KR20230109079A - Liquid crystal emulsion having an excellent effect on skin barrier improvement and skin moisturizing - Google Patents

Abstract

The present invention is arachidyl alcohol, behenyl alcohol, arachidyl glucoside, sorbitan sesquioleate, phytosterol, phytosphingosine, ceramide NP, octyldodecanol, cetearyl alcohol, glyceryl stearate, palmitic acid It relates to a liquid crystal emulsion composition with excellent liquid crystal formation by applying an emulsifier composition composed of stearic acid and myristic acid to an emulsion composition. there is.

Description

Liquid crystal emulsion having an excellent effect on skin barrier improvement and skin moisturizing {Liquid crystal emulsion having an excellent effect on skin barrier improvement and skin moisturizing}

The present invention relates to a liquid crystal emulsion composition having skin barrier improvement and skin moisturizing effect. Specifically, Arachidyl Alcohol, Behenyl Alcohol, Arachidyl Glucoside, Sorbitan Sesquioleate, Phytosterols, Phytosphingosine , Ceramide NP, Octyldodecanol, Cetearyl Alcohol, Glyceryl Stearate, Palmitic Acid, Stearic Acid, It relates to a liquid crystal emulsion composition having an excellent effect on skin barrier improvement and skin moisturizing by applying an emulsifier composition composed of myristic acid to an emulsion composition.

The skin is known as the largest organ of the human body. As the skin covers the body, it occupies the largest surface area of all organs. The skin is the first line of defense because it acts as a barrier tissue and forms a boundary that intruders cannot enter. The skin, which covers the outer surface of the body, serves an important defensive function. The epidermis protects the deeper tissue from excessive water loss, physical damage, and harmful chemicals.

In the stratum corneum, keratinocytes are flattened on the surface of the skin, and the nucleus is pushed to the edge of the cell, forming the stratum corneum. It is the thin outermost layer of the skin. Cells are flat, transparent and keratinized. It functions to prevent and protect the evaporation of moisture in the internal tissues.

When the skin becomes dry, scales appear and the surface becomes rough, which can cause discomfort due to dryness. In order to improve skin dryness, it is to supply and maintain moisture in the stratum corneum while minimizing water loss in the stratum corneum.

Liquid crystal cream can form a protective film on the skin and protect against moisture loss with a lamellar structure surrounding the dispersed particles in the emulsion. Similar to the skin lipid layer, it helps to improve the skin barrier function. The lamellar structure of the stratum corneum is a kind of multi-layered structure composed of phospholipids, in which an oil film and a dendritic film are sequentially stacked. The lamellar structure in the liquid crystal cream is very similar to the actual skin lipid layer, and due to this structure, the moisture of the skin can be protected. When a general cream is applied to the skin, moisture evaporates quickly and the moisturizing effect is reduced.

Publication No. 10-2019-0070644 (Emulsifier composition with excellent liquid crystal forming ability and cosmetic composition containing the same)

It aims to develop a liquid crystal emulsion composition.

It is an object of the present invention to provide a liquid crystal emulsified emulsion composition excellent in moisturizing and skin barrier improvement.

The purpose is to develop a liquid crystal emulsion composition composed of an optimal composition ratio for liquid crystal generation.

Therefore, Arachidyl Alcohol, Behenyl Alcohol, Arachidyl Glucoside, Sorbitan Sesquioleate, Phytosterols, Phytosphingosine, Ceramide Ceramide NP, Octyldodecanol, Cetearyl Alcohol, Glyceryl Stearate, Palmitic Acid, Stearic Acid, Myristic The purpose is to develop a liquid crystal emulsion composition that is excellent in moisturizing the skin and helps improve the skin barrier by applying an emulsifier composition composed of Myristic Acid in an optimal composition ratio to the emulsion composition.

In order to achieve the above object, the present invention provides a liquid crystal emulsion composition having excellent effects on skin barrier improvement and skin moisturizing.

