KR20240009912A - Porosity toothpaste composition for tooth care and its manufacturing method - Google Patents

Abstract

The disclosed porous toothpaste composition for tooth care and its manufacturing method include preparing a hydroxyapatite raw material containing calcium and phosphoric acid; Preparing porous hydroxyapatite powder using the hydroxyapatite raw material through spray pyrolysis; Preparing a first gelatin liquid forming a core layer of a toothpaste composition and a second gelatin liquid forming a shell layer using gelatin and the porous hydroxyapatite powder; Forming the core layer by molding the first gelatin liquid; And forming the shell layer by molding the second gelatin liquid on the outside of the core layer. By including this, not only can it have the effect of improving dental diseases such as toothache, but also improve cleaning power.

Description

Porous toothpaste composition for tooth care and method for manufacturing the same {POROSITY TOOTHPASTE COMPOSITION FOR TOOTH CARE AND ITS MANUFACTURING METHOD}

The present invention (Disclosure) relates to a porous toothpaste composition for tooth care and a method for manufacturing the same. Specifically, the present invention relates to a porous hydroxyapatite powder containing calcium and phosphoric acid through a spray pyrolysis method to produce porous hydroxyapatite powder, After preparing the first gelatin liquid forming the core layer of the toothpaste composition and the second gelatin liquid forming the shell layer using gelatin and porous hydroxyapatite powder, the first gelatin liquid is molded to form a core layer, and the core layer The present invention relates to a porous toothpaste composition for tooth care that not only has the effect of improving dental diseases such as syringe symptoms but also improves cleaning power by forming a shell layer by molding a second gelatin liquid on the outside, and a method of manufacturing the same.

Here, background information related to the present invention is provided, and this does not necessarily mean prior art (This section provides background information related to the present disclosure which is not necessarily prior art).

Among dental diseases, the symptom of sensitive teeth occurs when the enamel surrounding the teeth peels off due to various causes such as gingivitis, use of highly abrasive toothpaste, and gum recession due to aging, and the dentin existing inside is exposed to the outside. When dentin is exposed, nerve damage occurs. As external stimulation is transmitted to the dentinal tubules connected to the teeth, it can even make brushing one's teeth difficult, leading to gum disease or cavities.

Because teeth do not regenerate due to their nature, teeth become weaker as one ages, so these symptoms of sensitive teeth are inevitable for all adults, and various treatments have been developed to alleviate the symptoms of sensitive teeth.

There are two main types of treatment for sensitive teeth: dentinal tubule sealing and pulp nerve desensitization. The dentinal tubule sealing method is a method of restoring lost enamel by filling exposed dentinal tubules with resin or applying fluoride. Nerve desensitization is a treatment that prevents nerves from feeling pain by artificially increasing the content of potassium ions, considering that nerve transmission is controlled by the appropriate ratio of sodium ions and potassium ions.

These specialized treatments require going to a dentist, but for the general public, there are inconveniences and difficulties due to the process of making an appointment and visiting a dentist for treatment and the pain that comes with the treatment.

To solve this problem, toothpastes for tooth care that improve (relieve) the symptoms of sensitive teeth have been developed and are on the market. For example, Sensodyne from GloxoSmithKlein (USA) and Novamin Technology (USA) )'s Densheild toothpaste and Perio Sensitive toothpaste from Korea's LG Household & Health Care Co., Ltd. are being sold.

These toothpastes for tooth care contain a material that forms a coating layer on the tooth surface, but the effect of sealing the dentinal tubules is different and there are many problems such as the sealed dentinal tubules being exposed again later.

In addition, there is a continuous need for the development of toothpaste compositions that not only have the effect of improving dental diseases such as toothache, but also improve cleaning power.

1. Korean Patent Publication No. 10-2011-0129046 (published on December 1, 2011)

The present invention (Disclosure) is to manufacture porous hydroxyapatite powder through spray pyrolysis using hydroxyapatite raw materials containing calcium and phosphoric acid, and to form a core layer of a toothpaste composition using gelatin and porous hydroxyapatite powder. 1 After preparing the gelatin liquid and the second gelatin liquid forming the shell layer, the first gelatin liquid is molded to form a core layer, and the second gelatin liquid is molded on the outside of the core layer to form a shell layer, thereby reducing the symptoms of syringe. One purpose is to provide a porous toothpaste composition for tooth care that not only has the effect of improving dental diseases such as but also improves cleaning power and a method of manufacturing the same.

