KR20230138223A - A traditional Chinese medicine - Google Patents
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 206010049949 Intercostal neuralgia Diseases 0.000 claims abstract description 22
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 17
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 17
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 17
- 229940010454 licorice Drugs 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 7
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 6
- 244000170916 Paeonia officinalis Species 0.000 claims abstract 3
- 241000202807 Glycyrrhiza Species 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 235000021419 vinegar Nutrition 0.000 claims description 3
- 239000000052 vinegar Substances 0.000 claims description 3
- 241001671554 Asparagus aethiopicus Species 0.000 claims description 2
- 235000014375 Curcuma Nutrition 0.000 claims description 2
- 244000164480 Curcuma aromatica Species 0.000 claims description 2
- 244000061508 Eriobotrya japonica Species 0.000 claims description 2
- 235000009008 Eriobotrya japonica Nutrition 0.000 claims description 2
- 241000305491 Gastrodia elata Species 0.000 claims description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 241000736199 Paeonia Species 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000002513 Flank pain Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Abstract
본 발명은 시호 10 중량부, 교고람 10 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 8 중량부를 포함하는 약재로부터 제조된, 늑간 신경통 치료용 전통 중약을 제공한다. 임상적인 실험은 본 발명이 적절한 약재와 그 비율을 선택함으로써 늑간 신경통을 치료하는데 주목할 만한 효과가 있으며, 안전하고도 독성이 없음을 보여주었다.The present invention provides a traditional Chinese medicine for the treatment of intercostal neuralgia prepared from medicinal materials containing 10 parts by weight of Siho, 10 parts by weight of Gyogoram, 12 parts by weight of Jeok Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 8 parts by weight of Ukgeum. do. Clinical experiments have shown that the present invention has a notable effect in treating intercostal neuralgia by selecting appropriate medicinal ingredients and their ratios, and is safe and non-toxic.
Description
본 발명은 전통 중약에 관한 것으로, 특히 늑간 신경통 치료용 전통 중약 및 이의 제조방법에 관한 것이다.The present invention relates to traditional Chinese medicine, and particularly to traditional Chinese medicine for treating intercostal neuralgia and a method for producing the same.
늑간 신경통(intercostal neuralgia)은 한쪽 또는 양쪽 옆구리 통증을 주요 임상적 징후로 하는 질환을 말하며, 전통 중의학에서 옆구리 통증의 범주에 속하는 질환이다. 전통 중의학적 치료는 주로 간(liver)에서의 기(氣, qi)의 정체, 기 및 혈류의 정체, 간에서의 음(陰, yin)의 결핍 등의 양상으로 나타나는 증상 구별에 기초하여, 간을 진정시키고 기를 조절하며, 혈액 순환 촉진과 혈액의 정체를 제거하고, 음과 피를 보양하며 간을 부드럽게 하는 방식으로 이루어진다.Intercostal neuralgia refers to a disease whose main clinical symptom is pain in one or both flanks, and is a disease that falls into the category of flank pain in traditional Chinese medicine. Traditional Chinese medicine treatment is mainly based on distinguishing symptoms that appear in the form of stagnation of qi in the liver, stagnation of qi and blood flow, and deficiency of yin in the liver. It is done by calming the body, regulating energy, promoting blood circulation, eliminating blood stagnation, nourishing yin and blood, and softening the liver.
현재까지 늑간 신경통의 치료를 위한 안전성과 효능이 잘 알려진 전통 중약 및 양약이 부족한 실정이다.To date, there is a lack of traditional Chinese and Western medicines with well-known safety and efficacy for the treatment of intercostal neuralgia.
본 발명은 늑간 신경통 치료용 전통 중약 및 이의 제조방법을 제공하는 것을 목적으로 한다. 적합한 전통 중약 및 그 비율의 선택을 통해, 늑간 신경통 환자의 재활에 도움이 되는 유의적인 효과를 얻을 수 있으며, 이는 안전하면서도 독성이 없다.The purpose of the present invention is to provide traditional Chinese medicine for treating intercostal neuralgia and a method for producing the same. Through the selection of appropriate traditional Chinese medicine and its proportions, significant effects can be achieved to help rehabilitate patients with intercostal neuralgia, which are safe and non-toxic.
