KR20240015736A - 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물 - Google Patents

5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물 Download PDF

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Publication number
KR20240015736A
KR20240015736A KR1020247002754A KR20247002754A KR20240015736A KR 20240015736 A KR20240015736 A KR 20240015736A KR 1020247002754 A KR1020247002754 A KR 1020247002754A KR 20247002754 A KR20247002754 A KR 20247002754A KR 20240015736 A KR20240015736 A KR 20240015736A
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South Korea
Prior art keywords
desmopressin
administered
hours
administration
reductase inhibitor
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020247002754A
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English (en)
Korean (ko)
Inventor
시모어 에이치. 페인
린다 쳉
마리아 쳉
사무엘 헤르슈코비츠
Original Assignee
세레니티 파마슈티컬즈 엘엘씨
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Publication of KR20240015736A publication Critical patent/KR20240015736A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020247002754A 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물 Ceased KR20240015736A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361857428P 2013-07-23 2013-07-23
US61/857,428 2013-07-23
KR1020217025794A KR20210103590A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물
PCT/US2014/047897 WO2015013453A1 (en) 2013-07-23 2014-07-23 Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217025794A Division KR20210103590A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물

Publications (1)

Publication Number Publication Date
KR20240015736A true KR20240015736A (ko) 2024-02-05

Family

ID=51299054

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020247002754A Ceased KR20240015736A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물
KR1020167004345A Ceased KR20160034366A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물
KR1020217025794A Ceased KR20210103590A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020167004345A Ceased KR20160034366A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물
KR1020217025794A Ceased KR20210103590A (ko) 2013-07-23 2014-07-23 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물

Country Status (9)

Country Link
US (1) US9925232B2 (cg-RX-API-DMAC7.html)
EP (1) EP3024473A1 (cg-RX-API-DMAC7.html)
JP (3) JP2016525147A (cg-RX-API-DMAC7.html)
KR (3) KR20240015736A (cg-RX-API-DMAC7.html)
CN (1) CN105579056A (cg-RX-API-DMAC7.html)
AU (1) AU2014293140A1 (cg-RX-API-DMAC7.html)
CA (1) CA2919194A1 (cg-RX-API-DMAC7.html)
MX (1) MX2016001032A (cg-RX-API-DMAC7.html)
WO (1) WO2015013453A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105579057A (zh) 2013-07-23 2016-05-11 阿勒根公司 包含与β-3-肾上腺素能受体激动剂组合的去氨加压素的方法和组合物
CA2967390A1 (en) * 2014-11-20 2016-05-26 Allergan, Inc. Methods and compositions comprising desmopressin in combination with an alpha-adrenergic receptor antagonist
CN119421705A (zh) * 2022-06-24 2025-02-11 普渡制药公司 治疗或预防膀胱过度活动综合征的方法

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CH495957A (de) 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
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US4505616A (en) 1983-05-26 1985-03-19 Litton Systems, Inc. Self-locking chock system for a jack-up rig unit
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
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WO2005046707A1 (en) 2003-11-10 2005-05-26 Fein Seymour H Pharmaceutical compositions including low dosages of desmopressin
JP2007513199A (ja) 2003-12-08 2007-05-24 ベントレー ファーマスーティカルス，インコーポレイテッド インスリン治療のための薬学的組成物及び方法
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Also Published As

Publication number Publication date
KR20160034366A (ko) 2016-03-29
CN105579056A (zh) 2016-05-11
US9925232B2 (en) 2018-03-27
WO2015013453A1 (en) 2015-01-29
EP3024473A1 (en) 2016-06-01
CA2919194A1 (en) 2015-01-29
AU2014293140A1 (en) 2016-03-03
MX2016001032A (es) 2017-10-31
KR20210103590A (ko) 2021-08-23
JP2020114858A (ja) 2020-07-30
JP2022137252A (ja) 2022-09-21
JP2016525147A (ja) 2016-08-22
US20150031614A1 (en) 2015-01-29

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