KR20240014109A - 탄산 무수화효소 2 발현을 침묵화하기 위한 조성물 및 방법 - Google Patents

탄산 무수화효소 2 발현을 침묵화하기 위한 조성물 및 방법 Download PDF

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KR20240014109A
KR20240014109A KR1020237045007A KR20237045007A KR20240014109A KR 20240014109 A KR20240014109 A KR 20240014109A KR 1020237045007 A KR1020237045007 A KR 1020237045007A KR 20237045007 A KR20237045007 A KR 20237045007A KR 20240014109 A KR20240014109 A KR 20240014109A
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nucleotides
nucleotide
dsrna
strand
antisense strand
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KR1020237045007A
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Korean (ko)
Inventor
제프리 주버
제임스 디. 맥키닌치
마크 케이. 슐레겔
애덤 카스토레노
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알닐람 파마슈티칼스 인코포레이티드
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Publication of KR20240014109A publication Critical patent/KR20240014109A/ko
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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KR1020237045007A 2021-05-27 2022-05-27 탄산 무수화효소 2 발현을 침묵화하기 위한 조성물 및 방법 Pending KR20240014109A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163194073P 2021-05-27 2021-05-27
US63/194,073 2021-05-27
US202163289319P 2021-12-14 2021-12-14
US63/289,319 2021-12-14
PCT/US2022/031337 WO2022251629A2 (en) 2021-05-27 2022-05-27 Compositions and methods for silencing carbonic anhydrase 2 expression

Publications (1)

Publication Number Publication Date
KR20240014109A true KR20240014109A (ko) 2024-01-31

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ID=84230316

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237045007A Pending KR20240014109A (ko) 2021-05-27 2022-05-27 탄산 무수화효소 2 발현을 침묵화하기 위한 조성물 및 방법

Country Status (10)

Country Link
US (2) US20240254493A1 (https=)
EP (1) EP4347836A4 (https=)
JP (1) JP2024522106A (https=)
KR (1) KR20240014109A (https=)
AU (1) AU2022280088A1 (https=)
BR (1) BR112023024269A2 (https=)
CA (1) CA3220604A1 (https=)
IL (1) IL308574A (https=)
MX (1) MX2023014008A (https=)
WO (1) WO2022251629A2 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
HUE033977T2 (en) * 2004-08-23 2018-02-28 Sylentis Sau Treatment of eye disorders with siRNAs characterized by increased intraocular pressure
TW200639252A (en) * 2005-02-01 2006-11-16 Alcon Inc RNAi-mediated inhibition of ocular hypertension targets
RU2487716C2 (ru) * 2007-10-03 2013-07-20 Кварк Фармасьютикалс, Инк. Новые структуры малых интерферирующих рнк (sirna)
ES2351005B1 (es) * 2009-07-10 2011-11-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de anhidrasa carbónica ii para la elaboración de un medicamento.
WO2017019660A1 (en) * 2015-07-27 2017-02-02 Alnylam Pharmaceuticals, Inc. Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
MX2020011570A (es) * 2018-05-07 2020-11-24 Alnylam Pharmaceuticals Inc Administracion extrahepatica.
WO2022026531A1 (en) * 2020-07-29 2022-02-03 Alnylam Pharmaceuticals, Inc. Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases

Also Published As

Publication number Publication date
EP4347836A4 (en) 2025-11-26
EP4347836A2 (en) 2024-04-10
CA3220604A1 (en) 2022-12-01
US20240254493A1 (en) 2024-08-01
WO2022251629A2 (en) 2022-12-01
BR112023024269A2 (pt) 2024-01-30
WO2022251629A3 (en) 2023-01-12
JP2024522106A (ja) 2024-06-11
MX2023014008A (es) 2023-12-11
US20250084418A1 (en) 2025-03-13
IL308574A (en) 2024-01-01
AU2022280088A1 (en) 2023-11-23

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