KR20240013962A - Multi-array diagnostic chip - Google Patents

Abstract

The present invention relates to a multi-array diagnostic chip that can simultaneously determine various diseases with a single diagnostic sample as the flow channel through which the diagnostic sample moves is composed of a multi-array.
For this purpose, the present invention includes a diagnostic chip in which a flow channel through which a diagnostic sample moves is formed, an optical information detection unit that detects optical information of the diagnostic sample, and a control unit that controls the operation of the optical information detection unit, wherein the diagnostic chip An upper plate, a lower plate coupled to the lower part of the upper plate, a flow channel formed on the upper surface of the lower plate through which the diagnostic sample moves, and a flow channel formed on the flow channel and reacting with the diagnostic sample. It includes a sample reaction unit formed of a material, wherein the flow channel includes a sample injection line into which a diagnostic sample is introduced and movement of the diagnostic sample begins, and a plurality of sample movement lines connected to and branching from an end of the sample injection line. Provides a multi-array diagnostic chip characterized by:

Description

Multi-array diagnostic chip

The present invention relates to a multi-array diagnostic chip, and more specifically, to a multi-array diagnostic chip that can simultaneously determine various diseases with a single diagnostic sample as the flow channel through which the diagnostic sample moves is composed of a multi-array.

As the life expectancy of modern people increases and the types of diseases accompanying it increase, various diagnostic devices and diagnostic systems have been developed to prevent and diagnose diseases.

One of them, a diagnostic kit, tests or investigates the presence of single or multiple substances in a liquid sample, such as urine or blood sample. Specifically, modern diagnostic business areas are being integrated into Point-Of-Care Testing (POCT). POCT is a test performed outside of a centralized laboratory and refers to equipment that can be used by the general public without specialized knowledge. Currently, the scope of diagnosis is expanding from hospitals to the field and individuals.

For example, in a hospital, a patient is administered a large amount of antibiotics to fight an infection, and then a small amount of blood is collected to check whether an appropriate amount of antibiotics is present in the blood, or cognitive function. In the case of patients with damaged overdose or infants who are unable to communicate, examples of application include rapid investigation of the type of drug ingested in the human body to ensure appropriate treatment administration.

In particular, rapid diagnostic tests, represented by immunochromatographic analysis, are used in the healthcare field to confirm diseases or identify changes, and also qualitatively and quantitatively test trace amounts of analytes in various fields such as food and bioprocessing and the environment. It is being developed as a simple method. In the field of health care, the scope of application is expanding to pregnancy, ovulation, infectious diseases, drug abuse, acute myocardial infarction, and cancer.

In one embodiment of diagnosing a disease using a diagnostic kit, the diagnostic sample is preprocessed, light is irradiated to the diagnostic sample, and the disease is diagnosed based on the color information coming from the diagnostic sample. Currently, one Eurochannel per diagnostic kit is used. Since only one disease is detected in one diagnostic kit, diagnostic chips corresponding to the number of diseases must be provided in order to check various diseases, and since diagnostic samples must be injected into the diagnostic chips one by one, it takes a lot of time to confirm the disease. There is a problem that arises.

Republic of Korea Patent Publication No. 10-2015-0016043 (Title of invention: Microfluidic device and manufacturing method thereof, Publication date: February 11, 2015)

In order to solve the above-mentioned problems, the purpose of the present invention is to provide a multi-array diagnostic chip that can simultaneously determine various diseases with one diagnostic sample as the flow channel through which the diagnostic sample moves is composed of a multi-array. .

The problems of the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

In order to solve the above-described problem, the present invention includes a diagnostic chip main body in which a flow channel through which a diagnostic sample moves is formed, an optical information detection unit that detects optical information of the diagnostic sample, and a control unit that controls the operation of the optical information detection unit. Including, the diagnostic chip body is formed on an upper plate, a lower plate coupled to the lower part of the upper plate, a flow channel through which the diagnostic sample moves, and a flow channel formed on the flow channel, , a sample reaction unit formed of a material that reacts with the diagnostic sample, wherein the flow channel includes a sample injection line into which the diagnostic sample is introduced and movement of the diagnostic sample begins, and a plurality of branches connected to and branching from an end of the sample injection line. A multi-array diagnostic chip is provided, which includes two sample movement lines.

