As

Publication number Publication date
IL307880A (en) 2023-12-01
AU2022262659A1 (en) 2023-10-19
US20240368151A1 (en) 2024-11-07
EP4326718A1 (en) 2024-02-28
WO2022226408A1 (en) 2022-10-27
CA3223210A1 (en) 2022-12-27
JP2024516174A (ja) 2024-04-12
BR112023021970A2 (pt) 2023-12-26
MX2023012447A (es) 2023-10-31

Similar Documents

Publication Publication Date Title
KR20240019091A (ko) 신규한 에르골린 및 기분장애의 치료방법
US20230116703A1 (en) Novel ergolines and methods of treating mood disorders
TWI659951B (zh) 吡咯啶gpr40調節劑
CN109496213B (zh) 螺环化合物及其制备和使用方法
JP2016537369A (ja) カゼインキナーゼ1d/e阻害剤としての置換された4,5,6,7−テトラヒドロピラゾロ[1,5−a]ピラジン誘導体
CN111032034A (zh) 螺环化合物及其制造和使用方法
JP7237010B2 (ja) Hdac6選択的阻害剤およびその製造方法と使用
US20240166618A1 (en) Phenalkylamines and methods of making and using the same
JP6786566B2 (ja) ヘテロアリール化合物及びその使用方法
JP3268098B2 (ja) 二環性環状アミン誘導体
EP4704846A2 (en) Novel ergolines and methods of treating mood disorders
KR102325454B1 (ko) 방사성표지화를 위한 방법 및 시약
ES2782088T3 (es) Compuestos novedosos
AU2025205323A1 (en) Fused heterocycles as 5-ht2a receptor agonists
Shaikh et al. Synthesis and evaluation of antimicrobial activities of new piperidine derivatives
CN117677618A (zh) 新颖的麦角灵类和治疗心境障碍的方法
CN120787225A (zh) 新型麦角林类和治疗心境障碍的方法
WO2024059090A1 (en) Phenalkylamines and methods of making and using the same
KR20260053282A (ko) 정신 질환의 치료를 위한 피롤로피리딘 화합물
WO2026076497A1 (en) Structurally simplified analogues of lsd for the treatment of cns disorders
CN121712775A (zh) 5-ht2a受体调节剂及其使用方法
HK40004417A (en) Spirocycle compounds and methods of making and using same
HK1232519A1 (en) Novel compounds
HK1232519B (en) Novel compounds

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20231123

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250411

Comment text: Request for Examination of Application