In the present invention, arachidyl alcohol, behenyl alcohol, arachidyl glucoside, sorbitan sesquioleate, phytosterols, and phytos that form the liquid crystal structure Phytosphingosine, Ceramide NP, Octyldodecanol, Cetearyl Alcohol, Glyceryl Stearate, Palmitic Acid, Stearic Acid (Stearic Acid), an emulsifier composition consisting of myristic acid (Myristic Acid) is provided.

Arachidyl alcohol is a fatty alcohol having 20 carbon atoms obtained through hydrogenation of arachidic acid or arachidonic acid. It is used as a softening agent as a wax and helps to stabilize the emulsion.

Behenyl alcohol is a saturated higher alcohol with 22 carbon atoms obtained by fractionation and purification from reduced alcohol. It has high carbon number, high safety, and excellent emulsion stability. In addition, when added to an emulsion, it is used as a thickener of the emulsion because high viscosity is generated.

Arachidyl glucoside is a substance obtained from the condensation reaction of arachidyl alcohol and glucose. It helps to soften the skin softly and supplely, and helps to stabilize the emulsification of other ingredients that do not mix with each other in cosmetics.

Cetearyl alcohol is a mixture of fatty alcohols composed of cetyl and stearyl alcohol. It is used as a moisturizer by storing moisture in the skin, and helps to make the skin texture smooth and fine. It is also used as an emulsion stabilizer.

Glyceryl stearate is a mixture of glycerin and stearic acid that forms a protective barrier on the skin surface to prevent skin moisture loss and helps to stabilize the emulsion.

Palmitic acid is a saturated fatty acid with 16 carbon atoms widely distributed in nature as an oil and fat component of animals and plants. It forms a moisturizing film on the skin to help retain moisture, and is also used as an emulsifier and cleanser.

Stearic acid is a saturated higher fatty acid with 18 carbon atoms. As an ester with glycerol, it is widely contained in fats and oils and phospholipids of animal and vegetable systems, and is the most abundant fatty acid in nature. It helps to stabilize the emulsion and is also used as a detergent.

Myristic acid is a monobasic normal chain saturated fatty acid with 14 carbon atoms widely distributed in animal and vegetable oil fats in the form of glycerides. It is used as an antifoaming agent, cleaning agent, etc.

Sorbitan sesquioleate is composed of sorbitan or sorbide oleophosphoric acid diester, which helps in emulsification.

According to a preferred embodiment of the present invention, arachidyl alcohol (5 to 30% by weight), behenyl alcohol (3 to 20% by weight), arachidyl glucoside (1 to 10% by weight), sorbitances based on the total weight of the emulsifier composition Quioleate (1 to 10% by weight), phytosterol (1 to 5% by weight), phytosphingosine (0.1 to 1% by weight), ceramide NP (0.1 to 1% by weight), octyldodecanol (1 to 10 % by weight), cetearyl alcohol (5 to 50% by weight), glyceryl stearate (5 to 50% by weight), palmitic acid (1 to 30% by weight), stearic acid (1 to 20% by weight), It may include an emulsifier composition composed of myristic acid (0.1 to 1% by weight). The ratio of the emulsifier composition showing the best liquid crystal formation is arachidyl alcohol (27% by weight), behenyl alcohol (15% by weight), arachidyl glucoside (7% by weight), sorbitan sesquioleate (1% by weight) , Phytosterol (1% by weight), Phytosphingosine (0.1% by weight), Ceramide NP (0.1% by weight), Octyldodecanol (9.6% by weight), Cetearyl Alcohol (9.8% by weight), Glyceryl Stearate (19.6% by weight), palmitic acid (5.4% by weight), stearic acid (4.3% by weight), and myristic acid (0.1% by weight).

The emulsifier composition is used in an amount of 10% by weight based on the total weight of the liquid crystal emulsion composition.

