KR20240013203A - 간 질환 치료에 사용하기 위한 페마피브레이트 및/또는 토포글리플로진 - Google Patents
간 질환 치료에 사용하기 위한 페마피브레이트 및/또는 토포글리플로진 Download PDFInfo
- Publication number
- KR20240013203A KR20240013203A KR1020237044685A KR20237044685A KR20240013203A KR 20240013203 A KR20240013203 A KR 20240013203A KR 1020237044685 A KR1020237044685 A KR 1020237044685A KR 20237044685 A KR20237044685 A KR 20237044685A KR 20240013203 A KR20240013203 A KR 20240013203A
- Authority
- KR
- South Korea
- Prior art keywords
- patient
- score
- pharmaceutically acceptable
- acceptable salt
- nash
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZHKNLJLMDFQVHJ-RUZDIDTESA-N (2r)-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid Chemical compound CC[C@H](C(O)=O)OC1=CC=CC(CN(CCCOC=2C=CC(OC)=CC=2)C=2OC3=CC=CC=C3N=2)=C1 ZHKNLJLMDFQVHJ-RUZDIDTESA-N 0.000 title claims abstract description 45
- 229950009401 pemafibrate Drugs 0.000 title claims abstract description 45
- ZXOCGDDVNPDRIW-NHFZGCSJSA-N Tofogliflozin Chemical compound O.C1=CC(CC)=CC=C1CC1=CC=C(CO[C@@]23[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C2=C1 ZXOCGDDVNPDRIW-NHFZGCSJSA-N 0.000 title claims description 53
- 229950006667 tofogliflozin Drugs 0.000 title claims description 45
- 238000011282 treatment Methods 0.000 title abstract description 16
- 208000019423 liver disease Diseases 0.000 title abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 113
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims abstract description 83
- 210000004185 liver Anatomy 0.000 claims abstract description 47
- 206010061218 Inflammation Diseases 0.000 claims abstract description 25
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- 208000019425 cirrhosis of liver Diseases 0.000 claims abstract description 15
- 108010028554 LDL Cholesterol Proteins 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims description 48
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 37
- 206010016654 Fibrosis Diseases 0.000 claims description 34
- 230000004761 fibrosis Effects 0.000 claims description 33
- 230000007863 steatosis Effects 0.000 claims description 25
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 25
- 230000006872 improvement Effects 0.000 claims description 22
- 230000009467 reduction Effects 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 10
- 208000004930 Fatty Liver Diseases 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 8
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract description 3
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- 230000000977 initiatory effect Effects 0.000 description 20
- 229960004346 glimepiride Drugs 0.000 description 11
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 11
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- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
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- VWVKUNOPTJGDOB-BDHVOXNPSA-N Anhydrous tofogliflozin Chemical compound C1=CC(CC)=CC=C1CC1=CC=C(CO[C@@]23[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C2=C1 VWVKUNOPTJGDOB-BDHVOXNPSA-N 0.000 description 1
- 101710081722 Antitrypsin Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
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- 108060006698 EGF receptor Proteins 0.000 description 1
- 206010014935 Enzyme abnormality Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
- 101710197901 Galectin-3-binding protein Proteins 0.000 description 1
- 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 208000018565 Hemochromatosis Diseases 0.000 description 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
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- 102000023984 PPAR alpha Human genes 0.000 description 1
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- 206010038923 Retinopathy Diseases 0.000 description 1
- 108091006269 SLC5A2 Proteins 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
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- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163194088P | 2021-05-27 | 2021-05-27 | |
| US63/194,088 | 2021-05-27 | ||
| PCT/IB2022/054867 WO2022249071A1 (en) | 2021-05-27 | 2022-05-25 | Pemafibrate and/or tofogliflozin for use in treating liver disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240013203A true KR20240013203A (ko) | 2024-01-30 |
Family
ID=82020168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237044685A Pending KR20240013203A (ko) | 2021-05-27 | 2022-05-25 | 간 질환 치료에 사용하기 위한 페마피브레이트 및/또는 토포글리플로진 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240277745A1 (https=) |
| EP (1) | EP4346809A1 (https=) |
| JP (1) | JP2024520020A (https=) |
| KR (1) | KR20240013203A (https=) |
| CN (1) | CN117677385A (https=) |
| AU (1) | AU2022282651A1 (https=) |
| BR (1) | BR112023024701A2 (https=) |
| CA (1) | CA3221073A1 (https=) |
| MX (1) | MX2023013886A (https=) |
| WO (1) | WO2022249071A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4556006A4 (en) * | 2022-07-15 | 2026-01-07 | Kowa Co | MEDICATION TO LOWER LDL CHOLESTEROL IN THE BLOOD |
| CN115991682A (zh) * | 2023-03-21 | 2023-04-21 | 广州佳途科技股份有限公司 | 一种培马贝特-d4的制备方法及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI696462B (zh) | 2013-07-10 | 2020-06-21 | 日商興和股份有限公司 | 非酒精性脂肪性肝疾病治療劑 |
| WO2018131626A1 (ja) | 2017-01-11 | 2018-07-19 | 興和株式会社 | 非アルコール性脂肪性肝疾患の予防及び治療薬 |
-
2022
- 2022-05-25 US US18/564,115 patent/US20240277745A1/en active Pending
- 2022-05-25 AU AU2022282651A patent/AU2022282651A1/en active Pending
- 2022-05-25 BR BR112023024701A patent/BR112023024701A2/pt unknown
- 2022-05-25 EP EP22729797.5A patent/EP4346809A1/en active Pending
- 2022-05-25 CA CA3221073A patent/CA3221073A1/en active Pending
- 2022-05-25 JP JP2023572876A patent/JP2024520020A/ja active Pending
- 2022-05-25 CN CN202280050095.0A patent/CN117677385A/zh active Pending
- 2022-05-25 WO PCT/IB2022/054867 patent/WO2022249071A1/en not_active Ceased
- 2022-05-25 KR KR1020237044685A patent/KR20240013203A/ko active Pending
- 2022-05-25 MX MX2023013886A patent/MX2023013886A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN117677385A (zh) | 2024-03-08 |
| US20240277745A1 (en) | 2024-08-22 |
| WO2022249071A1 (en) | 2022-12-01 |
| CA3221073A1 (en) | 2022-12-01 |
| EP4346809A1 (en) | 2024-04-10 |
| MX2023013886A (es) | 2024-04-19 |
| AU2022282651A1 (en) | 2023-12-07 |
| BR112023024701A2 (pt) | 2024-02-15 |
| JP2024520020A (ja) | 2024-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20231222 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250421 Comment text: Request for Examination of Application |