KR20230106646A - 고형 암을 치료하기 위한 조성물 및 방법 - Google Patents

고형 암을 치료하기 위한 조성물 및 방법 Download PDF

Info

Publication number
KR20230106646A
KR20230106646A KR1020237019076A KR20237019076A KR20230106646A KR 20230106646 A KR20230106646 A KR 20230106646A KR 1020237019076 A KR1020237019076 A KR 1020237019076A KR 20237019076 A KR20237019076 A KR 20237019076A KR 20230106646 A KR20230106646 A KR 20230106646A
Authority
KR
South Korea
Prior art keywords
cancer
peroxide
oxidase
haloperoxidase
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237019076A
Other languages
English (en)
Korean (ko)
Inventor
로버트 씨. 알렌
주니어 잭슨 티. 스티븐스
Original Assignee
엑스옥세미스 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엑스옥세미스 인코퍼레이티드 filed Critical 엑스옥세미스 인코퍼레이티드
Publication of KR20230106646A publication Critical patent/KR20230106646A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/0101—Chloride peroxidase (1.11.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/02—Oxidoreductases acting on a peroxide as acceptor (1.11) with H2O2 as acceptor, one oxygen atom of which is incorporated into the product (1.11.2)
    • C12Y111/02002—Myeloperoxidase (1.11.2.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020237019076A 2020-11-11 2021-10-01 고형 암을 치료하기 위한 조성물 및 방법 Pending KR20230106646A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063112447P 2020-11-11 2020-11-11
US63/112,447 2020-11-11
PCT/US2021/053155 WO2022103515A1 (en) 2020-11-11 2021-10-01 Compositions and methods for treating solid cancer

Publications (1)

Publication Number Publication Date
KR20230106646A true KR20230106646A (ko) 2023-07-13

Family

ID=81601629

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237019076A Pending KR20230106646A (ko) 2020-11-11 2021-10-01 고형 암을 치료하기 위한 조성물 및 방법

Country Status (10)

Country Link
US (1) US20230398190A1 (https=)
EP (1) EP4243835A4 (https=)
JP (1) JP2023548406A (https=)
KR (1) KR20230106646A (https=)
CN (1) CN116710121A (https=)
AU (1) AU2021379542A1 (https=)
CA (1) CA3196357A1 (https=)
IL (1) IL302683A (https=)
MX (1) MX2023005171A (https=)
WO (1) WO2022103515A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250332226A1 (en) * 2022-04-13 2025-10-30 Exoxemis, Inc. Compositions and methods for treating solid cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486408A (en) * 1981-04-07 1984-12-04 Kiel Johnathan L Insoluble crosslinked cytotoxic oxidase-peroxidase system
WO2007103525A2 (en) * 2006-03-09 2007-09-13 Glanbia Nutritionals (Ireland) Limited Cationic whey protein composition
WO2013009910A2 (en) * 2011-07-11 2013-01-17 Exoxemis, Inc. Eosinophil peroxidase compositions and methods of their use
EP4548978A3 (en) * 2015-01-29 2025-08-06 Oxyrase, Inc. Methods for inhibiting tumor growth
US10213448B2 (en) * 2016-03-25 2019-02-26 Novazoi Theranostics Ethanolamine-based lipid biosynthetic compounds, method of making and use thereof
US20190271703A1 (en) * 2016-10-26 2019-09-05 Duke University Biomarkers and treatments for metastatic cancer

Also Published As

Publication number Publication date
US20230398190A1 (en) 2023-12-14
WO2022103515A1 (en) 2022-05-19
CA3196357A1 (en) 2022-05-19
EP4243835A1 (en) 2023-09-20
AU2021379542A1 (en) 2023-06-08
JP2023548406A (ja) 2023-11-16
IL302683A (en) 2023-07-01
AU2021379542A9 (en) 2024-09-05
MX2023005171A (es) 2023-06-26
EP4243835A4 (en) 2024-08-28
CN116710121A (zh) 2023-09-05

Similar Documents

Publication Publication Date Title
KR20080108996A (ko) 셀룰라이트 치료용 아교질분해효소
US20100178273A1 (en) Methods and compositions for treating mucositis
CN103764137A (zh) 嗜伊红粒细胞过氧化物酶组合物和它们的使用方法
KR20230106646A (ko) 고형 암을 치료하기 위한 조성물 및 방법
EP3442564B1 (en) Composition of proenzymes for cancer treatment
JP4891083B2 (ja) Ｅｃｓｏｄ及び細胞侵透性ｅｃｓｏｄとこれらの用途
JP3980088B2 (ja) 傷治癒を改善するプラスミノーゲン活性化因子からなる製剤の使用
US20250332226A1 (en) Compositions and methods for treating solid cancer
US5756091A (en) Method of treating tumour cells using catalase
WO2019099559A1 (en) Nuclear-targeted dna repair enzymes and methods of use
JP2006505290A (ja) 抗酸化医薬化合物、ポリペプチドの産生方法、治療方法
US6984619B1 (en) Method for protection against tumor metastasis formation
HK40098212A (zh) 用於治疗实体癌的组合物和方法
US20250127845A1 (en) Medicinal uses of oligopeptides in combination with an antiandrogen
CN102485272A (zh) 重组人Prx-6蛋白在治疗烧烫伤方面的用途
WO2009149201A1 (en) Methods of treatment for pulmonary fibrosis
JP3227673B2 (ja) 膵炎予防治療薬
US20130071375A1 (en) Compositions and methods for treating inflammation
EP0747477A4 (en) TRICHODERMA HARZIEANUM RIFAI STEM, METHOD FOR RECEIVING L-LYSINE-ALPHA-OXIDASE AS A VIRAL AND BACTERIAL ACTIVITY INHIBITOR, IMMUNOMODULATOR AND SKIN HEALING AGENT
CN105477627B (zh) 治疗前列腺癌的组合物及其用途
EP3373956B1 (en) Proenzyme composition
WO2002040498A2 (en) Reduction of antioxidant enzyme levels in tumor cells using antisense oligonucleotides
JPH03204818A (ja) ヒトａｄｆを含有する医薬組成物
CA2525672A1 (en) Use of peroxovanadium compounds as tumour cell growth suppressor
Bennett Defining a role for Xanthine oxidoreductase in promoting the healing of chronic ulcers

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20230607

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20240904

Comment text: Request for Examination of Application