Here, the sample movement line includes a sample buffer line connected to the end of the sample injection line, a sample preprocessing line connected to the end of the sample buffer line, a test line connected to the end of the sample preprocessing line, and the test line. It may include a reference line connected to the end of the line.

In addition, the sample reaction unit is disposed on the sample buffer line, and includes a sample buffer unit formed with a material that stabilizes the diagnostic sample moving from the sample injection line, and a sample pretreatment line, which is disposed on the sample buffer line. A preprocessing unit formed with a material for preprocessing the moving diagnostic sample, disposed on the test line, a test section formed with a material for testing the diagnostic sample moving from the sample preprocessing line, and disposed on the reference line, , may include a reference portion formed with a reference material for the diagnostic sample moving from the test line.

Additionally, the upper plate may include a diagnostic sample input hole connected to the sample injection line to allow the diagnostic sample to be injected into the diagnostic chip body.

The multi-array diagnostic chip according to the present invention has the following effects.

First, since the flow channel through which the diagnostic sample moves is composed of a multi-array, there is an advantage of being able to determine multiple diseases simultaneously with a single diagnostic sample.

Second, as it becomes possible to identify various diseases with a single diagnostic chip, the process of individually injecting diagnostic samples into the diagnostic chip is omitted, which has the advantage of shortening the time required to confirm the disease.

Third, the formation of a sample movement control hole that adjusts the moving distance of the diagnostic sample prevents asymmetric flow of the diagnostic sample even in situations where the multi-array diagnostic chip according to the present invention is not placed horizontally, thereby more accurately confirming the disease. There is an advantage to making this possible.

Fourth, the optical information detection unit is composed of a plurality of optical information detection units, and each optical information detection unit is arranged to individually correspond to each sample movement line, which has the advantage of enabling rapid disease detection.

Fifth, the optical information detection unit is composed of a single unit and moves in an inverted U-shape to detect the optical information of the diagnostic sample moving through a plurality of sample movement lines, and the control unit detects the optical information of the diagnostic sample detected as the optical information detection unit moves in an inverted U-shape. By organizing the information in the order of the sample buffer unit, preprocessing unit, test unit, and reference unit, there is an advantage in that the travel distance and travel time of the optical information detection unit can be shortened, enabling rapid disease detection.

Sixth, by including a flatness sensor attached to the diagnostic chip, the diagnostic chip is positioned horizontally from the ground to prevent asymmetric flow of the diagnostic sample, which has the advantage of enabling more accurate disease identification.

1 is a diagram illustrating the overall configuration of a multi-array diagnostic chip according to the present invention.
Figure 2 is a diagram illustrating the flow channel and sample response unit of the multi-array diagnostic chip according to the present invention.
Figures 3 and 4 are diagrams to explain embodiments of the flow channel and sample reaction unit of the multi-array diagnostic chip according to the present invention.
Figures 5 and 6 are diagrams to explain the sample movement control hole of the multi-array diagnostic chip according to the present invention.
FIG. 7 is a diagram illustrating examples of sample movement control holes formed corresponding to examples of the sample reaction unit shown in FIG. 4.
Figures 8 and 9 are diagrams to explain embodiments of the optical information detection unit of the multi-array diagnostic chip according to the present invention.

The advantages and features of the present invention and methods for achieving them will become clear by referring to the embodiments described in detail below along with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various different forms. The present embodiments are merely provided to ensure that the disclosure of the present invention is complete and to be understood by those skilled in the art. It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout the specification.

The terms used herein are used to describe specific embodiments and are not intended to limit the invention. As used herein, the singular forms include the plural forms unless the context clearly indicates otherwise. In addition, throughout this specification, when a part “includes” a certain element, this means that it may further include other elements unless specifically stated to the contrary.

