KR20230169458A - 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합 - Google Patents

암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합 Download PDF

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Publication number
KR20230169458A
KR20230169458A KR1020237041680A KR20237041680A KR20230169458A KR 20230169458 A KR20230169458 A KR 20230169458A KR 1020237041680 A KR1020237041680 A KR 1020237041680A KR 20237041680 A KR20237041680 A KR 20237041680A KR 20230169458 A KR20230169458 A KR 20230169458A
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South Korea
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cabozantinib
study
treatment
atezolizumab
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Ceased
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KR1020237041680A
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English (en)
Korean (ko)
Inventor
기셀라 슈왑
크리스챤 쉐폴드
콜린 헤셀
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엑셀리시스, 인코포레이티드
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Publication of KR20230169458A publication Critical patent/KR20230169458A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020237041680A 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합 Ceased KR20230169458A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762448869P 2017-01-20 2017-01-20
US62/448,869 2017-01-20
US201762458447P 2017-02-13 2017-02-13
US62/458,447 2017-02-13
KR1020197024015A KR102610764B1 (ko) 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합
PCT/US2018/014523 WO2018136796A1 (en) 2017-01-20 2018-01-19 Combinations of cabozantinib and atezolizumab to treat cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197024015A Division KR102610764B1 (ko) 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합

Publications (1)

Publication Number Publication Date
KR20230169458A true KR20230169458A (ko) 2023-12-15

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KR1020237041680A Ceased KR20230169458A (ko) 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합
KR1020197024015A Active KR102610764B1 (ko) 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합

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KR1020197024015A Active KR102610764B1 (ko) 2017-01-20 2018-01-19 암을 치료하기 위한 카보잔티닙 및 아테졸리주맙의 조합

Country Status (15)

Country Link
US (2) US11198731B2 (enExample)
EP (1) EP3570840B1 (enExample)
JP (3) JP7222895B2 (enExample)
KR (2) KR20230169458A (enExample)
CN (4) CN117771363A (enExample)
AU (2) AU2018210397B2 (enExample)
BR (1) BR112019015011A2 (enExample)
CA (1) CA3049452A1 (enExample)
ES (1) ES3031468T3 (enExample)
IL (1) IL268138B (enExample)
MA (1) MA47310A (enExample)
MX (2) MX389966B (enExample)
UA (1) UA126970C2 (enExample)
WO (1) WO2018136796A1 (enExample)
ZA (1) ZA201904652B (enExample)

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MA40386A (fr) 2014-07-31 2016-02-04 Exelixis Inc Procédé de préparation de cabozantinib marqué au fluor-18 et d'analogues de celui-ci
RU2748549C2 (ru) 2016-04-15 2021-05-26 Экселиксис, Инк. Способ лечения почечно-клеточного рака с использованием n-(4-(6,7-диметоксихинолин-4-илокси)фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида, (2s)-гидроксибутандиоата
CN110267960B (zh) 2017-01-18 2022-04-26 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
CA3049452A1 (en) * 2017-01-20 2018-07-26 Gisela Schwab Combinations of cabozantinib and atezolizumab to treat cancer
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TW201938169A (zh) 2018-01-18 2019-10-01 美商亞雷生物製藥股份有限公司 作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN111971286B (zh) 2018-01-18 2023-04-14 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
CN117624045A (zh) 2018-01-26 2024-03-01 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
CN113056282A (zh) * 2018-09-05 2021-06-29 文特里亚生物科学公司 免疫球蛋白a的制剂
ES2922314T3 (es) 2018-09-10 2022-09-13 Array Biopharma Inc Compuestos heterocíclicos condensados como inhibidores de cinasa RET
TW202207940A (zh) * 2020-04-14 2022-03-01 美商健生生物科技公司 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物
CN116437954A (zh) * 2020-07-31 2023-07-14 埃克塞里艾克西斯公司 用于治疗癌症的组合
US20230314440A1 (en) * 2020-08-21 2023-10-05 Exelixis, Inc. Method of treating cancer
EP4308243A4 (en) * 2021-03-19 2025-02-26 Merck Sharp & Dohme LLC METHODS FOR TREATING CANCER WITH ANTI-ILT3 ANTIBODIES
US11620580B2 (en) * 2021-04-01 2023-04-04 Banjo Health Inc. Methods and systems for probabilistic filtering of candidate intervention representations
AU2024215796A1 (en) 2023-01-31 2025-05-15 Handa Oncology, Llc Improved cabozantinib compositions and methods of use

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KR101733773B1 (ko) * 2009-01-16 2017-05-10 엑셀리시스, 인코포레이티드 N-(4-{〔6,7-비스(메틸옥시)퀴놀린-4-일〕옥시}페닐)-n'-(4-플루오로페닐)사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
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RU2748549C2 (ru) 2016-04-15 2021-05-26 Экселиксис, Инк. Способ лечения почечно-клеточного рака с использованием n-(4-(6,7-диметоксихинолин-4-илокси)фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида, (2s)-гидроксибутандиоата
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CA3049452A1 (en) * 2017-01-20 2018-07-26 Gisela Schwab Combinations of cabozantinib and atezolizumab to treat cancer

Also Published As

Publication number Publication date
EP3570840B1 (en) 2025-03-19
CN110352057A (zh) 2019-10-18
US11198731B2 (en) 2021-12-14
CN117205312A (zh) 2023-12-12
US20220056138A1 (en) 2022-02-24
CN117771363A (zh) 2024-03-29
ZA201904652B (en) 2024-11-27
JP2024019720A (ja) 2024-02-09
IL268138B (en) 2022-08-01
JP2020514311A (ja) 2020-05-21
CN117205313A (zh) 2023-12-12
EP3570840A1 (en) 2019-11-27
JP7222895B2 (ja) 2023-02-15
AU2024203472A1 (en) 2024-06-13
MX389966B (es) 2025-03-20
WO2018136796A1 (en) 2018-07-26
MX2022001718A (es) 2022-03-11
NZ755494A (en) 2025-06-27
MX2019008032A (es) 2019-12-16
KR20190107103A (ko) 2019-09-18
US20190352403A1 (en) 2019-11-21
AU2018210397A1 (en) 2019-07-25
KR102610764B1 (ko) 2023-12-07
AU2018210397B2 (en) 2024-02-29
CA3049452A1 (en) 2018-07-26
ES3031468T3 (en) 2025-07-09
UA126970C2 (uk) 2023-03-01
IL268138A (en) 2019-09-26
MA47310A (fr) 2019-11-27
JP2022121594A (ja) 2022-08-19
BR112019015011A2 (pt) 2020-04-28

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