KR20230092906A - 신규한 cxcr4 표적화 화합물 - Google Patents

신규한 cxcr4 표적화 화합물 Download PDF

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Publication number
KR20230092906A
KR20230092906A KR1020237013276A KR20237013276A KR20230092906A KR 20230092906 A KR20230092906 A KR 20230092906A KR 1020237013276 A KR1020237013276 A KR 1020237013276A KR 20237013276 A KR20237013276 A KR 20237013276A KR 20230092906 A KR20230092906 A KR 20230092906A
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South Korea
Prior art keywords
residue
forms
compound
moiety
independently
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Pending
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KR1020237013276A
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English (en)
Korean (ko)
Inventor
프랑수아 베르나르
궈-시안 린
젱싱 장
다니엘 권
데이비드 페린
미하일로 토도로비치
제롬 로자다
리 리 리
Original Assignee
프로빈셜 헬스 서비시즈 오쏘리티
더 유니버시티 오브 브리티시 콜롬비아
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Application filed by 프로빈셜 헬스 서비시즈 오쏘리티, 더 유니버시티 오브 브리티시 콜롬비아 filed Critical 프로빈셜 헬스 서비시즈 오쏘리티
Publication of KR20230092906A publication Critical patent/KR20230092906A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020237013276A 2020-10-21 2021-10-21 신규한 cxcr4 표적화 화합물 Pending KR20230092906A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063094839P 2020-10-21 2020-10-21
US63/094,839 2020-10-21
PCT/CA2021/051486 WO2022082312A1 (en) 2020-10-21 2021-10-21 Novel cxcr4-targeting compounds

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KR20230092906A true KR20230092906A (ko) 2023-06-26

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KR1020237013276A Pending KR20230092906A (ko) 2020-10-21 2021-10-21 신규한 cxcr4 표적화 화합물

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Country Link
US (1) US20240100203A1 (https=)
EP (1) EP4232459A4 (https=)
JP (1) JP2023549469A (https=)
KR (1) KR20230092906A (https=)
CN (1) CN116457028A (https=)
AU (1) AU2021366975A1 (https=)
CA (1) CA3194483A1 (https=)
IL (1) IL301342A (https=)
WO (1) WO2022082312A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4511384A1 (en) * 2022-04-20 2025-02-26 Provincial Health Services Authority Cxcr4-targeting compounds, and methods of making and using the same
US12614326B2 (en) * 2023-05-03 2026-04-28 GE Precision Healthcare LLC Methods and systems for scatter and tailing correction
US12514939B2 (en) 2024-02-14 2026-01-06 Alpha-9 Oncology, Inc. Stable radiopharmaceutical compositions and uses thereof
WO2025171492A1 (en) * 2024-02-14 2025-08-21 Alpha-9 Oncology Inc. Stable radiopharmaceutical compositions and uses thereof
WO2025218761A1 (zh) * 2024-04-17 2025-10-23 晶核生物医药科技(上海)有限公司 环状肽类化合物、其药物组合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006035705A1 (de) * 2006-08-01 2008-02-07 Robert Bosch Gmbh Kolben einer Fahrzeugbremsanlagen-Kolbenpumpe
EP2377579A1 (en) * 2007-05-30 2011-10-19 Eli Lilly and Company Cyclic peptide CXCR4 antagonists
CN113150068B (zh) * 2017-09-20 2023-04-04 尚华医药科技(江西)有限公司 一种肽类化合物、其应用及含其的组合物
JP2021165234A (ja) * 2018-07-03 2021-10-14 富士フイルム富山化学株式会社 Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体
US20220218852A1 (en) * 2019-04-18 2022-07-14 Provincial Health Services Authority Novel radiolabelled cxcr4-targeting compounds for diagnosis and therapy

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Publication number Publication date
US20240342321A1 (en) 2024-10-17
US20240100203A1 (en) 2024-03-28
EP4232459A4 (en) 2024-12-04
JP2023549469A (ja) 2023-11-27
CN116457028A (zh) 2023-07-18
EP4232459A1 (en) 2023-08-30
WO2022082312A1 (en) 2022-04-28
AU2021366975A1 (en) 2023-04-13
IL301342A (en) 2023-05-01
CA3194483A1 (en) 2022-04-28

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