When a component is said to be “connected” or “connected” to another component, it is understood that it may be directly connected to or connected to that other component, but that other components may exist in between. It should be. On the other hand, when a component is said to be “directly connected” or “directly connected” to another component, it should be understood that there are no other components in between. Other expressions to describe relationships between components should be interpreted similarly.

All terms, including technical or scientific terms, used in this specification have the same meaning as generally understood by those skilled in the art to which the present invention pertains, unless otherwise defined. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and unless clearly defined in this specification, should not be interpreted in an idealized or overly formal sense. No.

1 is a diagram illustrating the overall configuration of a multi-array diagnostic chip according to the present invention. The multi-array diagnostic chip according to the present invention includes a diagnostic chip body 1000, an optical information detection unit 2000, and a control unit. .

The diagnostic chip body 1000 is formed with a flow channel 1300 through which the diagnostic sample moves. Specifically, the diagnostic chip body 1000 includes an upper plate 1100, a lower plate 1200, and a flow channel 1300. and a sample reaction unit 1400.

The upper plate 1100 is coupled to the upper surface of the lower plate 1200 and is formed to cover the upper surface of the lower plate 1200, and is preferably made of a transparent material.

This allows the optical information detection unit 2000 to irradiate light to the diagnostic sample through the upper plate 1100 and detect color information from the diagnostic sample, without exposing the diagnostic sample to the outside. This is to ensure that disease diagnosis can proceed smoothly.

Additionally, a diagnostic sample input hole 1110 is formed in the upper plate 1100 to allow the diagnostic sample to be injected into the diagnostic chip body 1000.

The lower plate 1200 is coupled to the lower part of the upper plate 1100 and is preferably made of a material that does not react with the diagnostic sample and does not affect the diagnostic sample.

The flow channel 1300 is formed to move the diagnostic sample on the upper surface of the lower plate 1200. Specifically, the flow channel 1300 includes a sample injection line 1310 and a sample movement line 1320.

The sample injection line 1310 is disposed at a position corresponding to the diagnostic sample input hole 1110, and the diagnostic sample is injected and movement of the diagnostic sample begins.

The sample movement line 1320 is connected to the end of the sample injection line 1310, is formed in plural pieces, and branches off from the end of the sample injection line 1310, and a detailed description thereof will be provided later.

The sample reaction unit 1400 is formed on the flow channel 1300 and is made of a material that reacts with the diagnostic sample, which will be described later.

The optical information detection unit 2000 detects optical information of the diagnostic sample and specifically includes a light source unit 2100 and a detection unit 2200.

The light source unit 2100 radiates light to the diagnostic sample and proceeds along the moving direction of the diagnostic sample to irradiate light to the diagnostic sample.

The detection unit 2200 detects color information reflected from the diagnostic sample, moves along the moving direction of the diagnostic sample, and detects color information of the diagnostic sample.

Additionally, the light source unit 2100 and the detection unit 2200 are linked with the control unit and are controlled by driving the control unit.

Figure 2 is a diagram illustrating the flow channel 1300 and the sample reaction unit 1400 of the multi-array diagnostic chip according to the present invention. First, the sample movement line 1320 of the flow channel 1300 is explained. If you do so, it is as follows.

The sample movement line 1320 includes a sample buffer line 1321, a sample preprocessing line 1322, a test line 1323, and a reference line 1324.

The sample buffer line 1321 is connected to the end of the sample injection line 1310, the sample preprocessing line 1322 is connected to the end of the sample buffer line 1321, and the test line 1323 is connected to the end of the sample injection line 1310. It is connected to the end of the sample preprocessing line 1322, and the reference line 1324 is connected to the end of the test line 1323.

Additionally, the sample reaction unit includes a sample buffer unit 1410, a preprocessing unit 1420, a test unit 1430, and a reference unit 1440.