상기 목적을 달성하기 위해, 본 발명은 시호(, Asparagus sprengeri) 8-10 중량부, 교고람(, Gastrodia elata) 8-10 중량부, 적작약(, Radix pseudostellariae) 10-12중량부, 생감초(, Loquat) 6-8 중량부, 초지각(, fried fructus aurantii) 6-8 중량부 및 욱금(, curcuma) 6-8 중량부를 포함하는 약재(medicinal material)로부터 제조된, 늑간 신경통 치료용 전통 중약을 제공한다.In order to achieve the above object, the present invention has the symbol ( , Asparagus sprengeri) 8-10 parts by weight, Kyogoram ( , Gastrodia elata) 8-10 parts by weight, red peony ( , Radix pseudostellariae) 10-12 parts by weight, raw licorice ( , Loquat) 6-8 parts by weight, super crust ( , fried fructus aurantii) 6-8 parts by weight and ukgeum ( Provides a traditional Chinese medicine for the treatment of intercostal neuralgia prepared from a medicinal material containing 6-8 parts by weight of curcuma.
바람직한 실시형태에서, 본 발명의 늑간 신경통 치료용 전통 중약은 시호 10 중량부, 교고람 10 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 8 중량부를 포함하는 약재로부터 제조된다.In a preferred embodiment, the traditional Chinese medicine for treating intercostal neuralgia of the present invention comprises 10 parts by weight of Siho, 10 parts by weight of Gyogoram, 12 parts by weight of Red Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 8 parts by weight of Ukgeum. It is manufactured from
바람직한 실시형태에서, 본 발명의 늑간 신경통 치료용 전통 중약은 시호 9 중량부, 교고람 9 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 8 중량부를 포함하는 약재로부터 제조된다.In a preferred embodiment, the traditional Chinese medicine for treating intercostal neuralgia of the present invention is a herbal medicine comprising 9 parts by weight of Siho, 9 parts by weight of Gyogoram, 12 parts by weight of Red Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 8 parts by weight of Ukgeum. It is manufactured from
바람직한 실시형태에서, 본 발명의 늑간 신경통 치료용 전통 중약은 시호 10 중량부, 교고람 10 중량부, 적작약 10 중량부, 생감초 6 중량부, 초지각 6 중량부 및 욱금 8 중량부를 포함하는 약재로부터 제조된다.In a preferred embodiment, the traditional Chinese medicine for treating intercostal neuralgia of the present invention is a herbal medicine comprising 10 parts by weight of Siho, 10 parts by weight of Gyogoram, 10 parts by weight of Red Peony, 6 parts by weight of raw licorice, 6 parts by weight of Chojigak, and 8 parts by weight of Ukgeum. It is manufactured from
바람직한 실시형태에서, 본 발명의 늑간 신경통 치료용 전통 중약은 시호 9 중량부, 교고람 10 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 6 중량부를 포함하는 약재로부터 제조된다.In a preferred embodiment, the traditional Chinese medicine for treating intercostal neuralgia of the present invention comprises 9 parts by weight of Siho, 10 parts by weight of Gyogoram, 12 parts by weight of Red Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 6 parts by weight of Ukgeum. It is manufactured from
늑간 신경통 치료용 전통 중약의 제조방법은 하기 단계를 포함한다.The preparation method of traditional Chinese medicine for treating intercostal neuralgia includes the following steps.
