KR20230159367A - 키나아제 약물 내성 돌연변이와 관련된 질병의 치료에있어서의 헤테로사이클릭 화합물의 용도 및 그 방법 - Google Patents
키나아제 약물 내성 돌연변이와 관련된 질병의 치료에있어서의 헤테로사이클릭 화합물의 용도 및 그 방법 Download PDFInfo
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- KR20230159367A KR20230159367A KR1020237025273A KR20237025273A KR20230159367A KR 20230159367 A KR20230159367 A KR 20230159367A KR 1020237025273 A KR1020237025273 A KR 1020237025273A KR 20237025273 A KR20237025273 A KR 20237025273A KR 20230159367 A KR20230159367 A KR 20230159367A
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- PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- FIHKAOVJLKXDPF-UHFFFAOYSA-N tert-butyl 3-[5-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]pyridin-2-yl]-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Chemical compound CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3=CN=C(C=C3)N4CC5CC(C4)N5C(=O)OC(C)(C)C FIHKAOVJLKXDPF-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
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|---|---|---|---|
| CN202110316525.6 | 2021-03-24 | ||
| CN202110316525 | 2021-03-24 | ||
| CN2022074619 | 2022-01-28 | ||
| CN202210109766.8 | 2022-01-28 | ||
| CNPCT/CN2022/074619 | 2022-01-28 | ||
| CN202210109766 | 2022-01-28 | ||
| PCT/CN2022/081890 WO2022199503A1 (zh) | 2021-03-24 | 2022-03-21 | 杂环化合物治疗与激酶耐药突变相关的疾病的用途和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230159367A true KR20230159367A (ko) | 2023-11-21 |
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Family Applications (1)
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| KR1020237025273A Pending KR20230159367A (ko) | 2021-03-24 | 2022-03-21 | 키나아제 약물 내성 돌연변이와 관련된 질병의 치료에있어서의 헤테로사이클릭 화합물의 용도 및 그 방법 |
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| US (1) | US20250268897A1 (enExample) |
| EP (1) | EP4316490A4 (enExample) |
| JP (1) | JP2024511389A (enExample) |
| KR (1) | KR20230159367A (enExample) |
| CN (1) | CN116801882A (enExample) |
| AU (1) | AU2022242476A1 (enExample) |
| WO (1) | WO2022199503A1 (enExample) |
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| JP7688690B2 (ja) * | 2020-07-28 | 2025-06-04 | スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド | ピリミジン系化合物の塩、結晶形およびその調製方法 |
| CN120897743A (zh) | 2023-05-19 | 2025-11-04 | 四川科伦博泰生物医药股份有限公司 | 杂环化合物治疗与ret基因改变相关疾病的用途和方法 |
| WO2026017002A1 (zh) * | 2024-07-16 | 2026-01-22 | 四川科伦博泰生物医药股份有限公司 | 以杂环化合物为活性成分的药物组合物、其制备方法及用途 |
| GB202410599D0 (en) * | 2024-07-19 | 2024-09-04 | Ellipses Pharma Ltd | Therapeutics useful synergistic combinations |
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| WO2012154518A1 (en) * | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
| WO2018017983A1 (en) * | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| TWI791053B (zh) * | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| EP3740491A1 (en) * | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| WO2020114474A1 (zh) * | 2018-12-06 | 2020-06-11 | 苏州信诺维医药科技有限公司 | 一种杂环化合物、其应用及含其的药物组合物 |
| JP7615056B2 (ja) | 2019-02-19 | 2025-01-16 | スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド | 複素環化合物、これを含む薬物組成物、その製造方法および使用 |
| MX2021014273A (es) * | 2019-05-21 | 2022-01-06 | Voronoi Inc | Derivado de heteroarilo que contiene n y composicion farmaceutica que lo comprende como principio activo para la prevencion o el tratamiento de cancer. |
| CN113490670B (zh) * | 2019-08-05 | 2023-06-02 | 北京志健金瑞生物医药科技有限公司 | 含氮多环稠环类化合物,其药物组合物、制备方法和用途 |
-
2022
- 2022-03-21 WO PCT/CN2022/081890 patent/WO2022199503A1/zh not_active Ceased
- 2022-03-21 CN CN202280011390.5A patent/CN116801882A/zh active Pending
- 2022-03-21 AU AU2022242476A patent/AU2022242476A1/en active Pending
- 2022-03-21 KR KR1020237025273A patent/KR20230159367A/ko active Pending
- 2022-03-21 EP EP22774164.2A patent/EP4316490A4/en active Pending
- 2022-03-21 JP JP2023557142A patent/JP2024511389A/ja active Pending
- 2022-03-21 US US18/283,673 patent/US20250268897A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4316490A1 (en) | 2024-02-07 |
| EP4316490A4 (en) | 2025-03-05 |
| AU2022242476A1 (en) | 2023-10-26 |
| WO2022199503A1 (zh) | 2022-09-29 |
| JP2024511389A (ja) | 2024-03-13 |
| CN116801882A (zh) | 2023-09-22 |
| US20250268897A1 (en) | 2025-08-28 |
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