The sample buffer unit 1410 is formed on the sample buffer line 1321 of the flow channel 1300, and a sample buffer material that stabilizes the diagnostic sample is formed in the sample buffer unit 1410. Depending on the type of diagnostic sample, a plurality of sample buffer units 1410 may be formed, and the sample buffer material may be changed depending on the type and target material of the diagnostic sample. The sample buffer unit 1410 may be used to store diagnostic samples and It can be placed anywhere in the sample buffer line 1321 area depending on various conditions such as the time required for reaction, and this also applies to the preprocessing unit 1420, test unit 1430, and reference unit 1440, which will be described later. .

The preprocessing unit 1420 is formed on the sample preprocessing line 1322, and is formed with a preprocessing material for preprocessing the diagnostic sample that is buffered and moving in the sample buffer line 1321, and is configured to determine the type of the diagnostic sample. Accordingly, a plurality of preprocessing units 1420 may be formed, and the pretreatment material may be changed depending on the type and target material of the diagnostic sample.

The test unit 1430 is formed on the test line 1323, and is formed with a test material for testing the diagnostic sample that is preprocessed and moving in the sample preprocessing line 1322. By irradiating light to the rough diagnostic sample, disease diagnosis can be performed according to the color information emitted by the diagnostic sample.

Depending on the type of the diagnostic sample, a plurality of test units 1430 may be formed, and the test material may be changed depending on the type and target material of the diagnostic sample.

The reference portion 1440 is formed on the reference line 1324, and a reference material is formed in the reference line 1324 to confirm the reference level of the diagnostic sample that has been tested to diagnose a disease, and the reference By irradiating light to the diagnostic sample that has passed through the unit 1440, the reference level of the diagnostic sample can be confirmed according to the color information emitted by the diagnostic sample.

Depending on the type of the diagnostic sample, a plurality of reference units 1440 may be formed, and the reference material may be changed depending on the type and target material of the diagnostic sample.

Figures 3 and 4 are diagrams to explain embodiments of the flow channel 1300 and the sample reaction unit 1400 of the multi-array diagnostic chip according to the present invention.

First, an embodiment of the flow channel 1300 will be described with reference to FIG. 3 as follows.

As shown in (a) of FIG. 3, the flow channel 1300 includes the sample injection line 1310 and the sample movement line 1320, and the sample movement line 1320 is the sample injection line 1310. ) may be formed in a bent shape, and as shown in (b) of Figure 3, the sample movement line 1320 may be formed as a straight line from the sample injection line 1310, and the sample movement line The shape of 1320 may be selected according to the number of sample movement lines 1320 formed according to the number of diseases to be measured, the size of the diagnostic chip, etc.

In addition, as shown in FIG. 3, a first movement control hole 1121, which will be described later, must be opened so that the diagnostic sample can move to the sample movement line 1320. At this time, the first movement control hole 1121 must be opened. The movement of the diagnostic sample can be controlled according to the shape and arrangement of (1121).

First, as shown in (a) of FIG. 3, when the first movement control hole 1121 is formed in each of the plurality of sample movement lines 1320, the diagnostic sample is connected to the plurality of sample movement lines (1320). 1320), the first movement control hole 1121 moves only in the direction of the opened sample movement line 1320, thereby selectively controlling the movement of the diagnostic sample.

Alternatively, as shown in (b) of FIG. 3, when an integrated first movement control hole 1121 is formed in the plurality of sample movement lines 1320, the diagnostic sample is moved through the first movement control hole. As 1121 is opened, all samples connected to the sample injection line 1310 move in the direction of the sample movement line 1320, allowing the diagnostic sample to move quickly.

Additionally, with reference to FIG. 4, an example in which the sample reaction unit 1400 included in the flow channel 1300 is disposed will be described as follows.

First, as shown in (a) of FIG. 4, when a plurality of sample movement lines 1320a and 1320b branch from the sample injection line 1310, the sample buffer unit 1410, the preprocessor 1420 and the test unit ( 1430) and a reference unit 1440 may be formed on each of the sample movement lines 1320a and 1320b.

