KR20230090187A - Pharmaceutical composite formulation for treating vascular dementia with alzheimer's disease - Google Patents

Pharmaceutical composite formulation for treating vascular dementia with alzheimer's disease Download PDF

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KR20230090187A
KR20230090187A KR1020210179215A KR20210179215A KR20230090187A KR 20230090187 A KR20230090187 A KR 20230090187A KR 1020210179215 A KR1020210179215 A KR 1020210179215A KR 20210179215 A KR20210179215 A KR 20210179215A KR 20230090187 A KR20230090187 A KR 20230090187A
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South Korea
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vascular dementia
disease
alzheimer
components
double tablet
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KR1020210179215A
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Korean (ko)
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나도현
강경표
전진환
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메디케어제약 주식회사
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Publication of KR20230090187A publication Critical patent/KR20230090187A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 치료하는 도네페질(donepezil) 및 황련해독탕(黃連解毒湯) 성분을 포함하는 약제학적 복합제제에 관한 것이다.
본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 치료하는 경우, 각 성분의 제제를 개별적으로 복용해야 하는 번거로움과 약가 상승에 따른 경제적 비용 부담이 발생하는 문제점을 해결한다.
본 발명은 1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 알츠하이머병(Alzheimer's Disease)을 치료하기 위해 도네페질(donepezil) 성분을 포함하는 이중정, 1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 혈관성 치매(Vascular Dementia)를 치료하기 위해 황련해독탕(黃連解毒湯) 성분을 포함하는 이중정으로 구성된다.
본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 2종의 성분으로 복합 구성된 1개의 이중정으로 치료함으로써, 복용의 편의성과 경제적 효율성이 개선된 새로운 약제학적 복합제제 제공의 효과를 가진다.The present invention relates to a pharmaceutical combination preparation containing donepezil and hwangryeonhaedok-tang components for treating vascular dementia accompanied by Alzheimer's disease.
In the case of treating Vascular Dementia accompanied by Alzheimer's Disease, the present invention solves the problem of the burden of economic cost due to the increase in drug price and the hassle of taking formulations of each component individually .
The present invention is a double tablet containing donepezil component to treat Alzheimer's disease among the two components constituting a double tablet as one therapeutic agent, and two components comprising a double tablet as one therapeutic agent It consists of a double tablet containing a component of Hwangryeonhaedoktang (黃連解毒湯) to treat vascular dementia (Vascular Dementia) among the species' components.
The present invention treats Vascular Dementia accompanied by Alzheimer's Disease with one double tablet composed of two components, thereby providing a new pharmaceutical combination formulation with improved convenience and economic efficiency. have

Description

알츠하이머병을 동반한 혈관성 치매를 치료하는 약제학적 복합제제 {Pharmaceutical composite formulation for treating vascular dementia with alzheimer's disease}Pharmaceutical composite formulation for treating vascular dementia with alzheimer's disease}

본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 치료하는 도네페질(donepezil) 및 황련해독탕(黃連解毒湯) 성분을 포함하는 약제학적 복합제제에 관한 것이다.The present invention relates to a pharmaceutical combination preparation containing donepezil and hwangryeonhaedok-tang components for treating vascular dementia accompanied by Alzheimer's disease.

일반적으로 알츠하이머병(Alzheimer's Disease)은 도네페질(donepezil) 성분의 제제로 치료하고, In general, Alzheimer's Disease is treated with preparations containing donepezil,

혈관성 치매(Vascular Dementia)의 치료는 황련해독탕(黃連解毒湯) 성분의 제제로 치료한다.The treatment of Vascular Dementia is treated with preparations containing Hwangryeon Haedok-tang (黃連解毒湯).

알츠하이머병(Alzheimer's Disease)을 치료하기 위해 도네페질(donepezil) 성분의 제제는 1일 2회 정도 복용하고,To treat Alzheimer's Disease, preparations containing donepezil are taken twice a day,

혈관성 치매(Vascular Dementia)를 치료하기 위해 황련해독탕(黃連解毒湯) 성분의 제제는 1일 3회 정도 복용한다.In order to treat Vascular Dementia, preparations containing Hwangnyeon Haedok-tang (黃連解毒湯) are taken three times a day.