Here, a general summary of the present invention is provided, and this should not be construed as limiting the scope of the present invention (This section provides a general summary of the disclosure and is not a comprehensive disclosure of its full scope or all of its features).

In order to solve the above problem, a method for producing a porous toothpaste composition for tooth care according to one aspect among several aspects describing the present invention includes the step of producing a hydroxyapatite raw material containing calcium and phosphoric acid. ; Preparing porous hydroxyapatite powder using the hydroxyapatite raw material through spray pyrolysis; Preparing a first gelatin liquid forming a core layer of a toothpaste composition and a second gelatin liquid forming a shell layer using gelatin and the porous hydroxyapatite powder; Forming the core layer by molding the first gelatin liquid; and forming the shell layer by molding the second gelatin liquid on the outside of the core layer.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the step of preparing the hydroxyapatite raw material includes 50-69 parts by weight of the calcium and 30-30 parts by weight of the phosphoric acid based on 100 parts by weight of purified water. This can be done by adding 40 parts by weight and stirring for 1-2 hours at a speed range of 500-600 rpm.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, in the step of preparing the hydroxyapatite raw material, 5-10 parts by weight of nitric acid may be additionally added to 100 parts by weight of the purified water. .

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the step of preparing the porous hydroxyapatite powder includes adding polystyrene nanobeads to the hydroxyapatite raw material at an amount of 20-100 parts by weight of the purified water. 30 parts by weight can be added and stirred for 5-6 hours at a speed range of 500-600 rpm.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the step of preparing the porous hydroxyapatite powder may be performed by the spray pyrolysis method in a temperature range of 1000-1100°C.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the first gelatin solution contains 15-20 parts by weight of the gelatin, 15-20 parts by weight of vegetable juice, and lemon based on 100 parts by weight of purified water. It may include 1-5 parts by weight of juice, 5-10 parts by weight of the porous hydroxyapatite powder, 1-5 parts by weight of calcium carbonate, and 30-35 parts by weight of xylitol.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the second gelatin solution contains 15-20 parts by weight of the gelatin, 15-20 parts by weight of fruit juice, and lemon based on 100 parts by weight of purified water. It will contain 1-5 parts by weight of juice, 25-30 parts by weight of the porous hydroxyapatite powder, 1-5 parts by weight of calcium carbonate, 40-45 parts by weight of xylitol, 5-10 parts by weight of propolis extract, and 10-15 parts by weight of pactin. You can.

In the method for producing a porous toothpaste composition for tooth care according to an aspect of the invention, the step of forming the core layer includes adding the first gelatin liquid to the first silicone mold and heating it in the temperature range of 10-15°C. The core layer can be formed by molding for 3-4 hours.

In the method of manufacturing a porous toothpaste composition for tooth care according to an aspect of the invention, the step of forming the shell layer includes putting the core layer into a second silicone mold and filling the second gelatin liquid, The shell layer can be formed by molding for 3-4 hours at a temperature range of 10-15°C.

A porous toothpaste composition for tooth care according to another aspect among several aspects describing the present invention can be manufactured according to a method for producing a porous toothpaste composition for tooth care according to an aspect of the invention. .

According to the present invention, porous hydroxyapatite powder is manufactured through spray pyrolysis using hydroxyapatite raw materials containing calcium and phosphoric acid, and gelatin and porous hydroxyapatite powder are used to produce first gelatin forming the core layer of the toothpaste composition. After preparing the second gelatin liquid forming the liquid and shell layers, the first gelatin liquid is molded to form a core layer, and the second gelatin liquid is molded on the outside of the core layer to form a shell layer, thereby preventing symptoms such as syringe. Not only does it have the effect of improving dental disease, but it can also improve cleaning power.

1 is a flow chart showing the process of manufacturing a porous toothpaste composition for tooth care according to an embodiment of the present invention;
Figure 2 is a diagram for explaining the spray pyrolysis equipment and concept for producing porous hydroxyapatite powder according to an embodiment of the present invention.

Hereinafter, embodiments implementing the porous toothpaste composition for tooth care and its manufacturing method according to the present invention will be described in detail with reference to the drawings.

However, the essential technical idea of the present invention cannot be said to be limited to the embodiments described below, and based on the essential technical idea of the present invention, it cannot be said that the possible embodiments are limited by the embodiments described below. It is disclosed that the embodiment described in covers the scope that can be easily proposed by way of replacement or change.