Or, as shown in (b) of FIG. 4, when a plurality of sample movement lines 1320 branch from the sample injection line 1310, the start of the sample buffer line 1321 included in the sample movement line 1320. As the areas are arranged in the same area, the sample buffer unit 1410 is configured as one, and after the diagnostic sample passes through one sample buffer unit 1410, preprocessing is performed on each sample movement line (1320a, 1320b, 1320c). The unit 1420 may also move to the test unit 1430 and the reference unit 1440.

Or, as shown in (c) of FIG. 4, a plurality of sample movement lines 1320 branch from the sample injection line 1310 and include a first sample movement line 1320a and a second sample movement line 1320b. can do.

At this time, the second sample movement line 1320b may include a 2-1 sample movement line 1320b1 and a 2-2 sample movement line 1320b2.

That is, the 2-1 sample movement line (1320b1) includes a sample buffer unit (1410b1), a preprocessing unit (1420b1), a test unit (1430b1), and a reference unit (1440b1), and the 2-2 sample movement line (1320b2) is branched from the 2-1 sample movement line (1320b1), and is branched from the area between the pre-processing unit (1420b1) and the test unit (1430b1) formed in the 2-1 sample movement line (1320b1), It may include a test part (1430b2) and a reference part (1440b2) formed of a different material from the test part (1430b1) and the reference part (1440b1) formed in the 2-1 sample movement line (1320b1).

That is, the sample movement line 1320 is not only formed in plurality, but also an area between one of the sample buffer unit 1410, the preprocessing unit 1420, the test unit 1430, and the reference unit 1440. It may include a sample movement auxiliary line (1320b2 in FIG. 4 (c)) that additionally branches from.

Alternatively, as shown in (d) of FIG. 4, the sample injection lines may be formed in plurality and include a first sample injection line 1310a and a second sample injection line 1310b.

In addition, the sample movement line is branched into a plurality of sample movement lines from the first sample injection line 1310a and the second sample injection line 1310b, respectively, and is connected to the first sample injection line 1310a. 1-1 sample movement line (1320aa), 1-2 sample movement line (1320ab), 1-3 sample movement line (1320ac), and 2-1 sample movement connected to the second sample injection line (1310b) It may include a line 1320ba, a 2-2 sample movement line 1320bb, and a 2-3 sample movement line 1320bc.

That is, the user can diagnose the disease by injecting a diagnostic sample only into at least one of the first sample injection line (1310a) and the second sample injection line (1310b), and the hole cover portion (1130) By adjusting the opening, the first sample injection line (1310a) and the second sample injection line (1310b) are connected to the 1-1 sample movement line (1320aa), the 1-2 sample movement line (1320ab), and the 1-3 sample injection line (1310a). The movement of the diagnostic sample moving to the sample movement line (1320ac), the 2-1 sample movement line (1320ba), the 2-2 sample movement line (1320bb), and the 2-3 sample movement line (1320bc) can be controlled. there is.

Accordingly, when detecting different diseases, if the sample buffer and materials that must be preprocessed to detect the two diseases are the same, and the test material and reference material are made of different materials, the test unit 1430 ) and the sample movement auxiliary line so that only the reference unit 1440 is additionally added, thereby enabling more economical disease detection.

In addition, as shown in (e) of FIG. 4, the sample buffer unit 1410, the preprocessing unit 1420, the test unit 1430, and the reference unit formed in each of the plurality of sample movement lines 1320. At least one of (1440) may be omitted.

That is, when detecting different diseases with one reagent, if sample buffering or preprocessing does not need to be performed, more economical disease detection can be performed by omitting the sample buffer unit 1410 or the preprocessing unit 1420. You can do it.

Figures 5 and 6 are diagrams to explain the sample movement control hole 1120 of the multi-array diagnostic chip according to the present invention.

