KR20230169172A - 질량 분광법에 의한 인슐린-유사 성장 인자-i 변이체의 식별화 및 정량화 - Google Patents

질량 분광법에 의한 인슐린-유사 성장 인자-i 변이체의 식별화 및 정량화 Download PDF

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KR20230169172A
KR20230169172A KR1020237035826A KR20237035826A KR20230169172A KR 20230169172 A KR20230169172 A KR 20230169172A KR 1020237035826 A KR1020237035826 A KR 1020237035826A KR 20237035826 A KR20237035826 A KR 20237035826A KR 20230169172 A KR20230169172 A KR 20230169172A
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igf
sample
variants
mass
ions
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Korean (ko)
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이에브겐 모토리킨
니겔 클라케
마이클 제이. 맥파울
젠그루 우
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퀘스트 다이아그노스틱스 인베스트먼츠 엘엘씨
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Publication of KR20230169172A publication Critical patent/KR20230169172A/ko
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
KR1020237035826A 2021-03-19 2022-03-18 질량 분광법에 의한 인슐린-유사 성장 인자-i 변이체의 식별화 및 정량화 Pending KR20230169172A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163163502P 2021-03-19 2021-03-19
US63/163,502 2021-03-19
PCT/US2022/020906 WO2022198020A1 (en) 2021-03-19 2022-03-18 Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry

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KR20230169172A true KR20230169172A (ko) 2023-12-15

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US (2) US12222354B2 (enExample)
EP (1) EP4308923A4 (enExample)
JP (1) JP2024515443A (enExample)
KR (1) KR20230169172A (enExample)
CN (1) CN117178188A (enExample)
CA (1) CA3212218A1 (enExample)
WO (1) WO2022198020A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117589998B (zh) * 2023-10-09 2025-11-18 融智生物科技(青岛)有限公司 胰岛素样生长因子i变体的定量检测试剂盒
CN117589997B (zh) * 2023-10-09 2025-11-21 融智生物科技(青岛)有限公司 Igf-1变体的定量检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080064044A9 (en) 1995-05-23 2008-03-13 Nelson Randall W Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods
US20030027216A1 (en) * 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
EP1791551B1 (en) 2004-08-30 2020-02-26 Ipsen Biopharmaceuticals, Inc. Method and device for diagnosing and treating insulin-like growth factor deficiency disorders
EP1674113A1 (en) 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
ES2453108T3 (es) 2007-08-06 2014-04-04 Orion Genomics, Llc Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
EP2396429B1 (en) 2009-02-11 2015-05-27 Orion Genomics, LLC Combinations of polymorphisms for determining allele-specific expression of igf2
EP3095457B1 (en) 2009-11-05 2018-05-16 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i with high-resolution mass spectrometry
WO2015106224A2 (en) * 2014-01-12 2015-07-16 Hugh Mctavish Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
CN109957000B (zh) * 2017-12-14 2022-08-02 南开大学 一种促进细胞增殖的多肽衍生物及其制备方法及应用

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EP4308923A4 (en) 2025-01-08
EP4308923A1 (en) 2024-01-24
JP2024515443A (ja) 2024-04-10
BR112023018869A2 (pt) 2023-12-05
CN117178188A (zh) 2023-12-05
WO2022198020A1 (en) 2022-09-22
US20220299524A1 (en) 2022-09-22
US12222354B2 (en) 2025-02-11
CA3212218A1 (en) 2022-09-22
US20250155448A1 (en) 2025-05-15

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