In addition, the terms used below are selected for convenience of explanation, so in understanding the essential technical idea of the present invention, they are not limited to dictionary meanings and are appropriately interpreted as meanings that correspond to the technical idea of the present invention. It should be.

Hereinafter, embodiments of the present invention will be described in detail with reference to the attached drawings.

Figure 1 is a flow chart showing the process of manufacturing a porous toothpaste composition for tooth care according to an embodiment of the present invention, and Figure 2 is a spray pyrolysis equipment for producing porous hydroxyapatite powder according to an embodiment of the present invention and the same. This is a drawing to explain the concept.

Referring to Figures 1 and 2, hydroxyapatite raw material containing calcium and phosphoric acid can be manufactured (step 110).

In step 110, 50-69 parts by weight of calcium and 30-40 parts by weight of phosphoric acid are added to 100 parts by weight of purified water and stirred for 1-2 hours at a speed range of 500-600 rpm. An additional 5-10 parts by weight of nitric acid may be added per 100 parts by weight of purified water.

Here, nitric acid can be added to prevent the generation of precipitates. If it is added in less than 5 parts by weight, it is difficult to prevent the generation of precipitates, and if it is added in excess of 10 parts by weight, the effect of preventing the generation of precipitates is no longer effective. Since it does not increase, it can be added at 5-10 parts by weight.

Next, porous hydroxyapatite powder can be manufactured using hydroxyapatite raw material through spray pyrolysis (step 120).

In this step (120), 20-30 parts by weight of polystyrene nanobeads (PS nano beads) per 100 parts by weight of purified water are added to the hydroxyapatite raw material, and stirred for 5-6 hours at a speed range of 500-600 rpm. there is.

Here, in one embodiment of the present invention, it was described as stirring for 5-6 hours at a speed range of 500-600 rpm, but primary stirring was performed at a speed of 500 rpm for 1.5-2 hours, and then at a speed of 600 rpm. After secondary stirring for 2 hours, more uniform dispersion and mixing can be achieved by third stirring at a speed of 500 rpm for 1.5-2 hours.

The spray pyrolysis method as described above can be performed in the temperature range of 1000-1100°C. To briefly explain this, as shown in Figure 2, a solution is sprayed to create fine droplets and then dried and decomposed. This is a process for making fine powder, and one droplet acts as a small reactor, producing one particle from one droplet. It has the advantage of being simple, continuous processing, and easy to scale up. , a reaction unit (Furnace) in which the droplets generated from the droplet generator (ultrasonic nebulizer) react by high-temperature energy, and a trap that collects the generated particles.

Here, the droplet generator can, for example, use an industrial humidifier operating at a frequency of 1.7 MHz. Since the oscillator used in the industrial humidifier generates a lot of heat while generating droplets, there is a risk of damage to the oscillator and droplet generation. A failure will occur, and cooling water must be flowed around the vibrator to prevent this temperature rise and maintain a constant temperature of the spray solution.

The droplets generated by this ultrasonic droplet generator can be transported to a high-temperature tubular reactor (furnace) by a carrier gas, and the tubular reactor can be provided in the form of a quartz tube, and the inside of this tubular reactor can be The temperature can be maintained in the temperature range of 1000-1100 ℃.

Afterwards, the precursor powders obtained through the spray pyrolysis process can be calcined at 900-950°C for 3-3.5 hours, and the powders obtained through calcination are ball milled in ethanol using zirconia balls with a diameter of 2 mm. By grinding for 20-24 periods, porous hydroxyapatite powder can be produced.

This porous hydroxyapatite powder can be provided with an average particle size of 1-500 nm. If the average particle size is less than 1 nm, the particles agglomerate severely and the viscosity increases significantly, making it difficult to use as toothpaste. If it exceeds 500 nm, there is a problem in that the adsorption capacity for contaminants decreases and the ability to remove contaminants attached to teeth decreases.

Next, a first gelatin solution forming the core layer of the toothpaste composition and a second gelatin solution forming a shell layer can be prepared using gelatin and porous hydroxyapatite powder (step 130).

Here, the first gelatin solution contains 15-20 parts by weight of gelatin, 15-20 parts by weight of vegetable juice, 1-5 parts by weight of lemon juice, 5-10 parts by weight of porous hydroxyapatite powder, and 1 part by weight of calcium carbonate based on 100 parts by weight of purified water. It may contain -5 parts by weight and 30-35 parts by weight of xylitol, and vegetable juice can be mixed with 60 parts by weight of carrot juice and 40 parts by weight of tomato juice.