The upper plate 1100 includes a sample movement control hole 1120 and a hole cover portion 1130 that are connected to the sample movement line 1320 to control the movement distance of the diagnostic sample (S), and the sample movement The adjustment hole 1120 includes a first movement control hole 1121, a second movement control hole 1122, a third movement control hole 1123, and a fourth movement control hole 1124.

The first movement control hole 1121 is formed in an area facing the sample buffer line 1321, and the second movement control hole 1122 is formed in an area facing the sample preprocessing line 1322, The third movement control hole 1123 is formed in an area facing the test line 1323, and the fourth movement control hole 1124 is formed in an area facing the reference line 1324.

That is, in the initial state, all of the first movement control holes 1121 to the fourth movement control holes 1124 are covered with the hole cover part 1130, and the user using the multi-array diagnostic chip according to the present invention can perform the diagnosis. Remove the hole cover unit 1130 in consideration of the reaction time of the sample S with the sample buffer unit 1410, the preprocessor 1420, the test unit 1430, and the reference unit 1440, respectively. By cutting or drilling, the diagnostic sample (S) can move to the area where the hole cover portion 1130 has been removed.

As a result, as the sample movement control hole 1120 is formed, it is possible to control the movement distance of the diagnostic sample (S), and the sample movement can be controlled even in situations where the multi-array diagnostic chip according to the present invention is not placed horizontally. Since the diagnostic sample (S) moves only to the area where the hole (1120) is removed, it is possible to prevent asymmetric flow of the diagnostic sample (S) from occurring through opening and closing of the sample movement control hole (1120). Accurate identification of the disease becomes possible.

FIG. 7 is a diagram illustrating examples of sample movement control holes formed corresponding to examples of the sample reaction unit shown in FIG. 4.

First, Figure 7 (a) is a diagram showing the upper plate (1100a) coupled to the lower plate (1200) shown in Figure 4 (a), and the diagnostic sample input hole formed in the upper plate (1100a) and The first to fourth movement control holes are described as follows.

First, the diagnostic sample input hole 1110 is formed in an area corresponding to the sample injection line 1310 so that the diagnostic sample is injected.

Additionally, the first to fourth movement control holes are formed at positions corresponding to the sample movement lines 1320a and 1320b, respectively.

Specifically, the sample movement line 1320a branching to one side from the sample injection line 1310 includes the sample buffer unit 1410, the preprocessor 1420, the test unit 1430, and the sample buffer unit 1410 formed on the sample movement line 1320a. A first movement control hole (1121a), a second movement control hole (1122a), a third movement control hole (1123a), and a fourth movement control hole (1124a) are formed in the area corresponding to the reference unit 1440, respectively, The sample movement line 1320b branching from the sample injection line 1310 to the other side includes the sample buffer unit 1410, the preprocessing unit 1420, the test unit 1430, and the reference unit ( A first movement control hole (1121b), a second movement control hole (1122b), a third movement control hole (1123b), and a fourth movement control hole (1124b) are formed in the area corresponding to 1440, respectively.

That is, after the diagnostic sample is injected from the diagnostic sample input hole 1110 into the sample injection line 1310, the direction and opening are opened as the movement control holes formed in each of the sample movement lines 1320a and 1320b are opened. The diagnostic sample moves to the designated area.

At this time, the number of sample movement lines branching to one side from the sample injection line 1310 may be branched into two as in the example above, or may be a number corresponding to the number of diseases that can be diagnosed with one sample. It can be formed by branching.

For example, when a drug, myocardial infarction, or dementia disease can be confirmed with one diagnostic sample, the sample movement line may be divided into three.

At this time, since the reaction speed of the sample movement line for diagnosing each disease may be different, the movement control hole formed in each sample movement line may be opened at a different time based on each reaction speed.

In addition, even if the sample movement line is divided into three so that three diseases can be diagnosed, in the case of diagnosing only two diseases, narcotics and myocardial infarction, only the movement control hole formed in the corresponding sample movement line is opened to selectively Diseases can be diagnosed.

