KR20230111433A - A medicine for treating fatty liver - Google Patents

Abstract

Disclosed in the present invention is a herbal medicine composition for treating fatty liver disease composed of Curcuma longa, Crataegus pinnatifida, Taraxacum platycarpum, Gardenia jasminoides, Rheum rhabarbarum, Imperata cylindrical, and Glycyrrhiza uralensis according to the weight ratio. The present invention is effective in reducing fever, promoting moisture, and promoting energy and blood circulation, so it is mainly used to treat fatty liver.

Description

A medicine for treating fatty liver}

The present invention relates to a therapeutic agent for fatty liver. The therapeutic agent belongs to the pharmaceutical field as a herbal medicine.

Until now, there has been no effective drug to prevent and treat fatty liver in Western medicine. Oriental medicine can be recommended by an experienced oriental doctor. In general, it can be cured within 1 to 3 months, when B-ultrasound is the criterion for testing its effectiveness. Western medicines are frequently used to protect antioxidants, liver cells, and fat-removing agents, such as vitamins B, C, E, lecithin, ursodeoxycholic acid, silymarin, inosine, coenzyme A, reduced glutathione, taurine, carnitine orotate, gluconolactone, and some lipid-lowering drugs in the United States. There are many drugs mentioned above, but most of them still need further validation for their efficacy and safety. do

In oriental medicine, it is believed that fatty liver is mainly caused by overeating, obesity, excessive drinking, damp heat poisoning, emotional disorders, chronic diseases and weakness, accumulation of food, stagnation of qi, and prevalence of qi. Diseases involving the liver are closely related to the liver, gallbladder, spleen, stomach, kidneys and other internal organs. Many scholars view the pathogenesis of this disease as liver failure, spleen failure, internal accumulation of moist heat, sputum opacity and stagnation, hemorrhage, and eventually the formation of damp, sputum and blood clots, which block the liver, and form fatty liver. In addition to the pathological products of phlegm, dampness, and stagnation, there are people who think that it is related to the body's Qi and blood deficiency, liver dysregulation and loss of kidney water, and water that does not contain wood. In oriental medicine, it is mainly used to remove phlegm, remove dampness, promote blood circulation, remove blood stasis, soothe the liver, relieve depression, strengthen the spleen, and remove dampness to treat fatty liver. In addition, depending on the condition, it can lower heat, detoxify, accumulate bile, seduce the kidneys, and supply nutrients to the liver to replenish it.

Through years of research and practice summary, the present inventors have improved the original medicine for fatty liver treatment based on the traditional Chinese medicine theory and developed a new medicine for fatty liver treatment.

An object of the present invention is to provide a therapeutic agent for fatty liver, which is a herbal composition.

Another object of the present invention is to provide a method for preparing the above-mentioned fatty liver treatment agent. This method uses herbal medicine as raw material and is performed with modern pharmaceutical technology.

Another object of the present invention is to provide the use of the above-mentioned medicament in the treatment of fatty liver.

In the present invention, fried gardenia, hawthorn, turmeric, rhubarb, dandelion, licorice, etc. are prepared using rhizoma pinelliae as a main ingredient. manufactured using The composition ratio of the raw material is turmeric 20-60 parts by weight, hawthorn 20-60 parts by weight, dandelion 6-26 parts by weight, fried gardenia 60-100 parts by weight, rhubarb 4-44 parts by weight, licorice 20-60 parts by weight, Banha 44-84 parts by weight; Preferably, the composition ratio of the raw material is turmeric 40 parts by weight, hawthorn 40 parts by weight, dandelion 16 parts by weight, fried gardenia 80 parts by weight, rhubarb 24 parts by weight, licorice 40 parts by weight, banha 64 parts by weight.

In addition, according to the object of the present invention, the present invention provides a method for preparing a fatty liver treatment comprising the step of preparing a transparent ointment by mixing the raw materials in a ratio and granulating.