(1) 시호, 교고람, 적작약, 생감초 및 욱금을 용기에 넣고, 8-10배 양의 증류수를 첨가하여 이에 5-6시간 침지한 뒤, 3-4시간 동안 끓이고 추출한 다음; 다시 6-8배 양의 증류수를 첨가하고, 2-3시간 끓이고 추출한 후; 최종적으로, 4-6배 양의 증류수를 첨가하고, 가열한 후 1-2시간 끓이고 추출한 다음; 상기 3종의 추출물들을 합하고 여과하여 예비 여과액을 얻는 단계; (2) 초지각을 미세 분말로 분쇄하고, 이를 용기에 넣은 후, 진한 알코올을 첨가하고, 약간의 꿀을 첨가한 뒤, 이를 골고루 섞은 다음, 상기 용기를 밀봉하고, 15-25분간 물로 중탕(heating by water)하여 예비 페이스트를 얻는 단계; 및 (3) 상기 단계 (1) 내지 (2)에서 제조된 여과액과 페이스트를 혼합하고, 현대식 첨단 제약 기술을 사용하여 캡슐을 제조함으로써 본 발명의 전통 중약 제제를 수득하는 단계.(1) Put Shiho, Gyogoram, Red Peony, Raw Licorice and Ukgeum in a container, add 8-10 times the amount of distilled water, soak them for 5-6 hours, boil for 3-4 hours and extract; Add 6-8 times the amount of distilled water again, boil for 2-3 hours and extract; Finally, 4-6 times the amount of distilled water was added, heated, boiled for 1-2 hours, and then extracted; Combining and filtering the three extracts to obtain a prefiltrate; (2) Grind the vinegar into fine powder, put it in a container, add concentrated alcohol, add a little honey, mix it evenly, seal the container, and boil in water for 15-25 minutes ( Obtaining a preliminary paste by heating by water; and (3) mixing the filtrate and paste prepared in steps (1) to (2) above, and manufacturing capsules using modern, high-tech pharmaceutical technology to obtain the traditional Chinese medicine preparation of the present invention.
종래 기술과 비교할 때, 본 발명은 하기의 유리한 효과를 가진다.Compared with the prior art, the present invention has the following advantageous effects.
1. 본 발명의 전통 중약 제제는 늑간 신경통 치료에 대한 치료율이 높고, 안전하면서도 무독성이며, 관련 합병증을 예방할 수 있다. 약재의 양립성(compatibility)은 엄격하여, 의학적 양립성으로부터 비롯된 시너지를 온전히 이용하면서도, 본연의 효능을 상쇄하거나 약화시키는 의학적 효과의 상호 제한을 피해야 한다. 의약품의 독성 및 부작용의 강도를 줄이거나 없앨 수 있는 의학적 양립성 적용의 선택에 더 관심을 기울여 의학적 양립성으로부터 기인하는 독성 반응이나 강한 부작용을 확실하게 피해야 한다. 과학적 양립성을 통해, 복잡하고 급속하게 변하는 상황에서도 본 발명은 합리적인 치료를 효과적으로 구성하고 수행하여 질환을 없앨 수 있을 뿐만 아니라, 질환의 전염과 장기(viscera)의 내부 침범을 예방하는데 우수한 예방적 효과를 가져 임상적 적용에 있어 큰 가치를 지닌다.1. The traditional Chinese medicine preparation of the present invention has a high cure rate for the treatment of intercostal neuralgia, is safe and non-toxic, and can prevent related complications. Compatibility of medicinal substances must be strict, so as to fully exploit the synergy resulting from medical compatibility, while avoiding mutual limitations of medical effects that offset or weaken the original efficacy. Pay more attention to the selection of medical compatibility applications, which can reduce or eliminate the toxicity and intensity of side effects of medicines, so as to ensure that toxic reactions or strong side effects resulting from medical compatibility are avoided. Through scientific compatibility, even in complex and rapidly changing situations, the present invention not only eliminates the disease by effectively organizing and performing rational treatment, but also has an excellent preventive effect in preventing the spread of the disease and internal invasion of organs (viscera). It has great value in clinical application.
