KR20230160804A - 프로드러그 화합물 및 이의 제조 방법과 용도 - Google Patents

프로드러그 화합물 및 이의 제조 방법과 용도 Download PDF

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KR20230160804A
KR20230160804A KR1020237030622A KR20237030622A KR20230160804A KR 20230160804 A KR20230160804 A KR 20230160804A KR 1020237030622 A KR1020237030622 A KR 1020237030622A KR 20237030622 A KR20237030622 A KR 20237030622A KR 20230160804 A KR20230160804 A KR 20230160804A
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group
compound
molecule
pharmaceutically acceptable
substituted
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KR1020237030622A
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Korean (ko)
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유안샨 야오
아오 리
준웨이 시
구오킹 카오
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밍훼이 파마슈티컬 (항저우) 리미티드
밍훼이 파마슈티컬 (상하이) 리미티드
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Publication of KR20230160804A publication Critical patent/KR20230160804A/ko

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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