In a specific embodiment, the method for preparing the above-mentioned drug includes adding each raw material to water and decocting, preferably 3 times, combining the results, filtering, and concentrating the filtrate to obtain a clear ointment, and mixing it well with other medicinal excipients to prepare an oral preparation.

More specifically, the preparation method of the drug is as follows: each raw material is decocted in water three times for 3 hours, the second and third times for 2 hours, then the results are combined and filtered, and the filtrate is concentrated to make a clear ointment with 3 g of herbal medicine and a relative density of 1.20, and an appropriate amount of medicinal excipients are taken, mixed, granulated, and dried.

Another object of the present invention is to provide the use of the above-mentioned medicament in the treatment of fatty liver.

Fatty liver that can be treated by the fatty liver treatment agent of the present invention includes obesity fatty liver, alcoholic fatty liver, malnutrition fatty liver, diabetic fatty liver, pregnancy fatty liver, drug-induced fatty liver, and fatty liver caused by other diseases.

After conducting clinical medicine for a long time, we confirmed that when the pharmaceutical raw materials of the present invention are selected to form a drug, in particular, unexpected therapeutic effects occur when each raw material contains 40 parts by weight of turmeric, 40 parts by weight of hawthorn, 16 parts by weight of dandelion, 80 parts by weight of fried gardenia, 24 parts by weight of rhubarb, 40 parts by weight of licorice, and 64 parts by weight of Banha.

According to the theory of oriental medicine, the medicament of the present invention provides treatment according to syndrome differentiation and achieves excellent therapeutic effect.

In summary, western medicine for the treatment of fatty liver has been disclosed in the prior art, but so far there has been no report on the specific raw material ratio of the drug of the present invention, and the clinical therapeutic effect on the treatment of fatty liver of the drug prepared by selecting the raw material ratio of the present invention No one has disclosed.

embodiment

Example 1: Granules

40 g of turmeric, 40 g of hawthorn, 16 g of dandelion, 80 g of fried gardenia, 24 g of rhubarb, 40 g of licorice, and 64 g of Cheongbanha were weighed. They were decocted in water three times for 3, 2, and 2 hours, respectively. The decoction products were combined and filtered. The filtrate was concentrated to 1 g per 3 g of each raw material and to a relative density of 1.20 to make a clear ointment. White sugar and cyclodextrin were added in a 2:1:1 ratio to the clear ointment. The mixture was sufficiently and uniformly stirred, granulated according to the spray granulation method, dried, arranged, and packed to prepare granules.

Example 2: Tablets

Tablets were prepared by compressing the dry powder prepared by the method of the above example according to a conventional method.

Example 3: Capsule

The granules prepared by the method of the above example were packaged in gelatin capsules to prepare capsules.

Experiment 1: Quality standard study (granules)

[Appearance] This product is pale yellow granules.

Fried Gardenia: 10 g of this raw material was dissolved in 15 ml of water, extracted three times with ethyl acetate, 15 ml each time was taken, combined with ethyl acetate solution, concentrated to 2 ml, and used as a test solution. Separately, take 1 g of the fried gardenia control material, add 15 ml of water, ultrasonically extract for 30 minutes, filter, and extract the filtrate three times with ethyl acetate, take 15 ml each time, combine the ethyl acetate solution, and concentrate to 2 ml to obtain a control solution. According to the thin layer chromatography method, take 10 μl of each of the above two solutions and spot them on the same silica gel G thin layer plate. It was developed using ethyl acetate-chloroform-formic acid (6:4:2) as a developer, and then taken out and dried. A 5% vanillin sulfate test solution was sprayed and heated at 105° C. for about 5 minutes. In the chromatogram of the test solution, a spot of the same color appeared at the corresponding position in the chromatogram of the control solution.