2. 본 발명의 전통 중약 제제는 고품질의 전통 중약으로 만들어지고, 선택된 전통 중약의 양립성이 적절하여 전통 중의학 및 현대 의학의 연구 이론에 부합하며, 현대식 제약 기술을 사용하여 제조되어 안전하며, 독성 및 부작용이 없고, 증상 모두를 치료하는 목적을 달성하며, 임상적으로 적용할 가치가 있다.2. The traditional Chinese medicine preparation of the present invention is made of high-quality traditional Chinese medicine, has appropriate compatibility with selected traditional Chinese medicine, conforms to the research theories of traditional Chinese medicine and modern medicine, and is manufactured using modern pharmaceutical technology, so it is safe, non-toxic and It has no side effects, achieves the purpose of treating all symptoms, and is worthy of clinical application.
본 발명을 더욱 잘 이해하고 수행하기 위하여, 본 발명을 이하에서 구체적인 실시형태로 더 설명한다.In order to better understand and practice the present invention, the present invention is further described below in specific embodiments.
실시예 1Example 1
시호 10 중량부, 교고람 10 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 8 중량부를 칭량하였다. 하기 단계를 포함하였다.10 parts by weight of Siho, 10 parts by weight of Gyogoram, 12 parts by weight of Jeok Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 8 parts by weight of Ukgeum were weighed. It included the following steps.
(1) 시호, 교고람, 적작약, 생감초 및 욱금을 용기에 넣고, 8-10배 양의 증류수를 첨가하여 이에 5-6시간 침지한 뒤, 3-4시간 동안 끓이고 추출한 다음; 다시 6-8배 양의 증류수를 첨가하고, 2-3시간 끓이고 추출한 후; 최종적으로, 4-6배 양의 증류수를 첨가하고, 가열한 후 1-2시간 끓이고 추출한 다음; 상기 3종의 추출물들을 합하고 여과하여 예비 여과액을 얻는 단계; (2) 초지각을 미세 분말로 분쇄하고, 이를 용기에 넣은 후, 진한 알코올을 첨가하고, 약간의 꿀을 첨가한 뒤, 이를 골고루 섞은 다음, 상기 용기를 밀봉하고, 15-25분간 물로 중탕하여 예비 페이스트를 얻는 단계; 및 (3) 상기 단계 (1) 내지 (2)에서 제조된 여과액과 페이스트를 혼합하고, 현대식 첨단 제약 기술을 사용하여 캡슐을 제조함으로써 본 발명의 전통 중약 제제를 수득하는 단계.(1) Put Shiho, Gyogoram, Red Peony, Raw Licorice and Ukgeum in a container, add 8-10 times the amount of distilled water, soak them for 5-6 hours, boil for 3-4 hours and extract; Add 6-8 times the amount of distilled water again, boil for 2-3 hours and extract; Finally, 4-6 times the amount of distilled water was added, heated, boiled for 1-2 hours, and then extracted; Combining and filtering the three extracts to obtain a prefiltrate; (2) Grind the vinegar into fine powder, put it in a container, add concentrated alcohol, add a little honey, mix it well, seal the container, and boil in water for 15-25 minutes. Obtaining a preliminary paste; and (3) mixing the filtrate and paste prepared in steps (1) to (2) above, and manufacturing capsules using modern, high-tech pharmaceutical technology to obtain the traditional Chinese medicine preparation of the present invention.
사용법 및 복용량: 경구 투약, 하루 2회, 아침에 한번 저녁에 한번, 각각 1캡슐씩, 식사 후 따뜻한 끓인 물과 함께 복용하도록 하였다.Usage and dosage: Oral administration, twice a day, once in the morning and once in the evening, 1 capsule each, taken with warm boiled water after a meal.
실시예 2Example 2
시호 9 중량부, 교고람 9 중량부, 적작약 10 중량부, 생감초 6 중량부, 초지각 6 중량부 및 욱금 8 중량부를 칭량하였다. 9 parts by weight of Siho, 9 parts by weight of Gyogoram, 10 parts by weight of Red Peony, 6 parts by weight of raw licorice, 6 parts by weight of Chojigak, and 8 parts by weight of Ukgeum were weighed.