The liquid crystal emulsion composition is butylene glycol, caprylic / capric triglyceride, isononyl isononanoate, hydroxyethyl acrylate / sodium Acryloyldimethyl Taurate Copolymer (Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer) and 1,2-hexanediol (1,2-Hexanediol) are additionally included.

The liquid crystal emulsion composition is effective in improving skin barrier and skin moisturizing.

The emulsifier composition of the present invention contains arachidyl alcohol, behenyl alcohol, arachidyl glucoside, sorbitan sesquioleate, phytosterol, phytosphingosine, ceramide NP, octyldodecanol, cetearyl alcohol, glyceryl stearate, Composed of palmitic acid, stearic acid, and myristic acid, it can be applied to an emulsion composition to create excellent liquid crystals. By applying the liquid crystal emulsion composition, there is an effect of improving the skin barrier and improving skin moisturizing.

Hereinafter, the present invention will be described in more detail through examples. Although the present invention is described in detail through preparation examples, examples and test examples, the present invention is not limited by these examples.

[Example]

Examples 1 to 6: Emulsifier composition

Emulsifier compositions were prepared according to the compositions of Examples 1 to 6 shown in Table 1 below.

Example One 2 3 4 5 6 One Arachidyl Alcohol 27 27.0 27.0 27.0 27.0 27.0 2 behenyl alcohol 15 15.0 15.0 15.0 15.0 15.0 3 arachidyl glucoside 7 7.0 7.0 7.0 7.0 7.0 4 Sorbitan Sesquioleate One 1.0 1.0 1.0 1.0 1.0 5 phytosterols One 1.0 1.0 1.0 1.0 1.0 6 phytosphingosine 0.1 0.1 0.1 0.1 0.1 0.1 7 Ceramide NP 0.1 0.1 0.1 0.1 0.1 0.1 8 Octyldodecanol 9.8 9.8 9.5 9.6 9.6 9.6 9 Cetearyl Alcohol 39.0 - - 19.6 9.8 9.8 10 Glyceryl Stearate - 39.0 - 9.8 19.6 9.8 11 Palmitic Acid - - 21.6 5.4 5.4 10.8 12 Stearic Acid - - 17.3 4.3 4.3 8.6 13 myristic acid - - 0.4 0.1 0.1 0.2

Examples 7 to 12: liquid crystal emulsion composition

Liquid crystal emulsion compositions in Table 2 below were prepared using the emulsifier compositions of Examples 1 to 6.

First, among the components shown in Table 2, components 1 to 3 were warmed to 75 ° C, component 4 was dispersed, and then components 5 to 12 were heated to 75 ° C, emulsified for 5 minutes at 3500 rpm using a HOMO MIXER, and cooled to 32 ° C. The liquid crystal emulsion composition was completed. The unit of content of each component is grams (g).

Example 7 8 9 10 11 12 One Purified water balance balance balance balance balance balance 2 Butylene Glycol 10 10 10 10 10 10 3 1,2-Hexanediol 2 2 2 2 2 2 4 Hydroxyethyl Acrylate/Sodium Acryloyl Dimethyl Taurate Copolymer 0.7 0.7 0.7 0.7 0.7 0.7 5 Example 1 10 - - - - - 6 Example 2 - 10 - - - - 7 Example 3 - - 10 - - - 8 Example 4 - - - 10 - - 9 Example 5 - - - - 10 - 10 Example 6 - - - - - 10 11 capric triglyceride 7.5 7.5 7.5 7.5 7.5 7.5 12 Isononylisononanoate 7.5 7.5 7.5 7.5 7.5 7.5

Experimental Example 1: Observation of liquid crystal formation

Example 7

Example 8

Example 9

Example 10

Example 11

Example 12

Experimental Example 2: Observation of temperature stability liquid crystal formation

The liquid crystal emulsion composition prepared in Examples 7 to 12 was examined for stability for 1 month at 20 ° C, 40 ° C, 50 ° C, cycle (25 ° C → 45 ° C → 25 ° C → -5 ° C) to observe the liquid crystal state shown in Table 3.

Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 20℃ 2 4 5 2 One 3 40℃ 2 4 6 2 One 5 50℃ 3 5 6 3 2 5 Cycle 3 4 6 2 One 5

* Evaluation standard

1: The frequency of the liquid crystal phase is excellent, and the particle size is uniform.

2: The frequency of the liquid crystal phase is good, and the size of the particles is uniform.

3: The frequency of the liquid crystal phase is good, and the size of the particles is non-uniform.

4: The frequency of the liquid crystal phase is insufficient. The particle size is uniform.

5: The frequency of the liquid crystal phase is insufficient. Particle size is non-uniform.

6: liquid crystal phase not visible

Experimental Example 3: Evaluation of transepidermal water loss (TEWL)

In the liquid crystal emulsion composition prepared in Examples 7 to 12, the liquid crystal formation of Example 11 was the most excellent, and the liquid crystal emulsion composition of Example 11 was applied to 12 adult subjects aged 20-50 for 2 weeks with a test product and a control product twice a day. After showering in the morning and evening, the skin was applied to the face, and the amount of transepidermal water loss was measured immediately after use, 4 days, and 2 weeks after use. The forehead and the center of the right cheek were measured using the Dermalab USB TEWL probe. Transepidermal water loss was analyzed using Dermalab USB dedicated analysis program .Application softwareversion 1.09. The measurement site of the human body application test subject was vertically contacted with the probe and measured three times while keeping it horizontal while the value was read. The average value was calculated and the transepidermal water loss before and after product use was comparatively evaluated and shown in Table 4 below

Dermalab USB TEWL Probe was applied to analyze transepidermal water loss. The analyzed TEWL value represents the loss of skin moisture, and the lower the value, the better the skin condition. As a result of the experiment, the amount of transepidermal water loss decreased in both test sites of the subjects of the human application test. As a result, it was confirmed that the amount of facial transepidermal water loss decreased.

In order to express the TEWL value for each day of product use as the improvement rate of transepidermal water loss by using the test product, it was calculated according to the formula below,

Improvement rate (%) = 100 - [initial skin TEWL value / first day TEWL value x 100]

The rate of improvement in transepidermal water loss was evaluated by comparing the initial skin value and the first day value of each product use, and is shown in Table 5 below.

In order to confirm the skin moisturizing improvement rate by using the test product in the test area, the initial skin value and the value of each day of use were compared. When the center of the right cheek was measured on the 11th day, the highest improvement rate was 25.09%, and the average value of the area was 17.04% on the 4th day and 24.91% on the 11th day. It was confirmed that there is efficacy.

visit center of forehead right ball center average visit 1 16.61±4.29 16.42±5.91 16.51 Visit 1 (immediately after use) 16.17±5.33 16.39±4.09 16.26 Visit 2 (4th day of use) 13.7±5.79 13.7±5.92 13.7 Visit 3 (Day 11 of use) 12.5±2.76 12.3±4.99 12.4

center of forehead right ball center average Visit 1 (early skin) - Visit 1 (immediately after use) 2.64 0.36 1.5 Visit 1 (early skin) - Visit 2 (4th day of use) 17.51 16.56 17.04 Visit 1 (early skin) - Visit 3 (Day 11 of use) 24.74 25.09 24.91

Experimental Example 4: Evaluation of skin moisturizing moisture content

In the liquid crystal emulsion composition prepared in Examples 7 to 12, the liquid crystal formation of Example 11 was the most excellent, and the liquid crystal emulsion composition of Example 11 was administered to 12 adult subjects aged 20-50 for 2 weeks with a test product and a control product 2 times a day. After using it on the face after taking a shower in the morning and evening, the skin moisturizing moisture content was measured immediately after use, 4 days, and 2 weeks after use. Skin moisture content was measured non-invasively using a Corneometer CM 825 of MPA 5. Coneometer is a device that measures the water content within 30~40um depth of the stratum corneum, and is expressed in Arbitra unit (AU). After each measurement, the probe surface was wiped with a soft tissue after each measurement, and the measurement was repeated three times per test site (forehead, right cheek center), and the average was shown in Table 6 below.