This first gelatin solution may further contain 3-7 parts by weight of grape seed extract and 0.1-1 part by weight of fermented Baekhwago extract based on 100 parts by weight of purified water. Due to the addition of fermented Baekhwago extract, gums may irritate when brushing teeth. It has the advantage of being able to protect.

Meanwhile, the second gelatin solution contains 15-20 parts by weight of gelatin, 15-20 parts by weight of fruit juice, 1-5 parts by weight of lemon juice, 25-30 parts by weight of porous hydroxyapatite powder, and 1-1 part of calcium carbonate based on 100 parts by weight of purified water. It may contain 5 parts by weight, 40-45 parts by weight of xylitol, 5-10 parts by weight of propolis extract, and 10-15 parts by weight of pectin, and the fruit juice may be a mixture of 60 parts by weight of kiwi juice and 40 parts by weight of mango juice.

Here, if the gelatin is less than 15 parts by weight, it is difficult to obtain a jelly formulation, and if it exceeds 20 parts by weight, there is a problem that the porous toothpaste composition becomes hard.

Additionally, if the lemon juice is less than 1 part by weight, there is a problem of poor palatability, and if it exceeds 5 parts by weight, the lemon flavor becomes too strong.

In addition, if the calcium carbonate is less than 1 part by weight, the toothpaste does not show abrasiveness, so there is a problem of insufficient plaque cleaning power, and if it exceeds 5 parts by weight, there is a problem of damaging the gums.

On the other hand, if the amount of xylitol is less than 40 parts by weight, there is a problem that the cavity prevention effect is reduced, and if it exceeds 45 parts by weight, there is a problem that digestive problems occur.

Additionally, if the amount of propolis extract is less than 5 parts by weight, there is a problem that the cleaning power is reduced, and if it exceeds 10 parts by weight, there is a problem that inflammation occurs in the mouth.

In addition, if the pectin is less than 10 parts by weight, it is difficult to obtain a jelly formulation, and if it exceeds 15 parts by weight, the toothpaste becomes hard.

This second gelatin solution may further include 5-10 parts by weight of grape seed extract, 5-10 parts by weight of L-mantle, 1-3 parts by weight of glycerin, and 10-15 parts by weight of astaxanthin, based on 100 parts by weight of purified water. If the grape seed extract is less than 5 parts by weight, there is a problem that the cleansing power is reduced, and if it exceeds 10 parts by weight, there is a problem that it interferes with iron absorption.

In addition, if the L-mantle is less than 5 parts by weight, there is a problem that it does not sufficiently act as an anti-foaming agent, and if it exceeds 10 parts by weight, there is a problem that it irritates the stomach.

In addition, if the amount of glycerin is less than 1 part by weight, there is a problem that it does not sufficiently act as a humectant, and if it exceeds 3 parts by weight, there is a problem that it irritates the stomach.

On the other hand, if astaxanthin is less than 10 parts by weight, there is a problem that it does not sufficiently act as an antioxidant, and if it exceeds 15 parts by weight, there is a problem that the skin turns yellow.

To improve palatability, 0.1-1 part by weight of aged stevia can be additionally added to the second gelatin solution as described above, and the aged stevia is 0.1-1 part by weight of Bacillus natto per 100 parts by weight of stevia. It can be obtained by mixing 1-5 parts by weight of purified water with vidoceramic stone and aging for 20-30 days at a temperature range of 10-15 ℃.

Next, the first gelatin liquid can be molded to form a core layer (step 140).

In this step 140, the first gelatin solution can be added to the first silicone mold and molded for 3-4 hours at a temperature range of 10-15° C. to form a core layer.

Next, a shell layer can be formed by molding a second gelatin solution on the outside of the core layer (step 150).

In this step 150, the core layer can be placed in the second silicone mold, filled with the second gelatin liquid, and then molded for 3-4 hours at a temperature range of 10-15° C. to form the shell layer.

The weight ratio of the core layer and the shell layer as described above is 45-50 parts by weight for the core layer relative to 100 parts by weight of the shell layer to prepare a porous toothpaste composition according to an embodiment of the present invention in which the shell layer is formed on the outside of the core layer. You can.

Here, if the core layer is less than 45 parts by weight relative to 100 parts by weight of the shell layer, the cleaning power is reduced, and if it exceeds 50 parts by weight, there is a problem that the tactile feel becomes worse.