본 실시예의 제조 방법, 사용법 및 복용량은 실시예 1과 동일하였다.The preparation method, usage method, and dosage of this example were the same as Example 1.
실시예 3Example 3
시호 9 중량부, 교고람 10 중량부, 적작약 12 중량부, 생감초 8 중량부, 초지각 8 중량부 및 욱금 6 중량부를 칭량하였다. 9 parts by weight of Siho, 10 parts by weight of Gyogoram, 12 parts by weight of Jeok Peony, 8 parts by weight of raw licorice, 8 parts by weight of Chojigak, and 6 parts by weight of Ukgeum were weighed.
본 실시예의 제조 방법, 사용법 및 복용량은 실시예 1과 동일하였다.The preparation method, usage method, and dosage of this example were the same as Example 1.
임상 데이터:Clinical data:
1. 사례 선정(Case Selection)1. Case Selection
늑간 신경통 환자 56명이 임상 관찰 대상으로 선정됐다. 임상 증상은 늑간 신경통의 진단 및 치료 기준을 충족했다. 환자들은 치료군과 대조군으로 무작위로 나뉘었다. 치료군에 28건, 대조군에 28건의 사례가 있었다. 치료군과 대조군 내 질환의 진행 과정과 증상의 심각도는 기본적으로 동일해 유의적인 차이 및 비교가능성이 없었다.Fifty-six patients with intercostal neuralgia were selected for clinical observation. Clinical symptoms met the criteria for diagnosis and treatment of intercostal neuralgia. Patients were randomly divided into treatment and control groups. There were 28 cases in the treatment group and 28 cases in the control group. The course of the disease and the severity of symptoms in the treatment and control groups were basically the same, so there was no significant difference or comparability.
2. 의약품 선택(Medicine Selection)2. Medicine Selection
치료군은 본 발명의 실시예 1에서 제조된 전통 중약 캡슐을 경구로, 하루 2회, 아침에 한번 저녁에 한번, 각각 1캡슐씩, 식사 후 따뜻한 끓인 물과 함께 복용하였으며; 치료의 1 코스(course)은 5일이었고, 치료는 1-2 코스 동안 지속되었다.The treatment group took the traditional Chinese medicine capsule prepared in Example 1 of the present invention orally, twice a day, once in the morning and once in the evening, 1 capsule each, with warm boiled water after meals; One course of treatment was 5 days, and treatment lasted for 1-2 courses.
대조군은 통상적인 서양의학으로 치료했고, 치료 코스는 치료군과 동일했다.The control group was treated with conventional Western medicine, and the treatment course was the same as the treatment group.
두 코스 후, 두 그룹의 치료 효과를 비교하였으며, 모든 사례는 이후 6개월간 추적관찰되었다.After two courses, the treatment effects of the two groups were compared, and all cases were followed up for six months.
3. 효능 기준(Efficacy Criteria):3. Efficacy Criteria:
(1) 완치(Cured): 통증 및 그에 수반되는 증상들이 사라졌고, 반년 간의 추적 관찰 후에도 재발이 없었음.(1) Cured: Pain and accompanying symptoms disappeared, and there was no recurrence even after six months of follow-up.
(2) 개선됨(Improved): 치료 후 통증 및 그에 수반되는 증상이 상당히 개선되었음.(2) Improved: Pain and accompanying symptoms were significantly improved after treatment.
(3) 치료되지 않음(Not cured): 치료 후 통증 및 그에 수반되는 증상에 변화가 없으면 유효하지 않음.(3) Not cured: It is not effective if there is no change in pain and accompanying symptoms after treatment.
