BR112023024269A2 - Composições e métodos para silenciar a expressão da anidrase carbônica 2 - Google Patents

Composições e métodos para silenciar a expressão da anidrase carbônica 2

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Publication number
BR112023024269A2
BR112023024269A2 BR112023024269A BR112023024269A BR112023024269A2 BR 112023024269 A2 BR112023024269 A2 BR 112023024269A2 BR 112023024269 A BR112023024269 A BR 112023024269A BR 112023024269 A BR112023024269 A BR 112023024269A BR 112023024269 A2 BR112023024269 A2 BR 112023024269A2
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Brazil
Prior art keywords
compositions
carbonic anhydrase
expression
methods
silence
Prior art date
Application number
BR112023024269A
Other languages
English (en)
Inventor
Adam Castoreno
D Mcininch James
Jeffrey Zuber
K Schlegel Mark
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of BR112023024269A2 publication Critical patent/BR112023024269A2/pt

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

composições e métodos para silenciar a expressão da anidrase carbônica 2. a divulgação refere-se a composições de ácido ribonucleico de fita dupla (dsrna) direcionadas à anidrase carbônica 2 (ca2) e métodos de uso de tais composições de dsrna para alterar (por exemplo, inibir) expressão da anidrase carbônica 2.
BR112023024269A 2021-05-27 2022-05-27 Composições e métodos para silenciar a expressão da anidrase carbônica 2 BR112023024269A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163194073P 2021-05-27 2021-05-27
US202163289319P 2021-12-14 2021-12-14
PCT/US2022/031337 WO2022251629A2 (en) 2021-05-27 2022-05-27 Compositions and methods for silencing carbonic anhydrase 2 expression

Publications (1)

Publication Number Publication Date
BR112023024269A2 true BR112023024269A2 (pt) 2024-01-30

Family

ID=84230316

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023024269A BR112023024269A2 (pt) 2021-05-27 2022-05-27 Composições e métodos para silenciar a expressão da anidrase carbônica 2

Country Status (7)

Country Link
EP (1) EP4347836A2 (pt)
KR (1) KR20240014109A (pt)
AU (1) AU2022280088A1 (pt)
BR (1) BR112023024269A2 (pt)
CA (1) CA3220604A1 (pt)
IL (1) IL308574A (pt)
WO (1) WO2022251629A2 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200639252A (en) * 2005-02-01 2006-11-16 Alcon Inc RNAi-mediated inhibition of ocular hypertension targets
ES2351005B1 (es) * 2009-07-10 2011-11-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de anhidrasa carbónica ii para la elaboración de un medicamento.
CA3098623A1 (en) * 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery

Also Published As

Publication number Publication date
WO2022251629A2 (en) 2022-12-01
CA3220604A1 (en) 2022-12-01
WO2022251629A3 (en) 2023-01-12
IL308574A (en) 2024-01-01
EP4347836A2 (en) 2024-04-10
KR20240014109A (ko) 2024-01-31
AU2022280088A1 (en) 2023-11-23

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