Moisture content was analyzed using Corneometer CM 825. The analyzed AU value represents the moisture content of the skin surface, and the higher the AU value, the better the skin condition. As a result of measuring the center of the forehead, the moisture content decreased slightly on the 11th day of product use compared to the initial skin, but as a result of comparing the average values of the two test sites of the subjects for the human application test according to the day of use, the moisture content increased on the 11th day of use compared to the initial skin did

visit center of forehead right ball center average visit 1 70.35±8.6 28.78±17.97 49.56 Visit 1 (immediately after use) 78.4±6.4 19.4±15.31 48.9 Visit 2 (4th day of use) 65.9±5.92 34.5±12.57 50.2 Visit 3 (Day 11 of use) 65.3±6.45 38.4±15.41 51.85

Experimental Example 5: Skin moisturizing satisfaction evaluation

In the liquid crystal emulsion composition prepared in Examples 7 to 12, the liquid crystal formation of Example 11 was the most excellent, and the liquid crystal emulsion composition of Example 11 was applied to 12 adult subjects aged 20-50 for 2 weeks with a test product and a control product twice a day. After taking a shower in the morning and evening, it was used on the area around the eyes, and satisfaction was evaluated immediately after use, 4 days, and 2 weeks after use. After using the test product, the human body application test subject was asked to answer the degree of skin moisturizing improvement felt by the human body application test subject on a 10-step scale of feeling very moisturizing (10) to bad (0). The researcher determined the efficacy of the test product by obtaining the percentage of the number of subjects for each answer, and shown in Table 7 below.

In the satisfaction evaluation conducted on the degree of satisfaction with improvement in skin moisturizing function after using the test product, the percentage of the number of test subjects who evaluated 'good' or higher (more than 7 points) for each answer was obtained. As a result of the evaluation, 91.7% of the respondents rated the control product as good in the category of 'moisturize without tightness', and 83.3% rated it as good in 'feeling soft'. In addition, 75% were satisfied with the maintenance of the moisturizing feeling, confirming that the test product was highly satisfied with the skin moisturizing function.

Satisfaction with performance improvement immediately after use healthy
It's a feeling. smoothed out
It's a feeling. without hesitation
Moist. moisturizing feeling
maintain. flexible
It's a feeling. test product 50.00% 50.00% 58.3% 66.7% 66.7% Satisfaction with function improvement on the 4th day of use healthy
It's a feeling. smoothed out
It's a feeling. without hesitation
Moist. moisturizing feeling
maintain. flexible
It's a feeling. test product 66.7% 66.7% 91.7% 75.0% 66.7% Satisfaction with function improvement on the 11th day of use healthy
It's a feeling. smoothed out
It's a feeling. without hesitation
Moist. moisturizing feeling
maintain. flexible
It's a feeling. test product 66.7% 66.7% 83.3% 75.0% 83.3%

Claims (2)

Arachidyl alcohol (5 to 30% by weight), behenyl alcohol (3 to 20% by weight), arachidyl glucoside (1 to 10% by weight), sorbitan sesquioleate (1 to 10% by weight), phytosterol (1 to 5% by weight), phytosphingosine (0.1 to 1% by weight), ceramide NP (0.1 to 1% by weight), octyldodecanol (1 to 10% by weight), cetearyl alcohol (5 to 50% by weight) ), glyceryl stearate (5 to 50% by weight), palmitic acid (1 to 30% by weight), stearic acid (1 to 20% by weight), emulsifier composition consisting of myristic acid (0.1 to 1% by weight) A liquid crystal emulsion composition comprising 10% of the total weight. The liquid crystal emulsion composition according to claim 1, which is characterized in that it is effective in improving skin barrier and skin moisturizing.