KR20230141922A - T 세포를 자극 및 증대시키는 조성물 및 방법 - Google Patents

T 세포를 자극 및 증대시키는 조성물 및 방법 Download PDF

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KR20230141922A
KR20230141922A KR1020237032483A KR20237032483A KR20230141922A KR 20230141922 A KR20230141922 A KR 20230141922A KR 1020237032483 A KR1020237032483 A KR 1020237032483A KR 20237032483 A KR20237032483 A KR 20237032483A KR 20230141922 A KR20230141922 A KR 20230141922A
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cells
cell
antibody
hours
cell population
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Korean (ko)
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양빙 자오
샤오준 리우
칼 에이치. 준
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더 트러스티스 오브 더 유니버시티 오브 펜실베니아
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Priority to KR1020267017769A priority Critical patent/KR20260093431A/ko
Publication of KR20230141922A publication Critical patent/KR20230141922A/ko
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A61K39/4611—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C12N2501/50—Cell markers; Cell surface determinants
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KR1020237032483A 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법 Ceased KR20230141922A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267017769A KR20260093431A (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462073268P 2014-10-31 2014-10-31
US62/073,268 2014-10-31
PCT/US2015/058228 WO2016069993A1 (en) 2014-10-31 2015-10-30 Compositions and methods of stimulating and expanding t cells
KR1020177014806A KR102583138B1 (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

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KR1020177014806A Division KR102583138B1 (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

Related Child Applications (1)

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KR1020267017769A Division KR20260093431A (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

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KR20230141922A true KR20230141922A (ko) 2023-10-10

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KR1020237032483A Ceased KR20230141922A (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법
KR1020177014806A Active KR102583138B1 (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법
KR1020267017769A Pending KR20260093431A (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

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KR1020177014806A Active KR102583138B1 (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법
KR1020267017769A Pending KR20260093431A (ko) 2014-10-31 2015-10-30 T 세포를 자극 및 증대시키는 조성물 및 방법

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US (2) US11471487B2 (cg-RX-API-DMAC7.html)
EP (1) EP3217989B1 (cg-RX-API-DMAC7.html)
JP (1) JP6884697B2 (cg-RX-API-DMAC7.html)
KR (3) KR20230141922A (cg-RX-API-DMAC7.html)
CN (1) CN107106609A (cg-RX-API-DMAC7.html)
AU (1) AU2015339106B2 (cg-RX-API-DMAC7.html)
CA (1) CA2966035A1 (cg-RX-API-DMAC7.html)
ES (1) ES2910227T3 (cg-RX-API-DMAC7.html)
WO (1) WO2016069993A1 (cg-RX-API-DMAC7.html)

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EP3575319A4 (en) * 2016-12-30 2021-03-10 Shanghai Sinobio Biotech Co., Ltd. BIFUNCTIONAL MOLECULE AND USE OF IT
US11535666B2 (en) 2016-12-30 2022-12-27 Cytocares (Shanghai) Inc. Trifunctional molecule and application thereof
EP3633029A4 (en) * 2017-05-26 2021-06-09 Green Cross Lab Cell Corporation METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL
KR102546681B1 (ko) 2017-09-01 2023-06-22 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화
CA3113125A1 (en) 2018-09-28 2020-04-02 Octane Biotech Inc. Magnetic separation
JP7179986B2 (ja) 2018-11-14 2022-11-29 グリーン クロス ラボ セル コーポレーション 形質転換されたｔ細胞を用いた臍帯血由来のナチュラルキラー細胞の培養方法
JP7598864B2 (ja) 2018-12-21 2024-12-12 ロンザ ウォーカーズヴィル，インコーポレーテッド ウイルスベクターの自動産生方法
EP3898932A4 (en) 2018-12-21 2022-08-03 Octane Biotech Inc. CAROUSEL FOR MODULAR BIOLOGICAL PRODUCTION UNITS
SG11202108473XA (en) 2019-02-08 2021-09-29 Lonza Walkersville Inc Cell concentration methods and devices for use in automated bioreactors
EP4048773A4 (en) 2019-10-24 2024-01-03 Octane Biotech Inc. CELL CULTURE CHAMBER WITH IMPROVED CELL CONTACT SURFACES
JP2023501443A (ja) 2019-11-11 2023-01-18 ロンザ ウォーカーズヴィル，インコーポレーテッド 自動化された細胞処理のための品質制御方法
WO2021108543A1 (en) * 2019-11-27 2021-06-03 The Trustees Of The University Of Pennsylvania Anti-cd3 scfv and cytokine producing artificial antigen presenting cells
CN114606263B (zh) * 2022-05-11 2022-09-06 上海优替济生生物医药有限公司 分离的核酸分子及其用途

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