Therefore, according to one embodiment of the present invention, porous hydroxyapatite powder is manufactured through spray pyrolysis using hydroxyapatite raw materials containing calcium and phosphoric acid, and gelatin and porous hydroxyapatite powder are used to form the core of the toothpaste composition. After preparing the first gelatin liquid forming a layer and the second gelatin liquid forming a shell layer, the first gelatin liquid is molded to form a core layer, and the second gelatin liquid is molded on the outside of the core layer to form a shell layer. , it not only has the effect of improving dental diseases such as toothache, but also improves cleaning power.

Meanwhile, the porous toothpaste composition prepared according to the manufacturing method according to an embodiment of the present invention having the above-described configuration will be described.

A porous toothpaste composition for tooth care according to another embodiment of the present invention includes the steps of manufacturing a hydroxyapatite raw material containing calcium and phosphoric acid, and preparing a porous hydroxyapatite powder using the hydroxyapatite raw material through a spray pyrolysis method. , preparing a first gelatin liquid forming the core layer of the toothpaste composition and a second gelatin liquid forming a shell layer using gelatin and porous hydroxyapatite powder, forming a core layer by molding the first gelatin liquid, and core It may include forming a shell layer by molding a second gelatin liquid on the outside of the layer.

Here, the step of preparing the hydroxyapatite raw material involves adding 50-69 parts by weight of calcium and 30-40 parts by weight of phosphoric acid to 100 parts by weight of purified water and stirring for 1-2 hours at a speed range of 500-600 rpm. It can be performed by adding 5-10 parts by weight of nitric acid based on 100 parts by weight of purified water.

In addition, the step of preparing porous hydroxyapatite powder involves adding 20-30 parts by weight of polystyrene nanobeads to the hydroxyapatite raw material per 100 parts by weight of purified water, and stirring for 5-6 hours at a speed range of 500-600 rpm. It can be performed as:

The step of producing this porous hydroxyapatite powder may be performed by spray pyrolysis at a temperature range of 1000-1100°C.

Meanwhile, the first gelatin solution contains 15-20 parts by weight of gelatin, 15-20 parts by weight of vegetable juice, 1-5 parts by weight of lemon juice, 5-10 parts by weight of porous hydroxyapatite powder, and 1-1 part of calcium carbonate based on 100 parts by weight of purified water. It may contain 5 parts by weight and 30-35 parts by weight of xylitol.

And, the second gelatin solution contains 15-20 parts by weight of gelatin, 15-20 parts by weight of fruit juice, 1-5 parts by weight of lemon juice, 25-30 parts by weight of porous hydroxyapatite powder, and 1-1 part of calcium carbonate based on 100 parts by weight of purified water. It may include 5 parts by weight, 40-45 parts by weight of xylitol, 5-10 parts by weight of propolis extract, and 10-15 parts by weight of pectin.

Additionally, in the step of forming the core layer, the first gelatin solution can be poured into the first silicone mold and molded for 3-4 hours at a temperature range of 10-15° C. to form the core layer.

Meanwhile, in the step of forming the shell layer, the core layer can be placed in the second silicone mold, filled with the second gelatin liquid, and then molded for 3-4 hours at a temperature range of 10-15° C. to form the shell layer.

Therefore, according to another embodiment of the present invention, porous hydroxyapatite powder is manufactured through spray pyrolysis using hydroxyapatite raw materials containing calcium and phosphoric acid, and gelatin and porous hydroxyapatite powder are used to form the core of the toothpaste composition. After preparing the first gelatin liquid forming a layer and the second gelatin liquid forming a shell layer, the first gelatin liquid is molded to form a core layer, and the second gelatin liquid is molded on the outside of the core layer to form a shell layer. , it not only has the effect of improving dental diseases such as toothache, but also improves cleaning power.

Claims (1)

Preparing hydroxyapatite raw material containing calcium and phosphoric acid;
Preparing porous hydroxyapatite powder using the hydroxyapatite raw material through spray pyrolysis;
Preparing a first gelatin liquid forming a core layer of a toothpaste composition and a second gelatin liquid forming a shell layer using gelatin and the porous hydroxyapatite powder;
Forming the core layer by molding the first gelatin liquid; and
A method of producing a porous toothpaste composition for tooth care comprising: forming the shell layer by molding the second gelatin liquid on the outside of the core layer.