4. 결과4. Results
본 발명의 실시예 1의 전통 중약 캡슐을 복용한 치료군에서는 21건이 완치, 5건이 개선, 2건이 치료되지 않은 것으로 나타났다. 완치율은 75%, 총 유효율은 94.9%였다.In the treatment group that took the traditional Chinese medicine capsule of Example 1 of the present invention, 21 cases were completely cured, 5 cases were improved, and 2 cases were not cured. The cure rate was 75% and the total effectiveness rate was 94.9%.
대조군에서는 3건이 완치, 17건이 개선, 8건이 치료되지 않은 것으로 나타났다. 완치율은 10.7%, 총 유효율은 71.4%였다.In the control group, 3 cases were cured, 17 cases were improved, and 8 cases were not cured. The cure rate was 10.7% and the total effective rate was 71.4%.
상기 결과는 치료군의 완치율과 총 유효율이 대조군보다 유의미하게 더 높음을 보여주었다.The results showed that the cure rate and total effectiveness rate of the treatment group were significantly higher than those of the control group.
명백하게, 본 발명의 상기 실시형태들은 본 발명을 명확하게 설명하기 위한 예시일 뿐이며, 본 발명의 실시형태는 이에 제한되지 않는다. 통상의 기술자는 상기 설명에 근거하여 또 다른 상이한 형태의 변형이나 변경을 만들 수 있다. 모든 실시형태들을 본 명세서에 포함시킬 수는 없으며, 본 발명의 기술적 해결 수단으로 인한 모든 명백한 변형이나 변경은 여전히 본 발명의 보호 범위에 속한다.Obviously, the above embodiments of the present invention are only examples for clearly explaining the present invention, and the embodiments of the present invention are not limited thereto. A person skilled in the art may make other and different variations or modifications based on the above description. Not all embodiments can be included in this specification, and any obvious modification or change resulting from the technical solutions of the present invention still falls within the protection scope of the present invention.
Claims (6)
(1) 시호, 교고람, 적작약, 생감초 및 욱금을 용기에 넣고, 8-10배 양의 증류수를 첨가하여 이에 5-6시간 침지한 뒤, 3-4시간 동안 끓이고 추출한 다음; 다시 6-8배 양의 증류수를 첨가하고, 2-3시간 끓이고 추출한 후; 최종적으로, 4-6배 양의 증류수를 첨가하고, 가열한 후 1-2시간 끓이고 추출한 다음; 상기 3종의 추출물들을 합하고 여과하여 예비 여과액을 얻는 단계;
(2) 초지각을 미세 분말로 분쇄하고, 이를 용기에 넣은 후, 진한 알코올을 첨가하고, 약간의 꿀을 첨가한 뒤, 이를 골고루 섞은 다음, 상기 용기를 밀봉하고, 15-25분간 물로 중탕하여 예비 페이스트를 얻는 단계; 및
(3) 상기 단계 (1) 내지 (2)에서 제조된 여과액과 페이스트를 혼합하고, 현대식 첨단 제약 기술을 사용하여 캡슐을 제조함으로써 본 발명의 전통 중약 제제를 수득하는 단계.Method for producing traditional Chinese medicine for treating intercostal neuralgia, comprising the following steps:
(1) Put Shiho, Gyogoram, Red Peony, Raw Licorice and Ukgeum in a container, add 8-10 times the amount of distilled water, soak them for 5-6 hours, boil for 3-4 hours and extract; Add 6-8 times the amount of distilled water again, boil for 2-3 hours and extract; Finally, 4-6 times the amount of distilled water was added, heated, boiled for 1-2 hours, and then extracted; Combining and filtering the three extracts to obtain a prefiltrate;
(2) Grind the vinegar into fine powder, put it in a container, add concentrated alcohol, add a little honey, mix it well, seal the container, and boil in water for 15-25 minutes. Obtaining a preliminary paste; and
(3) mixing the filtrate and paste prepared in steps (1) to (2) above, and manufacturing capsules using modern, high-tech pharmaceutical technology to obtain the traditional Chinese medicine preparation of the present invention.
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