Licorice: 10 g of this raw material was dissolved in 15 ml of water, extracted twice with petroleum ether, 10 ml each time, and ethyl acetate solution was combined and concentrated to make 2 ml of the test solution. For control, 0.5 g of licorice raw material was separately added to 10 ml of water, ultrasonically extracted for 30 minutes, filtered, and the filtrate was extracted twice with petroleum ether, 10 ml each time, and ethyl acetate solution was combined to make 2 ml and used as a control solution. According to the thin layer chromatography method, 5 μl of each of the above two solutions was taken and spotted on the same silica gel G thin layer plate. It was developed using chloroform-methanol-water (6:4:2) as a developer, taken out and dried. A 5% vanillin sulfate test solution was sprayed and heated at 105° C. for about 5 minutes. In the chromatogram of the test solution, a spot of the same color appeared at the corresponding position of the chromatogram of the control solution.

Experiment 2: Acute toxicity test (granules)

Experiment method: 30 Kunming mice, half male and half female, were bred at 5 mice per cage. The ambient temperature was 18±2° C. and the relative humidity was 70±5%. The mice were fed the granules and allowed to drink the drinking water ad libitum. According to the results of the preliminary experiment, the test drug was administered by gavage after 16 hours of fasting (without water intake) at a dose of 1.2g/20g of body weight once, once every 6 hours, and a total dose of 60g/kg twice consecutively. After administration, food and drink were allowed freely. On the day of administration, the animal's response was closely observed and recorded, and observed continuously once a day in the morning and afternoon for 7 days.

Test results: As a result of observation for 7 days after administration, no toxic reaction occurred.

CONCLUSIONS: The maximum tolerated dose of this granule for Kunming mice by gavage was 60 g/kg. It is equivalent to 100 times the amount consumed by humans.

Experiment 3: Observation of fatty liver treatment (granules)

From 2003 to 2007, 200 patients with fatty liver and hyperlipidemia were observed using the granules. The effect was significant. The mechanism involved in the prescription can promote qi, promote blood circulation, remove heat and promote moisture. With this granule and some supplements as a basic prescription, 100 patients with fatty liver diagnosed by B-ultrasound were treated, 90 were alleviated and 10 were ineffective. The effective rates of hyperlipidemia and atherosclerosis patients were 91.3% and 85.2%, respectively. Eighty-five of the remission cases were followed up for 1 to 2 years. Remission was slow in only 5 patients with fatty liver, and the rest showed significant improvement. In 50 out of 60 patients with hyperlipidemia, total cholesterol decreased by 16% and triglyceride by 30% after taking it for one year.

The above granules have a significant therapeutic effect on fatty liver and have no apparent effect on the normal functions of the heart, brain, liver, kidney and blood. They tend to improve on electrocardiograms and cerebral blood flow graphs. Therefore, it shows certain clinical advantages as a new fatty liver and blood lipid lowering agent.

Claims (5)

A treatment for fatty liver characterized in that it is prepared by extracting active ingredients from the following raw materials:
Turmeric 20-60 parts by weight, hawthorn 20-60 parts by weight, dandelion 6-26 parts by weight, fried gardenia 60-100 parts by weight, rhubarb 4-44 parts by weight, licorice 20-60 parts by weight, banha 44-84 parts by weight. According to claim 1,
A treatment for fatty liver characterized in that it is prepared by extracting active ingredients from the following raw materials:
Turmeric 40 parts by weight, hawthorn 40 parts by weight, dandelion 16 parts by weight, fried gardenia 80 parts by weight, rhubarb 24 parts by weight, licorice 40 parts by weight, banha 64 parts by weight. According to any one of claims 1 to 2,
A method for producing a therapeutic agent for fatty liver comprising mixing the raw materials in a ratio to prepare a clear ointment and granulating. According to claim 3,
A manufacturing method characterized in that each raw material is decocted in water, filtered, and the filtrate is concentrated to obtain a clear ointment, and mixed well with other pharmaceutical excipients to prepare an oral preparation. According to claim 4,
A manufacturing method characterized in that the raw materials are decocted three times with water.