KR20240013766A - 2개의 trail 삼량체를 포함하는 수퍼-trail 분자 - Google Patents
2개의 trail 삼량체를 포함하는 수퍼-trail 분자 Download PDFInfo
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- KR20240013766A KR20240013766A KR1020237043997A KR20237043997A KR20240013766A KR 20240013766 A KR20240013766 A KR 20240013766A KR 1020237043997 A KR1020237043997 A KR 1020237043997A KR 20237043997 A KR20237043997 A KR 20237043997A KR 20240013766 A KR20240013766 A KR 20240013766A
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Catalysts (AREA)
- Lubricants (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| CNPCT/CN2021/096498 | 2021-05-27 | ||
| CN2021096498 | 2021-05-27 | ||
| PCT/CN2022/095472 WO2022247923A1 (en) | 2021-05-27 | 2022-05-27 | A super-trail molecule comprising two trail trimers |
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| KR20240013766A true KR20240013766A (ko) | 2024-01-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020237043997A Pending KR20240013766A (ko) | 2021-05-27 | 2022-05-27 | 2개의 trail 삼량체를 포함하는 수퍼-trail 분자 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240254193A1 (https=) |
| EP (1) | EP4347665A4 (https=) |
| JP (1) | JP2024519397A (https=) |
| KR (1) | KR20240013766A (https=) |
| CN (1) | CN117396520A (https=) |
| AU (1) | AU2022280269A1 (https=) |
| CA (1) | CA3220239A1 (https=) |
| IL (1) | IL308618A (https=) |
| WO (1) | WO2022247923A1 (https=) |
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| CN120475984A (zh) * | 2023-01-05 | 2025-08-12 | 国家纳米科学中心 | Dna-trail复合物及其治疗肿瘤的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| EP1894940A1 (en) * | 2006-08-28 | 2008-03-05 | Apogenix GmbH | TNF superfamily fusion proteins |
| CN102898526A (zh) * | 2011-07-28 | 2013-01-30 | 山东先声麦得津生物制药有限公司 | 一种肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用 |
| US20150038682A1 (en) * | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| PL3145530T3 (pl) * | 2014-04-21 | 2021-10-18 | D&D Pharmatech Inc. | Agonisty receptora trail w leczeniu chorób zwłóknieniowych |
| US10428149B2 (en) * | 2015-03-18 | 2019-10-01 | Universitat Stuttgart | Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof |
| WO2017194442A1 (en) * | 2016-05-11 | 2017-11-16 | F. Hoffmann-La Roche Ag | Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety |
| WO2018183671A1 (en) * | 2017-03-29 | 2018-10-04 | Tdw Group | Protein conjugates |
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2022
- 2022-05-27 KR KR1020237043997A patent/KR20240013766A/ko active Pending
- 2022-05-27 EP EP22810647.2A patent/EP4347665A4/en active Pending
- 2022-05-27 US US18/564,554 patent/US20240254193A1/en active Pending
- 2022-05-27 JP JP2023573077A patent/JP2024519397A/ja active Pending
- 2022-05-27 AU AU2022280269A patent/AU2022280269A1/en active Pending
- 2022-05-27 WO PCT/CN2022/095472 patent/WO2022247923A1/en not_active Ceased
- 2022-05-27 CA CA3220239A patent/CA3220239A1/en active Pending
- 2022-05-27 IL IL308618A patent/IL308618A/en unknown
- 2022-05-27 CN CN202280038107.8A patent/CN117396520A/zh active Pending
Non-Patent Citations (5)
| Title |
|---|
| 1. Wiley, S.R., et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 1995. 3 (6) : p. 673-82. |
| 2. Pitti, R.M., et al., Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem, 1996. 271 (22) : p. 12687-90. |
| 3. Graves, J.D., et al., Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity. Cancer Cell, 2014. 26 (2) : p. 177-89. |
| 4. Kim, S.H., et al., Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J Biol Chem, 2004. 279 (38) : p. 40044-52. |
| 5. Hutt, M., et al., Superior Properties of Fc-comprising scTRAIL Fusion Proteins. Mol Cancer Ther, 2017.16 (12) : p. 2792-2802. |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240254193A1 (en) | 2024-08-01 |
| AU2022280269A1 (en) | 2023-11-30 |
| JP2024519397A (ja) | 2024-05-10 |
| CN117396520A (zh) | 2024-01-12 |
| WO2022247923A1 (en) | 2022-12-01 |
| CA3220239A1 (en) | 2022-12-01 |
| EP4347665A4 (en) | 2025-07-30 |
| EP4347665A1 (en) | 2024-04-10 |
| IL308618A (en) | 2024-01-01 |
| AU2022280269A9 (en) | 2023-12-07 |
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