대한민국 특허 공개 제1020030027945호Korean Patent Publication No. 1020030027945

본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 치료하는 경우,When the present invention treats Vascular Dementia accompanied by Alzheimer's Disease,

각 성분의 제제를 개별적으로 복용해야 하는 번거로움과 약가 상승에 따른 경제적 비용 부담이 발생하는 문제점을 해결한다.It solves the problem of the inconvenience of taking each ingredient individually and the economic cost burden caused by the increase in drug prices.

본 발명은 1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 알츠하이머병(Alzheimer's Disease)을 치료하기 위해 도네페질(donepezil) 성분을 포함하는 이중정,The present invention is a double tablet containing a donepezil component to treat Alzheimer's disease among the two components constituting the double tablet as one therapeutic agent;

1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 혈관성 치매(Vascular Dementia)를 치료하기 위해 황련해독탕(黃連解毒湯) 성분을 포함하는 이중정으로 구성된다.Among the two ingredients that make up the double tablet as one therapeutic agent, it is composed of a double tablet containing the ingredient of Hwangnyeon Haedok-tang (黃連解毒湯) to treat vascular dementia.

본 발명은 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 2종의 성분으로 복합 구성된 1개의 이중정으로 치료함으로써,The present invention treats Vascular Dementia accompanied by Alzheimer's Disease with one double tablet composed of two components,

복용의 편의성과 경제적 효율성이 개선된 새로운 약제학적 복합제제 제공의 효과를 가진다.It has the effect of providing a new pharmaceutical combination preparation with improved ease of administration and economic efficiency.

도 1 : 본 발명의 상세도Figure 1 : Detailed view of the present invention

본 발명은 1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 알츠하이머병(Alzheimer's Disease)을 치료하기 위해 도네페질(donepezil) 성분을 포함하는 이중정(100),The present invention is a double tablet (100) containing a donepezil component to treat Alzheimer's disease among the two components constituting the double tablet as one therapeutic agent;

1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 혈관성 치매(Vascular Dementia)를 치료하기 위해 황련해독탕(黃連解毒湯) 성분을 포함하는 이중정(200)으로 구성된다.It consists of a double tablet (200) containing a component of Hwangnyeon Haedok-tang (黃連解毒湯) to treat vascular dementia (Vascular Dementia) among the two components that make up the double tablet as one therapeutic agent.

100. 도네페질(donepezil) 성분을 포함하는 이중정(100),
200. 황련해독탕(黃連解毒湯) 성분을 포함하는 이중정(200)100. Double tablet (100) containing donepezil ingredient,
200. Double tablets (200) containing the ingredients of Hwangnyeon Haedoktang (黃連解毒湯)

Claims (1)

1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 알츠하이머병(Alzheimer's Disease)을 치료하기 위해 도네페질(donepezil) 성분을 포함하는 이중정, 1개의 치료제로 이중정을 복합 구성하고 있는 2종의 성분 중에서 혈관성 치매(Vascular Dementia)를 치료하기 위해 황련해독탕(黃連解毒湯) 성분을 포함하는 이중정으로 구성되어, 알츠하이머병(Alzheimer's Disease)을 동반한 혈관성 치매(Vascular Dementia)를 치료하는 도네페질(donepezil) 및 황련해독탕(黃連解毒湯) 성분을 포함하는 약제학적 복합제제Among the two ingredients that make up the double tablet as one treatment, the double tablet containing donepezil to treat Alzheimer's Disease, and the two ingredients that make up the double tablet as one treatment Among them, it is composed of double tablets containing Hwangryeon Haedok-tang to treat Vascular Dementia, and donepezil to treat Vascular Dementia accompanied by Alzheimer's Disease. ) and a pharmaceutical combination formulation containing Huangnyeon Haedoktang (黃連解毒湯) ingredients
KR1020210179215A 2021-12-14 2021-12-14 Pharmaceutical composite formulation for treating vascular dementia with alzheimer's disease KR20230090187A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030027945A (en) 2000-09-01 2003-04-07 에자이 가부시키가이샤 1-benzyl-4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030027945A (en) 2000-09-01 2003-04-07 에자이 가부시키가이샤 1-benzyl-4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine

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