KR20230124682A - Rna를 봉입하는 아넬로바이러스 캡시드의 시험관 내어셈블리 - Google Patents
Rna를 봉입하는 아넬로바이러스 캡시드의 시험관 내어셈블리 Download PDFInfo
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Applications Claiming Priority (5)
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| US202063130360P | 2020-12-23 | 2020-12-23 | |
| US63/130,360 | 2020-12-23 | ||
| US202163147064P | 2021-02-08 | 2021-02-08 | |
| US63/147,064 | 2021-02-08 | ||
| PCT/US2021/064887 WO2022140560A1 (en) | 2020-12-23 | 2021-12-22 | In vitro assembly of anellovirus capsids enclosing rna |
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| KR20240114778A (ko) * | 2021-12-15 | 2024-07-24 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 표면이 변형된 바이러스 입자 및 모듈형 바이러스 입자 |
| WO2025007075A1 (en) * | 2023-06-29 | 2025-01-02 | Life Technologies Corporation | Molecules resistant to nuclease digestion |
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| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| KR101728655B1 (ko) | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| US9228242B2 (en) * | 2009-08-21 | 2016-01-05 | Virginia Tech Intellectual Properties, Inc. | Porcine torque teno virus vaccines and diagnosis |
| EP2653562A1 (en) * | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| IL239344B2 (en) | 2012-12-12 | 2024-06-01 | Broad Inst Inc | Systems engineering, methods and optimal guiding components for sequence manipulation |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| IL271275B1 (en) * | 2017-06-13 | 2026-04-01 | Flagship Pioneering Innovations V Inc | Preparations containing croons and their uses |
| CN111819185A (zh) | 2017-12-15 | 2020-10-23 | 旗舰创业创新第六有限责任公司 | 包含环状多核糖核苷酸的组合物及其用途 |
| MX2021006977A (es) * | 2018-12-12 | 2021-10-13 | Flagship Pioneering Innovations V Inc | Anellosomas y metodos de uso. |
| CA3119814A1 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering protein replacement therapeutic modalities |
| US11166996B2 (en) * | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
| KR20230036109A (ko) * | 2020-06-12 | 2023-03-14 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 바큘로바이러스 발현 시스템 |
| MX2022016475A (es) * | 2020-06-17 | 2023-04-11 | Flagship Pioneering Innovations V Inc | Metodos de identificacion y caracterizacion de anellovirus y usos de los mismos. |
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| US20220372519A1 (en) | 2022-11-24 |
| IL303892A (en) | 2023-08-01 |
| EP4267157A4 (en) | 2025-05-07 |
| CA3206361A1 (en) | 2022-06-30 |
| TW202235622A (zh) | 2022-09-16 |
| BR112023012460A2 (pt) | 2023-11-07 |
| MX2023007643A (es) | 2023-09-04 |
| WO2022140560A1 (en) | 2022-06-30 |
| EP4267157A1 (en) | 2023-11-01 |
| US20250257368A1 (en) | 2025-08-14 |
| JP2024501287A (ja) | 2024-01-11 |
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