FIG. 7(b) is a view showing the upper plate 1100b coupled to the lower plate 1200 shown in FIG. 4(b), and the diagnostic sample input hole formed in the upper plate 1100b and the first The movement control hole to the fourth movement control hole is explained as follows.

First, the diagnostic sample input hole 1110 is formed in an area corresponding to the sample injection line 1310 so that the diagnostic sample is injected.

Three sample movement lines (1320a, 1320b, 1320c) branch from the sample injection line 1310, and the sample buffer unit 1410 is located in the area where the three sample movement lines (1320a, 1320b, 1320c) start. is formed

Accordingly, the first movement control hole 1121 is composed of a single piece, and as the first movement control hole is opened, the diagnostic samples that can be moved to the three sample movement lines 1320a, 1320b, and 1320c described above are the same. It can be buffered properly.

Thereafter, as explained in (a) of FIG. 7, the second movement control holes (1222a, 1222b, 1222c) to the fourth movement control holes (1224a, 1224b, 1224c) depending on the type and number of diseases to be diagnosed. This can be selectively opened to perform a diagnosis of a disease.

Figure 7 (c) is a diagram showing the upper plate (1100c) coupled to the lower plate (1200) shown in Figure 4 (c), the diagnostic sample input hole formed in the upper plate (1100c) and the first The movement control hole to the fourth movement control hole is explained as follows.

The upper plate 1100 shown in (c) of FIG. 7 is partially similar to the upper plate shown in (a) of FIG. 7 described above.

However, the upper plate 1100 shown in (c) of FIG. 7 corresponds to the test unit 1430b2 and the reference unit 1440b2 formed on the 2-2 sample movement line 1320b2 shown in (c) of FIG. 4. It may further include a third movement control hole 1123b2 and a fourth movement control hole 1124b2 formed in the area, and can be used when diagnosing different diseases using the same sample buffer and diagnostic sample for which preprocessing is performed.

FIG. 7(d) is a diagram showing the upper plate 1100d coupled to the lower plate 1200 shown in FIG. 4(d), and the diagnostic sample input hole formed in the upper plate 1100d and the first The movement control hole to the fourth movement control hole is explained as follows.

The upper plate shown in (d) of FIG. 7 has a first diagnostic sample input hole 1110a and a second diagnostic sample input hole 1110a at positions corresponding to the first sample injection line 1310a and the second sample injection line 1310b. An input hole (1110b) is formed, and a movement control hole is formed in an area corresponding to the sample reaction unit formed in each sample movement line (1320aa, 1320ab, 1320ac, 1320ba, 1320bb, 1320bc).

That is, the same diagnostic sample or different types of diagnostic samples may be injected into the first diagnostic sample input hole 1110a and the second diagnostic sample input hole 1110b, so that different diagnostic samples can be used with one diagnostic chip. Diagnosis of diseases becomes possible using .

FIG. 7(e) is a view showing the upper plate 1100e coupled to the lower plate 1200 shown in FIG. 4(e), and the diagnostic sample input hole formed in the upper plate 1100e and the first The movement control hole to the fourth movement control hole is explained as follows.

As shown in (e) of FIG. 4, the sample buffer unit 1410, the preprocessing unit 1420, the test unit 1430, and the reference unit 1440 formed in each of the plurality of sample movement lines 1320. ), at least one of them may be omitted, and accordingly, the movement control hole is formed only in the area corresponding to the sample reaction unit, so that when detecting different diseases with one reagent, no sample buffer or preprocessing is required. In this case, more economical disease detection can be performed by omitting the sample buffer unit 1410 or the preprocessor 1420.

In addition, the multi-array diagnostic chip according to the present invention may further include a flatness sensor (not shown), where the flatness sensor is attached to the diagnostic chip body 1000 so that the diagnostic chip body 1000 is grounded. By measuring the flatness of the diagnostic chip body 1000 so that it is placed horizontally, asymmetrical flow of the diagnostic sample can be prevented.

Figures 8 and 9 are diagrams to explain embodiments of the optical information detection units 2000a and 2000b of the multi-array diagnostic chip according to the present invention.

