IL307880A - New ergolines and methods for treating mood disorders - Google Patents
New ergolines and methods for treating mood disordersInfo
- Publication number
- IL307880A IL307880A IL307880A IL30788023A IL307880A IL 307880 A IL307880 A IL 307880A IL 307880 A IL307880 A IL 307880A IL 30788023 A IL30788023 A IL 30788023A IL 307880 A IL307880 A IL 307880A
- Authority
- IL
- Israel
- Prior art keywords
- ergolines
- novel
- methods
- mood disorders
- treating mood
- Prior art date
Links
- 208000019022 Mood disease Diseases 0.000 title 1
- RHGUXDUPXYFCTE-ZWNOBZJWSA-N ergoline Chemical class C1=CC([C@@H]2[C@H](NCCC2)C2)=C3C2=CNC3=C1 RHGUXDUPXYFCTE-ZWNOBZJWSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163179053P | 2021-04-23 | 2021-04-23 | |
| US202263308376P | 2022-02-09 | 2022-02-09 | |
| PCT/US2022/026186 WO2022226408A1 (en) | 2021-04-23 | 2022-04-25 | Novel ergolines and methods of treating mood disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL307880A true IL307880A (en) | 2023-12-01 |
Family
ID=81648213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL307880A IL307880A (en) | 2021-04-23 | 2022-04-25 | New ergolines and methods for treating mood disorders |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240368151A1 (https=) |
| EP (1) | EP4326718A1 (https=) |
| JP (1) | JP2024516174A (https=) |
| KR (1) | KR20240019091A (https=) |
| AU (1) | AU2022262659A1 (https=) |
| BR (1) | BR112023021970A2 (https=) |
| CA (1) | CA3223210A1 (https=) |
| IL (1) | IL307880A (https=) |
| MX (1) | MX2023012447A (https=) |
| WO (1) | WO2022226408A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230116703A1 (en) * | 2021-04-23 | 2023-04-13 | Gilgamesh Pharmaceuticals, Inc. | Novel ergolines and methods of treating mood disorders |
| CN117355302A (zh) | 2021-04-30 | 2024-01-05 | 思维医学股份有限公司 | Lsd盐晶体形式 |
| JP2024529727A (ja) | 2021-08-19 | 2024-08-08 | マインド メディシン， インコーポレイテッド | 治療適用のためのｄ－リゼルグ酸ジエチルアミドの凍結乾燥された口腔内崩壊錠製剤 |
| JP2025525375A (ja) * | 2022-06-20 | 2025-08-05 | マインド メディシン， インコーポレイテッド | 修飾ｌｓｄ様作用を有するリゼルグ酸誘導体 |
| EP4630418B1 (en) * | 2022-12-31 | 2026-03-18 | Ceruvia Lifesciences LLC | Salts of 2-bromolysergic acid diethylamide |
| EP4704846A2 (en) * | 2023-05-04 | 2026-03-11 | Gilgamesh Pharmaceuticals, Inc. | Novel ergolines and methods of treating mood disorders |
| WO2025194238A1 (en) * | 2024-03-22 | 2025-09-25 | Blife Therapeutics Inc. | 2-bromo-lsd salts and polymorphs |
| WO2025235800A1 (en) | 2024-05-08 | 2025-11-13 | Cy Biopharma Ag | Ergoline derivatives and uses thereof |
| WO2025235784A2 (en) * | 2024-05-08 | 2025-11-13 | Cy Biopharma Ag | Ergoline derivatives and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2438259A (en) * | 1948-03-23 | D-lysergic acid diethyl amide | ||
| CN1087725C (zh) * | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| EP4219498A1 (en) * | 2019-03-07 | 2023-08-02 | Arbormentis LLC | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations |
| US20230295106A1 (en) * | 2019-10-14 | 2023-09-21 | The Regents Of The University Of California | Ergoline-like compounds for promoting neural plasticity |
| EP4178956A2 (en) * | 2020-07-07 | 2023-05-17 | COMPASS Pathfinder Limited | Improved method for the production of lysergic acid diethylamide (lsd) and novel derivatives thereof |
-
2022
- 2022-04-25 KR KR1020237040483A patent/KR20240019091A/ko active Pending
- 2022-04-25 EP EP22723308.7A patent/EP4326718A1/en active Pending
- 2022-04-25 IL IL307880A patent/IL307880A/en unknown
- 2022-04-25 BR BR112023021970A patent/BR112023021970A2/pt unknown
- 2022-04-25 JP JP2023564585A patent/JP2024516174A/ja active Pending
- 2022-04-25 WO PCT/US2022/026186 patent/WO2022226408A1/en not_active Ceased
- 2022-04-25 US US18/287,980 patent/US20240368151A1/en active Pending
- 2022-04-25 AU AU2022262659A patent/AU2022262659A1/en active Pending
- 2022-04-25 MX MX2023012447A patent/MX2023012447A/es unknown
- 2022-04-25 CA CA3223210A patent/CA3223210A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022262659A1 (en) | 2023-10-19 |
| US20240368151A1 (en) | 2024-11-07 |
| EP4326718A1 (en) | 2024-02-28 |
| WO2022226408A1 (en) | 2022-10-27 |
| CA3223210A1 (en) | 2022-12-27 |
| JP2024516174A (ja) | 2024-04-12 |
| KR20240019091A (ko) | 2024-02-14 |
| BR112023021970A2 (pt) | 2023-12-26 |
| MX2023012447A (es) | 2023-10-31 |
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