CA3212218A1 - Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry - Google Patents

Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry Download PDF

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Publication number
CA3212218A1
CA3212218A1 CA3212218A CA3212218A CA3212218A1 CA 3212218 A1 CA3212218 A1 CA 3212218A1 CA 3212218 A CA3212218 A CA 3212218A CA 3212218 A CA3212218 A CA 3212218A CA 3212218 A1 CA3212218 A1 CA 3212218A1
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CA
Canada
Prior art keywords
igf
mass
variants
sample
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3212218A
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English (en)
French (fr)
Inventor
Ievgen MOTORYKIN
Nigel Clarke
Michael J. MCPHAUL
Zengru WU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quest Diagnostics Investments LLC
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Quest Diagnostics Investments LLC
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Publication date
Application filed by Quest Diagnostics Investments LLC filed Critical Quest Diagnostics Investments LLC
Publication of CA3212218A1 publication Critical patent/CA3212218A1/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CA3212218A 2021-03-19 2022-03-18 Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry Pending CA3212218A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163163502P 2021-03-19 2021-03-19
US63/163,502 2021-03-19
PCT/US2022/020906 WO2022198020A1 (en) 2021-03-19 2022-03-18 Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry

Publications (1)

Publication Number Publication Date
CA3212218A1 true CA3212218A1 (en) 2022-09-22

Family

ID=83284520

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3212218A Pending CA3212218A1 (en) 2021-03-19 2022-03-18 Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry

Country Status (7)

Country Link
US (2) US12222354B2 (enExample)
EP (1) EP4308923A4 (enExample)
JP (1) JP2024515443A (enExample)
KR (1) KR20230169172A (enExample)
CN (1) CN117178188A (enExample)
CA (1) CA3212218A1 (enExample)
WO (1) WO2022198020A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117589998B (zh) * 2023-10-09 2025-11-18 融智生物科技（青岛）有限公司 胰岛素样生长因子i变体的定量检测试剂盒
CN117589997B (zh) * 2023-10-09 2025-11-21 融智生物科技（青岛）有限公司 Igf-1变体的定量检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080064044A9 (en) 1995-05-23 2008-03-13 Nelson Randall W Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods
US20030027216A1 (en) * 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
EP1791551B1 (en) 2004-08-30 2020-02-26 Ipsen Biopharmaceuticals, Inc. Method and device for diagnosing and treating insulin-like growth factor deficiency disorders
EP1674113A1 (en) 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
ES2453108T3 (es) 2007-08-06 2014-04-04 Orion Genomics, Llc Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
EP2396429B1 (en) 2009-02-11 2015-05-27 Orion Genomics, LLC Combinations of polymorphisms for determining allele-specific expression of igf2
EP3095457B1 (en) 2009-11-05 2018-05-16 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i with high-resolution mass spectrometry
WO2015106224A2 (en) * 2014-01-12 2015-07-16 Hugh Mctavish Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof
CN109957000B (zh) * 2017-12-14 2022-08-02 南开大学 一种促进细胞增殖的多肽衍生物及其制备方法及应用

Also Published As

Publication number Publication date
EP4308923A4 (en) 2025-01-08
EP4308923A1 (en) 2024-01-24
JP2024515443A (ja) 2024-04-10
BR112023018869A2 (pt) 2023-12-05
KR20230169172A (ko) 2023-12-15
CN117178188A (zh) 2023-12-05
WO2022198020A1 (en) 2022-09-22
US20220299524A1 (en) 2022-09-22
US12222354B2 (en) 2025-02-11
US20250155448A1 (en) 2025-05-15

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