First, as shown in FIG. 8, the optical information detection units 2000a and 2000b are composed of a plurality, and each of the optical information detection units 2000a and 2000b is configured to individually correspond to each of the sample movement lines 1320. can be placed.

Accordingly, each optical information detection unit (2000a, 2000b) is arranged and moved to individually correspond to each of the sample movement lines 1320, enabling rapid disease detection for each sample movement line 1320.

Alternatively, as shown in FIG. 9, the optical information detection unit 2000 is composed of a single unit, and moves in an inverted U-shape to detect optical information of a diagnostic sample moving through the plurality of sample movement lines 1320.

That is, the sample buffer unit 1410, the preprocessor 1420, the test unit 1430, and the reference unit 1440 formed on each of the plurality of sample movement lines 1320 do not detect optical information in that order. , moves to the shortest distance and detects optical information.

Thereafter, the control unit divides the optical information of the diagnostic sample detected as the optical information detection unit 2200 moves in an inverted U-shape into the sample buffer unit 1410, the preprocessor 1420, and the sample moving line 1320. By organizing the test unit 1430 and the reference unit 1440 in that order, diseases can be quickly detected for each sample movement line 1320.

As described above, preferred embodiments of the present invention have been shown and described with reference to the drawings, but the present invention is not limited to the specific embodiments described above, and the present invention is not limited to the above-described specific embodiments, and the present invention can be modified without departing from the gist of the present invention as claimed in the patent claims. Of course, various modifications can be made by those skilled in the art in the technical field to which the invention pertains, and these modified embodiments should not be understood individually from the technical idea or perspective of the present invention.

1000: Diagnostic chip body
1100: top plate
1110: Diagnostic sample input hole
1120: Sample movement control hole
1121: First movement control hole
1122: Second movement control hole
1123: Third movement control hole
1124: Fourth movement control hole
1130: Hole cover part
1200: lower plate
1300: Flow channel
1310: Sample injection line
1320: Sample movement line
1321: Sample buffer line
1322: Sample preprocessing line
1323: Test line
1324: Reference line
1400: Sample reaction unit
1410: Sample buffer unit
1420: Preprocessor
1430: Test department
1440: Reference section
2000, 2000a, 2000b: Optical information detection unit
2100: Light source unit
2200: detection unit

Claims (4)

In a multi-array diagnostic chip including a diagnostic chip body through which a diagnostic sample moves,
The diagnostic chip body is,
upper plate;
a lower plate coupled to the lower portion of the upper plate;
a flow channel formed on the upper surface of the lower plate, into which the diagnostic sample moves; and
It includes a sample reaction portion formed on the flow channel and made of a material that reacts with the diagnostic sample,
The flow channel is,
A sample injection line where the diagnostic sample is introduced and movement of the diagnostic sample begins; and
A multi-array diagnostic chip comprising a plurality of sample movement lines connected to and branched from an end of the sample injection line. According to paragraph 1,
The sample movement line is,
a sample buffer line connected to an end of the sample injection line;
A sample preprocessing line connected to an end of the sample buffer line;
a test line connected to an end of the sample pretreatment line;
A multi-array diagnostic chip comprising a reference line connected to an end of the test line. According to paragraph 2,
The sample reaction unit,
a sample buffer portion disposed on the sample buffer line and formed with a material that stabilizes the diagnostic sample moving from the sample injection line;
a preprocessing unit disposed on the sample preprocessing line and formed with a material for preprocessing the diagnostic sample moving from the sample buffer line;
a test unit disposed on the test line and formed of a material for testing the diagnostic sample moving from the sample preprocessing line; and
A multi-array diagnostic chip comprising: a reference portion disposed on the reference line and formed with a reference material for the diagnostic sample moving from the test line. According to paragraph 1,
The upper plate is connected to the sample injection line and includes a diagnostic sample input hole formed to inject the diagnostic sample into the diagnostic chip body.

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